coumarin has been researched along with Necrosis in 57 studies
2H-chromen-2-one: coumarin derivative
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 57-year-old male patient with advanced adenocarcinoma of the lung, who was administered oral anticoagulant therapy because of pulmonary embolism, developed coumarin necrosis confined to the penis and feet." | 8.80 | A case of coumarin necrosis with penile and pedal involvement. ( Baloğlu, H; Başak, M; Doğan, B; Harmanyeri, Y; Taşkapan, O, 1998) |
| "Coumarin-induced necrosis of the skin and subcutaneous tissue is an uncommon but well recognized complication of anticoagulant therapy." | 8.77 | Coumarin necrosis of the penis. ( Badalament, RA; Barkley, C; Drago, JR; Metz, EN; Nesbitt, J, 1989) |
| "Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis." | 7.74 | [Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I]. ( Behr, W; Ehret, W; Harwix, S; Murmann, K; Schlimok, G; Schulze, R; V Scheidt, W; Wittwer, H, 2008) |
| "Coumarin was identified as a mouse-lung carcinogen following oral gavage administration in a chronic bioassay, and was shown to cause the selective necrosis of terminal bronchiolar Clara (non-ciliated bronchiolar epithelial) cells in the mouse lung after acute administration." | 7.70 | Development of tolerance to Clara cell necrosis with repeat administration of coumarin. ( Born, SL; Caudill, D; Fix, AS; Lehman-McKeeman, LD, 1999) |
| " Coumarin skin necrosis developed after starting oral anticoagulant therapy." | 7.70 | Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features. ( Haan, J; Kamphuisen, PW; Rosekrans, PC; Van Der Meer, FJ, 1998) |
| "A severe thrombotic thrombocytopenic status, induced by heparin in a sixty-nine-year-old woman undergoing total hip joint arthroplasty, was treated by switching the anticoagulant therapy to coumarin, which induced skin necrosis." | 7.69 | Coumarin-induced skin necrosis following heparin-induced thrombocytopenia and thrombosis. A case report. ( Boda, Z; Pósán, E; Rigó, J; Shahak, A; Szücs, G, 1996) |
| " Coumarin (warfarin)-induced skin necrosis is thought to be due to a rapid elimination of protein C relative to other vitamin K-dependent factors during the initial phase of oral anticoagulation." | 7.68 | Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. ( Bauer, KA; Birkner, B; Linnau, Y; Rosenberg, RD; Schramm, W; Schwarz, HP; Spannagl, M, 1993) |
| "In three patients painful reddening of a well-circumscribed area of the skin occurred within five days of starting anticoagulant treatment with phenprocoumon (Marcumar), and within a short time it developed into a full-blown picture of coumarin necrosis." | 7.68 | [The clinical course of coumarin-induced necrosis]. ( Ellbrück, D; Rasche, H; Seifried, E; Wankmüller, H, 1991) |
| "Hemorrhagic skin necrosis of the toes was observed in a patient with heterozygous protein C deficiency (protein C:Ag 32% and protein C activity 30%) on the 4th day of coumarin treatment overlapping with effective intravenous anticoagulation with heparin." | 7.67 | Coumarin induced acral skin necrosis associated with hereditary protein C deficiency. ( Karnik, R; Lechner, K; Niessner, H; Pabinger, I; Slany, J, 1986) |
| "Coumarin necrosis, a rare complication of coumarin anticoagulation, typically presents with well-defined purpuric patches that progress to bullae formation and necrosis." | 7.67 | Acral purpura: an unusual sign of coumarin necrosis. ( Rosen, T; Stone, MS, 1986) |
