propranolol has been researched along with Necrosis in 82 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)." | 7.70 | The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000) |
| "Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis." | 7.67 | Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989) |
| "Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined." | 7.66 | Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981) |
| "Isoproterenol (ISO), a drug which causes an increased strength of myocardial contraction when administered to animals in mug/kg doses, causes myocardial necrosis when given mg/kg doses." | 7.65 | Calcium as mediator of isoproterenol-induced myocardial necrosis. ( Bloom, S; Davis, DL, 1972) |
| "Treatment with propranolol had a negative chronotropic effect throughout the observation period of 72 h." | 5.32 | Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. ( Briest, W; Deten, A; Holzl, A; Volz, HC; Zimmer, HG, 2003) |
| "Nitroglycerin has a reducing influence on these changes, but not down to the initial level." | 5.26 | [The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)]. ( Hochrein, H; Lehmann, HU; Oeff, M; Witt, E, 1981) |
| "Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion." | 5.26 | Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979) |
| ") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)." | 3.70 | The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000) |
| "Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis." | 3.67 | Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989) |
| "Effect of UM-272, a dimethyl propranolol has been studied in experimental myocardial necrosis induced by isoproterenol (ISP, 85 mg/kg, SC X 2 days) in rats." | 3.67 | Alterations in isoproterenol-induced cardiac metabolic changes by a quaternary analog of propranolol, UM-272. ( Gupta, M; Gupta, MP; Manchanda, SC; Seth, SD; Srivastava, LM, 1985) |
| "The experiments on rats with a 3-day myocardial infarction caused by the left coronary artery ligation have shown that multiple lidocaine and pyromecaine injections according to a given scheme decrease the size of the necrosis area." | 3.67 | [Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct]. ( Chichkanov, GG; Goldshteĭne, GKh; Tsorin, IB, 1986) |
| "Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported." | 3.67 | [The so-called dihydralazine hepatitis. A contribution to the pathogenesis]. ( Jahn, G; Krombholz, B; Machnik, G; Reinhardt, M, 1985) |
| "Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined." | 3.66 | Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981) |
| "Previous studies have shown that oral administration of minoxidil on 2 consecutive days produces an increase in heart rate and myocardial necrosis in Beagle dogs." | 3.66 | Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs. ( Balazs, T; Ferrans, VJ; Herman, EH; Young, RS, 1981) |
| " The beta receptor blocking propranolol prevented functional lesion, moderated fatty degeneration and liver cell necrosis in chronic carbon tetrachloride injury." | 3.66 | Estrogens as disposing factors in experimental liver injury. ( Gomba, S; Kulcsár, A; Kulscár-Gergely, J, 1978) |
| "Isoproterenol (ISO), a drug which causes an increased strength of myocardial contraction when administered to animals in mug/kg doses, causes myocardial necrosis when given mg/kg doses." | 3.65 | Calcium as mediator of isoproterenol-induced myocardial necrosis. ( Bloom, S; Davis, DL, 1972) |
| "Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage." | 1.40 | Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy. ( Dai, W; Kloner, RA; Sachdeva, J, 2014) |
| " Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique." | 1.38 | Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012) |
| "Treatment with propranolol had a negative chronotropic effect throughout the observation period of 72 h." | 1.32 | Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. ( Briest, W; Deten, A; Holzl, A; Volz, HC; Zimmer, HG, 2003) |
| " Vasoactive drugs may therefore be of value to diminish adverse side effects of the combination cytostatic agent + DSM, probably decreasing overspill into normal tissues." | 1.28 | Reduction by norepinephrine of the side effects induced by combined hepatic arterial administration of degradable strach microspheres and adriamycin in rats with a liver adenocarcinoma. ( Jakobsson, B; Roos, G; Stenram, U; Teder, H, 1991) |
| "Propranolol treatment limited progressive death of myocardial cell population, reducing by 37% myocardial infarction size by day 7 of the experimental study, as compared to the situation in the untreated animals." | 1.27 | [Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion]. ( Irgashev, ShB; Iuldashev, NM; Mavridi, DI, 1988) |
| " Increased dosage of propranolol to 4 mg did not produce any further reduction of portal pressure or mucosal damage." | 1.27 | Propranolol reduces ethanol-induced gastric mucosal damage in portal hypertensive rats. ( Ivey, KJ; Maeda, R; Mason, GR; Sankary, H; Sarfeh, IJ; Tarnawski, A, 1986) |
| " Chronic administration of propranolol to SHR for three consecutive weeks by Alzet minipump reduced systolic arterial pressure but did not reverse the indices of myocardial hypertrophy." | 1.26 | Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats. ( Greenberg, S; Wilborn, WM, 1982) |
| "Nitroglycerin has a reducing influence on these changes, but not down to the initial level." | 1.26 | [The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)]. ( Hochrein, H; Lehmann, HU; Oeff, M; Witt, E, 1981) |
| "Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion." | 1.26 | Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979) |
| "Pretreatment with propranolol reduced necrosis from 85 +/- 3% (untreated) to 52 +/- 4% (P less than 0." | 1.26 | Infarct size reduction by propranolol before and after coronary ligation in dogs. ( Jennings, RB; Kloner, RA; Rasmussen, MM; Reimer, KA, 1977) |
| "Pretreatment with propranolol and pargyline protected against ISO-induced necrosis and myocardial hypertrophy, but did not influence the ISO-induced depletion of NE stores." | 1.25 | Alterations in norepinephrine pattern in the damaged myocardium in the rat. ( Bhagat, B; Dhalla, NS; Sullivan, JM, 1975) |
| "Trichlorofluoromethane (FC 11) provoked arrhythmia in all three animal species, dichlorodifluoromethane (FC 12) in monkeys and rats but not in mice, and difluoroethane (FC 152a) only in rats." | 1.25 | Toxicity of aerosol propellants in the respiratory and circulatory systems. VI. Influence of cardiac and pulmonary vascular lesions in the rat. ( Aviado, DM; Doherty, RE, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (82.93) | 18.7374 |
| 1990's | 6 (7.32) | 18.2507 |
| 2000's | 4 (4.88) | 29.6817 |
| 2010's | 3 (3.66) | 24.3611 |
| 2020's | 1 (1.22) | 2.80 |
| Authors | Studies |
|---|---|
| Freiha, M | 1 |
| Achim, M | 1 |
| Gheban, BA | 1 |
| Moldovan, R | 1 |
| Filip, GA | 1 |
| Sachdeva, J | 1 |
| Dai, W | 1 |
| Kloner, RA | 2 |
| Dinato, SL | 1 |
| Dinato, MC | 1 |
| Dinato, MM | 1 |
| Ribeiro, MC | 1 |
| Yamashiro, CY | 1 |
| Romiti, N | 1 |
| Kumar, V | 1 |
| Murali, M | 1 |
| Li, P | 1 |
| Robertson, TA | 1 |
| Zhang, Q | 1 |
| Fletcher, LM | 1 |
| Crawford, DH | 1 |
| Weiss, M | 1 |
| Roberts, MS | 1 |
| Deten, A | 1 |
| Volz, HC | 1 |
| Holzl, A | 1 |
| Briest, W | 1 |
| Zimmer, HG | 1 |
| Bhatt, LK | 1 |
| Nandakumar, K | 1 |
| Bodhankar, SL | 1 |
| Bansal, J | 1 |
| Piplani, P | 1 |
| Hashimoto, H | 1 |
| Ogawa, K | 1 |
| Gichka, SG | 1 |
| Greenberg, S | 1 |
| Wilborn, WM | 1 |
| Seth, SD | 4 |
| Gupta, MP | 4 |
| Gupta, M | 2 |
| Manchanda, SC | 3 |
| Häggendal, J | 2 |
| Johansson, G | 2 |
| Jönsson, L | 2 |
| Thorén-Tolling, K | 2 |
| Wray, RC | 1 |
| Young, VL | 1 |
| Lehmann, HU | 1 |
| Oeff, M | 1 |
| Witt, E | 1 |
| Hochrein, H | 1 |
| Stewart, JR | 1 |
| Gibson, JK | 1 |
| Lucchesi, BR | 1 |
| Bloksma, N | 1 |
| Hofhuis, FM | 1 |
| Willers, JM | 1 |
| Popov, VG | 1 |
| Jdanova, NS | 1 |
| Jelnov, VV | 1 |
| Alushkov, MV | 1 |
| Barishnikova, GA | 1 |
| Herman, EH | 2 |
| Balazs, T | 2 |
| Ferrans, VJ | 2 |
| Young, RS | 1 |
| Ganguly, PK | 1 |
| Srivastava, LM | 2 |
| Bora, PS | 1 |
| El-Hage, A | 1 |
| Ehrreich, SJ | 1 |
| Johnson, GL | 1 |
| Atkinson, JC | 1 |
| West, WL | 1 |
| Gvatua, NA | 1 |
| Kravtsov, VL | 1 |
| Ivanova, LK | 1 |
| Shkliar, LV | 1 |
| Shumakov, VA | 1 |
| Galenko-Iaroshevskiĭ, PA | 1 |
| Melkumova, ER | 1 |
| Bartashevich, VV | 1 |
| Uvarov, AV | 1 |
| Turovaia, AIu | 1 |
| Khankoeva, AI | 1 |
| Galygo, DS | 1 |
| Blidaru, M | 1 |
| Cuparencu, B | 1 |
| Pleşca-Manea, L | 1 |
| Strubelt, O | 2 |
| Siegers, CP | 2 |
| Bhagat, B | 1 |
| Sullivan, JM | 1 |
| Dhalla, NS | 1 |
| Lossnitzer, K | 1 |
| Konrad, A | 1 |
| Heine, HW | 1 |
| Ziegler, E | 1 |
| Stauch, M | 1 |
| Gokal, R | 1 |
| Dornan, TL | 1 |
| Ledingham, JG | 1 |
| Fox, KM | 1 |
| Chopra, MP | 1 |
| Portal, RW | 1 |
| Aber, CP | 1 |
| Doherty, RE | 1 |
| Aviado, DM | 1 |
| Neil-Dwyer, G | 1 |
| Walter, P | 1 |
| Cruickshank, JM | 1 |
| Doshi, B | 1 |
| O'Gorman, P | 1 |
| Finseth, F | 1 |
| Adelberg, MG | 1 |
| Hoffbrand, BI | 1 |
| Saxena, KK | 1 |
