Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 4539 |
| CHEMBL ID | 9 |
| CHEBI ID | 100246 |
| SCHEMBL ID | 3473 |
| MeSH ID | M0014980 |
| Synonym |
|---|
| BIDD:GT0725 |
| AC-6855 |
| AKOS000417391 |
| norfloxacinum [inn-latin] |
| brn 0567897 |
| 3-quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)- |
| c16h18fn3o3 |
| norfloxacine [inn-french] |
| norfloxacino [inn-spanish] |
| 1-ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure |
| am 715 |
| ccris 6302 |
| mk 0366 |
| einecs 274-614-4 |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid (norfloxacin) |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid(1-norfloxacin) |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid(norfloxacin) |
| (norfloxacin)1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid |
| bdbm50045000 |
| (nflx)1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4,4a,8a-tetrahydro-quinoline-3-carboxylic acid (norfloxacin) |
| AB00052059-18 |
| AB00052059-19 |
| BRD-K11196887-001-05-5 |
| smr000058200 |
| DIVK1C_000084 |
| KBIO1_000084 |
| barazan |
| fulgram |
| norflo |
| sebercim |
| lexinor |
| baccidal |
| am-715 |
| mk-0366 |
| nflx |
| noroxin (tn) |
| norfloxacin (jp17/usp/inn) |
| D00210 |
| SPECTRUM_001017 |
| PRESTWICK_633 |
| cas-70458-96-7 |
| NCGC00016916-01 |
| BSPBIO_000261 |
| SMP1_000216 |
| OPREA1_375152 |
| BPBIO1_000289 |
| IDI1_000084 |
| SPECTRUM5_001154 |
| PRESTWICK2_000221 |
| PRESTWICK3_000221 |
| BCBCMAP01_000218 |
| chibroxin |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid |
| 3-quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)- |
| noroxin |
| mk-366 |
| norfloxacine |
| C06687 |
| 70458-96-7 |
| norfloxacin |
| 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid |
| 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid |
| DB01059 |
| NCGC00021725-04 |
| NCGC00021725-03 |
| 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid |
| STK177250 |
| MLS000069650 , |
| KBIO2_001497 |
| KBIOSS_001497 |
| KBIO3_001607 |
| KBIOGR_000866 |
| KBIO2_006633 |
| KBIO2_004065 |
| PRESTWICK0_000221 |
| SPECTRUM3_000524 |
| SPECTRUM2_001017 |
| SPBIO_001173 |
| NINDS_000084 |
| SPECTRUM4_000453 |
| SPBIO_002182 |
| PRESTWICK1_000221 |
| SPECTRUM1500440 |
| BSPBIO_002107 |
| NCGC00016916-02 |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid |
| HMS2091J16 |
| HMS2090F03 |
| nsc-757250 |
| CHEMBL9 , |
| HMS500E06 |
| HMS1568N03 |
| HMS1920B16 |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid |
| norfloxacinum |
| CHEBI:100246 , |
| norfloxacino |
| HMS2095N03 |
| 1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid |
| n0f8p22l1p , |
| hsdb 8029 |
| unii-n0f8p22l1p |
| norfloxacin [usan:usp:inn:ban:jan] |
| nsc 757250 |
| 1-ethyl-6-fluoro-4-oxo-7-piperazinylhydroquinoline-3-carboxylic acid |
| tox21_113441 |
| N0817 |
| BBL005569 |
| nsc757250 |
| pharmakon1600-01500440 |
| dtxsid7037680 , |
| dtxcid5017680 |
| tox21_110682 |
| zoroxin |
| NORFLOXACIN - NORXACIN |
| HMS2235G03 |
| CCG-40235 |
| NCGC00016916-09 |
| NCGC00016916-08 |
| NCGC00016916-06 |
| NCGC00016916-03 |
| NCGC00016916-05 |
| NCGC00016916-07 |
| NCGC00016916-04 |
| BCP9000993 |
| FT-0630800 |
| NCGC00016916-12 |
| norfloxacin [mi] |
| norfloxacin [usp impurity] |
| norfloxacin [vandf] |
| 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid |
| norfloxacin [jan] |
| norfloxacin [ep monograph] |
| norfloxacin [usp-rs] |
| norfloxacin [usan] |
| norfloxacin [who-dd] |
| norfloxacin [inn] |
| norfloxacin [mart.] |
| norfloxacin [orange book] |
| EPITOPE ID:119068 |
| S1509 |
| HY-B0132 |
| CS-1906 |
| 1-ethyl-4-oxo-6-fluoro-7-(piperazinyl)-1,4-dihydro-quinoline-3-carboxylic acid |
| 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylicacid |
| 1-ethyl-1,4-dihydro-6-fluoro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid |
| 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid |
| 1-ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| 1-ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid |
| 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid |
| 7-(1-piperazinyl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid |
| MLS006011446 |
| SCHEMBL3473 |
| NCGC00016916-11 |
| tox21_110682_1 |
| KS-5007 |
| norfloxacin, antibiotic for culture media use only |
| N-8650 |
| chibroxine |
| utinor |
| noflo |
| chibroxol |
| noraxin |
| 1-ethyl-3-carboxy-6-fluoro-7-(piperazinyl-1)-quinolin-4(1h)-one |
| norocin |
| uroxacin |
| nolicin |
| norxacin |
| 1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid # |
| gonorcin |
| noroxine |
| noracin |
| norphloxacine |
| OPERA_ID_1423 |
| AB00052059_21 |
| AB00052059_20 |
| mfcd00079532 |
| sr-01000000222 |
| SR-01000000222-2 |
| norfloxacin, united states pharmacopeia (usp) reference standard |
| norfloxacin, vetranal(tm), analytical standard |
| norfloxacin, european pharmacopoeia (ep) reference standard |
| norfloxacin, analytical standard, >=98% (tlc) |
| norfloxacin for system suitability, european pharmacopoeia (ep) reference standard |
| norfloxacin, pharmaceutical secondary standard; certified reference material |
| norfloxacin for peak identification, european pharmacopoeia (ep) reference standard |
| Z56926638 |
| SR-01000000222-3 |
| SBI-0051464.P002 |
| HMS3712N03 |
| rkl10074 |
| norfloxacin, british pharmacopoeia (bp) reference standard |
| norfloxacin protomer i |
| norfloxacin protomer ii |
| FT-0673085 |
| Q417897 |
| 1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid |
| SY051390 |
| norfloxacin (norxacin) |
| norfloxacine,(s) |
| norfloxacin 100 microg/ml in acetonitrile |
| BCP27734 |
| BRD-K11196887-001-15-4 |
| EN300-06467 |
| norfloxacin for peak identification |
| norfloxacin for system suitability |
| gtpl12408 |
| j01ma06 |
| s01ae02 |
| norfloxacino (inn-spanish) |
| norfloxacin (usan:usp:inn:ban:jan) |
| 1-ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaure |
| norfloxacin (usp impurity) |
| norfloxacin (ep monograph) |
| norfloxacin (mart.) |
| norfloxacina |
| norfloxacinum (inn-latin) |
| norfloxacin (usp-rs) |
| norfloxacine (inn-french) |
Norfloxacin is an early third-generation quinolone antibiotic that has been widely used in animal husbandry and aquaculture because of its bactericidal properties. It is a fluoroquinolone that presents low solubility and low permeability, and as a consequence, low bioavailability.
Norfloxacin has a much wider spectrum than nalidixic acid which includes pseudomonas and Gram-positive cocci. It has a low aqueous solubility which leads to poor dissolution.
Norfloxacin has a much wider spectrum than nalidixic acid which includes pseudomonas and Gram-positive cocci. It has some activity in vitro against Chlamydia trachomatis and Ureaplasma urealyticum, although not at levels attainable in serum. NorfloxACin has been incriminated previously as a cause once only, with acute interstitial nephritis as the histopathological finding.
Norfloxacin treatment will save $195.85 per patient, resulting in an aggregate saving of more than $40 million annually. Treatment failure was not related to drug resistance or to insufficient absorption of the drug.
Norfloxacin is safe and effective against Escherichia coli, Klebsiella and Proteus, the commonly encountered organisms in urinary tract infections. Adverse effects in the lomefloxAcin group were observed on 20 occasions in 12 patients. No serious treatment-related adverse events were reported.
