Proteins > 5-hydroxytryptamine receptor 5A
Page last updated: 2024-08-07 13:18:40
5-hydroxytryptamine receptor 5A
A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898]
Synonyms
5-HT-5;
5-HT-5A;
5-HT5A;
Serotonin receptor 5A
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
Compounds (47)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| methylbufotenin | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| metergoline | Homo sapiens (human) | Activity | 0.5620 | 1 | 1 |
[no title available]Journal of natural products, , 03-26, Volume: 84, Issue:3, 2021
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Binding of beta-carbolines at 5-HT(2) serotonin receptors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003
Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Binding of beta-carbolines at 5-HT(2) serotonin receptors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003
Discovery of G Protein-Biased Antagonists against 5-HTJournal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled serotonin receptor activity | molecular function | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai] |
| neurotransmitter receptor activity | molecular function | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling] |
| serotonin binding | molecular function | Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:ai] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| perikaryon | cellular component | The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl] |
| postsynaptic specialization membrane | cellular component | The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
Involved In
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| hippocampus development | biological process | The progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421] |
| response to estradiol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123] |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| adenylate cyclase-inhibiting serotonin receptor signaling pathway | biological process | An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] |