4-dimethylaminostilbene: RN given refers to cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 640024 |
| CHEMBL ID | 83880 |
| SCHEMBL ID | 1557242 |
| MeSH ID | M0050685 |
| Synonym |
|---|
| CHEMBL83880 |
| unii-1v7p79915n |
| 1v7p79915n , |
| 4-12-00-03400 (beilstein handbook reference) |
| 838-95-9 |
| nsc30991 |
| wln: 1n1&r d1u1r |
| benzenamine,n-dimethyl-4-(2-phenylethenyl)- |
| stilbenyl-n,n-dimethylamine |
| nsc-30991 |
| 4-stilbenamine,n-dimethyl- |
| 4-dimethylaminostilbene |
| 1145-73-9 |
| 4-dimethylaminostilben |
| IDI1_014233 |
| benzenamine, n,n-dimethyl-4-[(e)-2-phenylethenyl]- |
| inchi=1/c16h17n/c1-17(2)16-12-10-15(11-13-16)9-8-14-6-4-3-5-7-14/h3-13h,1-2h3/b9-8 |
| n,n-dimethyl-4-[(e)-2-phenylvinyl]aniline |
| SR-01000641230-1 |
| 4-stilbenamine, n,n-dimethyl-, (e)- |
| benzenamine, n,n-dimethyl-4-(2-phenylethenyl)- |
| trans-4-dimethylaminostilbene |
| 4-stilbenamine, trans-n,n-dimethyl- |
| brn 2211373 |
| benzenamine, n,n-dimethyl-4-(2-phenylethenyl)-, (e)- |
| ccris 988 |
| trans-4-(dimethylamino)stilbene |
| trans-n,n-dimethyl-4-stilbenamine |
| trans-p-(dimethylamino)stilbene |
| D0255 |
| 4-(dimethylamino)stilbene |
| HMS1439B08 |
| n,n-dimethyl-4-[(e)-2-phenylethenyl]aniline |
| CCG-51967 |
| AKOS015850692 |
| benzenamine, n,n-dimethyl-4-((1e)-2-phenylethenyl)- |
| bdbm150266 |
| us8980954, 4cc |
| SCHEMBL1557242 |
| n,n-dimethyl-4-[(e)-2-phenylethenyl]aniline # |
| 4-dimethylamino-trans-stilbene |
| XGHHHPDRXLIMPM-CMDGGOBGSA-N |
| n,n-dimethyl-4-styrylaniline |
| mfcd00017151 |
| AS-66960 |
| 4-stilbenamine,n,n-dimethyl-,e- |
| benzenamine, n,n-dimethyl-4-[(1e)-2-phenylethenyl]- |
| (e)-n,n-dimethyl-4-styrylaniline |
| BRD-K62258207-001-01-3 |
| Q27252942 |
| A894190 |
| DTXSID401020720 |
| (e)-4-dimethylaminostilbene |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID168085 | Carcinogenic activity on liver after oral administration of the compound | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3 | Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines. |
| AID168112 | Carcinogenic activity after oral administration | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3 | Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines. |
| AID692960 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Axin-2 protein level at 10 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID273485 | Antioxidant activity measured as ability to reduce ferric tripyridyltriazine complex at 15 uM by FRAP assay | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID273486 | Inhibition of TNF-alpha-induced NF-kappaB activation in HEK293T cells | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID273490 | Suppression of LPS-stimulated COX2 mRNA expression in mouse BV2 cells at 0.15 uM | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID167955 | Carcinogenic activity on ear duct after oral administration | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3 | Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines. |
| AID692957 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in c-Myc protein level at 30 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID692959 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in c-Myc protein level at 10 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID273484 | Antioxidant activity measured as ability to react with ABTS radical cation at 15 uM by TRAP assay | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID167927 | Carcinogenic activity on all sites after oral administration | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3 | Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines. |
| AID167940 | Tested for carcinogenic activity on breast after oral administration of the compound; - denotes non carcinogenic activity. | 1981 | Journal of medicinal chemistry, Mar, Volume: 24, Issue:3 | Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines. |
| AID660956 | Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD at 1 uM after 60 mins by TR-FRET assay | 2012 | Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6 | (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. |
| AID692958 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Axin-2 protein level at 30 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID692961 | Inhibition of Wnt/beta-casein in human LS174T cells assessed as effect on beta-casein protein level at 10 uM by Western blotting | 2011 | Journal of medicinal chemistry, Mar-10, Volume: 54, Issue:5 | Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. |
| AID273487 | Loss in viability of human HEK293T cells at 15 uM after 7 hrs relative to control | 2006 | Journal of medicinal chemistry, Nov-30, Volume: 49, Issue:24 | Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 19 (79.17) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 25 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Correlation of nucleic acid binding by metabolites of trans-4-aminostilbene derivatives with tissue specific acute toxicity and carcinogenicity in rats. Carcinogenesis, Volume: 1, Issue: 10 | 1980 |
| Tissue specific, acute toxic effects of the carcinogen trans-4-dimethylaminostilbene. Archives of toxicology, Volume: 56, Issue: 3 | 1985 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. Journal of medicinal chemistry, Mar-22, Volume: 55, Issue: 6 | 2012 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. Journal of medicinal chemistry, Mar-10, Volume: 54, Issue: 5 | 2011 |
| Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. Journal of medicinal chemistry, Nov-30, Volume: 49, Issue: 24 | 2006 |
| Biochemical effects and early lesions in regard to dose-response studies. Oncology, Volume: 37, Issue: 4 | 1980 |
| Dose-response relationship in the primary lesion of strong electrophilic carcinogens. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, Volume: 3 | 1980 |
| Some examples of dose-response studies in chemical carcinogenesis. Oncology, Volume: 33, Issue: 2 | 1976 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |