Page last updated: 2024-11-03

propranolol and Necrosis

propranolol has been researched along with Necrosis in 82 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)."7.70The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000)
"Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis."7.67Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989)
"Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined."7.66Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981)
"Isoproterenol (ISO), a drug which causes an increased strength of myocardial contraction when administered to animals in mug/kg doses, causes myocardial necrosis when given mg/kg doses."7.65Calcium as mediator of isoproterenol-induced myocardial necrosis. ( Bloom, S; Davis, DL, 1972)
"Treatment with propranolol had a negative chronotropic effect throughout the observation period of 72 h."5.32Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. ( Briest, W; Deten, A; Holzl, A; Volz, HC; Zimmer, HG, 2003)
"Nitroglycerin has a reducing influence on these changes, but not down to the initial level."5.26[The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)]. ( Hochrein, H; Lehmann, HU; Oeff, M; Witt, E, 1981)
"Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion."5.26Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979)
") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)."3.70The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000)
"Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis."3.67Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989)
"Effect of UM-272, a dimethyl propranolol has been studied in experimental myocardial necrosis induced by isoproterenol (ISP, 85 mg/kg, SC X 2 days) in rats."3.67Alterations in isoproterenol-induced cardiac metabolic changes by a quaternary analog of propranolol, UM-272. ( Gupta, M; Gupta, MP; Manchanda, SC; Seth, SD; Srivastava, LM, 1985)
"The experiments on rats with a 3-day myocardial infarction caused by the left coronary artery ligation have shown that multiple lidocaine and pyromecaine injections according to a given scheme decrease the size of the necrosis area."3.67[Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct]. ( Chichkanov, GG; Goldshteĭne, GKh; Tsorin, IB, 1986)
"Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported."3.67[The so-called dihydralazine hepatitis. A contribution to the pathogenesis]. ( Jahn, G; Krombholz, B; Machnik, G; Reinhardt, M, 1985)
"Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined."3.66Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981)
"Previous studies have shown that oral administration of minoxidil on 2 consecutive days produces an increase in heart rate and myocardial necrosis in Beagle dogs."3.66Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs. ( Balazs, T; Ferrans, VJ; Herman, EH; Young, RS, 1981)
" The beta receptor blocking propranolol prevented functional lesion, moderated fatty degeneration and liver cell necrosis in chronic carbon tetrachloride injury."3.66Estrogens as disposing factors in experimental liver injury. ( Gomba, S; Kulcsár, A; Kulscár-Gergely, J, 1978)
"Isoproterenol (ISO), a drug which causes an increased strength of myocardial contraction when administered to animals in mug/kg doses, causes myocardial necrosis when given mg/kg doses."3.65Calcium as mediator of isoproterenol-induced myocardial necrosis. ( Bloom, S; Davis, DL, 1972)
"Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage."1.40Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy. ( Dai, W; Kloner, RA; Sachdeva, J, 2014)
" Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique."1.38Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012)
"Treatment with propranolol had a negative chronotropic effect throughout the observation period of 72 h."1.32Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. ( Briest, W; Deten, A; Holzl, A; Volz, HC; Zimmer, HG, 2003)
" Vasoactive drugs may therefore be of value to diminish adverse side effects of the combination cytostatic agent + DSM, probably decreasing overspill into normal tissues."1.28Reduction by norepinephrine of the side effects induced by combined hepatic arterial administration of degradable strach microspheres and adriamycin in rats with a liver adenocarcinoma. ( Jakobsson, B; Roos, G; Stenram, U; Teder, H, 1991)
"Propranolol treatment limited progressive death of myocardial cell population, reducing by 37% myocardial infarction size by day 7 of the experimental study, as compared to the situation in the untreated animals."1.27[Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion]. ( Irgashev, ShB; Iuldashev, NM; Mavridi, DI, 1988)
" Increased dosage of propranolol to 4 mg did not produce any further reduction of portal pressure or mucosal damage."1.27Propranolol reduces ethanol-induced gastric mucosal damage in portal hypertensive rats. ( Ivey, KJ; Maeda, R; Mason, GR; Sankary, H; Sarfeh, IJ; Tarnawski, A, 1986)
" Chronic administration of propranolol to SHR for three consecutive weeks by Alzet minipump reduced systolic arterial pressure but did not reverse the indices of myocardial hypertrophy."1.26Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats. ( Greenberg, S; Wilborn, WM, 1982)
"Nitroglycerin has a reducing influence on these changes, but not down to the initial level."1.26[The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)]. ( Hochrein, H; Lehmann, HU; Oeff, M; Witt, E, 1981)
"Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion."1.26Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979)
"Pretreatment with propranolol reduced necrosis from 85 +/- 3% (untreated) to 52 +/- 4% (P less than 0."1.26Infarct size reduction by propranolol before and after coronary ligation in dogs. ( Jennings, RB; Kloner, RA; Rasmussen, MM; Reimer, KA, 1977)
"Pretreatment with propranolol and pargyline protected against ISO-induced necrosis and myocardial hypertrophy, but did not influence the ISO-induced depletion of NE stores."1.25Alterations in norepinephrine pattern in the damaged myocardium in the rat. ( Bhagat, B; Dhalla, NS; Sullivan, JM, 1975)
"Trichlorofluoromethane (FC 11) provoked arrhythmia in all three animal species, dichlorodifluoromethane (FC 12) in monkeys and rats but not in mice, and difluoroethane (FC 152a) only in rats."1.25Toxicity of aerosol propellants in the respiratory and circulatory systems. VI. Influence of cardiac and pulmonary vascular lesions in the rat. ( Aviado, DM; Doherty, RE, 1975)

