propranolol has been researched along with Necrosis in 82 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
Excerpt | Relevance | Reference |
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") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)." | 7.70 | The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000) |
"Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis." | 7.67 | Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989) |
"Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined." | 7.66 | Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981) |
"Isoproterenol (ISO), a drug which causes an increased strength of myocardial contraction when administered to animals in mug/kg doses, causes myocardial necrosis when given mg/kg doses." | 7.65 | Calcium as mediator of isoproterenol-induced myocardial necrosis. ( Bloom, S; Davis, DL, 1972) |
"Treatment with propranolol had a negative chronotropic effect throughout the observation period of 72 h." | 5.32 | Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. ( Briest, W; Deten, A; Holzl, A; Volz, HC; Zimmer, HG, 2003) |
"Nitroglycerin has a reducing influence on these changes, but not down to the initial level." | 5.26 | [The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)]. ( Hochrein, H; Lehmann, HU; Oeff, M; Witt, E, 1981) |
"Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion." | 5.26 | Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979) |
") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)." | 3.70 | The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000) |
"Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis." | 3.67 | Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989) |
"Effect of UM-272, a dimethyl propranolol has been studied in experimental myocardial necrosis induced by isoproterenol (ISP, 85 mg/kg, SC X 2 days) in rats." | 3.67 | Alterations in isoproterenol-induced cardiac metabolic changes by a quaternary analog of propranolol, UM-272. ( Gupta, M; Gupta, MP; Manchanda, SC; Seth, SD; Srivastava, LM, 1985) |
"The experiments on rats with a 3-day myocardial infarction caused by the left coronary artery ligation have shown that multiple lidocaine and pyromecaine injections according to a given scheme decrease the size of the necrosis area." | 3.67 | [Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct]. ( Chichkanov, GG; Goldshteĭne, GKh; Tsorin, IB, 1986) |
"Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported." | 3.67 | [The so-called dihydralazine hepatitis. A contribution to the pathogenesis]. ( Jahn, G; Krombholz, B; Machnik, G; Reinhardt, M, 1985) |
"Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined." | 3.66 | Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981) |
"Previous studies have shown that oral administration of minoxidil on 2 consecutive days produces an increase in heart rate and myocardial necrosis in Beagle dogs." | 3.66 | Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs. ( Balazs, T; Ferrans, VJ; Herman, EH; Young, RS, 1981) |
" The beta receptor blocking propranolol prevented functional lesion, moderated fatty degeneration and liver cell necrosis in chronic carbon tetrachloride injury." | 3.66 | Estrogens as disposing factors in experimental liver injury. ( Gomba, S; Kulcsár, A; Kulscár-Gergely, J, 1978) |
"Isoproterenol (ISO), a drug which causes an increased strength of myocardial contraction when administered to animals in mug/kg doses, causes myocardial necrosis when given mg/kg doses." | 3.65 | Calcium as mediator of isoproterenol-induced myocardial necrosis. ( Bloom, S; Davis, DL, 1972) |
"Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage." | 1.40 | Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy. ( Dai, W; Kloner, RA; Sachdeva, J, 2014) |
" Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique." | 1.38 | Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012) |
"Treatment with propranolol had a negative chronotropic effect throughout the observation period of 72 h." | 1.32 | Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. ( Briest, W; Deten, A; Holzl, A; Volz, HC; Zimmer, HG, 2003) |
" Vasoactive drugs may therefore be of value to diminish adverse side effects of the combination cytostatic agent + DSM, probably decreasing overspill into normal tissues." | 1.28 | Reduction by norepinephrine of the side effects induced by combined hepatic arterial administration of degradable strach microspheres and adriamycin in rats with a liver adenocarcinoma. ( Jakobsson, B; Roos, G; Stenram, U; Teder, H, 1991) |
"Propranolol treatment limited progressive death of myocardial cell population, reducing by 37% myocardial infarction size by day 7 of the experimental study, as compared to the situation in the untreated animals." | 1.27 | [Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion]. ( Irgashev, ShB; Iuldashev, NM; Mavridi, DI, 1988) |
" Increased dosage of propranolol to 4 mg did not produce any further reduction of portal pressure or mucosal damage." | 1.27 | Propranolol reduces ethanol-induced gastric mucosal damage in portal hypertensive rats. ( Ivey, KJ; Maeda, R; Mason, GR; Sankary, H; Sarfeh, IJ; Tarnawski, A, 1986) |
" Chronic administration of propranolol to SHR for three consecutive weeks by Alzet minipump reduced systolic arterial pressure but did not reverse the indices of myocardial hypertrophy." | 1.26 | Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats. ( Greenberg, S; Wilborn, WM, 1982) |
"Nitroglycerin has a reducing influence on these changes, but not down to the initial level." | 1.26 | [The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)]. ( Hochrein, H; Lehmann, HU; Oeff, M; Witt, E, 1981) |
"Propranolol pretreatment decreased the accumulation of radioactivity in a dose-dependent fashion." | 1.26 | Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline. ( Athari-Nejad, A; Holcslaw, TL; Ryan, CF, 1979) |
"Pretreatment with propranolol reduced necrosis from 85 +/- 3% (untreated) to 52 +/- 4% (P less than 0." | 1.26 | Infarct size reduction by propranolol before and after coronary ligation in dogs. ( Jennings, RB; Kloner, RA; Rasmussen, MM; Reimer, KA, 1977) |
"Pretreatment with propranolol and pargyline protected against ISO-induced necrosis and myocardial hypertrophy, but did not influence the ISO-induced depletion of NE stores." | 1.25 | Alterations in norepinephrine pattern in the damaged myocardium in the rat. ( Bhagat, B; Dhalla, NS; Sullivan, JM, 1975) |
"Trichlorofluoromethane (FC 11) provoked arrhythmia in all three animal species, dichlorodifluoromethane (FC 12) in monkeys and rats but not in mice, and difluoroethane (FC 152a) only in rats." | 1.25 | Toxicity of aerosol propellants in the respiratory and circulatory systems. VI. Influence of cardiac and pulmonary vascular lesions in the rat. ( Aviado, DM; Doherty, RE, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 68 (82.93) | 18.7374 |
1990's | 6 (7.32) | 18.2507 |
2000's | 4 (4.88) | 29.6817 |
2010's | 3 (3.66) | 24.3611 |
2020's | 1 (1.22) | 2.80 |
Authors | Studies |
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Freiha, M | 1 |
Achim, M | 1 |
Gheban, BA | 1 |
Moldovan, R | 1 |
Filip, GA | 1 |
Sachdeva, J | 1 |
Dai, W | 1 |
Kloner, RA | 2 |
Dinato, SL | 1 |
Dinato, MC | 1 |
Dinato, MM | 1 |
Ribeiro, MC | 1 |
Yamashiro, CY | 1 |
Romiti, N | 1 |
Kumar, V | 1 |
Murali, M | 1 |
Li, P | 1 |
Robertson, TA | 1 |
Zhang, Q | 1 |
Fletcher, LM | 1 |
Crawford, DH | 1 |
Weiss, M | 1 |
Roberts, MS | 1 |
Deten, A | 1 |
Volz, HC | 1 |
Holzl, A | 1 |
Briest, W | 1 |
Zimmer, HG | 1 |
Bhatt, LK | 1 |
Nandakumar, K | 1 |
Bodhankar, SL | 1 |
Bansal, J | 1 |
Piplani, P | 1 |
Hashimoto, H | 1 |
Ogawa, K | 1 |
Gichka, SG | 1 |
Greenberg, S | 1 |
Wilborn, WM | 1 |
Seth, SD | 4 |
Gupta, MP | 4 |
Gupta, M | 2 |
Manchanda, SC | 3 |
Häggendal, J | 2 |
Johansson, G | 2 |
Jönsson, L | 2 |
Thorén-Tolling, K | 2 |
Wray, RC | 1 |
Young, VL | 1 |
Lehmann, HU | 1 |
Oeff, M | 1 |
Witt, E | 1 |
Hochrein, H | 1 |
Stewart, JR | 1 |
Gibson, JK | 1 |
Lucchesi, BR | 1 |
Bloksma, N | 1 |
Hofhuis, FM | 1 |
Willers, JM | 1 |
Popov, VG | 1 |
Jdanova, NS | 1 |
Jelnov, VV | 1 |
Alushkov, MV | 1 |
Barishnikova, GA | 1 |
Herman, EH | 2 |
Balazs, T | 2 |
Ferrans, VJ | 2 |
Young, RS | 1 |
Ganguly, PK | 1 |
Srivastava, LM | 2 |
Bora, PS | 1 |
El-Hage, A | 1 |
Ehrreich, SJ | 1 |
Johnson, GL | 1 |
Atkinson, JC | 1 |
West, WL | 1 |
Gvatua, NA | 1 |
Kravtsov, VL | 1 |
Ivanova, LK | 1 |
Shkliar, LV | 1 |
Shumakov, VA | 1 |
Galenko-Iaroshevskiĭ, PA | 1 |
Melkumova, ER | 1 |
Bartashevich, VV | 1 |
Uvarov, AV | 1 |
Turovaia, AIu | 1 |
Khankoeva, AI | 1 |
Galygo, DS | 1 |
Blidaru, M | 1 |
Cuparencu, B | 1 |
Pleşca-Manea, L | 1 |
Strubelt, O | 2 |
Siegers, CP | 2 |
Bhagat, B | 1 |
Sullivan, JM | 1 |
Dhalla, NS | 1 |
Lossnitzer, K | 1 |
Konrad, A | 1 |
Heine, HW | 1 |
Ziegler, E | 1 |
Stauch, M | 1 |
Gokal, R | 1 |
Dornan, TL | 1 |
Ledingham, JG | 1 |
Fox, KM | 1 |
Chopra, MP | 1 |
Portal, RW | 1 |
Aber, CP | 1 |
Doherty, RE | 1 |
Aviado, DM | 1 |
Neil-Dwyer, G | 1 |
Walter, P | 1 |
Cruickshank, JM | 1 |
Doshi, B | 1 |
O'Gorman, P | 1 |
Finseth, F | 1 |
Adelberg, MG | 1 |
Hoffbrand, BI | 1 |
Saxena, KK | 1 |
Gupta, B | 1 |
Srivastava, VK | 1 |
Kulshrestha, VK | 1 |
Prasad, DN | 1 |
Allen, JD | 1 |
Pantridge, JF | 1 |
Patton, JN | 1 |
Ryan, CF | 1 |
Athari-Nejad, A | 1 |
Holcslaw, TL | 1 |
Mickleborough, L | 1 |
Huttner, I | 1 |
Symes, J | 1 |
Poirier, N | 1 |
Sniderman, AD | 1 |
Eliot, RS | 2 |
Todd, GL | 1 |
Clayton, FC | 1 |
Pieper, GM | 1 |
Falk, RH | 1 |
Casscells, W | 1 |
Kulscár-Gergely, J | 1 |
Kulcsár, A | 1 |
Gomba, S | 1 |
Baroldi, G | 1 |
Silver, MD | 1 |
Lixfeld, W | 1 |
McGregor, DC | 1 |
Rasmussen, MM | 2 |
Reimer, KA | 2 |
Jennings, RB | 2 |
Hoffmann, A | 1 |
Sierra-Callejas, JL | 1 |
Fleming, JS | 1 |
Buchanan, JO | 1 |
Buyniski, JP | 1 |
Kogan, AK | 1 |
Kudrin, AN | 1 |
Losev, NI | 1 |
Lopes, AC | 1 |
Borrotchin, L | 1 |
Sasso, WS | 1 |
DiDio, LJ | 1 |
Jakobsson, B | 1 |
Teder, H | 1 |
Roos, G | 1 |
Stenram, U | 1 |
Massa, MC | 1 |
Jason, SM | 1 |
Gradini, R | 1 |
Welykyj, S | 1 |
Forrest, CR | 1 |
Pang, CY | 1 |
Zhong, AG | 1 |
Neligan, PC | 1 |
Benjamin, IJ | 1 |
Jalil, JE | 1 |
Tan, LB | 1 |
Cho, K | 1 |
Weber, KT | 1 |
Clark, WA | 1 |
Irgashev, ShB | 1 |
Mavridi, DI | 1 |
Iuldashev, NM | 1 |
Tsuchida, K | 1 |
Yamazaki, R | 1 |
Kaneko, K | 1 |
Aihara, H | 1 |
Pavlenko, VS | 1 |
Slepushkin, VD | 1 |
Zoloev, GK | 1 |
Titov, MI | 1 |
Sankary, H | 1 |
Sarfeh, IJ | 1 |
Tarnawski, A | 1 |
Maeda, R | 1 |
Ivey, KJ | 1 |
Mason, GR | 1 |
Goldshteĭne, GKh | 1 |
Tsorin, IB | 1 |
Chichkanov, GG | 1 |
Kunze, KD | 1 |
Porst, H | 1 |
Lohmann, J | 1 |
Tschöpel, L | 1 |
Reinhardt, M | 1 |
Machnik, G | 1 |
Krombholz, B | 1 |
Jahn, G | 1 |
Auty, RM | 1 |
Branch, RA | 1 |
Smith, ER | 1 |
Katz, AM | 1 |
Guy, CR | 1 |
Dorigotti, L | 1 |
Gaetani, M | 1 |
Glässer, AH | 1 |
Turolla, E | 1 |
Bloom, S | 2 |
Davis, D | 1 |
Theve, NO | 2 |
Corley, KC | 1 |
Sheil, FO | 1 |
Mauck, HP | 1 |
Hoff, EC | 1 |
Braunwald, E | 2 |
Maroko, PR | 2 |
Libby, P | 2 |
Gazzard, BG | 1 |
Hughes, RD | 1 |
Portmann, B | 1 |
Dordoni, B | 1 |
Williams, R | 1 |
Carlström, A | 1 |
Hallberg, D | 1 |
Akermark, C | 1 |
Bartsokas, SK | 1 |
Katapoti, Z | 1 |
Papadimitriou, DG | 1 |
Ginks, W | 1 |
Ross, J | 1 |
Sybers, HD | 2 |
Vander Ark, GD | 1 |
Norton, LW | 1 |
Pomerantz, M | 1 |
Diaz, RG | 1 |
Somberg, J | 1 |
Freeman, E | 1 |
Levitt, B | 1 |
Sobel, BE | 1 |
Bloor, CM | 1 |
Shell, WE | 1 |
Covell, JW | 1 |
Davis, DL | 1 |
Savoie, LL | 1 |
Lehr, D | 2 |
Yarom, R | 1 |
Braun, K | 1 |
Krukowski, M | 1 |
Colón, R | 1 |
Kako, K | 1 |
5 reviews available for propranolol and Necrosis
Article | Year |
---|---|
Effect of infarct size limitation by propranolol on ventricular arrhythmias after myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Dogs; Humans; Myocardial Infarction; | 1982 |
Acute myocardial infarction and muscle salvage: a potential role for pharmacological agents.
Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Assisted Circulation; Collateral Circulation; Coronar | 1974 |
Biochemical "defect" in the hypertrophied and failing heart: deleterious or compensatory?
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Cardiomegaly; Coronary Disease; | 1973 |
The pathophysiologic vulnerability of the subendocardium of the left ventricle.
Topics: Arrhythmias, Cardiac; Capillaries; Cardiomegaly; Coronary Disease; Coronary Vessels; Endocardium; He | 1973 |
Reduction of infarct size following coronary occlusion.
Topics: Anaerobiosis; Animals; Assisted Circulation; Coronary Vessels; Creatine Kinase; Electrocardiography; | 1974 |
1 trial available for propranolol and Necrosis
Article | Year |
---|---|
Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Humans; Male; Mid | 1978 |
76 other studies available for propranolol and Necrosis
Article | Year |
---|---|
In Vivo Study of the Effects of Propranolol, Timolol, and Minoxidil on Burn Wound Healing in Wistar Rats.
Topics: Animals; Antioxidants; Burns; Female; Fibrosis; Inflammation; Minoxidil; Necrosis; Propranolol; Rats | 2023 |
Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Echo | 2014 |
[Necrotizing vasculitis as a manifestation of hypersensitivity to propylthiouracil].
Topics: Adolescent; Antithyroid Agents; Humans; Male; Necrosis; Prednisone; Propranolol; Propylthiouracil; V | 2009 |
Large cavernous hemangioma.
Topics: Abdomen; Disseminated Intravascular Coagulation; Fatal Outcome; Female; Hemangioma, Cavernous; Human | 2010 |
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2012 |
Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Collagen; Cytokines; Female; Gene Expression; | 2003 |
Beta-blocking activity of PP-34, a newly synthesized aryloxypropanolamine derivative, and its cardioprotective effect against ischaemia/reperfusion injury in laboratory animals.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Atenolol; Benzylamines; Female; Guinea P | 2007 |
Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis.
Topics: Animals; Aspirin; Body Weight; Creatine Kinase; Cyclic AMP; Heart; Isoproterenol; Male; Myocardial I | 1981 |
[Morphological criteria of the effectiveness of nitroglycerin, dipyridamole and propranolol hydrochloride in an experimental metabolic lesion of the myocardium].
Topics: Animals; Cardiomyopathies; Dipyridamole; Drug Evaluation, Preclinical; Histocytochemistry; Male; Myo | 1984 |
Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats.
Topics: Animals; Body Water; Cardiomegaly; Clonidine; Glycosaminoglycans; Heart; Hypertension; Muscle Protei | 1982 |
Oxyfedrine and propranolol. A comparative experimental approach to protect myocardium against isoprenaline-induced myocardial necrosis.
Topics: Animals; Cardiomyopathies; Female; Glycolysis; Isoproterenol; Male; Myocardium; Necrosis; Oxyfedrine | 1984 |
Effect of phenoxybenzamine on myocardial cell necroses and blood levels of catecholamines in pigs subjected to stress.
Topics: Animals; Cardiomyopathies; Catecholamines; Coronary Vessels; Female; Humans; Male; Necrosis; Phenoxy | 1984 |
Drug treatment and flap survival.
Topics: Administration, Oral; Animals; Drug Evaluation; Graft Survival; Heparin; Infusions, Parenteral; Isox | 1984 |
[The treatment of acute myocardial infarctions with beta-receptor-blockers. II. Hemodynamic effects of propranolol with and without combination therapy with nitroglycerin (author's transl)].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; | 1981 |
Effect of propranolol on myocardial cell necroses and blood levels of catecholamines in pigs subjected to stress.
Topics: Animals; Cardiomyopathies; Catecholamines; Female; Male; Necrosis; Propranolol; Restraint, Physical; | 1982 |
Effect of adrenoceptor blockade on hemorrhagic necrosis of meth A sarcomata induced by endotoxin or tumor necrosis serum.
Topics: Animals; Dose-Response Relationship, Drug; Endotoxins; Female; Fibrosarcoma; Immune Sera; Mice; Necr | 1982 |
Biochemical basis of the protective effect of propranolol pretreatment in experimental myocardial necrosis.
Topics: Animals; Female; Glycogen; Heart; Isoproterenol; Male; Myocardium; Necrosis; Propranolol; Rats; Rats | 1982 |
Precardiac mapping of R waves and ST intervals. Results in patients in acute period of extensive anterior myocardial infarction and effect of some drugs on the periinfarction zone.
Topics: Acute Disease; Body Surface Area; Digoxin; Electrocardiography; Humans; Myocardial Infarction; Necro | 1981 |
Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs.
Topics: Animals; Dogs; Drug Interactions; Furosemide; Heart Diseases; Heart Rate; Hydrochlorothiazide; Male; | 1981 |
Nifedipine--a new calcium antagonist in experimental myocardial necrosis.
Topics: Animals; Calcium; Male; Myocardial Infarction; Myocardium; Necrosis; Nifedipine; Propranolol; Pyridi | 1981 |
Study of the mechanism of hydralazine-induced myocardial necrosis in the rat.
Topics: Animals; Calcium; Cardiomyopathies; Dihydrotachysterol; Heart Rate; Hydralazine; Male; Necrosis; Pro | 1981 |
[Use of obzidan in the acute period of myocardial infarct].
Topics: Adult; Aged; Creatine Kinase; Drug Evaluation; Electrocardiography; Hemodynamics; Humans; Male; Midd | 1980 |
[Comparative evaluation of the effect of dimebon, obzidan, finoptin, and cordarone on the functional state of the ischemic focus and the size of necrosis zone during experimental myocardial infarction].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cats; Histamine H1 Antagonists; Indoles; Myocardial Inf | 1996 |
The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Injections, Intr | 2000 |
Role of cardiovascular and ionic changes in pathogenesis and prevention of isoprenaline-induced cardiac necrosis.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiomyopathies; Heart Rate; Hydrogen-Ion Concentration; I | 1975 |
Alterations in norepinephrine pattern in the damaged myocardium in the rat.
Topics: Animals; Cardiomegaly; Cardiomyopathies; Isoproterenol; Male; Monoamine Oxidase; Myocardium; Necrosi | 1975 |
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard | 1975 |
Peripheral skin necrosis complicating beta-blockage.
Topics: Aged; Atenolol; Drug Eruptions; Female; Foot; Foot Dermatoses; Humans; Ischemia; Male; Middle Aged; | 1979 |
Long-term beta blockade: possible protection from myocardial infarction.
Topics: Adrenergic beta-Antagonists; Aspartate Aminotransferases; Blood Sedimentation; Body Temperature; Cor | 1975 |
Toxicity of aerosol propellants in the respiratory and circulatory systems. VI. Influence of cardiac and pulmonary vascular lesions in the rat.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic beta-Antagonists; Aerosol Propellants; Aerosols; Animals; | 1975 |
Experimental work with isoxuprine for prevention of skin flap necrosis and for treatment of the failing flap.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Rejection; Injections, I | 1979 |
Peripheral skin necrosis complicating beta-blockade.
Topics: Aged; Female; Humans; Male; Middle Aged; Necrosis; Propranolol; Skin; Skin Ulcer; Toes | 1979 |
On significance of plasma fibrinogen level to assess severity of myocardial damage--an experimental study.
Topics: Animals; Cardiomyopathies; Female; Fibrinogen; Isoproterenol; Male; Myocardial Infarction; Myocardiu | 1979 |
Autonomic nervous activity and myocardial necrosis after DC shocks from cardiac defibrillators [proceedings].
Topics: Animals; Dogs; Electric Countershock; Heart; Myocardium; Necrosis; Propranolol; Reserpine | 1979 |
Quantitation of isoproterenol-induced myocardial necrosis with 3H-tetracycline.
Topics: Animals; Cardiomyopathies; Dose-Response Relationship, Drug; Isoproterenol; Male; Myocardium; Necros | 1979 |
Significance of epicardial Q waves as an acute marker of myocardial necrosis in dogs.
Topics: Animals; Coronary Disease; Creatine Kinase; Dogs; Electrocardiography; Heart; Male; Myocardium; Necr | 1978 |
Experimental catecholamine-induced acute myocardial necrosis.
Topics: Acute Disease; Animals; Catecholamines; Dogs; Heart; Hemodynamics; Infusions, Parenteral; Isoprotere | 1978 |
Effects of drugs on myocardial necrosis after subarachnoid haemorrhage.
Topics: Humans; Myocardium; Necrosis; Phentolamine; Propranolol; Subarachnoid Hemorrhage | 1978 |
Estrogens as disposing factors in experimental liver injury.
Topics: Animals; Biotransformation; Carbon Tetrachloride Poisoning; Drug Interactions; Estrogens; Female; He | 1978 |
Irreversible myocardial damage resembling catecholamine necrosis secondary to acute coronary occlusion in dogs: its prevention by propranolol.
Topics: Animals; Dogs; Myocardial Infarction; Myocardium; Necrosis; Propranolol | 1977 |
Infarct size reduction by propranolol before and after coronary ligation in dogs.
Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; Hemodynamics; Male; Myocardial I | 1977 |
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myoc | 1976 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Mal | 1976 |
The mechanisms of free-radical lipids and antioxidant heart protection in experimental ischaemia and infarction.
Topics: Animals; Female; Free Radicals; Lipid Peroxidation; Male; Malondialdehyde; Microscopy, Electron; Myo | 1992 |
Action of propranolol on the atrial cardiomyocytes of rats submitted to cold stress.
Topics: Actin Cytoskeleton; Animals; Cold Temperature; Cytoplasmic Granules; Heart Atria; Mitochondria; Myoc | 1992 |
Reduction by norepinephrine of the side effects induced by combined hepatic arterial administration of degradable strach microspheres and adriamycin in rats with a liver adenocarcinoma.
Topics: Adenocarcinoma; Animals; Doxorubicin; Hepatic Artery; Injections, Intra-Arterial; Liver; Liver Neopl | 1991 |
Lichenoid drug eruption secondary to propranolol.
Topics: Aged; Drug Eruptions; Humans; Keratosis; Lichen Planus; Male; Necrosis; Penile Diseases; Propranolol | 1991 |
Role of noradrenaline in the pathogenesis of skin flap ischemic necrosis in the pig.
Topics: Animals; Ischemia; Necrosis; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Skin; Surg | 1990 |
Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Cardiomegaly; DNA; DNA Replication; Fibrosis; Hear | 1989 |
Alterations in isoproterenol-induced cardiac metabolic changes by a quaternary analog of propranolol, UM-272.
Topics: Animals; Anti-Arrhythmia Agents; Creatine Kinase; Dose-Response Relationship, Drug; Energy Metabolis | 1985 |
[Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion].
Topics: Acute Disease; Animals; Coronary Disease; Drug Evaluation, Preclinical; Energy Metabolism; Male; Myo | 1988 |
Effects of propranolol on tissue necrosis in experimental myocardial infarction in dogs.
Topics: Animals; Coronary Disease; Dogs; Electrophoresis, Polyacrylamide Gel; Female; Hydrogen-Ion Concentra | 1986 |
[Effect of enkephalins on the course of experimental izadrin-induced myocardial necrosis in the rabbit].
Topics: Animals; Cardiomyopathies; Creatine Kinase; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Isoe | 1985 |
Propranolol reduces ethanol-induced gastric mucosal damage in portal hypertensive rats.
Topics: Animals; Blood Pressure; Ethanol; Gastric Mucosa; Hypertension, Portal; Male; Necrosis; Portal Syste | 1986 |
[Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct].
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Dogs; Drug Evaluation, Preclinical; Electroca | 1986 |
[Liver lesions induced by dihydralazine and propranolol].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydralazine; Female; Humans; Hydralaz | 1985 |
[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Therapy, Combinatio | 1985 |
Letter: Paracetamol toxicity and propranolol.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antago | 1973 |
Competitive antagonism of isoprenaline-induced cardiac necroses by beta-adrenoreceptor blocking agents.
Topics: Animals; Biological Assay; Ethanolamines; Heart Diseases; Injections, Subcutaneous; Isoproterenol; M | 1969 |
Isoproterenol myocytolysis and myocardial calcium.
Topics: Animals; Biological Transport; Calcium; Cardiomyopathies; Dose-Response Relationship, Drug; Isoprote | 1974 |
Fat necrosis. Studies in rats with experimentally induced pancreatitis.
Topics: Adipose Tissue; Animals; Calcium; Cholesterol; Common Bile Duct; Epididymis; Fatty Acids, Nonesterif | 1972 |
The effect of vagal stimulation on the myocardium in the cat.
Topics: Animals; Blood Pressure; Cats; Cordotomy; Electric Stimulation; Electrodes; Heart; Heart Rate; Myoca | 1973 |
Protection of rats against the hepatotoxic effect of paracetamol.
Topics: Acetaminophen; Administration, Oral; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Inter | 1974 |
Reduction by propranolol of myocardial necrosis following temporary coronary artery occlusion in dogs.
Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Female; Heart; Heart Rate; Male; Myocardial Infarct | 1973 |
The effect of a beta adrenergic blocking agent, propranolol, on the development of experimental fat necrosis in the rat.
Topics: Adipose Tissue; Animals; Calcium; Depression, Chemical; Glycerol; Lipid Metabolism; Lipid Mobilizati | 1973 |
Inhibition of vasopressin-induced morbid effects on the rat kidney by pindolol and propranolol.
Topics: Animals; Female; Kidney; Kidney Cortex; Kidney Medulla; Male; Necrosis; Pindolol; Propranolol; Rats; | 1974 |
Prevention of gross myocardial infarction in the canine heart.
Topics: Animals; Assisted Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Heart Ventricles; Hyp | 1974 |
The effects of brain stem compression on the heart.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bradycardia; Brain Injuries; Brain Stem; Ca | 1974 |
Myocardial infarction after propranolol withdrawal.
Topics: Angina Pectoris; Animals; Arteriosclerosis; Coronary Disease; Dogs; Humans; Myocardial Infarction; N | 1974 |
Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion.
Topics: Animals; Coronary Disease; Coronary Vessels; Creatine Kinase; Disease Models, Animal; Dogs; Drug Com | 1972 |
Calcium as mediator of isoproterenol-induced myocardial necrosis.
Topics: Animals; Calcium; Heart; Injections, Intraperitoneal; Isoproterenol; Myocardial Infarction; Myocardi | 1972 |
[Role of antikaliuretics and catecholamines in the prevention of cardiac necroses of metabolic origin].
Topics: Adrenal Cortex Hormones; Amiloride; Animals; Catecholamines; Digitoxin; Diuretics; Epinephrine; Hear | 1971 |
Tissue electrolyte alteration in disseminated myocardial necrosis.
Topics: Animals; Calcium; Electrolytes; Heart Diseases; Isoproterenol; Kidney; Magnesium; Myocardium; Necros | 1969 |
Cardiovascular effects of scorpion venom, morphological changes in the myocardium.
Topics: Animals; Antivenins; Coronary Vessels; Dibenzylchlorethamine; Dogs; Heart; Heart Diseases; Hemorrhag | 1970 |
Correlation of myocardial and renal necrosis with tissue electrolyte changes.
Topics: Animals; Calcium, Dietary; Catecholamines; Electrolytes; Kidney Diseases; Magnesium; Male; Metaramin | 1966 |
The effect of a beta adrenergic blocking agent on chemical changes in isoproterenol-induced myocardial necrosis.
Topics: Adenine Nucleotides; Animals; Body Weight; Cholesterol; Creatine; Glycogen; Heart; Isoproterenol; La | 1966 |