| "Defiency of protein C has been reported to be associated with recurrent thrombosis and pulmonary embolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis and peripheral gangrene." | 7.67 | Recurrent thromboembolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis associated with protein C deficiency. ( Lie, JT, 1988) |
| "A patient with evidence of both heparin-related thrombocytopenia and coumarin-induced skin necrosis is presented." | 7.67 | Coumarin skin necrosis in a patient with heparin-induced thrombocytopenia--a case report. ( Banson, B; Berman, JA; Celoria, GM; Friedmann, P; Rhee, SW; Steingart, RH, 1988) |
| "The histogenesis of coumarin-induced cholangiofibrosis in the rat has been determined." | 7.67 | Studies on the induction of cholangiofibrosis by coumarin in the rat. ( Appleby, EC; Conning, DM; Evans, JG; Lake, BG, 1989) |
| "On two occasions, an acquired functional protein C deficiency was present." | 5.27 | Recurrent coumarin-induced skin necrosis in a patient with an acquired functional protein C deficiency. ( Broekmans, AW; Loeliger, EA; Nienhuis, AM; Teepe, RG; Vermeer, BJ, 1986) |
| "Coumarin-induced skin necrosis is believed to be due to a transient hypercoagulable state resulting from a more rapid decline of the protein C activity relative to that of coagulation factors (F) II, IX and X during initiation of oral anticoagulant therapy." | 5.08 | Inhibition rather than enhancement of hemostatic system activation during initiation of oral anticoagulant treatment. ( Brockmeier, J; Eichinger, S; Eichler, HG; Kyrle, PA; Lechner, K; Speiser, W; Weltermann, A, 1997) |
| "A 57-year-old male patient with advanced adenocarcinoma of the lung, who was administered oral anticoagulant therapy because of pulmonary embolism, developed coumarin necrosis confined to the penis and feet." | 4.80 | A case of coumarin necrosis with penile and pedal involvement. ( Baloğlu, H; Başak, M; Doğan, B; Harmanyeri, Y; Taşkapan, O, 1998) |
| "Skin necrosis is an uncommon complication associated with coumarin or heparin therapy." | 4.79 | [Skin necrosis: a paradoxical complication of anticoagulation]. ( Balestra, B, 1995) |
| "Coumarin-induced necrosis of the skin and subcutaneous tissue is an uncommon but well recognized complication of anticoagulant therapy." | 4.77 | Coumarin necrosis of the penis. ( Badalament, RA; Barkley, C; Drago, JR; Metz, EN; Nesbitt, J, 1989) |
| " Therefore, the aim of our study was to investigate the effect of simple coumarins (osthole, umbelliferone, esculin, and 4-hydroxycoumarin) combined with sorafenib (specific inhibitor of Raf (Rapidly Accelerated Fibrosarcoma) kinase) in programmed death induction in human glioblastoma multiforme (T98G) and anaplastic astrocytoma (MOGGCCM) cells lines." | 3.96 | Antiglioma Potential of Coumarins Combined with Sorafenib. ( Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Rzeski, W; Skalicka-Woźniak, K; Sumorek-Wiadro, J; Zając, A, 2020) |
| " The disease arrived during longterm coumarin therapy because of a deep vein thrombosis and an antiphospholipid syndrome." | 3.78 | [Coumarin-induced necrotic purpura of the skin -- case report and review of the literature]. ( Colucci, G; Meierhofer, S; Steiner, S, 2012) |
| " The lesion was red, swollen and very painful, with central necrosis and arose shortly after starting coumarine therapy." | 3.78 | [A man with a skin lesion on his abdomen]. ( Mostard, GJ; Thijssen, AY, 2012) |
| "Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis." | 3.74 | [Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I]. ( Behr, W; Ehret, W; Harwix, S; Murmann, K; Schlimok, G; Schulze, R; V Scheidt, W; Wittwer, H, 2008) |
| " Coumarin-induced skin necrosis was a recurrent feature during oral anticoagulation therapy, forcing her physicians to treat her with nadroparin (Fraxiparin) for only a few months." | 3.72 | Late onset of clinical symptoms and recurrent ecchymotic skin lesions in a 12-year-old girl with a severe double heterozygous protein C deficiency. ( Alhenc-Gelas, M; Corazza, F; Demulder, A; Ferster, A; Loop, M, 2004) |
| " Coumarin skin necrosis developed after starting oral anticoagulant therapy." | 3.70 | Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features. ( Haan, J; Kamphuisen, PW; Rosekrans, PC; Van Der Meer, FJ, 1998) |
| "Coumarin was identified as a mouse-lung carcinogen following oral gavage administration in a chronic bioassay, and was shown to cause the selective necrosis of terminal bronchiolar Clara (non-ciliated bronchiolar epithelial) cells in the mouse lung after acute administration." | 3.70 | Development of tolerance to Clara cell necrosis with repeat administration of coumarin. ( Born, SL; Caudill, D; Fix, AS; Lehman-McKeeman, LD, 1999) |
| "A randomized sampling protocol coupled with quantitative morphometry has been used to evaluate the inter-lobe variation in centrilobular hepatic necrosis in the mouse, and periportal hepatic necrosis in the beta-naphthoflavone-induced rat, both in response to treatment with coumarin." | 3.69 | Further studies on the lobar heterogeneity in response to coumarin-mediated hepatotoxicity. ( Fry, JR; Jack, KR; Kho, K; Thomas, NW, 1996) |
| "A severe thrombotic thrombocytopenic status, induced by heparin in a sixty-nine-year-old woman undergoing total hip joint arthroplasty, was treated by switching the anticoagulant therapy to coumarin, which induced skin necrosis." | 3.69 | Coumarin-induced skin necrosis following heparin-induced thrombocytopenia and thrombosis. A case report. ( Boda, Z; Pósán, E; Rigó, J; Shahak, A; Szücs, G, 1996) |
| "In three patients painful reddening of a well-circumscribed area of the skin occurred within five days of starting anticoagulant treatment with phenprocoumon (Marcumar), and within a short time it developed into a full-blown picture of coumarin necrosis." | 3.68 | [The clinical course of coumarin-induced necrosis]. ( Ellbrück, D; Rasche, H; Seifried, E; Wankmüller, H, 1991) |
| " Coumarin (warfarin)-induced skin necrosis is thought to be due to a rapid elimination of protein C relative to other vitamin K-dependent factors during the initial phase of oral anticoagulation." | 3.68 | Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. ( Bauer, KA; Birkner, B; Linnau, Y; Rosenberg, RD; Schramm, W; Schwarz, HP; Spannagl, M, 1993) |
| "The histogenesis of coumarin-induced cholangiofibrosis in the rat has been determined." | 3.67 | Studies on the induction of cholangiofibrosis by coumarin in the rat. ( Appleby, EC; Conning, DM; Evans, JG; Lake, BG, 1989) |
| "A patient with evidence of both heparin-related thrombocytopenia and coumarin-induced skin necrosis is presented." | 3.67 | Coumarin skin necrosis in a patient with heparin-induced thrombocytopenia--a case report. ( Banson, B; Berman, JA; Celoria, GM; Friedmann, P; Rhee, SW; Steingart, RH, 1988) |
| "The administration of single doses of coumarin to the rat was found to produce hepatic centrilobular necrosis and also to depress a number of hepatic enzyme activities within 24 h." | 3.67 | Investigations into the mechanism of coumarin-induced hepatotoxicity in the rat. ( Lake, BG, 1984) |
| "Defiency of protein C has been reported to be associated with recurrent thrombosis and pulmonary embolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis and peripheral gangrene." | 3.67 | Recurrent thromboembolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis associated with protein C deficiency. ( Lie, JT, 1988) |
| "Coumarin necrosis, a rare complication of coumarin anticoagulation, typically presents with well-defined purpuric patches that progress to bullae formation and necrosis." | 3.67 | Acral purpura: an unusual sign of coumarin necrosis. ( Rosen, T; Stone, MS, 1986) |
| "Hemorrhagic skin necrosis of the toes was observed in a patient with heterozygous protein C deficiency (protein C:Ag 32% and protein C activity 30%) on the 4th day of coumarin treatment overlapping with effective intravenous anticoagulation with heparin." | 3.67 | Coumarin induced acral skin necrosis associated with hereditary protein C deficiency. ( Karnik, R; Lechner, K; Niessner, H; Pabinger, I; Slany, J, 1986) |
| "Coumarin was administered to male rats as a single dose or for 4 consecutive days, and samples were obtained 4 or 24 h after a single dose or 24 h after the repeated doses." | 1.43 | Relationship between coumarin-induced hepatocellular toxicity and mitochondrial function in rats. ( Fujii, W; Hori, H; Kitagawa, Y; Ozaki, K; Tanaka, Y, 2016) |
| "Coumarin is a known hepatotoxicant in laboratory animals, particularly rats." | 1.30 | Selective Clara cell injury in mouse lung following acute administration of coumarin. ( Born, SL; Caudill, D; Fix, AS; Lehman-McKeeman, LD, 1998) |
| "Treatment with coumarin reduced hepatic microsomal ethylmorphine N-demethylase and 7-ethoxycoumarin O-deethylase activities, whereas one or both mixed-function oxidases appeared to be induced by treatment with 3,4-DMC, 4-MC, 3-MOHC and 4-MOHC." | 1.29 | Studies on the acute effects of coumarin and some coumarin derivatives in the rat. ( Evans, JG; Lake, BG; Lewis, DF; Price, RJ, 1994) |
| "Skin necrosis associated with protein C deficiency has recently been reported to occur in hemodialysis patients." | 1.28 | Protein S deficiency and skin necrosis associated with continuous ambulatory peritoneal dialysis. ( Brubaker, R; Coots, MC; Glueck, HI; Kant, KS; Penn, I; Tonne, VA, 1992) |
| "Toxic gangrene is most commonly caused by extravasation of intravenously administered cytotoxic antineoplastic drugs but has also been associated with the use of coumarin congeners and the bite of the brown recluse spider." | 1.27 | Necrotizing dermatitis in patients receiving cancer chemotherapy. ( Bodey, GP; Dreizen, S; Keating, MJ; McCredie, KB, 1987) |
| "On two occasions, an acquired functional protein C deficiency was present." | 1.27 | Recurrent coumarin-induced skin necrosis in a patient with an acquired functional protein C deficiency. ( Broekmans, AW; Loeliger, EA; Nienhuis, AM; Teepe, RG; Vermeer, BJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (38.60) | 18.7374 |
| 1990's | 22 (38.60) | 18.2507 |
| 2000's | 6 (10.53) | 29.6817 |
| 2010's | 6 (10.53) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Sumorek-Wiadro, J | 1 |
| Zając, A | 1 |
| Langner, E | 1 |
| Skalicka-Woźniak, K | 1 |
| Maciejczyk, A | 1 |
| Rzeski, W | 1 |
| Jakubowicz-Gil, J | 1 |
| Magnolo, N | 1 |
| Jeskowiak, A | 1 |
| Goerge, T | 1 |
| Tanaka, Y | 1 |
| Fujii, W | 1 |
| Hori, H | 1 |
| Kitagawa, Y | 1 |
| Ozaki, K | 1 |
| Yaghmaei, S | 1 |
| Ghalayani, P | 1 |
| Salami, S | 1 |
| Nourmohammadian, F | 1 |
| Koohestanimobarhan, S | 1 |
| Imeni, V | 1 |
| Olah, Z | 1 |
| Bereczky, Z | 1 |
| Szarvas, M | 1 |
| Boda, Z | 2 |
| Meierhofer, S | 1 |
| Colucci, G | 1 |
| Steiner, S | 1 |
| Thijssen, AY | 1 |
| Mostard, GJ | 1 |
| VERHAGEN, H | 2 |
| WIERSEMA, MU | 1 |
| DUYZINGS, AJ | 1 |
| WICKE, G | 1 |
| JORDAL, R | 1 |
| SHAPIRO, SS | 1 |
| McKAY, DG | 1 |
| STOECKLI, A | 1 |
| NALBANDIAN, RM | 1 |
| MADER, IJ | 1 |
| BARRETT, JL | 1 |
| PEARCE, JF | 1 |
| RUPP, EC | 1 |
| MAYER, GA | 1 |
| Loop, M | 1 |
| Ferster, A | 1 |
| Corazza, F | 1 |
| Alhenc-Gelas, M | 1 |
| Demulder, A | 1 |
| Itin, P | 1 |
| Wernli, M | 1 |
| Sanchez-Politta, S | 1 |
| Angelillo-Scherrer, A | 1 |
| Masouyé, I | 1 |
| Borradori, L | 1 |
| Warkentin, TE | 1 |
| Brodmann, M | 1 |
| Seinost, G | 1 |
| Pilger, E | 1 |
| Schulze, R | 1 |
| Behr, W | 1 |
| Wittwer, H | 1 |
| Harwix, S | 1 |
| Murmann, K | 1 |
| V Scheidt, W | 1 |
| Ehret, W | 1 |
| Schlimok, G | 1 |
| Lake, BG | 4 |
| Balestra, B | 1 |
| Griffin, JP | 1 |
| Tamir, A | 1 |
| Wolf, R | 1 |
| Brenner, S | 1 |
| Wattiaux, MJ | 1 |
| Hervé, R | 1 |
| Robert, A | 1 |
| Cabane, J | 1 |
| Housset, B | 1 |
| Imbert, JC | 1 |
| Evans, JG | 3 |
| Lewis, DF | 1 |
| Price, RJ | 1 |
| Schramm, W | 1 |
| Spannagl, M | 1 |
| Bauer, KA | 3 |
| Rosenberg, RD | 1 |
| Birkner, B | 1 |
| Linnau, Y | 1 |
| Schwarz, HP | 1 |
| Shahak, A | 1 |
| Pósán, E | 1 |
| Szücs, G | 1 |
| Rigó, J | 1 |
| Jack, KR | 1 |
| Kho, K | 1 |
| Thomas, NW | 1 |
| Fry, JR | 1 |
| Ghosh, P | 1 |
| Markin, RS | 1 |
| Sorrell, MF | 1 |
| Hermes, B | 1 |
| Haas, N | 1 |
| Henz, BM | 1 |
| Kyrle, PA | 1 |
| Brockmeier, J | 1 |
| Weltermann, A | 1 |
| Eichinger, S | 1 |
| Speiser, W | 1 |
| Lechner, K | 2 |
| Eichler, HG | 1 |
| Kamphuisen, PW | 1 |
| Haan, J | 1 |
| Rosekrans, PC | 1 |
| Van Der Meer, FJ | 1 |
| Harmanyeri, Y | 1 |
| Taşkapan, O | 1 |
| Doğan, B | 1 |
| Baloğlu, H | 1 |
| Başak, M | 1 |
| Born, SL | 2 |
| Fix, AS | 2 |
| Caudill, D | 2 |
| Lehman-McKeeman, LD | 2 |
| Kant, KS | 1 |
| Glueck, HI | 1 |
| Coots, MC | 1 |
| Tonne, VA | 1 |
| Brubaker, R | 1 |
| Penn, I | 1 |
| Goldberg, SL | 1 |
| Orthner, CL | 1 |
| Yalisove, BL | 1 |
| Elgart, ML | 1 |
| Kessler, CM | 1 |
| Ellbrück, D | 2 |
| Wankmüller, H | 2 |
| Rasche, H | 1 |
| Seifried, E | 2 |
| Chambers, M | 1 |
| Thornes, RD | 1 |
| McKernan, M | 1 |
| Grimaudo, V | 1 |
| Gueissaz, F | 1 |
| Hauert, J | 1 |
| Sarraj, A | 1 |
| Kruithof, EK | 1 |
| Bachmann, F | 1 |
| Moreb, J | 1 |
| Kitchens, CS | 1 |
| Appleby, EC | 1 |
| Conning, DM | 1 |
| Barkley, C | 1 |
| Badalament, RA | 1 |
| Metz, EN | 1 |
| Nesbitt, J | 1 |
| Drago, JR | 1 |
| Celoria, GM | 1 |
| Steingart, RH | 1 |
| Banson, B | 1 |
| Friedmann, P | 1 |
| Rhee, SW | 1 |
| Berman, JA | 1 |
| Scheffler, P | 1 |
| Kiehl, R | 1 |
| Braun, B | 1 |
| Hellstern, P | 1 |
| Wenzel, E | 1 |
| Lie, JT | 1 |
| Dreizen, S | 1 |
| McCredie, KB | 1 |
| Bodey, GP | 1 |
| Keating, MJ | 1 |
| Stone, MS | 1 |
| Rosen, T | 1 |
| Pabinger, I | 1 |
| Karnik, R | 1 |
| Slany, J | 1 |
| Niessner, H | 1 |
| Teepe, RG | 1 |
| Broekmans, AW | 1 |
| Vermeer, BJ | 1 |
| Nienhuis, AM | 1 |
| Loeliger, EA | 1 |
7 reviews available for coumarin and Necrosis
| Article | Year |
|---|---|
[Skin necrosis: a paradoxical complication of anticoagulation].
Topics: Anticoagulants; Coumarins; Heparin; Humans; Necrosis; Skin; Thrombosis | 1995 |
Anticoagulants and skin necrosis.
Topics: Administration, Oral; Anticoagulants; Coumarins; Heparin; Humans; Necrosis; Protein C Deficiency; Pr | 1994 |
Management of patients with hereditary defects predisposing to thrombosis including pregnant women.
Topics: Abnormalities, Drug-Induced; Anticoagulants; Antithrombin III; Antithrombin III Deficiency; Blood Pr | 1995 |
Coumarin-induced hepatic necrosis.
Topics: Aged; Antineoplastic Agents; Biopsy; Chemical and Drug Induced Liver Injury; Coumarins; Humans; Live | 1997 |
A case of coumarin necrosis with penile and pedal involvement.
Topics: Adenocarcinoma; Anticoagulants; Coumarins; Foot Dermatoses; Humans; Lung Neoplasms; Male; Middle Age | 1998 |
[The pathophysiology, clinical picture and treatment of coumarin-induced necrosis].
Topics: Administration, Oral; Coumarins; Humans; Incidence; Necrosis; Recurrence; Risk Factors; Skin Disease | 1991 |
Coumarin necrosis of the penis.
Topics: Coumarins; Humans; Male; Middle Aged; Necrosis; Penis; Protein C Deficiency; Pulmonary Embolism | 1989 |
1 trial available for coumarin and Necrosis
| Article | Year |
|---|---|
Inhibition rather than enhancement of hemostatic system activation during initiation of oral anticoagulant treatment.
Topics: Administration, Oral; Adult; Anticoagulants; Biomarkers; Bleeding Time; Blood Coagulation Factors; C | 1997 |
49 other studies available for coumarin and Necrosis
| Article | Year |
|---|---|
Antiglioma Potential of Coumarins Combined with Sorafenib.
Topics: 4-Hydroxycoumarins; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Beclin-1; Caspase 3; Ce | 2020 |
Extensive coumarin-induced necrosis - a vasculopathy following oral anticoagulation.
Topics: Administration, Oral; Adult; Anticoagulants; Buttocks; Coumarins; Diagnosis, Differential; Female; H | 2014 |
Relationship between coumarin-induced hepatocellular toxicity and mitochondrial function in rats.
Topics: Aconitate Hydratase; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Dose-Response Relat | 2016 |
Hybrid Benzoxazole-Coumarin Compounds Induce Death Receptor-Mediated Switchable Apoptotic and Necroptotic Cell Death on HN-5 Head and Neck Cancer Cell Line.
Topics: Antineoplastic Agents; Apoptosis; Benzoxazoles; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cou | 2017 |
Coagulation: cascade!
Topics: Aged; Anticoagulants; Coumarins; Enoxaparin; Gangrene; Heparin; Humans; International Normalized Rat | 2011 |
[Coumarin-induced necrotic purpura of the skin -- case report and review of the literature].
Topics: Adult; Anticoagulants; Antiphospholipid Syndrome; Blood Coagulation Tests; Coumarins; Diagnosis, Dif | 2012 |
[A man with a skin lesion on his abdomen].
Topics: Abscess; Anticoagulants; Anus Diseases; Coumarins; Humans; Male; Middle Aged; Necrosis; Skin Disease | 2012 |
[Cutaneous hemorrhage and necrosis after dicumol or dicumacyl administration in thrombosis].
Topics: Coumarins; Drug Eruptions; Necrosis; Thrombosis | 1952 |
[Subcutaneous hemorrhage with necrosis caused by dicumarol].
Topics: Coumarins; Dicumarol; Necrosis | 1952 |
Local haemorrhage and necrosis of the skin and underlying tissues, during anti-coagulant therapy with dicumarol or dicumacyl.
Topics: Coagulants; Coumarins; Dicumarol; Gangrene; Hemorrhage; Humans; Necrosis; Skin | 1954 |
[Local necroses after dicoumarin therapy].
Topics: Coumarins; Dicumarol; Humans; Necrosis; Skin Diseases | 1955 |
Necrosing cutaneous haemorrhages as a complication in dicumarol treatment.
Topics: Administration, Cutaneous; Coumarins; Dicumarol; Gangrene; Hemorrhage; Necrosis; Skin | 1956 |
The prevention of the generalized Shwartzman reaction with sodium warfarin.
Topics: Animals; Coumarins; Disseminated Intravascular Coagulation; Endotoxins; Hypersensitivity; Kidney; Ne | 1958 |
[Skin necroses due to coumarin medication].
Topics: Coumarins; Hematoma; Humans; Necrosis; Skin Diseases | 1962 |
PETECHIAE, ECCHYMOSES, AND NECROSIS OF SKIN INDUCED BY COUMARIN CONGENERS: RARE, OCCASIONALLY LETHAL COMPLICATION OF ANTICOAGULANT THERAPY.
Topics: Acenocoumarol; Anticoagulants; Coumarins; Dicumarol; Drug Therapy; Ecchymosis; Ethyl Biscoumacetate; | 1965 |
A RARE COMPLICATION OF COUMARIN-CONGENER ANTICOAGULANT THERAPY.
Topics: Anticoagulants; Coumarins; Drug Therapy; Hemorrhage; Humans; Necrosis; Skin Diseases; Toxicology | 1965 |
Late onset of clinical symptoms and recurrent ecchymotic skin lesions in a 12-year-old girl with a severe double heterozygous protein C deficiency.
Topics: Age of Onset; Anticoagulants; Child; Coumarins; DNA Mutational Analysis; Ecchymosis; Family Health; | 2004 |
[What is your diagnosis? Coumarin necrosis].
Topics: Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Coumarins; Diagnosis, Differential; | 2004 |
Widespread skin necrosis associated with unfractionated heparin therapy in a patient under chronic coumarin anticoagulation.
Topics: Aged; Anticoagulants; Arm; Cardiomyopathies; Colonic Neoplasms; Coumarins; Diagnosis, Differential; | 2006 |
Should vitamin K be administered when HIT is diagnosed after administration of coumarin?
Topics: Aged, 80 and over; Anticoagulants; Cardiac Surgical Procedures; Coumarins; Extremities; Gangrene; He | 2006 |
Images in vascular medicine. Coumarin skin necrosis: a severe complication of oral anticoagulation.
Topics: Administration, Oral; Adult; Anticoagulants; Coumarins; Drug Eruptions; Female; Humans; Necrosis; Se | 2006 |
[Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I].
Topics: Adult; Anticoagulants; Coumarins; Female; Humans; Necrosis; Protein C; Protein C Deficiency | 2008 |
Investigations into the mechanism of coumarin-induced hepatotoxicity in the rat.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Kinetics; Liver; Liver D | 1984 |
Leukocytoclastic vasculitis: another coumarin-induced hemorrhagic reaction.
Topics: Aged; Coumarins; Drug Eruptions; Hemorrhage; Humans; Male; Necrosis; Skin; Vasculitis, Leukocytoclas | 1994 |
Coumarin-induced skin necrosis associated with acquired protein S deficiency and antiphospholipid antibody syndrome.
Topics: Adult; Antiphospholipid Syndrome; Coumarins; Family Health; Female; Humans; Necrosis; Protein S Defi | 1994 |
Studies on the acute effects of coumarin and some coumarin derivatives in the rat.
Topics: 7-Alkoxycoumarin O-Dealkylase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical | 1994 |
Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat.
Topics: Alanine Transaminase; Animals; Aroclors; Aspartate Aminotransferases; Coumarins; Dose-Response Relat | 1993 |
Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate.
Topics: Aged; Coumarins; Female; Humans; Necrosis; Protein C; Protein C Deficiency; Skin | 1993 |
Coumarin-induced skin necrosis.
Topics: Aged; Coumarins; Female; Humans; Male; Middle Aged; Necrosis; Protein C; Protein C Deficiency; Skin | 1993 |
Coumarin-induced skin necrosis following heparin-induced thrombocytopenia and thrombosis. A case report.
Topics: Aged; Anticoagulants; Coumarins; Female; Heparin; Hip Prosthesis; Humans; Necrosis; Postoperative Co | 1996 |
Further studies on the lobar heterogeneity in response to coumarin-mediated hepatotoxicity.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Coumarins; Liver; Male; Mice; Necrosis; Or | 1996 |
Immunopathological events of adverse cutaneous reactions to coumarin and heparin.
Topics: Coumarins; Drug Eruptions; Female; Heparin; Humans; Middle Aged; Necrosis; Skin; Thromboembolism; Tu | 1997 |
Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features.
Topics: Aged; Anticoagulants; Coumarins; Drug Eruptions; Factor V; Humans; Lupus Coagulation Inhibitor; Male | 1998 |
Selective Clara cell injury in mouse lung following acute administration of coumarin.
Topics: Administration, Oral; Animals; Anticoagulants; Bronchi; Carcinogens; Coumarins; Dose-Response Relati | 1998 |
Development of tolerance to Clara cell necrosis with repeat administration of coumarin.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carcinogens; Coumarins; Cytochrome P-450 Enzyme S | 1999 |
Protein S deficiency and skin necrosis associated with continuous ambulatory peritoneal dialysis.
Topics: Blood Proteins; Coumarins; Female; Glycoproteins; Humans; Kidney Failure, Chronic; Middle Aged; Necr | 1992 |
Skin necrosis following prolonged administration of coumarin in a patient with inherited protein S deficiency.
Topics: Adult; Blood Proteins; Coumarins; Glycoproteins; Humans; Male; Necrosis; Protein S; Skin; Time Facto | 1991 |
[The clinical course of coumarin-induced necrosis].
Topics: Adult; Coumarins; Drug Hypersensitivity; Drug Therapy, Combination; Female; Heparin; Humans; Middle | 1991 |
Necrosis of the skin induced by coumarin.
Topics: Coumarins; Humans; Necrosis; Skin | 1989 |
Necrosis of skin induced by coumarin in a patient deficient in protein S.
Topics: Coumarins; Glycoproteins; Humans; Male; Middle Aged; Necrosis; Protein S; Skin | 1989 |
Acquired functional protein S deficiency, cerebral venous thrombosis, and coumarin skin necrosis in association with antiphospholipid syndrome: report of two cases.
Topics: Blood Coagulation Disorders; Blood Coagulation Factors; Coumarins; Female; Glycoproteins; Humans; In | 1989 |
Studies on the induction of cholangiofibrosis by coumarin in the rat.
Topics: Animals; Atrophy; Bile Ducts, Intrahepatic; Body Weight; Coumarins; Fibrosis; gamma-Glutamyltransfer | 1989 |
Coumarin skin necrosis in a patient with heparin-induced thrombocytopenia--a case report.
Topics: Aorta; Aorta, Thoracic; Coumarins; Female; Femoral Artery; Heparin; Humans; Intermittent Claudicatio | 1988 |
[Thromboembolism complications and coumarin necrosis in a patient with congenital antithrombin III deficiency].
Topics: Adult; Antithrombin III Deficiency; Coumarins; Female; Humans; Ischemia; Necrosis; Pedigree; Thrombo | 1988 |
Recurrent thromboembolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis associated with protein C deficiency.
Topics: Adolescent; Blood Coagulation; Coumarins; Disseminated Intravascular Coagulation; Female; Gangrene; | 1988 |
Necrotizing dermatitis in patients receiving cancer chemotherapy.
Topics: Antineoplastic Agents; Bacterial Infections; Cellulitis; Coumarins; Dermatitis; Female; Gangrene; Hu | 1987 |
Acral purpura: an unusual sign of coumarin necrosis.
Topics: Coumarins; Humans; Male; Middle Aged; Necrosis; Purpura; Skin; Toes; Warfarin | 1986 |
Coumarin induced acral skin necrosis associated with hereditary protein C deficiency.
Topics: Adult; Antigen-Antibody Complex; Cesarean Section; Complement C4; Coumarins; Female; Glycoproteins; | 1986 |
Recurrent coumarin-induced skin necrosis in a patient with an acquired functional protein C deficiency.
Topics: Biopsy; Blood Coagulation Factors; Coumarins; Female; Humans; Middle Aged; Necrosis; Protein C Defic | 1986 |