| Gupta, B | 1 |
| Srivastava, VK | 1 |
| Kulshrestha, VK | 1 |
| Prasad, DN | 1 |
| Allen, JD | 1 |
| Pantridge, JF | 1 |
| Patton, JN | 1 |
| Ryan, CF | 1 |
| Athari-Nejad, A | 1 |
| Holcslaw, TL | 1 |
| Mickleborough, L | 1 |
| Huttner, I | 1 |
| Symes, J | 1 |
| Poirier, N | 1 |
| Sniderman, AD | 1 |
| Eliot, RS | 2 |
| Todd, GL | 1 |
| Clayton, FC | 1 |
| Pieper, GM | 1 |
| Falk, RH | 1 |
| Casscells, W | 1 |
| Kulscár-Gergely, J | 1 |
| Kulcsár, A | 1 |
| Gomba, S | 1 |
| Baroldi, G | 1 |
| Silver, MD | 1 |
| Lixfeld, W | 1 |
| McGregor, DC | 1 |
| Rasmussen, MM | 2 |
| Reimer, KA | 2 |
| Jennings, RB | 2 |
| Hoffmann, A | 1 |
| Sierra-Callejas, JL | 1 |
| Fleming, JS | 1 |
| Buchanan, JO | 1 |
| Buyniski, JP | 1 |
| Kogan, AK | 1 |
| Kudrin, AN | 1 |
| Losev, NI | 1 |
| Lopes, AC | 1 |
| Borrotchin, L | 1 |
| Sasso, WS | 1 |
| DiDio, LJ | 1 |
| Jakobsson, B | 1 |
| Teder, H | 1 |
| Roos, G | 1 |
| Stenram, U | 1 |
| Massa, MC | 1 |
| Jason, SM | 1 |
| Gradini, R | 1 |
| Welykyj, S | 1 |
| Forrest, CR | 1 |
| Pang, CY | 1 |
| Zhong, AG | 1 |
| Neligan, PC | 1 |
| Benjamin, IJ | 1 |
| Jalil, JE | 1 |
| Tan, LB | 1 |
| Cho, K | 1 |
| Weber, KT | 1 |
| Clark, WA | 1 |
| Irgashev, ShB | 1 |
| Mavridi, DI | 1 |
| Iuldashev, NM | 1 |
| Tsuchida, K | 1 |
| Yamazaki, R | 1 |
| Kaneko, K | 1 |
| Aihara, H | 1 |
| Pavlenko, VS | 1 |
| Slepushkin, VD | 1 |
| Zoloev, GK | 1 |
| Titov, MI | 1 |
| Sankary, H | 1 |
| Sarfeh, IJ | 1 |
| Tarnawski, A | 1 |
| Maeda, R | 1 |
| Ivey, KJ | 1 |
| Mason, GR | 1 |
| Goldshteĭne, GKh | 1 |
| Tsorin, IB | 1 |
| Chichkanov, GG | 1 |
| Kunze, KD | 1 |
| Porst, H | 1 |
| Lohmann, J | 1 |
| Tschöpel, L | 1 |
| Reinhardt, M | 1 |
| Machnik, G | 1 |
| Krombholz, B | 1 |
| Jahn, G | 1 |
| Auty, RM | 1 |
| Branch, RA | 1 |
| Smith, ER | 1 |
| Katz, AM | 1 |
| Guy, CR | 1 |
| Dorigotti, L | 1 |
| Gaetani, M | 1 |
| Glässer, AH | 1 |
| Turolla, E | 1 |
| Bloom, S | 2 |
| Davis, D | 1 |
| Theve, NO | 2 |
| Corley, KC | 1 |
| Sheil, FO | 1 |
| Mauck, HP | 1 |
| Hoff, EC | 1 |
| Braunwald, E | 2 |
| Maroko, PR | 2 |
| Libby, P | 2 |
| Gazzard, BG | 1 |
| Hughes, RD | 1 |
| Portmann, B | 1 |
| Dordoni, B | 1 |
| Williams, R | 1 |
| Carlström, A | 1 |
| Hallberg, D | 1 |
| Akermark, C | 1 |
| Bartsokas, SK | 1 |
| Katapoti, Z | 1 |
| Papadimitriou, DG | 1 |
| Ginks, W | 1 |
| Ross, J | 1 |
| Sybers, HD | 2 |
| Vander Ark, GD | 1 |
| Norton, LW | 1 |
| Pomerantz, M | 1 |
| Diaz, RG | 1 |
| Somberg, J | 1 |
| Freeman, E | 1 |
| Levitt, B | 1 |
| Sobel, BE | 1 |
| Bloor, CM | 1 |
| Shell, WE | 1 |
| Covell, JW | 1 |
| Davis, DL | 1 |
| Savoie, LL | 1 |
| Lehr, D | 2 |
| Yarom, R | 1 |
| Braun, K | 1 |
| Krukowski, M | 1 |
| Colón, R | 1 |
| Kako, K | 1 |
5 reviews available for propranolol and Necrosis
| Article | Year |
|---|---|
Effect of infarct size limitation by propranolol on ventricular arrhythmias after myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Dogs; Humans; Myocardial Infarction; | 1982 |
Acute myocardial infarction and muscle salvage: a potential role for pharmacological agents.
Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Assisted Circulation; Collateral Circulation; Coronar | 1974 |
Biochemical "defect" in the hypertrophied and failing heart: deleterious or compensatory?
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Cardiomegaly; Coronary Disease; | 1973 |
The pathophysiologic vulnerability of the subendocardium of the left ventricle.
Topics: Arrhythmias, Cardiac; Capillaries; Cardiomegaly; Coronary Disease; Coronary Vessels; Endocardium; He | 1973 |
Reduction of infarct size following coronary occlusion.
Topics: Anaerobiosis; Animals; Assisted Circulation; Coronary Vessels; Creatine Kinase; Electrocardiography; | 1974 |
1 trial available for propranolol and Necrosis
| Article | Year |
|---|---|
Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Humans; Male; Mid | 1978 |
76 other studies available for propranolol and Necrosis
| Article | Year |
|---|---|
In Vivo Study of the Effects of Propranolol, Timolol, and Minoxidil on Burn Wound Healing in Wistar Rats.
Topics: Animals; Antioxidants; Burns; Female; Fibrosis; Inflammation; Minoxidil; Necrosis; Propranolol; Rats | 2023 |
Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Echo | 2014 |
[Necrotizing vasculitis as a manifestation of hypersensitivity to propylthiouracil].
Topics: Adolescent; Antithyroid Agents; Humans; Male; Necrosis; Prednisone; Propranolol; Propylthiouracil; V | 2009 |
Large cavernous hemangioma.
Topics: Abdomen; Disseminated Intravascular Coagulation; Fatal Outcome; Female; Hemangioma, Cavernous; Human | 2010 |
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2012 |
Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Collagen; Cytokines; Female; Gene Expression; | 2003 |
Beta-blocking activity of PP-34, a newly synthesized aryloxypropanolamine derivative, and its cardioprotective effect against ischaemia/reperfusion injury in laboratory animals.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Atenolol; Benzylamines; Female; Guinea P | 2007 |
Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis.
Topics: Animals; Aspirin; Body Weight; Creatine Kinase; Cyclic AMP; Heart; Isoproterenol; Male; Myocardial I | 1981 |
[Morphological criteria of the effectiveness of nitroglycerin, dipyridamole and propranolol hydrochloride in an experimental metabolic lesion of the myocardium].
Topics: Animals; Cardiomyopathies; Dipyridamole; Drug Evaluation, Preclinical; Histocytochemistry; Male; Myo | 1984 |
Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats.
Topics: Animals; Body Water; Cardiomegaly; Clonidine; Glycosaminoglycans; Heart; Hypertension; Muscle Protei | 1982 |
Oxyfedrine and propranolol. A comparative experimental approach to protect myocardium against isoprenaline-induced myocardial necrosis.
Topics: Animals; Cardiomyopathies; Female; Glycolysis; Isoproterenol; Male; Myocardium; Necrosis; Oxyfedrine | 1984 |
Effect of phenoxybenzamine on myocardial cell necroses and blood levels of catecholamines in pigs subjected to stress.
Topics: Animals; Cardiomyopathies; Catecholamines; Coronary Vessels; Female; Humans; Male; Necrosis; Phenoxy | 1984 |
Drug treatment and flap survival.
Topics: Administration, Oral; Animals; Drug Evaluation; Graft Survival; Heparin; Infusions, Parenteral; Isox | 1984 |
[The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; | 1981 |
Effect of propranolol on myocardial cell necroses and blood levels of catecholamines in pigs subjected to stress.
Topics: Animals; Cardiomyopathies; Catecholamines; Female; Male; Necrosis; Propranolol; Restraint, Physical; | 1982 |
Effect of adrenoceptor blockade on hemorrhagic necrosis of meth A sarcomata induced by endotoxin or tumor necrosis serum.
Topics: Animals; Dose-Response Relationship, Drug; Endotoxins; Female; Fibrosarcoma; Immune Sera; Mice; Necr | 1982 |
Biochemical basis of the protective effect of propranolol pretreatment in experimental myocardial necrosis.
Topics: Animals; Female; Glycogen; Heart; Isoproterenol; Male; Myocardium; Necrosis; Propranolol; Rats; Rats | 1982 |
Precardiac mapping of R waves and ST intervals. Results in patients in acute period of extensive anterior myocardial infarction and effect of some drugs on the periinfarction zone.
Topics: Acute Disease; Body Surface Area; Digoxin; Electrocardiography; Humans; Myocardial Infarction; Necro | 1981 |
Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs.
Topics: Animals; Dogs; Drug Interactions; Furosemide; Heart Diseases; Heart Rate; Hydrochlorothiazide; Male; | 1981 |
Nifedipine--a new calcium antagonist in experimental myocardial necrosis.
Topics: Animals; Calcium; Male; Myocardial Infarction; Myocardium; Necrosis; Nifedipine; Propranolol; Pyridi | 1981 |
Study of the mechanism of hydralazine-induced myocardial necrosis in the rat.
Topics: Animals; Calcium; Cardiomyopathies; Dihydrotachysterol; Heart Rate; Hydralazine; Male; Necrosis; Pro | 1981 |
[Use of obzidan in the acute period of myocardial infarct].
Topics: Adult; Aged; Creatine Kinase; Drug Evaluation; Electrocardiography; Hemodynamics; Humans; Male; Midd | 1980 |
[Comparative evaluation of the effect of dimebon, obzidan, finoptin, and cordarone on the functional state of the ischemic focus and the size of necrosis zone during experimental myocardial infarction].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cats; Histamine H1 Antagonists; Indoles; Myocardial Inf | 1996 |
The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Injections, Intr | 2000 |
Role of cardiovascular and ionic changes in pathogenesis and prevention of isoprenaline-induced cardiac necrosis.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiomyopathies; Heart Rate; Hydrogen-Ion Concentration; I | 1975 |
Alterations in norepinephrine pattern in the damaged myocardium in the rat.
Topics: Animals; Cardiomegaly; Cardiomyopathies; Isoproterenol; Male; Monoamine Oxidase; Myocardium; Necrosi | 1975 |
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard | 1975 |
Peripheral skin necrosis complicating beta-blockage.
Topics: Aged; Atenolol; Drug Eruptions; Female; Foot; Foot Dermatoses; Humans; Ischemia; Male; Middle Aged; | 1979 |
Long-term beta blockade: possible protection from myocardial infarction.
Topics: Adrenergic beta-Antagonists; Aspartate Aminotransferases; Blood Sedimentation; Body Temperature; Cor | 1975 |
Toxicity of aerosol propellants in the respiratory and circulatory systems. VI. Influence of cardiac and pulmonary vascular lesions in the rat.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic beta-Antagonists; Aerosol Propellants; Aerosols; Animals; | 1975 |
Experimental work with isoxuprine for prevention of skin flap necrosis and for treatment of the failing flap.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Rejection; Injections, I | 1979 |
Peripheral skin necrosis complicating beta-blockade.
Topics: Aged; Female; Humans; Male; Middle Aged; Necrosis; Propranolol; Skin; Skin Ulcer; Toes | 1979 |
On significance of plasma fibrinogen level to assess severity of myocardial damage--an experimental study.
Topics: Animals; Cardiomyopathies; Female; Fibrinogen; Isoproterenol; Male; Myocardial Infarction; Myocardiu | 1979 |
Autonomic nervous activity and myocardial necrosis after DC shocks from cardiac defibrillators [proceedings].
Topics: Animals; Dogs; Electric Countershock; Heart; Myocardium; Necrosis; Propranolol; Reserpine | 1979 |
Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline.
Topics: Animals; Cardiomyopathies; Dose-Response Relationship, Drug; Isoproterenol; Male; Myocardium; Necros | 1979 |
Significance of epicardial Q waves as an acute marker of myocardial necrosis in dogs.
Topics: Animals; Coronary Disease; Creatine Kinase; Dogs; Electrocardiography; Heart; Male; Myocardium; Necr | 1978 |
Experimental catecholamine-induced acute myocardial necrosis.
Topics: Acute Disease; Animals; Catecholamines; Dogs; Heart; Hemodynamics; Infusions, Parenteral; Isoprotere | 1978 |
Effects of drugs on myocardial necrosis after subarachnoid haemorrhage.
Topics: Humans; Myocardium; Necrosis; Phentolamine; Propranolol; Subarachnoid Hemorrhage | 1978 |
Estrogens as disposing factors in experimental liver injury.
Topics: Animals; Biotransformation; Carbon Tetrachloride Poisoning; Drug Interactions; Estrogens; Female; He | 1978 |
Irreversible myocardial damage resembling catecholamine necrosis secondary to acute coronary occlusion in dogs: its prevention by propranolol.
Topics: Animals; Dogs; Myocardial Infarction; Myocardium; Necrosis; Propranolol | 1977 |
Infarct size reduction by propranolol before and after coronary ligation in dogs.
Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; Hemodynamics; Male; Myocardial I | 1977 |
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myoc | 1976 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Mal | 1976 |
The mechanisms of free-radical lipids and antioxidant heart protection in experimental ischaemia and infarction.
Topics: Animals; Female; Free Radicals; Lipid Peroxidation; Male; Malondialdehyde; Microscopy, Electron; Myo | 1992 |
Action of propranolol on the atrial cardiomyocytes of rats submitted to cold stress.
Topics: Actin Cytoskeleton; Animals; Cold Temperature; Cytoplasmic Granules; Heart Atria; Mitochondria; Myoc | 1992 |
Reduction by norepinephrine of the side effects induced by combined hepatic arterial administration of degradable strach microspheres and adriamycin in rats with a liver adenocarcinoma.
Topics: Adenocarcinoma; Animals; Doxorubicin; Hepatic Artery; Injections, Intra-Arterial; Liver; Liver Neopl | 1991 |
Lichenoid drug eruption secondary to propranolol.
Topics: Aged; Drug Eruptions; Humans; Keratosis; Lichen Planus; Male; Necrosis; Penile Diseases; Propranolol | 1991 |
Role of noradrenaline in the pathogenesis of skin flap ischemic necrosis in the pig.
Topics: Animals; Ischemia; Necrosis; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Skin; Surg | 1990 |
Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Cardiomegaly; DNA; DNA Replication; Fibrosis; Hear | 1989 |
Alterations in isoproterenol-induced cardiac metabolic changes by a quaternary analog of propranolol, UM-272.
Topics: Animals; Anti-Arrhythmia Agents; Creatine Kinase; Dose-Response Relationship, Drug; Energy Metabolis | 1985 |
[Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion].
Topics: Acute Disease; Animals; Coronary Disease; Drug Evaluation, Preclinical; Energy Metabolism; Male; Myo | 1988 |
Effects of propranolol on tissue necrosis in experimental myocardial infarction in dogs.
Topics: Animals; Coronary Disease; Dogs; Electrophoresis, Polyacrylamide Gel; Female; Hydrogen-Ion Concentra | 1986 |
[Effect of enkephalins on the course of experimental izadrin-induced myocardial necrosis in the rabbit].
Topics: Animals; Cardiomyopathies; Creatine Kinase; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Isoe | 1985 |
Propranolol reduces ethanol-induced gastric mucosal damage in portal hypertensive rats.
Topics: Animals; Blood Pressure; Ethanol; Gastric Mucosa; Hypertension, Portal; Male; Necrosis; Portal Syste | 1986 |
[Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct].
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Dogs; Drug Evaluation, Preclinical; Electroca | 1986 |
[Liver lesions induced by dihydralazine and propranolol].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydralazine; Female; Humans; Hydralaz | 1985 |
[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Therapy, Combinatio | 1985 |
Letter: Paracetamol toxicity and propranolol.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antago | 1973 |
Competitive antagonism of isoprenaline-induced cardiac necroses by beta-adrenoreceptor blocking agents.
Topics: Animals; Biological Assay; Ethanolamines; Heart Diseases; Injections, Subcutaneous; Isoproterenol; M | 1969 |
Isoproterenol myocytolysis and myocardial calcium.
Topics: Animals; Biological Transport; Calcium; Cardiomyopathies; Dose-Response Relationship, Drug; Isoprote | 1974 |
Fat necrosis. Studies in rats with experimentally induced pancreatitis.
Topics: Adipose Tissue; Animals; Calcium; Cholesterol; Common Bile Duct; Epididymis; Fatty Acids, Nonesterif | 1972 |
The effect of vagal stimulation on the myocardium in the cat.
Topics: Animals; Blood Pressure; Cats; Cordotomy; Electric Stimulation; Electrodes; Heart; Heart Rate; Myoca | 1973 |
Protection of rats against the hepatotoxic effect of paracetamol.
Topics: Acetaminophen; Administration, Oral; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Inter | 1974 |
Reduction by propranolol of myocardial necrosis following temporary coronary artery occlusion in dogs.
Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Female; Heart; Heart Rate; Male; Myocardial Infarct | 1973 |
The effect of a beta adrenergic blocking agent, propranolol, on the development of experimental fat necrosis in the rat.
Topics: Adipose Tissue; Animals; Calcium; Depression, Chemical; Glycerol; Lipid Metabolism; Lipid Mobilizati | 1973 |
Inhibition of vasopressin-induced morbid effects on the rat kidney by pindolol and propranolol.
Topics: Animals; Female; Kidney; Kidney Cortex; Kidney Medulla; Male; Necrosis; Pindolol; Propranolol; Rats; | 1974 |
Prevention of gross myocardial infarction in the canine heart.
Topics: Animals; Assisted Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Heart Ventricles; Hyp | 1974 |
The effects of brain stem compression on the heart.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bradycardia; Brain Injuries; Brain Stem; Ca | 1974 |
Myocardial infarction after propranolol withdrawal.
Topics: Angina Pectoris; Animals; Arteriosclerosis; Coronary Disease; Dogs; Humans; Myocardial Infarction; N | 1974 |
Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion.
Topics: Animals; Coronary Disease; Coronary Vessels; Creatine Kinase; Disease Models, Animal; Dogs; Drug Com | 1972 |
Calcium as mediator of isoproterenol-induced myocardial necrosis.
Topics: Animals; Calcium; Heart; Injections, Intraperitoneal; Isoproterenol; Myocardial Infarction; Myocardi | 1972 |
[Role of antikaliuretics and catecholamines in the prevention of cardiac necroses of metabolic origin].
Topics: Adrenal Cortex Hormones; Amiloride; Animals; Catecholamines; Digitoxin; Diuretics; Epinephrine; Hear | 1971 |
Tissue electrolyte alteration in disseminated myocardial necrosis.
Topics: Animals; Calcium; Electrolytes; Heart Diseases; Isoproterenol; Kidney; Magnesium; Myocardium; Necros | 1969 |
Cardiovascular effects of scorpion venom, morphological changes in the myocardium.
Topics: Animals; Antivenins; Coronary Vessels; Dibenzylchlorethamine; Dogs; Heart; Heart Diseases; Hemorrhag | 1970 |
Correlation of myocardial and renal necrosis with tissue electrolyte changes.
Topics: Animals; Calcium, Dietary; Catecholamines; Electrolytes; Kidney Diseases; Magnesium; Male; Metaramin | 1966 |
The effect of a beta adrenergic blocking agent on chemical changes in isoproterenol-induced myocardial necrosis.
Topics: Adenine Nucleotides; Animals; Body Weight; Cholesterol; Creatine; Glycogen; Heart; Isoproterenol; La | 1966 |