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Alpha-1A adrenergic receptor
An alpha-1A adrenergic receptor that is encoded in the genome of rabbit. [OMA:O02824, PRO:DNx]
Synonyms
Alpha-1A adrenoreceptor;
Alpha-1A adrenoceptor;
Alpha-1C adrenergic receptor
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (19)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| alfuzosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0100 | 1 | 1 |
| doxazosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0032 | 1 | 1 |
| prazosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0002 | 1 | 1 |
| terazosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0398 | 1 | 1 |
| 5-methylurapidil | Oryctolagus cuniculus (rabbit) | Ki | 0.0006 | 1 | 1 |
| wb 4101 | Oryctolagus cuniculus (rabbit) | Ki | 0.0002 | 1 | 1 |
| indoramin | Oryctolagus cuniculus (rabbit) | Ki | 0.0040 | 1 | 1 |
| sk&f 104856 | Oryctolagus cuniculus (rabbit) | Ki | 0.0251 | 1 | 1 |
| tamsulosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0021 | 1 | 2 |
| cyclazosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0251 | 1 | 1 |
| rec 15-2739 | Oryctolagus cuniculus (rabbit) | Ki | 0.0010 | 1 | 1 |
| bmy 7378 | Oryctolagus cuniculus (rabbit) | Ki | 0.2512 | 1 | 1 |
| rs 17053 | Oryctolagus cuniculus (rabbit) | Ki | 0.0006 | 1 | 1 |
| silodosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0000 | 1 | 1 |
| dexniguldipine | Oryctolagus cuniculus (rabbit) | Ki | 0.0002 | 1 | 2 |
| ro 70-0004 | Oryctolagus cuniculus (rabbit) | Ki | 0.0010 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| prazosin | Oryctolagus cuniculus (rabbit) | Kd | 0.0050 | 1 | 1 |
| terazosin | Oryctolagus cuniculus (rabbit) | Kd | 0.0200 | 1 | 1 |
| 5-methylurapidil | Oryctolagus cuniculus (rabbit) | Kd | 0.0040 | 1 | 1 |
| phentolamine | Oryctolagus cuniculus (rabbit) | Kd | 0.0063 | 1 | 1 |
| tamsulosin | Oryctolagus cuniculus (rabbit) | Kd | 0.0002 | 1 | 1 |
| rs 17053 | Oryctolagus cuniculus (rabbit) | Kd | 0.0501 | 1 | 1 |
| abt 866 | Oryctolagus cuniculus (rabbit) | EC50 | 0.3300 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bmy 7378 | Oryctolagus cuniculus (rabbit) | Kb | 1.4500 | 1 | 1 |
N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.Journal of medicinal chemistry, , Aug-15, Volume: 40, Issue:17, 1997
Pharmacological options in the treatment of benign prostatic hyperplasia.Journal of medicinal chemistry, , Apr-25, Volume: 40, Issue:9, 1997
N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.Journal of medicinal chemistry, , Aug-15, Volume: 40, Issue:17, 1997
Pharmacological options in the treatment of benign prostatic hyperplasia.Journal of medicinal chemistry, , Apr-25, Volume: 40, Issue:9, 1997
N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.Journal of medicinal chemistry, , Aug-15, Volume: 40, Issue:17, 1997
Pharmacological options in the treatment of benign prostatic hyperplasia.Journal of medicinal chemistry, , Apr-25, Volume: 40, Issue:9, 1997
N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.Journal of medicinal chemistry, , Aug-15, Volume: 40, Issue:17, 1997
Pharmacological options in the treatment of benign prostatic hyperplasia.Journal of medicinal chemistry, , Apr-25, Volume: 40, Issue:9, 1997
N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.Journal of medicinal chemistry, , Aug-15, Volume: 40, Issue:17, 1997
Pharmacological options in the treatment of benign prostatic hyperplasia.Journal of medicinal chemistry, , Apr-25, Volume: 40, Issue:9, 1997
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.Bioorganic & medicinal chemistry, , May-01, Volume: 16, Issue:9, 2008
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002