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-199068 (82.93)18.7374
1990's6 (7.32)18.2507
2000's4 (4.88)29.6817
2010's3 (3.66)24.3611
2020's1 (1.22)2.80

Authors

AuthorsStudies
Freiha, M1
Achim, M1
Gheban, BA1
Moldovan, R1
Filip, GA1
Sachdeva, J1
Dai, W1
Kloner, RA2
Dinato, SL1
Dinato, MC1
Dinato, MM1
Ribeiro, MC1
Yamashiro, CY1
Romiti, N1
Kumar, V1
Murali, M1
Li, P1
Robertson, TA1
Zhang, Q1
Fletcher, LM1
Crawford, DH1
Weiss, M1
Roberts, MS1
Deten, A1
Volz, HC1
Holzl, A1
Briest, W1
Zimmer, HG1
Bhatt, LK1
Nandakumar, K1
Bodhankar, SL1
Bansal, J1
Piplani, P1
Hashimoto, H1
Ogawa, K1
Gichka, SG1
Greenberg, S1
Wilborn, WM1
Seth, SD4
Gupta, MP4
Gupta, M2
Manchanda, SC3
Häggendal, J2
Johansson, G2
Jönsson, L2
Thorén-Tolling, K2
Wray, RC1
Young, VL1
Lehmann, HU1
Oeff, M1
Witt, E1
Hochrein, H1
Stewart, JR1
Gibson, JK1
Lucchesi, BR1
Bloksma, N1
Hofhuis, FM1
Willers, JM1
Popov, VG1
Jdanova, NS1
Jelnov, VV1
Alushkov, MV1
Barishnikova, GA1
Herman, EH2
Balazs, T2
Ferrans, VJ2
Young, RS1
Ganguly, PK1
Srivastava, LM2
Bora, PS1
El-Hage, A1
Ehrreich, SJ1
Johnson, GL1
Atkinson, JC1
West, WL1
Gvatua, NA1
Kravtsov, VL1
Ivanova, LK1
Shkliar, LV1
Shumakov, VA1
Galenko-Iaroshevskiĭ, PA1
Melkumova, ER1
Bartashevich, VV1
Uvarov, AV1
Turovaia, AIu1
Khankoeva, AI1
Galygo, DS1
Blidaru, M1
Cuparencu, B1
Pleşca-Manea, L1
Strubelt, O2
Siegers, CP2
Bhagat, B1
Sullivan, JM1
Dhalla, NS1
Lossnitzer, K1
Konrad, A1
Heine, HW1
Ziegler, E1
Stauch, M1
Gokal, R1
Dornan, TL1
Ledingham, JG1
Fox, KM1
Chopra, MP1
Portal, RW1
Aber, CP1
Doherty, RE1
Aviado, DM1
Neil-Dwyer, G1
Walter, P1
Cruickshank, JM1
Doshi, B1
O'Gorman, P1
Finseth, F1
Adelberg, MG1
Hoffbrand, BI1
Saxena, KK1
Gupta, B1
Srivastava, VK1
Kulshrestha, VK1
Prasad, DN1
Allen, JD1
Pantridge, JF1
Patton, JN1
Ryan, CF1
Athari-Nejad, A1
Holcslaw, TL1
Mickleborough, L1
Huttner, I1
Symes, J1
Poirier, N1
Sniderman, AD1
Eliot, RS2
Todd, GL1
Clayton, FC1
Pieper, GM1
Falk, RH1
Casscells, W1
Kulscár-Gergely, J1
