A histone-lysine N-methyltransferase, H3 lysine-9 specific 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H9B1]
EC 2.1.1.-;
Euchromatic histone-lysine N-methyltransferase 1;
Eu-HMTase1;
G9a-like protein 1;
GLP;
GLP1;
Histone H3-K9 methyltransferase 5;
H3-K9-HMTase 5;
Lysine N-methyltransferase 1D
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 11 (84.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| disulfiram | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| ebselen | Homo sapiens (human) | IC50 | 0.7300 | 1 | 1 |
| thiram | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| cystamine dihydrochloride | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cysteamine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 9,10-anthraquinone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 1,4-naphthoquinone | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| ninhydrin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| diphenyldiselenide | Homo sapiens (human) | IC50 | 0.8600 | 1 | 1 |
| benzeneseleninic acid | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| sodium selenate | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 2,2'-dipyridyl disulfide | Homo sapiens (human) | IC50 | 2.7000 | 1 | 1 |
| glutathione disulfide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| sinefungin | Homo sapiens (human) | IC50 | 180.5000 | 3 | 3 |
| s-adenosylhomocysteine | Homo sapiens (human) | IC50 | 0.2300 | 1 | 1 |
| ditiocarb sodium | Homo sapiens (human) | IC50 | 81.0000 | 1 | 1 |
| azodicarbonamide | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| sgi-1027 | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| bix 01294 | Homo sapiens (human) | IC50 | 8.8401 | 9 | 9 |
| unc 0638 | Homo sapiens (human) | IC50 | 0.0175 | 4 | 4 |
| unc 0321 | Homo sapiens (human) | IC50 | 0.0190 | 2 | 2 |
| 6,7-dimethoxy-2-(pyrrolidin-1-yl)-n-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| transcription corepressor binding | molecular function | Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc] |
| p53 binding | molecular function | Binding to one of the p53 family of proteins. [GOC:hjd] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group to an acceptor molecule. [ISBN:0198506732] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| protein-lysine N-methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. [PMID:12054878] |
| histone H3K9 methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein. [GOC:ai] |
| histone H3K27 methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein. [GOC:ai] |
| C2H2 zinc finger domain binding | molecular function | Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. [GOC:BHF, GOC:mah, Pfam:PF00096] |
| histone H3K9me2 methyltransferase activity | molecular function | Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3. [RHEA:60280] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| nuclear body | cellular component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin organization | biological process | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130] |
| DNA methylation-dependent heterochromatin formation | biological process | Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:mah] |
| peptidyl-lysine monomethylation | biological process | The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. [RESID:AA0076] |
| peptidyl-lysine dimethylation | biological process | The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. [RESID:AA0075] |
| negative regulation of DNA-templated transcription | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| regulation of embryonic development | biological process | Any process that modulates the frequency, rate or extent of embryonic development. [GOC:go_curators] |
| response to fungicide | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. [GOC:dph] |
| positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |