An aromatic-L-amino-acid decarboxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20711]
AADC;
EC 4.1.1.28;
DOPA decarboxylase;
DDC
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| chelerythrine | Homo sapiens (human) | IC50 | 1,280.0000 | 1 | 1 |
| nitidine | Homo sapiens (human) | IC50 | 1,340.0000 | 1 | 1 |
| piritrexim | Homo sapiens (human) | IC50 | 0.0006 | 1 | 1 |
| sanguinarine chloride | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| aromatic-L-amino-acid decarboxylase activity | molecular function | Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. [EC:4.1.1.28] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
| 5-hydroxy-L-tryptophan decarboxylase activity | molecular function | Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. [GOC:bf, GOC:PARL, RHEA:18533] |
| L-dopa decarboxylase activity | molecular function | Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. [GOC:bf, GOC:PARL, RHEA:12272] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| kidney development | biological process | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] |
| amino acid metabolic process | biological process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. [ISBN:0198506732] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| gene expression | biological process | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. [GOC:txnOH-2018, PMID:25934543, PMID:31580950] |
| carboxylic acid metabolic process | biological process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). [ISBN:0198506732] |
| dopamine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732] |
| serotonin biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:jl, ISBN:0198506732] |
| catecholamine metabolic process | biological process | The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:jl, ISBN:0198506732] |