A sialidase-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3R4]
EC 3.2.1.18;
Cytosolic sialidase;
N-acetyl-alpha-neuraminidase 2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| danthron | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| emodin | Homo sapiens (human) | IC50 | 760.0000 | 1 | 1 |
| rhein | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| zanamivir | Homo sapiens (human) | IC50 | 9.7922 | 9 | 8 |
| zanamivir | Homo sapiens (human) | Ki | 8.5250 | 4 | 3 |
| oseltamivir | Homo sapiens (human) | IC50 | 2,333.3333 | 3 | 3 |
| 2-deoxy-2,3-dehydro-n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 43.6786 | 14 | 13 |
| 2-deoxy-2,3-dehydro-n-acetylneuraminic acid | Homo sapiens (human) | Ki | 40.8333 | 6 | 5 |
| 9,10-anthraquinone 2-carboxylic acid | Homo sapiens (human) | IC50 | 800.0000 | 1 | 1 |
| 5-hydroxyflavone | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| (-)-catechin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| sakuranetin | Homo sapiens (human) | IC50 | 890.0000 | 1 | 1 |
| bcx 1812 | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| bcx 1812 | Homo sapiens (human) | Ki | 193.0000 | 2 | 2 |
| n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| 4-amino-2-deoxy-2,3-didehydro-n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 44.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 160.0000 | 1 | 1 |
| acacetin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 570.0000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 230.0000 | 1 | 1 |
| genistein | Homo sapiens (human) | IC50 | 380.0000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| chrysin | Homo sapiens (human) | IC50 | 890.0000 | 1 | 1 |
| genkwanin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| scutellarein | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| tricetin | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| 4',7-dihydroxyflavone | Homo sapiens (human) | IC50 | 470.0000 | 1 | 1 |
| 5,7,2'-trihydroxyflavone | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| exo-alpha-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. [EC:3.2.1.18] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| exo-alpha-(2->3)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
| exo-alpha-(2->6)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
| exo-alpha-(2->8)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| catalytic complex | cellular component | A protein complex which is capable of catalytic activity. [GOC:bhm, GOC:TermGenie, PMID:8077207] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| glycoprotein catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732] |
| ganglioside catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. [ISBN:0198547684] |
| oligosaccharide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732] |
| glycosphingolipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198506732] |