Enoxacin (250 mg/l) demonstrated the highest peak concentration (median) in the urine (0-6 h), followed by ciprofloxacIn (237 mg/ l) and norfloxAcin (157 mg/L) as determined by the HPLC assay. The serum half-life of norfl Oxacin was found to be 3.5 hours.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Pharmacokinetic studies demonstrated that THEO serum levels and elimination were not altered by concurrent CP administration." | ( Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. Schwark, WS; Vancutsem, PM, 1992) | 0.28 |
| " Pharmacokinetic variables were calculated, using a 2-compartment open model." | ( Pharmacokinetics of norfloxacin and its N-desethyl- and oxo-metabolites in broiler chickens. Anadón, A; Bringas, P; Díaz, MJ; Martinez-Larrañaga, MR; Velez, C, 1992) | 0.61 |
| "Urodynamic model was developed which, in conjunction with a compartmental pharmacokinetic model, was used for study of factors influencing drug concentrations in urine: urine flow rate, residual bladder urine, maximal bladder urine, stage of renal failure, and elimination kinetics of drugs." | ( Urodynamic modeling of norfloxacin pharmacokinetics by means of computer simulation. Drinovec, J; Karba, R; Kozjek, F; Mrhar, A; Primozic, S, 1991) | 0.59 |
| " The overall elimination half-life was 19." | ( Single-dose pefloxacin pharmacokinetics and metabolism in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Dombros, N; Nikolaidis, P; Oreopoulos, DG; Paton, TW; Tourkantonis, A; Walker, SE, 1991) | 0.28 |
| "The pharmacokinetic properties of the new fluoroquinolones are characterized by a high volume of distribution, long biological half-life, low serum protein binding, elimination by renal and extrarenal mechanisms with high total and renal clearances, limited biotransformation and moderate to excellent bioavailability after oral administration." | ( Quinolone pharmacokinetics and metabolism. Boeckk, M; Borner, K; Deppermann, N; Höffken, G; Koeppe, P; Lode, H, 1990) | 0.28 |
| " For the other new quinolones, a decrease in glomerular filtration rate below 20-30 ml/min induces an increase in terminal half-life and a decrease in plasma and renal clearance, related to the degree of renal impairment." | ( Pharmacokinetics of quinolones in renal insufficiency. Borsa-Lebas, F; Dhib, M; Fillastre, JP; Humbert, G; Leroy, A; Moulin, B, 1990) | 0.28 |
| "Quinolone is reported to interact with caffeine, often resulting in an increase both in the plasma half-life and AUC, a decrease in total plasma clearance, and little change in the absorption rate constant and maximum plasma level." | ( Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition. Barnett, G; Carbó, M; de la Torre, R; Segura, J, 1990) | 0.28 |
| " All the data was processed by KMCP computer software and the pharmacokinetic parameters were calculated, based on one-compartment model." | ( [Comparative study on the pharmacokinetics and bioequivalence of two brands of norfloxacin preparation]. Chen, IJ; Chiang, CH; Hwang, KP; Wu, BN; Yang, JM; Yeh, JL, 1990) | 0.51 |
| " The elimination half-life (T 1/2), total body clearance (CL) and volume of distribution at steady state (Vss) of theophylline were calculated using model-independent methods." | ( Effect of quinolone antimicrobials on theophylline pharmacokinetics. Adair, CG; Casabar, E; Kasik, JE; Lettieri, J; Prince, RA; Wexler, DB, 1989) | 0.28 |
| " A dosing schedule for the quinolones was proposed on the basis of pharmacokinetic parameters and microbiologic activity." | ( Pharmacokinetics of the quinolones in volunteers: a proposed dosing schedule. Andrews, JM; Griggs, D; Wise, R, ) | 0.13 |
| " Blood specimens were obtained for pharmacokinetic profiles following the first and fifteenth doses." | ( Chronic dose urinary and serum pharmacokinetics of norfloxacin in the elderly. Deaney, NB; Kelly, JG; Lavan, J; Noel, J, 1988) | 0.53 |
| " The peak serum concentrations, total area under the serum concentration curve, rate of elimination and serum half-life in the beta-phase were all similar during the acute phase of the disease as well as after normalization of the intestinal function." | ( Consequences of diarrhoeal disease on the pharmacokinetics of norfloxacin. Bergan, T; Cheong, MK; Lolekha, S; Patancharoen, S; Poh, CL, 1988) | 0.52 |
| "The pharmacokinetic profile of norfloxacin, an oral fluoroquinolone, is more complex than that of many antibacterial agents." | ( Review of the bioavailability and pharmacokinetics of oral norfloxacin. Stein, GE, 1987) | 0.8 |
| "3 years) were administered aminophylline, 5 mg/kg, before and after a 6-day course of norfloxacin, 400 mg every 12 hours, and changes in pharmacokinetic parameters were measured and compared." | ( Evaluation of the effect of norfloxacin on the pharmacokinetics of theophylline. Dales, RE; Ho, G; Tierney, MG, 1988) | 0.79 |
| "The pharmacokinetic profile of pefloxacin is one of the major assets of this new antibiotic of the quinolone family." | ( [Pharmacokinetic behavior of pefloxacin in man]. Fourtillan, JB, 1986) | 0.27 |
| " The mean elimination half-life was significantly increased in the patients (29." | ( Oral pharmacokinetics and ascitic fluid penetration of pefloxacin in cirrhosis. Beauchant, M; Becq-Giraudon, B; Bouquet, S; Breux, JP; Cardey, J; Fourtillan, JP; Silvain, C, 1987) | 0.27 |
| "The pharmacokinetic properties of the new quinolones are characterised by a high volume of distribution, long biological half-life, low serum protein binding, elimination mainly by the kidneys, high total and renal clearances, limited biotransformation and a moderate to excellent bioavailability after oral administration." | ( Comparative pharmacokinetics of new quinolones. Borner, K; Glatzel, P; Höffken, G; Koeppe, P; Lode, H; Olschewski, P; Prinzing, C; Reimnitz, D; Sievers, B; Wiley, R, 1987) | 0.27 |
| " The mean serum elimination half-life was 11." | ( Pharmacokinetics and tissue penetration of orally administered pefloxacin. Andrews, JM; Ashby, JP; McLeod, A; Webberley, JM; Wise, R, 1987) | 0.27 |
| " The mean apparent elimination half-life was 13." | ( Pharmacokinetics of pefloxacin in renal insufficiency. Bariety, J; Cunci, R; Jacquot, C; Montay, G, 1985) | 0.27 |
| " Serum half-life of norfloxacin in rodents and monkeys was similar to that in humans." | ( Pharmacokinetic studies of norfloxacin in laboratory animals. Bland, JA; Gadebusch, HH; Gilfillan, EC; Malatesta, PF; Pelak, BA, 1984) | 0.89 |
| "The pharmacokinetic properties of norfloxacin were determined in healthy pigs after single intramuscular (i." | ( Pharmacokinetics and tissue residues of norfloxacin and its N-desethyl- and oxo-metabolites in healthy pigs. Anadón, A; Diaz, MJ; Fernandez, MC; Fernandez, R; Martinez, MA; Martinez-Larrañaga, MR, 1995) | 0.84 |
| " We employed a rat model of chronic bacterial prostatitis to investigate any pharmacokinetic differences that may exist between uninflamed and inflamed prostate glands." | ( Antibiotic pharmacokinetics in the inflamed prostate. Ceri, H; Clark, J; Downey, J; Nickel, JC; Olson, M, 1995) | 0.29 |
| " The in vitro activity of NFN for microorganisms isolated from swine and the pharmacokinetic properties of NFN following single intravenous (i." | ( Clinical pharmacokinetic characterization of norfloxacin nicotinate in swine following systemic administration. Shem-Tov, M; Ziv, G, 1994) | 0.55 |
| " Overall, results indicated (1) no marked differences in pharmacokinetic parameters in pregnant versus nonpregnant females, (2) fleroxacin levels in embryonic tissues were similar to maternal plasma levels, and (3) there was a correlation between exposure and embryolethal doses for all fluoroquinolones which resulted in embryolethality except norfloxacin." | ( Developmental toxicity of fleroxacin and comparative pharmacokinetics of four fluoroquinolones in the cynomolgus macaque (Macaca fascicularis). Hendrickx, AG; Hummler, H; Richter, WF, 1993) | 0.46 |
| " However, a significant difference was observed in clearance, mean residence time and the half-life values between the unweaned and weaned calves." | ( Norfloxacin nicotinate pharmacokinetics in unweaned and weaned calves. Gips, M; Soback, S, 1996) | 1.74 |
| " In addition, urine levels, drug level/MIC ratio, and urine antibacterial activity 72 to 84 h after treatment initiation were determined in a subgroup of patients for pharmacodynamic assessment." | ( Single-dose rufloxacin versus 3-day norfloxacin treatment of uncomplicated cystitis: clinical evaluation and pharmacodynamic considerations. Aguilar, L; Caffaratti, J; Dal-Ré, R; Dalet, F; Del Río, G, 1996) | 0.57 |
| " The Cmax was reduced 29-85%, while the area under the norfloxacin serum concentration-time curve (AUC0-infinity) was reduced by 29-79%." | ( Interaction of norfloxacin with divalent and trivalent pharmaceutical cations. In vitro complexation and in vivo pharmacokinetic studies in the dog. Bredhauer, MG; Charles, BG; Duckworth, PA; Filippich, LJ; Gahan, LR; Wallis, SC, 1996) | 0.89 |
| " It was shown that the elimination half-life (T1/2) of norfloxacin at 20 degrees C (10 ppm: 13." | ( Comparative pharmacokinetics and tissue distribution of norfloxacin-glycine acetate in flounder, (Paralichthys olivaceus) at two different temperatures. Oh, TK; Park, SC; Yun, HI, 1996) | 0.79 |
| " Doses of pefloxacin and concentrations in cerebrospinal fluid and plasma (total and unbound) at the pharmacodynamic endpoint were all independent of infusion rate, whereas only cerebrospinal fluid concentrations of norfloxacin were independent of infusion rate." | ( Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats. Bouquet, S; Couet, W; Courtois, P; Delon, A; Huguet, F; Vierfond, JM, 1997) | 0.7 |
| " Enoxacin (250 mg/l) demonstrated the highest peak concentration (median) in the urine (0-6 h), followed by ciprofloxacin (237 mg/l) and norfloxacin (157 mg/l) as determined by the HPLC assay." | ( Urinary bactericidal activity and pharmacokinetics of enoxacin versus norfloxacin and ciprofloxacin in healthy volunteers after a single oral dose. Kinzig-Schippers, M; Naber, KG; Sörgel, F; Well, M, 1998) | 0.74 |
| " The pharmacokinetic characteristics of all formulations were fitted by a two-compartment open model." | ( Comparative pharmacokinetic profiles of two norfloxacin formulations after oral administration in rabbits. Oh, TK; Park, SC; Yun, HI, 1998) | 0.56 |
| ") administration was determined in order to assess the influence of the rumen on the pharmacokinetic behaviour of NF in sheep." | ( Influence of ruminal distribution on norfloxacin pharmacokinetics in adult sheep. González, F; Lucas, JJ; Nieto, J; Rodríguez, C; San Andrés, MD; San Andrés, MI; Vicente, ML; Waxman, S, 2001) | 0.58 |
| "These findings showed that the quantitative isobolographic approach is appropriate to assess the nature and intensity of the pharmacodynamic interaction between two drugs when data are collected within the biophase, but that data interpretation outside the biophase can be risky due to further pharmacokinetic complexities, in particular slow or/and nonlinear diffusion into the biophase." | ( Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats. Bouquet, S; Cadart, M; Couet, W; Marchand, S; Pariat, C, 2002) | 0.54 |
| "The pharmacokinetic properties of norfloxacin-glycine acetate (NFLXGA) were determined in six horses following a single intravenous (i." | ( Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and intramuscular administration to horses. Park, SC; Yun, HI, 2003) | 0.89 |
| " The best pharmacokinetic (PK) modelling was obtained by considering that ECF concentrations were part of the central compartment, with a proportionality factor." | ( Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats. Chenel, M; Couet, W; Dupuis, A; Lamarche, I; Marchand, S; Paquereau, J; Pariat, C, 2004) | 0.53 |
| " No statistically significant differences were determined between the pharmacokinetic parameters calculated after the first and seventh doses for either CIP or NOR." | ( Ciprofloxacin and norfloxacin pharmacokinetics and prostatic fluid penetration in dogs after multiple oral dosing. Albarellos, GA; Ambros, LA; Hallu, R; Kreil, V; Montoya, L; Rebuelto, M; Waxman, S, 2006) | 0.67 |
| " The purpose of this study was to determine whether three widely used fluoroquinolone antibiotics (ciprofloxacin, ofloxacin, and norfloxacin) are substrates of Bcrp1/BCRP and to investigate the possible role of this transporter in the in vivo pharmacokinetic profile of these compounds and their secretion into the milk." | ( Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Alvarez, AI; Merino, G; Molina, AJ; Prieto, JG; Pulido, MM; Schinkel, AH, 2006) | 0.54 |
| "To explore the urine bactericidal activity of co-amoxiclav and norfloxacin against Escherichia coli in an in vitro pharmacodynamic model simulating the human urinary concentrations observed after administration of a single oral dose of 2000/125 mg sustained-release co-amoxiclav and 400 mg norfloxacin." | ( Urine bactericidal activity against resistant Escherichia coli in an in vitro pharmacodynamic model simulating urine concentrations obtained after 2000/125 mg sustained-release co-amoxiclav and 400 mg norfloxacin administration. Aguilar, L; Alou, L; Cafini, F; Giménez, MJ; Prieto, J; Relaño, MT; Sevillano, D; Valero, E, 2006) | 0.76 |
| " In this study, we aimed to develop a novel pharmacokinetic model to describe NQs-metal cation interactions in order to estimate the optimal dosing interval." | ( Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations. Miyata, K; Ohtani, H; Sawada, Y; Tsujimoto, M, 2007) | 0.54 |
| "Plasma concentration-time profiles of NQs after administration without or with metal cations at various dosing intervals were collected from the literature and analyzed with a pharmacokinetic model incorporating the formation ofNQs-metal cations complex." | ( Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations. Miyata, K; Ohtani, H; Sawada, Y; Tsujimoto, M, 2007) | 0.54 |
| "Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration." | ( Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits. Jayakumar, K; Pavithra, BH; Prakash, N, 2009) | 0.83 |
| " This method can be applied to the pharmacokinetic study of norfloxacin and enoxacin after repeated administration to assess changes in CYP1A2 activity in healthy subjects." | ( A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition. Homma, M; Kobayashi, D; Kobayashi, T; Kohda, Y; Momo, K, 2011) | 0.87 |
| " Various pharmacokinetic parameters of RIF significantly differ when administered alone or in combination with OXC and NXC." | ( Effect of ofloxacin and norfloxacin on rifampicin pharmacokinetics in man. Barikpoar, E; Brown, S; Ezejiofor, NA; Orisakwe, OE, ) | 0.44 |
| " The validated method was applied to assay real plasma samples used for pharmacokinetic studies and therapeutic drug monitoring of the selected drugs." | ( Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, and gatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers. Helmy, SA, 2013) | 0.64 |
| "This assay method was valid within a wide range of plasma concentrations and may be proposed as a suitable method for pharmacokinetic studies, therapeutic drug monitoring implementation, and routine clinical applications, especially for some populations of patients who receive a combination of these drugs." | ( Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, and gatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers. Helmy, SA, 2013) | 0.64 |
| " Various pharmacokinetic parameters of INH significantly differed when administered alone or in combination with OXC or with NXC." | ( Isoniazid Pharmacokinetics in the Presence of Ofloxacin and Norfloxacin Antibiotics. Anusiem, CA; Barikpoar, E; Brown, SA; Ezejiofor, NA; Orisakwe, OE, ) | 0.37 |
| " The pharmacokinetic parameters of common carp were similar to those of crucian carp." | ( Comparative pharmacokinetics of norfloxacin nicotinate in common carp (Cyprinus carpio) and crucian carp (Carassius auratus) after oral administration. Ai, X; Liu, Y; Xu, N; Yang, Q, 2015) | 0.7 |
| " NOR concentrations were measured using liquid chromatography-mass spectrometry, and pharmacokinetic parameters were calculated using a non-compartmental method." | ( Effect of flowing water on the pharmacokinetic properties of norfloxacin in channel catfish (Ictalurus punctatus) after single-dose oral administration. Chen, J; Cheng, B; Dong, L; Gan, J; He, L; Liu, T; Lu, X; Peng, J; Yu, Y; Zhang, L, 2023) | 1.15 |
The aac(6')-Ib-cr gene, in spite of producing low-level resistance by itself, plays a relevant role in acquisition of a clinical level of ciprofloxacin and norfloxACin resistance. In this study, the effect of infection with oncolytic H-1 parvovirus (H-1PV) combined with antibiotics was tested.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Calcium carbonate and H2 receptor antagonists do not appear to interact with quinolones and may be considered as an alternative to sucralfate or magnesium- and aluminum-containing antacids when quinolones are administered." | ( Update on quinolone drug interactions. Hulisz, D; Miller, K, 1990) | 0.28 |
| "The antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods compared to results obtained with the combination of imipenem with amikacin." | ( In vitro antibacterial activity of imipenem in combination with newer quinolone derivatives. Gulden, H; Kern, W; Kurrle, E; Vanek, E, 1988) | 0.52 |
| "The antifungal activity of amphotericin B (AMB), mepartricin (MEPA), 5-fluorocytosine (5FC) and three imidazoles was tested in combination with each of four quinolones against 60 clinical yeast isolates." | ( In-vitro activity of antifungal agents in combination with four quinolones. Petrou, MA; Rogers, TR, 1988) | 0.27 |
| "The in vitro activity of fosfomycin alone and in combination with rifampin, pefloxacin and imipenem was studied by the time-kill method against staphylococci." | ( In vitro activity of fosfomycin combined with rifampin, pefloxacin and imipenem against staphylococci: a study by the time-kill curve method. Bebear, C; Lafferriere, C; Noury, P; Quentin, C; Saivin, S, 1987) | 0.27 |
| " Pefloxacin combined with oxacillin or vancomycin killed staphylococci more rapidly than oxacillin or vancomycin alone but less rapidly than pefloxacin alone." | ( In vitro antistaphylococcal activity of pefloxacin alone and in combination with other antistaphylococcal drugs. Fass, RJ; Helsel, VL, 1987) | 0.27 |
| " Fosfomycin combined with pefloxacin was found to be additive or moderately synergistic." | ( [In vitro action of fosfomycin combined with rifampicin, pefloxacin and imipenem on staphylococci (checkerboard method in a liquid medium)]. Bebear, C; Laurent, C; Noury, P; Quentin, C; Saivin, S, 1987) | 0.27 |
| "Convulsant activity of pazufloxacin mesilate (PZFX mesilate), a new quinolone antibacterial agent for intravenous use, in combination with nonsteroidal anti-inflammatory drug (NSAID) was investigated in mice after intravenous or intracerebroventricular administration." | ( [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration]. Fukuda, H; Kawamura, Y, 2002) | 0.31 |
| " According to this concept, even chemically inert drugs can stimulate T cells because certain drugs interact in a direct way with T-cell receptors (TCR) and possibly major histocompatibility complex molecules without the need for metabolism and covalent binding to a carrier." | ( Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds. Depta, JP; Lüthi, M; Pichler, WJ; Schmid, DA, 2006) | 0.33 |
| " In base to the differences in the kinetic behaviour of ofloxacin with respect to ciprofloxacin and norfloxacin, binary mixtures of the drugs were resolved by using the time-resolved chemiluminescence signals, in combination with first-order partial least-squares (PLS) multivariate calibration." | ( Resolution of ofloxacin-ciprofloxacin and ofloxacin-norfloxacin binary mixtures by flow-injection chemiluminescence in combination with partial least squares multivariate calibration. Alañón Molina, A; Durán Merás, I; Jiménez Girón, A; Muñoz de la Peña, A; Murillo, JA, 2007) | 0.81 |
| " In this study, the effect of infection with oncolytic H-1 parvovirus (H-1PV) combined with antibiotic norfloxacin (NFX) or phytoalexin resveratrol on the survival of cell lines Panc-1 and BxPC3 derived from human pancreatic carcinoma was tested." | ( Anticancer effects of an oncolytic parvovirus combined with non-conventional therapeutics on pancreatic carcinoma cell lines. Angelova, A; Galabov, AS; Georgieva, PB; Raykov, Z; Rommelaere, J, 2009) | 0.57 |
| " As the dendrimeric chelator has a large molecular weight, its combination with norfloxacin may find application in the treatment of external infections." | ( In vitro antimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin. Hider, RC; Zhang, MX; Zhou, T; Zhou, YJ, 2014) | 0.84 |
| "The aac(6')-Ib-cr gene, in spite of producing low-level resistance by itself, plays a relevant role in acquisition of a clinical level of ciprofloxacin and norfloxacin resistance, when combined with three or four chromosomal mutations, both in vitro and in vivo." | ( Impact of AAC(6')-Ib-cr in combination with chromosomal-mediated mechanisms on clinical quinolone resistance in Escherichia coli. Díaz-De-Alba, P; Docobo-Perez, F; Machuca, J; Ortiz, M; Pascual, Á; Recacha, E; Rodríguez-Martínez, JM, 2016) | 0.63 |
| " The enhanced in vitro biological properties of the drug-drug salt hydrate may be attributed to the higher extent of its supersaturation with respect to the individual components, which leads to higher diffusion rates." | ( A Drug-Drug Salt Hydrate of Norfloxacin and Sulfathiazole: Enhancement of in Vitro Biological Properties via Improved Physicochemical Properties. Desiraju, GR; Ganguly, S; Gopi, SP, 2016) | 0.73 |
| "To systematically review the efficacy and safety of Huoxiang Zhengqi Pills combined with Western medicine in the treatment of acute gastroenteritis." | ( [Systematic review and Meta-analysis of Huoxiang Zhengqi Pills combined with Western medicine for acute gastroenteritis]. Li, HM; Liao, X; Wang, GQ; Xie, YM; Yu, DD; Zhang, YL; Zhao, J, 2019) | 0.51 |
| "In this study, the degradation of norfloxacin was investigated by ionizing radiation combined with Fenton-like oxidation in order to enhance the degradation and mineralization of norfloxacin." | ( Assessment of degradation characteristic and mineralization efficiency of norfloxacin by ionizing radiation combined with Fenton-like oxidation. Chen, X; Wang, J; Zhuan, R, 2021) | 1.13 |
| "FIC, AI-2 activity assay, real-time RT-PCR and biofilm inhibition assays were performed to investigate the in vitro effect of paeoniflorin combined with norfloxacin." | ( Paeoniflorin combined with norfloxacin ameliorates drug-resistant Streptococcus suis infection. Fan, Q; Grenier, D; Hou, X; Li, J; Sun, L; Wang, Y; Wei, Y; Xue, B; Yi, L; Zhang, X; Zuo, J, 2022) | 1.22 |
Coadministration of sucralfate reduced the bioavailability of norfloxacin by 91%. Bioavailability was not affected. No dose adjustment should be necessary in patients with diarrhoea. Prodrug approach using diglyceride as a promoiety is a promising strategy.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Oral bioavailability of norfloxacin was found to be 57." | ( Pharmacokinetics of norfloxacin and its N-desethyl- and oxo-metabolites in broiler chickens. Anadón, A; Bringas, P; Díaz, MJ; Martinez-Larrañaga, MR; Velez, C, 1992) | 0.91 |
| " The bioavailability of NFLX from the acetoxyethyl carbamate was lower compared to an equivalent dose of NFLX when given as an oral suspension in rhesus monkeys, presumably because of the lower aqueous solubility of the prodrug." | ( (Acyloxy)alkyl carbamate prodrugs of norfloxacin. Alexander, J; Bland, JA; Fromtling, RA; Gilfillan, EC; Pelak, BA, 1991) | 0.55 |
| " Relative to the IV dose the bioavailability following oral administration of pefloxacin was 76%." | ( Single-dose pefloxacin pharmacokinetics and metabolism in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Dombros, N; Nikolaidis, P; Oreopoulos, DG; Paton, TW; Tourkantonis, A; Walker, SE, 1991) | 0.28 |
| "The pharmacokinetic properties of the new fluoroquinolones are characterized by a high volume of distribution, long biological half-life, low serum protein binding, elimination by renal and extrarenal mechanisms with high total and renal clearances, limited biotransformation and moderate to excellent bioavailability after oral administration." | ( Quinolone pharmacokinetics and metabolism. Boeckk, M; Borner, K; Deppermann, N; Höffken, G; Koeppe, P; Lode, H, 1990) | 0.28 |
| "Quinolone is reported to interact with caffeine, often resulting in an increase both in the plasma half-life and AUC, a decrease in total plasma clearance, and little change in the absorption rate constant and maximum plasma level." | ( Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition. Barnett, G; Carbó, M; de la Torre, R; Segura, J, 1990) | 0.28 |
| " Following oral administration, norfloxacin and ciprofloxacin are well absorbed and the bioavailability of ofloxacin is almost 100%." | ( The pharmacokinetics of oral quinolones (norfloxacin, ciprofloxacin, ofloxacin). Alestig, K, 1990) | 0.83 |
| " The area under the plasma concentration-versus-time curve from time zero to infinity and urinary recovery were used to compare the relative bioavailability of norfloxacin with antacids with that of norfloxacin alone." | ( Inhibition of norfloxacin absorption by antacids. Distlerath, L; Nix, DE; Norman, A; Ronald, B; Williams, VC; Wilton, JH, 1990) | 0.84 |
| " Comparison of the area under the curve (AUC; derived, using model-independent calculations) after iv administration (5 mg/kg) with AUC after oral administration (5 mg/kg) in the same dogs indicated bioavailability of 35." | ( Pharmacokinetics of norfloxacin in dogs after single intravenous and single and multiple oral administrations of the drug. Brown, SA; Buck, JM; Cooper, J; Gauze, JJ; Greco, DS; Weise, DW, 1990) | 0.6 |
| " Bioavailability studies in mice showed that 4 liberated a higher concentration of NFLX in plasma than NFLX itself when administered orally." | ( Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . Kawahata, Y; Kondo, H; Sakamoto, F; Tsukamoto, G; Uno, T, 1989) | 0.49 |
| "The effect of sucralfate on the bioavailability of norfloxacin after single 400-mg doses of norfloxacin was evaluated in eight healthy males." | ( Sucralfate reduces the gastrointestinal absorption of norfloxacin. Goldstein, HR; Hejmanowski, LG; Nix, DE; Parpia, SH; Schentag, JJ; Wilton, JH, 1989) | 0.78 |
| " Out of the three quinolone compounds, only colon-coated pefloxacin was associated with a considerable absorption rate at colonic level." | ( Quinolones and colonization resistance in human volunteers. Geitz, JN; Lerk, CF; Tarko-Smit, NJ; Van Saene, HK; Van Saene, JJ, 1986) | 0.27 |
| " However, since the bioavailability was not affected, norfloxacin is obviously absorbed at a lower intestinal level and no dose adjustment should be necessary in patients with diarrhoea." | ( Consequences of diarrhoeal disease on the pharmacokinetics of norfloxacin. Bergan, T; Cheong, MK; Lolekha, S; Patancharoen, S; Poh, CL, 1988) | 0.76 |
| " They are well absorbed after oral administration, and some achieve serum and tissue levels well exceeding the minimal inhibitory concentrations for susceptible bacteria." | ( Symposium on antimicrobial agents. The quinolones. Walker, RC; Wright, AJ, 1987) | 0.27 |
| " The bioavailability of pefloxacin was complete and plasma concentrations after iv or oral administration were similar." | ( Pharmacokinetics of pefloxacin after repeated intravenous and oral administration (400 mg bid) in young healthy volunteers. Djebbar, F; Fourtillan, JB; Frydman, AM; Gaillot, J; Le Roux, Y; Lefebvre, MA, 1986) | 0.27 |
| "The pharmacokinetic properties of the new quinolones are characterised by a high volume of distribution, long biological half-life, low serum protein binding, elimination mainly by the kidneys, high total and renal clearances, limited biotransformation and a moderate to excellent bioavailability after oral administration." | ( Comparative pharmacokinetics of new quinolones. Borner, K; Glatzel, P; Höffken, G; Koeppe, P; Lode, H; Olschewski, P; Prinzing, C; Reimnitz, D; Sievers, B; Wiley, R, 1987) | 0.27 |
| "An in vitro study was made of the bactericidal activity against Escherichia coli of fosfomycin trometamol, a new fosfomycin salt characterized by high bioavailability in relation to the pH, inoculum and culture medium, the latter being nutrient broth or human urine." | ( Influence of pH, inoculum and media on the in vitro bactericidal activity of fosfomycin trometamol, norfloxacin and cotrimoxazole. Albini, E; Belluco, G; Marca, G, 1986) | 0.49 |
| " norfloxacin and ciprofloxacin, are poorly absorbed and will markedly reduce the faecal aerobes without selecting other bacterial species." | ( Principles for targeted antibiotic use in urinary tract and enteric infections: a review with special emphasis on norfloxacin. Norrby, SR, 1986) | 1.39 |
| " The compound was moderately well absorbed following oral dosing in these animal species." | ( Pharmacokinetic studies of norfloxacin in laboratory animals. Bland, JA; Gadebusch, HH; Gilfillan, EC; Malatesta, PF; Pelak, BA, 1984) | 0.56 |
| " Oral bioavailability was rather poor (9." | ( Intravenous disposition kinetics, oral and intramuscular bioavailability and urinary excretion of norfloxacin nicotinate in donkeys. Glickman, A; Lavy, E; Ziv, G, 1995) | 0.51 |
| " Intramuscular bioavailability was found to be 53." | ( Pharmacokinetics and tissue residues of norfloxacin and its N-desethyl- and oxo-metabolites in healthy pigs. Anadón, A; Diaz, MJ; Fernandez, MC; Fernandez, R; Martinez, MA; Martinez-Larrañaga, MR, 1995) | 0.56 |
| " Bioavailability was 51-64%." | ( Clinical pharmacokinetic characterization of norfloxacin nicotinate in swine following systemic administration. Shem-Tov, M; Ziv, G, 1994) | 0.55 |
| "The authors studied the effect of milk on the bioavailability of norfloxacin in six healthy male volunteers in a randomized crossover trial." | ( Effect of milk on absorption of norfloxacin in healthy volunteers. Higashi, A; Inotsume, N; Matsuda, I; Minami, R; Nakano, M; Sudo, Y, 1993) | 0.81 |
| " These results strongly suggest that adsorption of quinolones by aluminum hydroxide reprecipitated in the small intestine would play an important role in the reduced bioavailability of quinolones after coadministration with aluminum-containing antacids." | ( Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide. Aoki, H; Fujisawa, C; Hakusui, H; Kurata, T; Ohshima, Y; Okazaki, O; Tanaka, M, 1993) | 0.29 |
| "The dissolution rates and bioavailability of norfloxacin in seven batches of norfloxacin capsules produced by five pharmaceutical factories were studied with rotating basket and UV-spectrophotometry." | ( [Study on dissolution rate and bioavailability of norfloxacin capsule by UV-spectrophotometry]. Gong, W; Ke, Z; Wang, L; Zhang, Z, 1993) | 0.8 |
| "The complexation of the fluoroquinolone antimicrobials is important because it has been implicated in reduced oral bioavailability and reduced antimicrobial activity when the drugs are co-administered with antacids or multi-vitamin preparations containing iron." | ( Characterization of the complexation of fluoroquinolone antimicrobials with metal ions by nuclear magnetic resonance spectroscopy. Riley, CM; Ross, DL; Takusagawa, F; Vander Velde, D, 1993) | 0.29 |
| " The absorption rate after intramuscular administration appeared to change as a result of dose increase." | ( Norfloxacin nicotinate pharmacokinetics in unweaned and weaned calves. Gips, M; Soback, S, 1996) | 1.74 |
| " Combinations of metal ion and norfloxacin which result in only a small extent (< 20%) of norfloxacin complex formation can result in relatively large decreases in oral bioavailability of this antimicrobial agent." | ( Interaction of norfloxacin with divalent and trivalent pharmaceutical cations. In vitro complexation and in vivo pharmacokinetic studies in the dog. Bredhauer, MG; Charles, BG; Duckworth, PA; Filippich, LJ; Gahan, LR; Wallis, SC, 1996) | 0.93 |
| " The bioavailability of norfloxacin 400 mg administered as single oral dose was compared in an Indian preparation A (Torrent) and imported preparation B (Merck Sharp and Dohme (MSD), USA)." | ( Comparative bioavailability of two brands of norfloxacin. Beotra, A; Seth, S; Seth, SD, 1995) | 0.86 |
| "The freeze-dried ternary formulations of meclizine (MZ, an anti-motion sickness drug), prednisolone (PRED, an anti-inflammatory drug) and norfloxacin (NFLX, an anti-microbial drug) which are poorly water-soluble and are low bioavailability drugs, were prepared using egg albumin and olive oil." | ( Pharmaceutical properties of freeze-dried formulations of egg albumin, several drugs and olive oil. Kakegawa, H; Matsumoto, H; Miyataka, H; Nishiki, M; Satoh, T; Tsuji, Y, 1996) | 0.5 |
| " Norfloxacin was poorly absorbed after oral administration (60 mg." | ( Age-related differences in norfloxacin pharmacokinetic behaviour following intravenous and oral administration in sheep. De Vicente, ML; González, F; Nieto, J; Rodríguez, C; San Andrés, MD; San Andrés, MI, 1997) | 1.5 |
| " The absolute bioavailability (F) of NFLX, NFLXN and NFLXGA was calculated as 29%, 45% and 40%." | ( Comparative pharmacokinetic profiles of two norfloxacin formulations after oral administration in rabbits. Oh, TK; Park, SC; Yun, HI, 1998) | 0.56 |
| " It was demonstrated that S/P is a function of the quotient of the rate of absorption and venous plasma drug concentration." | ( Kinetics of 4-fluoroquinolones permeation into saliva. Antolic, G; Grabnar, I; Kozjek, F; Mrhar, A; Suturkova, LJ, 1999) | 0.3 |
| " bioavailability of NF in ruminants could not be attributed to ruminal degradation." | ( Influence of ruminal distribution on norfloxacin pharmacokinetics in adult sheep. González, F; Lucas, JJ; Nieto, J; Rodríguez, C; San Andrés, MD; San Andrés, MI; Vicente, ML; Waxman, S, 2001) | 0.58 |
| "The EDTA and sodium caprate (Na caprate) effects on the oral bioavailability of norfloxacin were tested." | ( Improvement of norfloxacin oral bioavailability by EDTA and sodium caprate. Bonini, F; Dos Santos, I; Fawaz, F; Lagueny, AM, 2003) | 0.9 |
| " We conclude that Bcrp1 is one of the determinants for the bioavailability of fluoroquinolones and their secretion into the milk." | ( Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Alvarez, AI; Merino, G; Molina, AJ; Prieto, JG; Pulido, MM; Schinkel, AH, 2006) | 0.33 |
| " This increase in activity is being considered due to increased bioavailability of the metal drug complex." | ( Bismuth-norfloxacin complex: synthesis, physicochemical and antimicrobial evaluation. Giridhar, R; Shaikh, AR; Yadav, MR, 2007) | 0.77 |
| " For "selective intestinal decontamination", poorly absorbed oral norfloxacin is the preferred schedule." | ( [Bacterial infections in liver cirrhosis]. Farkas, A; Papp, M; Tornai, I; Udvardy, M, 2007) | 0.58 |
| "To assess the bioavailability of norfloxacin from urinary excretion relative to plasma concentration." | ( Comparative bioavailability of norfloxacin tablets based on blood and urine data. El Gholmy, ZA; Khalafallah, NM; Nada, AH; Sharaf, MA, 2007) | 0.91 |
| " Relative bioavailability values calculated for the local and previously developed products relative to Noroxin were higher than 85% based on area under the curve and urinary excretion." | ( Comparative bioavailability of norfloxacin tablets based on blood and urine data. El Gholmy, ZA; Khalafallah, NM; Nada, AH; Sharaf, MA, 2007) | 0.63 |
| "Urinary excretion of norfloxacin may be a useful noninvasive tool for bioavailability assessment of norfloxacin oral formulations." | ( Comparative bioavailability of norfloxacin tablets based on blood and urine data. El Gholmy, ZA; Khalafallah, NM; Nada, AH; Sharaf, MA, 2007) | 0.94 |
| " These "in combo" PAMPA data were used to predict the human absolute bioavailability of the ampholytes." | ( The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. Avdeef, A; Sun, N; Tam, KY; Tsinman, O, 2010) | 0.36 |
| " To show the importance of physicochemical properties, the classic QSAR and CoMFA of neonicotinoids and prediction of bioavailability of pesticides in terms of membrane permeability in comparison with drugs are described." | ( Importance of physicochemical properties for the design of new pesticides. Akamatsu, M, 2011) | 0.37 |
| "Prodrug approach using diglyceride as a promoiety is a promising strategy to improve bioavailability of poorly absorbed drugs and the same was explored in the present work to improve oral bioavailability of norfloxacin; a second generation fluoroquinolone antibacterial." | ( Diglyceride prodrug strategy for enhancing the bioavailability of norfloxacin. Dhaneshwar, S; Ghosh, P; Godbole, D; Joshi, S; Tewari, K, 2011) | 0.79 |
| " Its oral bioavailability is 30-40% and is a case for improvement by appropriate formulation design." | ( Development of sustained release floating drug delivery system for norfloxacin: in vitro and in vivo evaluation. Bomma, R; Guguloth, M; Veerabrahma, K, ) | 0.37 |
| " Bioavailability studies were conducted in healthy male human volunteers, and the pharmacokinetic parameters of the best formulation were compared with that of the marketed conventional (Norbid) tablet." | ( Development of sustained release floating drug delivery system for norfloxacin: in vitro and in vivo evaluation. Bomma, R; Guguloth, M; Veerabrahma, K, ) | 0.37 |
| " NXC reduced the extent and rate of absorption of RIF." | ( Effect of ofloxacin and norfloxacin on rifampicin pharmacokinetics in man. Barikpoar, E; Brown, S; Ezejiofor, NA; Orisakwe, OE, ) | 0.44 |
| " This way, these formulations could provide an increased bioavailability in vivo." | ( Formulation development and stability studies of norfloxacin extended-release matrix tablets. Bernardi, LS; Klein, L; Mendes, C; Oliveira, PR; Sangoi, Mda S; Silva, MA, 2013) | 0.64 |
| " The bioavailability indices of INH in the saliva and plasma were similar in all the groups." | ( Isoniazid Pharmacokinetics in the Presence of Ofloxacin and Norfloxacin Antibiotics. Anusiem, CA; Barikpoar, E; Brown, SA; Ezejiofor, NA; Orisakwe, OE, ) | 0.37 |
| "In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), novel organic salts containing fluoroquinolones (e." | ( Novel organic salts based on fluoroquinolone drugs: synthesis, bioavailability and toxicological profiles. Branco, LC; Costa, A; Duarte, CM; Florindo, C; Marrucho, IM; Matias, AN; Matos, C; Nunes, SL; Rebelo, LP, 2014) | 0.4 |
| ", solubility in an aqueous medium and lipophilic properties, which have an effect on the bioavailability of five selected fluoroquinolones." | ( Experimental and theoretical studies on the molecular properties of ciprofloxacin, norfloxacin, pefloxacin, sparfloxacin, and gatifloxacin in determining bioavailability. Betlejewska-Kielak, K; Biernacka, J; Grudzień, M; Kłosińska-Szmurło, E; Mazurek, AP; Pluciński, FA, 2014) | 0.63 |
| " Finally, the relative bioavailability of NOR after a single oral dosage of 1:5 and 1:10 NOR-CTS was enhanced to 148." | ( Chitosan Influences the Expression of P-gp and Metabolism of Norfloxacin in Grass Carp. Hu, K; Jin, T; Li, HR; Li, Y; Ruan, J; Xie, X; Yang, XL; Zhao, YN, 2015) | 0.66 |
| ", lipophilicity and consequently, modified bioavailability of norfloxacin." | ( Synthesis, Characterization and Antimicrobial Evaluation of Lipid Based Norfloxacin Prodrug. Piplani, M; Rajak, H; Sharma, PC, 2018) | 0.95 |
| " Compound 12g with MIC values of 5 μg/ml as a representative may possess better oral bioavailability and indicated high permeability by the parallel artificial membrane permeation assay of the blood-brain barrier (PAMPA-BBB)." | ( Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold. An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T, 2018) | 0.48 |
| " The aim of the present study was to clarify the effect of the changes in MC on in vivo drug absorption after nasal application, and to justify the pharmacokinetic model to which the MC parameter was introduced, to enable prediction of bioavailability after intranasal administration." | ( Quantitative Estimation of the Effect of Nasal Mucociliary Function on in Vivo Absorption of Norfloxacin after Intranasal Administration to Rats. Furubayashi, T; Higaki, K; Inoue, D; Katsumi, H; Kimura, S; Kiriyama, A; Ogawara, KI; Sakane, T; Tanaka, A; Yamamoto, A; Yutani, R, 2018) | 0.7 |
| "NOR:HPβCD:GA was the best approach for improving the bioavailability of NOR." | ( Binary and ternary complexes of norfloxacin to improve the solubility of the active pharmaceutical ingredient. Aloisio, C; Garnero, C; Gracia-Vásquez, S; Longhi, M; Ponce-Ponte, M; Romero-Guerra, DM, 2018) | 0.76 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| " In conclusion, the Norfloxacin oral bioavailability can be improved with this binary systems, that could be applied in the production of an alternative pharmaceutical formulation of the drug." | ( β-cyclodextrin complexation as an approach to enhance the biopharmaceutical properties of Norfloxacin B Hydrate. Bongioanni, A; Bueno, MS; Chierentin, L; Garnero, C; Longhi, MR; Nunes Salgado, HR, 2019) | 1.06 |
| "The nasal drug application has drawn much attention as the strategy for the delivery route of many drug modalities such as the poorly absorbed drugs, peptides, nucleic acid, and central nervous system drugs." | ( [Development of Prediction System for Drug Absorption after Intranasal Administration Incorporating Physiologic Functions of Nose -Estimation of in Vivo Drug Permeation through Nasal Mucosa Using in Vitro Membrane Permeability]. Inoue, D, 2021) | 0.62 |
The pharmacokinetics and dosage regimen of norfloxacin-glycine acetate (NFLXGA) was investigated in pigs. Reasons for inappropriate use in the remaining seven patients included isolation of fewer bacteria than required by the criteria in asymptomatic patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The CL was surgically removed from 16 gravid females on GD 19 in order to focus on placental-derived P; ten were dosed with norfloxacin and six received vehicle only." | ( Embryotoxicity studies of norfloxacin in cynomolgus monkeys. II. Role of progesterone. Cukierski, MA; Hendrickx, AG; Hess, DL; Lasley, BL; Peter, CP; Prahalada, S; Robertson, RT; Tarantal, AF; Tarara, R, 1992) | 0.79 |
| "Norfloxacin was given to 2 groups of chickens (8 chickens/group) at a dosage of 8 mg/kg of body weight, IV and orally." | ( Pharmacokinetics of norfloxacin and its N-desethyl- and oxo-metabolites in broiler chickens. Anadón, A; Bringas, P; Díaz, MJ; Martinez-Larrañaga, MR; Velez, C, 1992) | 2.05 |
| " A dose-response relationship was not observed in sperm morphology changes." | ( Induction of sperm abnormalities in mice by norfloxacin. Maura, A; Pino, A, 1991) | 0.54 |
| " The simplified dosage regimen (single dose) and its favorable benefit/risk ratio justifies the use of Fosfomycin trometamol as a treatment for uncomplicated urinary tract infections in female patients." | ( Single-dose fosfomycin trometamol (Monuril) versus multiple-dose norfloxacin: results of a multicenter study in females with uncomplicated lower urinary tract infections. de Jong, Z; Plante, P; Pontonnier, F, 1991) | 0.52 |
| " Dosage adjustments are required, particularly in severe renal failure and for the drugs almost exclusively excreted, in unchanged form, via the renal route." | ( Pharmacokinetics of quinolones in renal insufficiency. Borsa-Lebas, F; Dhib, M; Fillastre, JP; Humbert, G; Leroy, A; Moulin, B, 1990) | 0.28 |
| " Some clinicians recommend a 30% empiric reduction in theophylline dosage when ciprofloxacin therapy is initiated." | ( Update on quinolone drug interactions. Hulisz, D; Miller, K, 1990) | 0.28 |
| " Aqueous and sera samples were dosed using HPLC." | ( [Intraocular penetration of topical norfloxacin in humans. Preliminary study]. Adenis, JP; Bron, A; Chirpaz, L; Kamcierkzak, A; Pechinot, M; Razakarivony, H, ) | 0.41 |
| " Our data show that NOR given at dosage higher than those usually recommended (e." | ( [A clinical study on the use of norfloxacin in the therapy of urethritis caused by Chlamydia trachomatis]. Cespa, M; Concia, E; Cruciani, M; Donadini, A; Gusmitta, A; Rabbiosi, G, 1990) | 0.56 |
| " Norfloxacin and nalidixic acid were subcutaneously administered to rats and rabbits, orally administered to dogs, and norfloxacin was orally dosed to monkeys once a day for 7 consecutive days." | ( Toxicokinetic study of norfloxacin-induced arthropathy in juvenile animals. Aijima, H; Ishida, R; Kusajima, H; Machida, M; Maeda, A; Uchida, H, 1990) | 1.5 |
| " A dose-response relationship was observed between doses/body weight and peak serum concentrations." | ( [Basic and clinical studies on norfloxacin in the pediatric field]. Iwai, N; Kasai, K; Katayama, M; Miyazu, M; Nakamura, H, 1990) | 0.57 |
| "Norfloxacin was given to 6 healthy dogs at a dosage of 5 mg/kg of body weight IV and orally in a complete crossover study, and orally at dosages of 5, 10, and 20 mg/kg to 6 healthy dogs in a 3-way crossover study." | ( Pharmacokinetics of norfloxacin in dogs after single intravenous and single and multiple oral administrations of the drug. Brown, SA; Buck, JM; Cooper, J; Gauze, JJ; Greco, DS; Weise, DW, 1990) | 2.05 |
| " This study was designed to investigate whether the fluoroquinolone norfloxacin at the usual clinical dosage interacts with the anticoagulant agent warfarin." | ( Norfloxacin does not alter warfarin's disposition or anticoagulant effect. Bjornsson, TD; Distlerath, LM; Gregg, MH; Rocci, ML; Vlasses, PH; Wheeler, SC; Zing, W, 1990) | 1.96 |
| " In this prospective randomized study, norfloxacin and trimethoprim-sulfamethoxazole were given on the same dosage schedule with the former drug given as a 400-mg tablet twice daily and the latter drug given as a double strength tablet twice daily." | ( Treatment of recurrent urinary tract infection with norfloxacin versus trimethoprim-sulfamethoxazole. Amy, BG; Childs, SJ; Hurst, AT; Krisch, EB; McCabe, RE; Seidmon, EJ; Truant, AL, 1990) | 0.8 |
| " Forty-six pregnant monkeys were dosed with a control vehicle or 200 mg/kg/day norfloxacin for one of three 10-day periods on GD 36-45, 71-80, or 111-120." | ( Embryotoxicity studies of norfloxacin in cynomolgus monkeys: I. Teratology studies and norfloxacin plasma concentration in pregnant and nonpregnant monkeys. Cukierski, MA; Cukierski, MJ; Hess, DL; Nyland, T; Peter, CP; Prahalada, S; Robertson, RT; Rodgers, JD; Tarantal, AF; Zacchei, AG, 1989) | 0.8 |
| " The 200-mg dosage of norfloxacin seemed to cause fewer side effects than the 400-mg dosage." | ( Coordinated multicenter study of norfloxacin versus trimethoprim-sulfamethoxazole treatment of symptomatic urinary tract infections. The Urinary Tract Infection Study Group. , 1987) | 0.87 |
| "Norfloxacin, a 4-quinolone antibiotic, was administered orally to 4 healthy dogs at dosages of 11 and 22 mg/kg of body weight, every 12 hours for 4 days, with a 4-week interval between dosing regimens." | ( Serum and tissue fluid norfloxacin concentrations after oral administration of the drug to healthy dogs. Budsberg, SC; MacDonald, KH; Rosser, EJ; Stein, GE; Walker, RD, 1989) | 2.03 |
| " This risk may depend on the dosing schedule and may be reduced by combined therapy." | ( Resistance occurring after fluoroquinolone therapy of experimental Pseudomonas aeruginosa peritonitis. Auckenthaler, R; Michéa-Hamzehpour, M; Pechère, JC; Regamey, P, 1987) | 0.27 |
| "In 12 recent clinical studies, norfloxacin given in various dosage regimens was shown to be highly effective in treating 1,588 gonococcal infections in 1,486 patients." | ( Norfloxacin in the treatment of gonorrhea due to penicillinase and non-penicillinase producing Neisseria gonorrheae: a review. Lee, CT; Wong, EC, 1988) | 2 |
| " A dosing schedule for the quinolones was proposed on the basis of pharmacokinetic parameters and microbiologic activity." | ( Pharmacokinetics of the quinolones in volunteers: a proposed dosing schedule. Andrews, JM; Griggs, D; Wise, R, ) | 0.13 |
| " Oral administration and twice daily dosing are significant advantages." | ( Norfloxacin in the eradication of enteric infections in AIDS patients. Appleman, MD; Causey, DM; Corrado, ML; Heseltine, PN; Leedom, JM, 1988) | 1.72 |
| " A daily dosage of 1,000 mg ciprofloxacin or 800 mg norfloxacin is recommended for infection prevention in severely granulocytopenic patients." | ( Ciprofloxacin and norfloxacin for selective decontamination in patients with severe granulocytopenia. Daenen, S; De Vries-Hospers, HG; Dekker, AW; Gaus, W; Gutzler, F; Haralambie, E; Kern, W; König, W; Maschmeyer, G; Sizoo, W, ) | 0.72 |
| " Dosage modification is, therefore, necessary when the glomerular filtration rate falls below 20 ml/minute." | ( Review of the bioavailability and pharmacokinetics of oral norfloxacin. Stein, GE, 1987) | 0.52 |
| " The dosage of 400 mg gave a mean serum concentration peak (11." | ( [Treatment of peritonitis in kidney failure patients under continuous ambulatory peritoneal dialysis by pefloxacine. Results and pharmacokinetics]. Benevent, D; Denis, F; Lagarde, C; Mounier, M, 1987) | 0.27 |
| " Compared with non-burned subjects, burn patients exhibit a shorter elimination half-life, but modifications in dosage regimen are not required." | ( [Pharmacokinetics of pefloxacin in burn patients]. Baron, D; Drugeon, HB; Meignier, M; Montay, G; Potel, G; Touzé, MD, 1987) | 0.27 |
| "The chemistry, mechanism of action, antimicrobial spectrum, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of ciprofloxacin and norfloxacin are reviewed, and mechanisms of antimicrobial resistance and drug and laboratory interactions are described." | ( Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials. DeVito, JM; Nix, DE, 1987) | 0.8 |
| " Given these findings, we advise that, for patients who are treated with theophylline and are subsequently treated with norfloxacin, adjustment of the theophylline dosage may be necessary in some patients to minimize the risk of theophylline toxicity." | ( Evaluation of the effect of norfloxacin on the pharmacokinetics of theophylline. Dales, RE; Ho, G; Tierney, MG, 1988) | 0.78 |
| "90% in 5 days after dosing with an average of 13." | ( [Fecal and urinary excretion of norfloxacin in adults]. Aramaki, M; Fujimoto, T; Kawakami, A; Koga, T; Motohiro, T; Oda, K; Sakata, Y; Shimada, Y; Tanaka, K; Tomita, S, 1987) | 0.56 |
| " With the present dosage regimen, CSF quickly attains therapeutic levels of pefloxacin." | ( Transfer kinetics of pefloxacin into cerebro-spinal fluid after one hour i.v. infusion of 400 mg in man. Chazal, J; Djebbar, F; Dow, J; Frydman, AM; Gaillot, J; Janny, P; Woehrle, R, 1986) | 0.27 |
| " Since renal excretion of the unchanged drug is less important, there is no need to modify the dosage in case of renal impairment." | ( [Pharmacokinetic behavior of pefloxacin in man]. Fourtillan, JB, 1986) | 0.27 |
| " However, further clinical studies are required to determine the duration, dosage and in-vivo activity of the antibiotics." | ( In-vitro susceptibility of Pseudomonas pseudomallei isolated in Malaysia to some new cephalosporins and a quinolone. Cheong, YM; Joseph, PG; Koay, AS, 1987) | 0.27 |
| " This study suggests that a twice or possibly once daily dosage may be sufficient to treat systemic infections caused by susceptible pathogens." | ( Pharmacokinetics and tissue penetration of orally administered pefloxacin. Andrews, JM; Ashby, JP; McLeod, A; Webberley, JM; Wise, R, 1987) | 0.27 |
| "We reviewed, the structure, pharmacokinetic properties, mode of actions, antibacterial spectrum, therapeutic dosage and side effects of fluoroquinolones in this article." | ( [Fluoroquinolones]. Akalin, E; Baykal, M, 1987) | 0.27 |
| " The rate of bacterial killing (delta log10 CFU/ml per h) did not change over a dosage range of 1 to 15 mg/kg per h (-0." | ( Evaluation of pefloxacin in experimental Escherichia coli meningitis. Hackbarth, CJ; Sande, MA; Shibl, AM, 1986) | 0.27 |
| " Ciprofloxacin is effective in single dosage against urogenital gonococcal infections, and probably also against rectal and pharyngeal infections." | ( Ciprofloxacin in the treatment of gonorrhoea and non-gonococcal urethritis. Oriel, JD, 1986) | 0.27 |
| " It is difficult to generalize their clinical usefulness, since these agents exhibit different pharmacokinetic profiles, antimicrobial activity (with varied minimum inhibitory concentrations among similar organisms), and dosage regimens." | ( Review of the 4-quinolones. Eggleston, M; Park, SY, 1987) | 0.27 |
| " On the 5th day before the start of dosing, on the first, 3rd and 5th days (last dosing day) of dosing, and on the 3rd, 5th, 10th and 20th days after the end of dosing, effects of the drug on the fecal flora were examined and its fecal levels were determined." | ( [Effect of norfloxacin on bacterial flora in human feces]. Aramaki, M; Fujimoto, T; Kawakami, A; Koga, T; Motohiro, T; Oda, K; Sakata, Y; Shimada, Y; Tanaka, K; Tomita, S, 1987) | 0.66 |
| " To test this idea, a teratologic study was conducted in which rabbits were dosed on Days 6 to 18 of gestation with norfloxacin given orally at 100 mg/kg/day or subcutaneously at 20 mg/kg/day." | ( Association between adverse maternal and embryo-fetal effects in norfloxacin-treated and food-deprived rabbits. Bland, JA; Bokelman, DL; Clark, RL; Nolan, TE; Oppenheimer, L; Peter, CP; Robertson, RT, 1986) | 0.72 |
| " It is proposed that the decreased plasma clearance of pefloxacin in patients with cirrhosis is a result of decreased hepatic metabolism of the drug, and that the dosage should probably be modified in these patients." | ( Pefloxacin kinetics in cirrhosis. Cunci, R; Danan, G; Erlinger, S; Montay, G, 1985) | 0.27 |
| " Therefore, dosage adjustment is advisable in patients with creatinine clearance less than 20 ml/min, although it will inevitably cause lower urinary concentrations." | ( Pharmacokinetics of norfloxacin in chronic renal failure. Arrigo, G; Broccali, G; Cavaliere, G; D'Amico, G; Passarella, E, 1985) | 0.59 |
| " To assess the presence of norfloxacin conjugates in the urine of dosed individuals, the effects of urine hydrolysis on drug quantitation were examined." | ( Quantitation of norfloxacin, a new antibacterial agent in human plasma and urine by ion-pair reverse-phase chromatography. Bayne, WF; Musson, DG; Pauliukonis, LT, 1984) | 0.91 |
| " Patients with a glomerular filtration rate of less than 30 ml/min require dosage reduction and we would recommend a reduction to half the usual dosage." | ( Pharmacokinetics of norfloxacin (MK 366) in patients with impaired kidney function--some preliminary results. Asscher, AW; Hughes, PJ; Webb, DB, 1984) | 0.59 |
| " The compound was moderately well absorbed following oral dosing in these animal species." | ( Pharmacokinetic studies of norfloxacin in laboratory animals. Bland, JA; Gadebusch, HH; Gilfillan, EC; Malatesta, PF; Pelak, BA, 1984) | 0.56 |
| " After multiple dosing some local swelling was observed at the injection site." | ( Intravenous disposition kinetics, oral and intramuscular bioavailability and urinary excretion of norfloxacin nicotinate in donkeys. Glickman, A; Lavy, E; Ziv, G, 1995) | 0.51 |
| ") dosage of 8 mg/kg body weight." | ( Pharmacokinetics and tissue residues of norfloxacin and its N-desethyl- and oxo-metabolites in healthy pigs. Anadón, A; Diaz, MJ; Fernandez, MC; Fernandez, R; Martinez, MA; Martinez-Larrañaga, MR, 1995) | 0.56 |
| " Since a relatively small amount of norfloxacin is removed by hemodialysis, dosage adjustment is not necessary to compensate for the extracorporeal removal." | ( Hemodialysis removal of norfloxacin. Fitzloff, J; Jain, R; Lau, AH; Tang, I, 1994) | 0.87 |
| "A simple, precise, stability-indicating reversed-phase high-performance liquid chromatographic method for norfloxacin glutamate and norfloxacin glucuronate in liquid and solid dosage forms is described." | ( High-performance liquid chromatographic method for the determination of norfloxacin glutamate and glucuronate in solid and liquid dosage forms and its application to stability testing. Chen, C; Liu, X; Wu, R, 1993) | 0.73 |
| " dosing best fitted a 2-compartment open system pharmacokinetic model." | ( Clinical pharmacokinetic characterization of norfloxacin nicotinate in swine following systemic administration. Shem-Tov, M; Ziv, G, 1994) | 0.55 |
| " One of five new quinolones was orally administered, before transurethral resection of the prostate, at the dosage of 200 mg three times daily for 3 consecutive days." | ( Accumulation of new quinolones in the blood of elderly patients. Abe, Y; Hasuda, A; Morita, M; Nakagawa, H; Suzuki, K, ) | 0.13 |
| "5 mM) by 20% of the control in the in situ ligated loop experiment, in which partial precipitation of aluminum hydroxide was observed in the dosing solution." | ( Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide. Aoki, H; Fujisawa, C; Hakusui, H; Kurata, T; Ohshima, Y; Okazaki, O; Tanaka, M, 1993) | 0.29 |
| " There were no significant differences between the two dosage levels." | ( Efficacy of norfloxacin nicotinate treatment of broiler breeders against Haemophilus paragallinarum. Lublin, A; Malkinson, M; Mechani, S; Weisman, Y, ) | 0.51 |
| " These profiles are misleading because the uniformity of dosage units was tested before the dissolution studies." | ( Determination of norfloxacin by fluorescence in the presence of different antacids: quantification of analytical interferences. Bernabé, I; Córdoba-Borrego, M; Córdoba-Díaz, D; Córdoba-Díaz, M, 1996) | 0.63 |