Kulcsár, A1
Gomba, S1
Baroldi, G1
Silver, MD1
Lixfeld, W1
McGregor, DC1
Rasmussen, MM2
Reimer, KA2
Jennings, RB2
Hoffmann, A1
Sierra-Callejas, JL1
Fleming, JS1
Buchanan, JO1
Buyniski, JP1
Kogan, AK1
Kudrin, AN1
Losev, NI1
Lopes, AC1
Borrotchin, L1
Sasso, WS1
DiDio, LJ1
Jakobsson, B1
Teder, H1
Roos, G1
Stenram, U1
Massa, MC1
Jason, SM1
Gradini, R1
Welykyj, S1
Forrest, CR1
Pang, CY1
Zhong, AG1
Neligan, PC1
Benjamin, IJ1
Jalil, JE1
Tan, LB1
Cho, K1
Weber, KT1
Clark, WA1
Irgashev, ShB1
Mavridi, DI1
Iuldashev, NM1
Tsuchida, K1
Yamazaki, R1
Kaneko, K1
Aihara, H1
Pavlenko, VS1
Slepushkin, VD1
Zoloev, GK1
Titov, MI1
Sankary, H1
Sarfeh, IJ1
Tarnawski, A1
Maeda, R1
Ivey, KJ1
Mason, GR1
Goldshteĭne, GKh1
Tsorin, IB1
Chichkanov, GG1
Kunze, KD1
Porst, H1
Lohmann, J1
Tschöpel, L1
Reinhardt, M1
Machnik, G1
Krombholz, B1
Jahn, G1
Auty, RM1
Branch, RA1
Smith, ER1
Katz, AM1
Guy, CR1
Dorigotti, L1
Gaetani, M1
Glässer, AH1
Turolla, E1
Bloom, S2
Davis, D1
Theve, NO2
Corley, KC1
Sheil, FO1
Mauck, HP1
Hoff, EC1
Braunwald, E2
Maroko, PR2
Libby, P2
Gazzard, BG1
Hughes, RD1
Portmann, B1
Dordoni, B1
Williams, R1
Carlström, A1
Hallberg, D1
Akermark, C1
Bartsokas, SK1
Katapoti, Z1
Papadimitriou, DG1
Ginks, W1
Ross, J1
Sybers, HD2
Vander Ark, GD1
Norton, LW1
Pomerantz, M1
Diaz, RG1
Somberg, J1
Freeman, E1
Levitt, B1
Sobel, BE1
Bloor, CM1
Shell, WE1
Covell, JW1
Davis, DL1
Savoie, LL1
Lehr, D2
Yarom, R1
Braun, K1
Krukowski, M1
Colón, R1
Kako, K1

Reviews

5 reviews available for propranolol and Necrosis

ArticleYear
Effect of infarct size limitation by propranolol on ventricular arrhythmias after myocardial infarction.
    Annals of the New York Academy of Sciences, 1982, Volume: 382

    Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Dogs; Humans; Myocardial Infarction;

1982
Acute myocardial infarction and muscle salvage: a potential role for pharmacological agents.
    Canadian journal of surgery. Journal canadien de chirurgie, 1974, Volume: 17, Issue:2

    Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Assisted Circulation; Collateral Circulation; Coronar

1974
Biochemical "defect" in the hypertrophied and failing heart: deleterious or compensatory?
    Circulation, 1973, Volume: 47, Issue:5

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Cardiomegaly; Coronary Disease;

1973
The pathophysiologic vulnerability of the subendocardium of the left ventricle.
    Advances in cardiology, 1973, Volume: 9

    Topics: Arrhythmias, Cardiac; Capillaries; Cardiomegaly; Coronary Disease; Coronary Vessels; Endocardium; He

1973
Reduction of infarct size following coronary occlusion.
    Circulation research, 1974, Volume: 35 Suppl 3

    Topics: Anaerobiosis; Animals; Assisted Circulation; Coronary Vessels; Creatine Kinase; Electrocardiography;

1974

Trials

1 trial available for propranolol and Necrosis

ArticleYear
Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage.
    British medical journal, 1978, Oct-07, Volume: 2, Issue:6143

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Humans; Male; Mid

1978

Other Studies

76 other studies available for propranolol and Necrosis

ArticleYear
In Vivo Study of the Effects of Propranolol, Timolol, and Minoxidil on Burn Wound Healing in Wistar Rats.
    Journal of burn care & research : official publication of the American Burn Association, 2023, 11-02, Volume: 44, Issue:6

    Topics: Animals; Antioxidants; Burns; Female; Fibrosis; Inflammation; Minoxidil; Necrosis; Propranolol; Rats

2023
Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.
    Journal of the American Heart Association, 2014, Jun-23, Volume: 3, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Echo

2014
[Necrotizing vasculitis as a manifestation of hypersensitivity to propylthiouracil].
    Arquivos brasileiros de endocrinologia e metabologia, 2009, Volume: 53, Issue:3

    Topics: Adolescent; Antithyroid Agents; Humans; Male; Necrosis; Prednisone; Propranolol; Propylthiouracil; V

2009
Large cavernous hemangioma.
    Indian pediatrics, 2010, Volume: 47, Issue:6

    Topics: Abdomen; Disseminated Intravascular Coagulation; Fatal Outcome; Female; Hemangioma, Cavernous; Human

2010
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
    Pharmaceutical research, 2012, Volume: 29, Issue:6

    Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti

2012
Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats.
    Molecular and cellular biochemistry, 2003, Volume: 251, Issue:1-2

    Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Collagen; Cytokines; Female; Gene Expression;

2003
Beta-blocking activity of PP-34, a newly synthesized aryloxypropanolamine derivative, and its cardioprotective effect against ischaemia/reperfusion injury in laboratory animals.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Atenolol; Benzylamines; Female; Guinea P

2007
Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis.
    Japanese heart journal, 1981, Volume: 22, Issue:4

    Topics: Animals; Aspirin; Body Weight; Creatine Kinase; Cyclic AMP; Heart; Isoproterenol; Male; Myocardial I

1981
[Morphological criteria of the effectiveness of nitroglycerin, dipyridamole and propranolol hydrochloride in an experimental metabolic lesion of the myocardium].
    Vrachebnoe delo, 1984, Issue:7

    Topics: Animals; Cardiomyopathies; Dipyridamole; Drug Evaluation, Preclinical; Histocytochemistry; Male; Myo

1984
Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 255, Issue:1

    Topics: Animals; Body Water; Cardiomegaly; Clonidine; Glycosaminoglycans; Heart; Hypertension; Muscle Protei

1982
Oxyfedrine and propranolol. A comparative experimental approach to protect myocardium against isoprenaline-induced myocardial necrosis.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:6

    Topics: Animals; Cardiomyopathies; Female; Glycolysis; Isoproterenol; Male; Myocardium; Necrosis; Oxyfedrine

1984
Effect of phenoxybenzamine on myocardial cell necroses and blood levels of catecholamines in pigs subjected to stress.
    Acta pharmacologica et toxicologica, 1984, Volume: 55, Issue:3

    Topics: Animals; Cardiomyopathies; Catecholamines; Coronary Vessels; Female; Humans; Male; Necrosis; Phenoxy

1984
Drug treatment and flap survival.
    Plastic and reconstructive surgery, 1984, Volume: 73, Issue:6

    Topics: Administration, Oral; Animals; Drug Evaluation; Graft Survival; Heparin; Infusions, Parenteral; Isox

1984
[The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)].
    Zeitschrift fur Kardiologie, 1981, Volume: 70, Issue:10

    Topics: Adult; Aged; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged;

1981
Effect of propranolol on myocardial cell necroses and blood levels of catecholamines in pigs subjected to stress.
    Acta pharmacologica et toxicologica, 1982, Volume: 50, Issue:1

    Topics: Animals; Cardiomyopathies; Catecholamines; Female; Male; Necrosis; Propranolol; Restraint, Physical;

1982
Effect of adrenoceptor blockade on hemorrhagic necrosis of meth A sarcomata induced by endotoxin or tumor necrosis serum.
    Immunopharmacology, 1982, Volume: 4, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Endotoxins; Female; Fibrosarcoma; Immune Sera; Mice; Necr

1982
Biochemical basis of the protective effect of propranolol pretreatment in experimental myocardial necrosis.
    Indian journal of experimental biology, 1982, Volume: 20, Issue:1

    Topics: Animals; Female; Glycogen; Heart; Isoproterenol; Male; Myocardium; Necrosis; Propranolol; Rats; Rats

1982
Precardiac mapping of R waves and ST intervals. Results in patients in acute period of extensive anterior myocardial infarction and effect of some drugs on the periinfarction zone.
    Advances in cardiology, 1981, Volume: 28

    Topics: Acute Disease; Body Surface Area; Digoxin; Electrocardiography; Humans; Myocardial Infarction; Necro

1981
Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs.
    Toxicology, 1981, Volume: 20, Issue:2-3

    Topics: Animals; Dogs; Drug Interactions; Furosemide; Heart Diseases; Heart Rate; Hydrochlorothiazide; Male;

1981
Nifedipine--a new calcium antagonist in experimental myocardial necrosis.
    The Indian journal of medical research, 1981, Volume: 73

    Topics: Animals; Calcium; Male; Myocardial Infarction; Myocardium; Necrosis; Nifedipine; Propranolol; Pyridi

1981
Study of the mechanism of hydralazine-induced myocardial necrosis in the rat.
    Toxicology and applied pharmacology, 1981, Volume: 59, Issue:3

    Topics: Animals; Calcium; Cardiomyopathies; Dihydrotachysterol; Heart Rate; Hydralazine; Male; Necrosis; Pro

1981
[Use of obzidan in the acute period of myocardial infarct].
    Kardiologiia, 1980, Volume: 20, Issue:10

    Topics: Adult; Aged; Creatine Kinase; Drug Evaluation; Electrocardiography; Hemodynamics; Humans; Male; Midd

1980
[Comparative evaluation of the effect of dimebon, obzidan, finoptin, and cordarone on the functional state of the ischemic focus and the size of necrosis zone during experimental myocardial infarction].
    Biulleten' eksperimental'noi biologii i meditsiny, 1996, Volume: 122, Issue:12

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cats; Histamine H1 Antagonists; Indoles; Myocardial Inf

1996
The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats.
    Acta physiologica Hungarica, 2000, Volume: 87, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Injections, Intr

2000
Role of cardiovascular and ionic changes in pathogenesis and prevention of isoprenaline-induced cardiac necrosis.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiomyopathies; Heart Rate; Hydrogen-Ion Concentration; I

1975
Alterations in norepinephrine pattern in the damaged myocardium in the rat.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Cardiomegaly; Cardiomyopathies; Isoproterenol; Male; Monoamine Oxidase; Myocardium; Necrosi

1975
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
    Zeitschrift fur Kardiologie, 1975, Volume: Suppl 2

    Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard

1975
Peripheral skin necrosis complicating beta-blockage.
    British medical journal, 1979, Mar-17, Volume: 1, Issue:6165

    Topics: Aged; Atenolol; Drug Eruptions; Female; Foot; Foot Dermatoses; Humans; Ischemia; Male; Middle Aged;

1979
Long-term beta blockade: possible protection from myocardial infarction.
    British medical journal, 1975, Jan-18, Volume: 1, Issue:5950

    Topics: Adrenergic beta-Antagonists; Aspartate Aminotransferases; Blood Sedimentation; Body Temperature; Cor

1975
Toxicity of aerosol propellants in the respiratory and circulatory systems. VI. Influence of cardiac and pulmonary vascular lesions in the rat.
    Toxicology, 1975, Volume: 3, Issue:2

    Topics: Adrenal Glands; Adrenalectomy; Adrenergic beta-Antagonists; Aerosol Propellants; Aerosols; Animals;

1975
Experimental work with isoxuprine for prevention of skin flap necrosis and for treatment of the failing flap.
    Plastic and reconstructive surgery, 1979, Volume: 63, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Rejection; Injections, I

1979
Peripheral skin necrosis complicating beta-blockade.
    British medical journal, 1979, Apr-21, Volume: 1, Issue:6170

    Topics: Aged; Female; Humans; Male; Middle Aged; Necrosis; Propranolol; Skin; Skin Ulcer; Toes

1979
On significance of plasma fibrinogen level to assess severity of myocardial damage--an experimental study.
    Indian journal of experimental biology, 1979, Volume: 17, Issue:6

    Topics: Animals; Cardiomyopathies; Female; Fibrinogen; Isoproterenol; Male; Myocardial Infarction; Myocardiu

1979
Autonomic nervous activity and myocardial necrosis after DC shocks from cardiac defibrillators [proceedings].
    The Journal of physiology, 1979, Volume: 293

    Topics: Animals; Dogs; Electric Countershock; Heart; Myocardium; Necrosis; Propranolol; Reserpine

1979
Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 25, Issue:3

    Topics: Animals; Cardiomyopathies; Dose-Response Relationship, Drug; Isoproterenol; Male; Myocardium; Necros

1979
Significance of epicardial Q waves as an acute marker of myocardial necrosis in dogs.
    Cardiovascular research, 1978, Volume: 12, Issue:6

    Topics: Animals; Coronary Disease; Creatine Kinase; Dogs; Electrocardiography; Heart; Male; Myocardium; Necr

1978
Experimental catecholamine-induced acute myocardial necrosis.
    Advances in cardiology, 1978, Volume: 25

    Topics: Acute Disease; Animals; Catecholamines; Dogs; Heart; Hemodynamics; Infusions, Parenteral; Isoprotere

1978
Effects of drugs on myocardial necrosis after subarachnoid haemorrhage.
    British medical journal, 1978, Nov-25, Volume: 2, Issue:6150

    Topics: Humans; Myocardium; Necrosis; Phentolamine; Propranolol; Subarachnoid Hemorrhage

1978
Estrogens as disposing factors in experimental liver injury.
    Experimentelle Pathologie, 1978, Volume: 16, Issue:1-6

    Topics: Animals; Biotransformation; Carbon Tetrachloride Poisoning; Drug Interactions; Estrogens; Female; He

1978
Irreversible myocardial damage resembling catecholamine necrosis secondary to acute coronary occlusion in dogs: its prevention by propranolol.
    Journal of molecular and cellular cardiology, 1977, Volume: 9, Issue:8

    Topics: Animals; Dogs; Myocardial Infarction; Myocardium; Necrosis; Propranolol

1977
Infarct size reduction by propranolol before and after coronary ligation in dogs.
    Circulation, 1977, Volume: 56, Issue:5

    Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; Hemodynamics; Male; Myocardial I

1977
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
    Acta pharmacologica et toxicologica, 1976, Volume: 39, Issue:3

    Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myoc

1976
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
    European journal of pharmacology, 1976, Volume: 40, Issue:1

    Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Mal

1976
The mechanisms of free-radical lipids and antioxidant heart protection in experimental ischaemia and infarction.
    Cor et vasa, 1992, Volume: 34, Issue:3

    Topics: Animals; Female; Free Radicals; Lipid Peroxidation; Male; Malondialdehyde; Microscopy, Electron; Myo

