Proteins > Low molecular weight phosphotyrosine protein phosphatase
Page last updated: 2024-08-07 13:08:31
Low molecular weight phosphotyrosine protein phosphatase
A low molecular weight phosphotyrosine protein phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24666]
Synonyms
LMW-PTP;
LMW-PTPase;
EC 3.1.3.48;
Adipocyte acid phosphatase;
Low molecular weight cytosolic acid phosphatase;
3.1.3.2;
Red cell acid phosphatase 1
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
Compounds (29)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pyridoxal phosphate | Homo sapiens (human) | Ki | 13.0000 | 1 | 1 |
| pyrimethamine | Homo sapiens (human) | IC50 | 15.6150 | 2 | 0 |
| adrenalone | Homo sapiens (human) | IC50 | 80.0000 | 1 | 0 |
| chlorendic acid | Homo sapiens (human) | IC50 | 80.0000 | 1 | 0 |
| oleanolic acid | Homo sapiens (human) | IC50 | 22.0500 | 4 | 4 |
| erythromycin | Homo sapiens (human) | IC50 | 47.1000 | 1 | 0 |
| ursolic acid | Homo sapiens (human) | IC50 | 9.1500 | 2 | 2 |
| abt 980 | Homo sapiens (human) | IC50 | 13.2000 | 1 | 0 |
| moronic acid | Homo sapiens (human) | IC50 | 24.0000 | 2 | 2 |
| morolic acid | Homo sapiens (human) | IC50 | 22.0000 | 2 | 2 |
| cefsulodin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 4-chloro-N-(3,4,5-trimethoxyphenyl)-5-dithiazolimine | Homo sapiens (human) | IC50 | 80.0000 | 1 | 0 |
| 6-(1,4,5,7-tetramethyl-6-pyrrolo[3,4-d]pyridazinyl)quinoline | Homo sapiens (human) | IC50 | 45.2000 | 1 | 0 |
| 5-(5-bromo-2-chlorophenyl)-3-pyridin-4-yl-1,2,4-oxadiazole | Homo sapiens (human) | IC50 | 80.0000 | 1 | 0 |
| N-(2-furanylmethyl)-2-imino-5-oxo-1-(2-phenylethyl)-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamide | Homo sapiens (human) | IC50 | 80.0000 | 1 | 0 |
| (4,7-dichloro-1,3-benzothiazol-2-yl)hydrazine | Homo sapiens (human) | IC50 | 80.0000 | 1 | 0 |
| 1-cyclopropyl-7-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1-piperazinyl]-6-fluoro-4-oxo-3-quinolinecarboxylic acid | Homo sapiens (human) | IC50 | 2.8900 | 1 | 0 |
| N-[4-[[[(3-bromo-4-methylphenyl)-oxomethyl]hydrazo]-oxomethyl]phenyl]pentanamide | Homo sapiens (human) | IC50 | 17.2000 | 1 | 0 |
| 2-[[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]thio]-1-(1H-pyrrol-2-yl)ethanone | Homo sapiens (human) | IC50 | 38.1000 | 1 | 0 |
| 2-phenyl-N-(2-piperidin-1-ylethyl)quinolin-4-amine | Homo sapiens (human) | IC50 | 3.3500 | 3 | 0 |
| 2-[4-(2-methyl-4-quinolinyl)-1-piperazinyl]-4-phenylthiazole | Homo sapiens (human) | IC50 | 9.2700 | 1 | 0 |
| 2-[8-(6-amino-1H-benzimidazol-2-yl)octyl]-3H-benzimidazol-5-amine | Homo sapiens (human) | IC50 | 11.4000 | 1 | 0 |
| 4-(dimethylsulfamoyl)benzoic acid [2-oxo-2-(3-oxo-4H-1,4-benzoxazin-6-yl)ethyl] ester | Homo sapiens (human) | IC50 | 29.3000 | 1 | 0 |
| 2-[2-[(3-chloro-1-benzothiophen-2-yl)-oxomethyl]imino-6-sulfamoyl-1,3-benzothiazol-3-yl]acetic acid ethyl ester | Homo sapiens (human) | IC50 | 16.4000 | 1 | 0 |
| cefdinir | Homo sapiens (human) | IC50 | 21.5000 | 1 | 0 |
| 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid | Homo sapiens (human) | IC50 | 31.1000 | 1 | 1 |
| rk 682 | Homo sapiens (human) | IC50 | 8.6000 | 1 | 1 |
| akt-i-1,2 compound | Homo sapiens (human) | IC50 | 7.4300 | 1 | 0 |
| 3-benzyladenine | Homo sapiens (human) | IC50 | 13.6000 | 1 | 1 |
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| acid phosphatase activity | molecular function | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. [EC:3.1.3.2] |
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| non-membrane spanning protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cytoplasmic side of plasma membrane | cellular component | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| sarcolemma | cellular component | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |