Proteins > Polyunsaturated fatty acid lipoxygenase ALOX15
Page last updated: 2024-08-07 16:01:23
Polyunsaturated fatty acid lipoxygenase ALOX15
A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16050]
Synonyms
12/15-lipoxygenase;
Arachidonate 12-lipoxygenase, leukocyte-type;
12-LOX;
1.13.11.31;
Arachidonate 15-lipoxygenase;
15-LOX;
15-LOX-1;
1.13.11.33;
Arachidonate omega-6 lipoxygenase;
Hepoxilin A3 synthase Alox15;
1.1
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 16 (55.17) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
Compounds (60)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| chloroxine | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| hexylresorcinol | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| masoprocol | Homo sapiens (human) | IC50 | 1.5114 | 7 | 7 |
| probucol | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| tetrabromobisphenol a | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| phenidone | Homo sapiens (human) | IC50 | 1.3100 | 2 | 2 |
| 2-bromophenol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4-bromophenol | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| indolizine | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| indolizine | Homo sapiens (human) | Ki | 25.0000 | 1 | 1 |
| 3-hydroxyflavone | Homo sapiens (human) | IC50 | 73.0000 | 1 | 1 |
| 3-bromophenol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 2,6-dibromophenol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 2,4-dibromophenol | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| zileuton | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| 6-hydroxyflavone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| puupehenone | Homo sapiens (human) | IC50 | 3.3800 | 2 | 2 |
| l 656224 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| moracin c | Homo sapiens (human) | IC50 | 1.2100 | 1 | 1 |
| pd 146176 | Homo sapiens (human) | IC50 | 0.8100 | 1 | 1 |
| pd 146176 | Homo sapiens (human) | Ki | 3.8100 | 2 | 2 |
| boswellic acid | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| 2-(4-chlorophenyl)-5-(methylamino)-4-oxazolecarbonitrile | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| 3,6-dihydroxyflavone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| aurapten | Homo sapiens (human) | IC50 | 23.9000 | 1 | 1 |
| umbelliprenin | Homo sapiens (human) | IC50 | 16.7000 | 1 | 1 |
| 4-fluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0100 | 2 | 2 |
| 4-methoxybenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0100 | 1 | 1 |
| 4-bromobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0100 | 1 | 1 |
| 2-benzofurancarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| 3,5-dibromo-2-(2,4-dibromophenoxy)phenol | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]-2-butyn-1-ol | Homo sapiens (human) | Ki | 3.5000 | 1 | 1 |
| 1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 4-chlorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0100 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 15-keto-5,8,11,13-eicosatetraenoic acid | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 33.1800 | 2 | 5 |
| baicalein | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| fisetin | Homo sapiens (human) | IC50 | 1.4000 | 1 | 1 |
| mangostin | Homo sapiens (human) | IC50 | 26.5500 | 2 | 2 |
| daidzein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 2 |
| caffeic acid phenethyl ester | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| 7-hydroxyflavone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 5-oxo-6,8,11,14-eicosatetraenoic acid | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| 6,7,4'-trihydroxyisoflavone | Homo sapiens (human) | IC50 | 49.0000 | 1 | 1 |
| 7-hydroxyisoflavone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 2 |
| 3,7-dihydroxyflavone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 13-oxo-9,11-octadecadienoic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| dysidenin | Homo sapiens (human) | Ki | 8.0000 | 1 | 1 |
| jaspaquinol | Homo sapiens (human) | IC50 | 9.6500 | 2 | 2 |
| halisulfate 1 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| N-[4-cyano-2-(1-naphthalenyl)-5-oxazolyl]acetamide | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 5-amino-2-(1-naphthalenyl)-4-oxazolecarbonitrile | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| 4-(dimethylamino)benzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| 2-methoxybenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.4700 | 1 | 1 |
| 2-naphthalenecarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | IC50 | 5.6314 | 9 | 9 |
| 2-naphthalenecarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0220 | 1 | 1 |
| 1H-imidazole-5-carboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 3.4567 | 3 | 3 |
| 1H-indole-4-carboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester | Homo sapiens (human) | Ki | 0.0760 | 1 | 1 |
| N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide | Homo sapiens (human) | IC50 | 65.0000 | 1 | 2 |
| ML355 | Homo sapiens (human) | IC50 | 9.7000 | 1 | 1 |
Drugs with Other Measurements
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.Journal of medicinal chemistry, , May-22, Volume: 57, Issue:10, 2014
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.Journal of medicinal chemistry, , Aug-11, Volume: 54, Issue:15, 2011
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.Journal of natural products, , Volume: 72, Issue:10, 2009
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 17, Issue:14, 2007
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.Journal of natural products, , Volume: 66, Issue:2, 2003
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.Journal of medicinal chemistry, , Jun-06, Volume: 45, Issue:12, 2002
A facile synthesis of 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, a selective 15-lipoxygenase inhibitor.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.Journal of natural products, , Volume: 72, Issue:10, 2009
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.Journal of natural products, , Volume: 66, Issue:2, 2003
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
A potent and selective inhibitor targeting human and murine 12/15-LOX.Bioorganic & medicinal chemistry, , Mar-15, Volume: 24, Issue:6, 2016
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.Journal of medicinal chemistry, , Oct-08, Volume: 58, Issue:19, 2015
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.Journal of medicinal chemistry, , Oct-08, Volume: 58, Issue:19, 2015
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.Journal of medicinal chemistry, , Oct-28, Volume: 53, Issue:20, 2010
In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases.Chemical biology & drug design, , Volume: 82, Issue:3, 2013
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.Journal of medicinal chemistry, , Aug-11, Volume: 54, Issue:15, 2011
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.Journal of natural products, , Volume: 72, Issue:10, 2009
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.Journal of natural products, , Volume: 66, Issue:2, 2003
Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency.Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.Journal of medicinal chemistry, , Oct-28, Volume: 53, Issue:20, 2010
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| arachidonate 12(S)-lipoxygenase activity | molecular function | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. [EC:1.13.11.31, RHEA:10428] |
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| phosphatidylinositol-4,5-bisphosphate binding | molecular function | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. [GOC:bf, GOC:jl] |
| linoleate 13S-lipoxygenase activity | molecular function | Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. [EC:1.13.11.12, GOC:lb] |
| arachidonate 15-lipoxygenase activity | molecular function | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. [EC:1.13.11.33] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cytoplasmic side of plasma membrane | cellular component | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 25 target(s):
| Target | Category | Definition |
|---|
| ossification | biological process | The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:mtg_mpo, PMID:17572649] |
| negative regulation of adaptive immune response | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. [GOC:add] |
| lipid metabolic process | biological process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma] |
| phosphatidylethanolamine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| positive regulation of cell-substrate adhesion | biological process | Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb] |
| arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
| lipoxygenase pathway | biological process | The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. [GOC:mah, PMID:17163881] |
| fatty acid oxidation | biological process | The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. [ISBN:0198506732, MetaCyc:FAO-PWY] |
| bone mineralization | biological process | The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354] |
| positive regulation of actin filament polymerization | biological process | Any process that activates or increases the frequency, rate or extent of actin polymerization. [GOC:mah] |
| response to endoplasmic reticulum stress | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:cjm, GOC:mah] |
| regulation of peroxisome proliferator activated receptor signaling pathway | biological process | Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. [GOC:bf] |
| cellular response to interleukin-13 | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. [GOC:sjw, PMID:20100461] |
| wound healing | biological process | The series of events that restore integrity to a damaged tissue, following an injury. [GOC:bf, PMID:15269788] |
| long-chain fatty acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [PMID:18390550] |
| apoptotic cell clearance | biological process | The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. [GOC:rk, PMID:14685684] |
| linoleic acid metabolic process | biological process | The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. [Wikipedia:Linoleic_Acid] |
| regulation of inflammatory response | biological process | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai] |
| hepoxilin biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. [GOC:ai] |
| positive regulation of ERK1 and ERK2 cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| cellular response to calcium ion | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:mah] |
| regulation of engulfment of apoptotic cell | biological process | Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell. [GO:kmv, GOC:TermGenie, PMID:19402756] |
| lipoxin A4 biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. [GOC:mw] |
| lipid oxidation | biological process | The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. [GOC:BHF, GOC:mah] |