1992
Action of propranolol on the atrial cardiomyocytes of rats submitted to cold stress.
    Journal of submicroscopic cytology and pathology, 1992, Volume: 24, Issue:2

    Topics: Actin Cytoskeleton; Animals; Cold Temperature; Cytoplasmic Granules; Heart Atria; Mitochondria; Myoc

1992
Reduction by norepinephrine of the side effects induced by combined hepatic arterial administration of degradable strach microspheres and adriamycin in rats with a liver adenocarcinoma.
    Selective cancer therapeutics, 1991,Fall, Volume: 7, Issue:3

    Topics: Adenocarcinoma; Animals; Doxorubicin; Hepatic Artery; Injections, Intra-Arterial; Liver; Liver Neopl

1991
Lichenoid drug eruption secondary to propranolol.
    Cutis, 1991, Volume: 48, Issue:1

    Topics: Aged; Drug Eruptions; Humans; Keratosis; Lichen Planus; Male; Necrosis; Penile Diseases; Propranolol

1991
Role of noradrenaline in the pathogenesis of skin flap ischemic necrosis in the pig.
    The Journal of surgical research, 1990, Volume: 48, Issue:3

    Topics: Animals; Ischemia; Necrosis; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Skin; Surg

1990
Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis.
    Circulation research, 1989, Volume: 65, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Autoradiography; Cardiomegaly; DNA; DNA Replication; Fibrosis; Hear

1989
Alterations in isoproterenol-induced cardiac metabolic changes by a quaternary analog of propranolol, UM-272.
    Acta cardiologica, 1985, Volume: 40, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Creatine Kinase; Dose-Response Relationship, Drug; Energy Metabolis

1985
[Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion].
    Kardiologiia, 1988, Volume: 28, Issue:8

    Topics: Acute Disease; Animals; Coronary Disease; Drug Evaluation, Preclinical; Energy Metabolism; Male; Myo

1988
Effects of propranolol on tissue necrosis in experimental myocardial infarction in dogs.
    Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:10

    Topics: Animals; Coronary Disease; Dogs; Electrophoresis, Polyacrylamide Gel; Female; Hydrogen-Ion Concentra

1986
[Effect of enkephalins on the course of experimental izadrin-induced myocardial necrosis in the rabbit].
    Kardiologiia, 1985, Volume: 25, Issue:12

    Topics: Animals; Cardiomyopathies; Creatine Kinase; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Isoe

1985
Propranolol reduces ethanol-induced gastric mucosal damage in portal hypertensive rats.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:2

    Topics: Animals; Blood Pressure; Ethanol; Gastric Mucosa; Hypertension, Portal; Male; Necrosis; Portal Syste

1986
[Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct].
    Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 101, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Dogs; Drug Evaluation, Preclinical; Electroca

1986
[Liver lesions induced by dihydralazine and propranolol].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1985, Volume: 130, Issue:1

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydralazine; Female; Humans; Hydralaz

1985
[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1985, Volume: 45, Issue:6

    Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Therapy, Combinatio

1985
Letter: Paracetamol toxicity and propranolol.
    Lancet (London, England), 1973, Dec-29, Volume: 2, Issue:7844

    Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antago

1973
Competitive antagonism of isoprenaline-induced cardiac necroses by beta-adrenoreceptor blocking agents.
    The Journal of pharmacy and pharmacology, 1969, Volume: 21, Issue:3

    Topics: Animals; Biological Assay; Ethanolamines; Heart Diseases; Injections, Subcutaneous; Isoproterenol; M

1969
Isoproterenol myocytolysis and myocardial calcium.
    Recent advances in studies on cardiac structure and metabolism, 1974, Volume: 4

    Topics: Animals; Biological Transport; Calcium; Cardiomyopathies; Dose-Response Relationship, Drug; Isoprote

1974
Fat necrosis. Studies in rats with experimentally induced pancreatitis.
    Acta chirurgica Scandinavica. Supplementum, 1972, Volume: 434

    Topics: Adipose Tissue; Animals; Calcium; Cholesterol; Common Bile Duct; Epididymis; Fatty Acids, Nonesterif

1972
The effect of vagal stimulation on the myocardium in the cat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 144, Issue:3

    Topics: Animals; Blood Pressure; Cats; Cordotomy; Electric Stimulation; Electrodes; Heart; Heart Rate; Myoca

1973
Protection of rats against the hepatotoxic effect of paracetamol.
    British journal of experimental pathology, 1974, Volume: 55, Issue:6

    Topics: Acetaminophen; Administration, Oral; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Inter

1974
Reduction by propranolol of myocardial necrosis following temporary coronary artery occlusion in dogs.
    Circulation research, 1973, Volume: 33, Issue:3

    Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Female; Heart; Heart Rate; Male; Myocardial Infarct

1973
The effect of a beta adrenergic blocking agent, propranolol, on the development of experimental fat necrosis in the rat.
    Acta chirurgica Scandinavica, 1973, Volume: 139, Issue:7

    Topics: Adipose Tissue; Animals; Calcium; Depression, Chemical; Glycerol; Lipid Metabolism; Lipid Mobilizati

1973
Inhibition of vasopressin-induced morbid effects on the rat kidney by pindolol and propranolol.
    Experientia, 1974, Mar-15, Volume: 30, Issue:3

    Topics: Animals; Female; Kidney; Kidney Cortex; Kidney Medulla; Male; Necrosis; Pindolol; Propranolol; Rats;

1974
Prevention of gross myocardial infarction in the canine heart.
    Archives of pathology, 1974, Volume: 97, Issue:6

    Topics: Animals; Assisted Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Heart Ventricles; Hyp

1974
The effects of brain stem compression on the heart.
    Surgical neurology, 1974, Volume: 2, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bradycardia; Brain Injuries; Brain Stem; Ca

1974
Myocardial infarction after propranolol withdrawal.
    American heart journal, 1974, Volume: 88, Issue:2

    Topics: Angina Pectoris; Animals; Arteriosclerosis; Coronary Disease; Dogs; Humans; Myocardial Infarction; N

1974
Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion.
    Circulation, 1972, Volume: 45, Issue:6

    Topics: Animals; Coronary Disease; Coronary Vessels; Creatine Kinase; Disease Models, Animal; Dogs; Drug Com

1972
Calcium as mediator of isoproterenol-induced myocardial necrosis.
    The American journal of pathology, 1972, Volume: 69, Issue:3

    Topics: Animals; Calcium; Heart; Injections, Intraperitoneal; Isoproterenol; Myocardial Infarction; Myocardi

1972
[Role of antikaliuretics and catecholamines in the prevention of cardiac necroses of metabolic origin].
    Pathologia Europaea, 1971, Volume: 6, Issue:4

    Topics: Adrenal Cortex Hormones; Amiloride; Animals; Catecholamines; Digitoxin; Diuretics; Epinephrine; Hear

1971
Tissue electrolyte alteration in disseminated myocardial necrosis.
    Annals of the New York Academy of Sciences, 1969, Jan-31, Volume: 156, Issue:1

    Topics: Animals; Calcium; Electrolytes; Heart Diseases; Isoproterenol; Kidney; Magnesium; Myocardium; Necros

1969
Cardiovascular effects of scorpion venom, morphological changes in the myocardium.
    Toxicon : official journal of the International Society on Toxinology, 1970, Volume: 8, Issue:1

    Topics: Animals; Antivenins; Coronary Vessels; Dibenzylchlorethamine; Dogs; Heart; Heart Diseases; Hemorrhag

1970
Correlation of myocardial and renal necrosis with tissue electrolyte changes.
    JAMA, 1966, Jul-11, Volume: 197, Issue:2

    Topics: Animals; Calcium, Dietary; Catecholamines; Electrolytes; Kidney Diseases; Magnesium; Male; Metaramin

1966
The effect of a beta adrenergic blocking agent on chemical changes in isoproterenol-induced myocardial necrosis.
    Canadian journal of physiology and pharmacology, 1966, Volume: 44, Issue:4

    Topics: Adenine Nucleotides; Animals; Body Weight; Cholesterol; Creatine; Glycogen; Heart; Isoproterenol; La

1966