| " Clinafloxacin at higher dosage (45 mg/kg/d) resulted in a decrease in myeloid progenitors in BM." | ( Enhanced hematopoiesis in sublethally irradiated mice treated with various quinolones. Fabian, I; Gruss, T; Kletter, Y; Shalit, I; Weiss, K, 1997) | 0.3 |
| " Inaccurate estimations of ex vivo antibacterial activity of a suspected active metabolite (as with rufloxacin) when an adequate cutoff is not established may have dosing implications." | ( Suspicion of quinolone active metabolite following discrepancy between predicted and experimental urine bactericidal activities. Aguilar, L; Costa, J; Dal-Ré, R; Giménez, MJ; Prieto, J, 1997) | 0.3 |
| " In the survival study, a dose-response effect of ciprofloxacin on survival was observed (ciprofloxacin: 10 mg/kg, 10%; 50 mg/kg, 26%; and 100 mg/kg, 35%) with the results in the 100-mg/kg-treated group being significant when compared with the 5% survival rate in saline-treated controls (P < ." | ( The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure. Assy, N; Gauthier, T; Kaita, KD; Meyers, AF; Minuk, GY; Zhang, M, 1998) | 0.3 |
| "The development and validation study of a sensitive, rapid, reproducible, easy and precise reversed-phase high-performance liquid chromatographic assay for norfloxacin (NFLX) samples from photo-stability of solid dosage forms, without using gradient elution, extraction methods and without using counter-ion has been carried out." | ( Validation of a high-performance liquid chromatographic method for the determination of norfloxacin and its application to stability studies (photo-stability study of norfloxacin). Córdoba-Borrego, M; Córdoba-Díaz, D; Córdoba-Díaz, M, 1999) | 0.72 |
| " Reasons for inappropriate use in the remaining seven patients included isolation of fewer bacteria than required by the criteria in asymptomatic patients (3 cases), isolation of organisms not sensitive to norfloxacin (1 case) and lack of dosage adjustment for renal insufficiency (3 cases)." | ( The use of norfloxacin in a university hospital. Alaniz, C; Stumpf, JL; Townsend, KA, 1991) | 0.86 |
| " The proposed method has been applied to the determination of these drugs in their each pharmaceutical dosage forms with satisfactory results." | ( Study on the charge-transfer reaction between 7,7,8,8-tetracyanoquinodimethane and drugs. Bian-zhen, X; Feng-lin, Z; Shen-yang, T; Zhi-quan, Z, 1999) | 0.3 |
| " Cultures were grown at 28 degrees C in sucrose/peptone broth for 18 days after dosing with ciprofloxacin (300 microM) or norfloxacin (313 microM)." | ( The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin. Freeman, JP; Heinze, TM; Moody, JD; Parshikov, IA; Sutherland, JB; Williams, AJ, 2001) | 0.74 |
| " The efficacies of two different dosing methods, continuous and pulse dosing, were compared." | ( Treatment of experimentally induced Pasteurella multocida infections in broilers and turkeys: comparative studies of different oral treatment regimens. Horváth, E; Laczay, P; Sarközy, G; Semjén, G, 2002) | 0.31 |
| " Using this model, the efficacy of two different dosing methods of norfloxacin (continuous and pulse dosing) was evaluated." | ( Pulse and continuous oral norfloxacin treatment of experimentally induced Escherichia coli infection in broiler chicks and turkey poults. Horváth, E; Laczay, P; Sárközy, G; Schmidt, J; Semjén, G, 2002) | 0.85 |
| " Many of the fluoroquinolone agents have once-daily dosing regimens, enhancing patient adherence." | ( The expanding role of fluoroquinolones. Schaeffer, AJ, 2002) | 0.31 |
| " In addition, concurrent dosing of BPAA (1 microgram/body) did not reduce the convulsion-inducing dose of PZFX mesilate." | ( [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration]. Fukuda, H; Kawamura, Y, 2002) | 0.31 |
| " Hydrogels C-AMFQ behave as a reservoir of AMFQ able to deliver it at a constant rate and would be useful to design topical and or systemic dosage forms." | ( Release kinetics and up-take studies of model fluoroquinolones from carbomer hydrogels. Allemandi, DA; Alovero, F; Jimenez-Kairuz, A; Manzo, RH; Olivera, ME; Vilches, AP, 2002) | 0.31 |
| " The knowledge of the correlation between blood levels and tissue concentrations can be helpful for adequate dosing of these drugs." | ( Determination of norfloxacin free interstitial levels in skeletal muscle by microdialysis. Dalla Costa, T; Freddo, RJ, 2002) | 0.65 |
| " The optimal dosage for each administration route was calculated from the pharmacokinetic data on the basis of the area under the inhibitory plasma concentration-time curve (AUIC) every 24h and was found to be 13." | ( Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and intramuscular administration to horses. Park, SC; Yun, HI, 2003) | 0.61 |
| " The method has been successfully applied to the determination of norfloxacin in commercial dosage forms." | ( Kinetic spectrophotometric method for the determination of norfloxacin in pharmaceutical formulations. Ahmad, Y; Hejaz Azmi, SN; Rahman, N, 2004) | 0.8 |
| "Norfloxacin was administered orally to chickens and turkeys at 15 mg/kg body weight by pulse dosing at 24 h intervals and by continuous dosing at 100 mg/L in drinking water for five days." | ( Disposition of norfloxacin in broiler chickens and turkeys after different methods of oral administration. Laczay, P; Sárközy, G; Semjén, G, 2004) | 2.12 |
| " The pharmacokinetics of pefloxacin and its active metabolite norfloxacin were investigated in chickens after a single oral administration of pefloxacin at a dosage of 10 mg/kg." | ( Pharmacokinetics and tissue residues of pefloxacin and its metabolite norfloxacin in broiler chickens. Malik, JK; Pant, S; Rao, GS; Sastry, KV; Tripathi, HC, 2005) | 0.8 |
| " cultures in a sorbitol-yeast extract medium were dosed with 100 microg ml(-1) of norfloxacin and incubated for 7 days." | ( Transformation of the antibacterial agent norfloxacin by environmental mycobacteria. Adjei, MD; Deck, J; Freeman, JP; Heinze, TM; Sutherland, JB; Williams, AJ, 2006) | 0.82 |
| " Urine samples were taken every 2 h during the whole dosing interval of the particular antibiotic." | ( Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model. Bedenic, B; Bubonja, M; Budimir, A; Topic, M, 2006) | 0.33 |
| " In this study, we aimed to develop a novel pharmacokinetic model to describe NQs-metal cation interactions in order to estimate the optimal dosing interval." | ( Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations. Miyata, K; Ohtani, H; Sawada, Y; Tsujimoto, M, 2007) | 0.54 |
| "Plasma concentration-time profiles of NQs after administration without or with metal cations at various dosing intervals were collected from the literature and analyzed with a pharmacokinetic model incorporating the formation ofNQs-metal cations complex." | ( Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations. Miyata, K; Ohtani, H; Sawada, Y; Tsujimoto, M, 2007) | 0.54 |
| "The developed model can adequately describe the extent of interaction between NQs and metal cations, and should be clinically useful to design dosage regimens to circumvent the interaction." | ( Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations. Miyata, K; Ohtani, H; Sawada, Y; Tsujimoto, M, 2007) | 0.54 |
| "0% were obtained with a considerable degree of accuracy when the suggested methods were applied to analysis of synthetic binary mixtures, some commercial dosage forms such as tablets and oral suspension without interference from the commonly encountered excipients and additives." | ( Determination of two antibacterial binary mixtures by chemometrics-assisted spectrophotometry. Abdelmageed, OH; Mohamed, Ael-M; Refaat, IH, ) | 0.13 |
| "The pharmacokinetics and dosage regimen of norfloxacin-glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i." | ( Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs. Chang, ZQ; Hwang, MH; Jeong, KS; Kim, JC; Lee, MH; Oh, BC; Park, SC; Yun, HI, 2007) | 0.89 |
| " The method is simple, rapid, and convenient for purity control of norfloxacin in both raw materials and dosage forms." | ( Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals. Agbaba, D; Marković, S; Miseljić, B; Popović, G; Simonovska, B; Vovk, I, ) | 0.61 |
| " The methods developed were applied successfully to the determination of the subject drugs in their pharmaceutical dosage forms with good precision and accuracy compared to official and reported methods as revealed by t- and F-tests." | ( Study of fluorescence characteristics of the charge-transfer reaction of quinolone agents with bromanil. Chen, XF; Li, WY; Xuan, CS, 2009) | 0.35 |
| " Instead, the active pharmaceutical ingredients (APIs) currently used in solid dosage forms, norfloxacin and ciprofloxacin hydrochloride, proved to be BCS class 4 (low solubility/low permeability)." | ( Solubility behavior and biopharmaceutical classification of novel high-solubility ciprofloxacin and norfloxacin pharmaceutical derivatives. Breda, SA; Jimenez-Kairuz, AF; Manzo, RH; Olivera, ME, 2009) | 0.79 |
| " These studies suggest that there is a possibility that high dosage of caffeine can harm the unborn baby or new born babies, if the mothers use caffeine." | ( Effect of caffeine, norfloxacin and nimesulide on heartbeat and VEGF expression of zebrafish larvae. Agoramoorthy, G; Chakraborty, C; Hsu, CH; Lin, CS; Wen, ZH, 2011) | 0.69 |
| " The removal efficiency of norfloxacin was enhanced with the increase of temperature, catalysts dosage and H2O2 concentration." | ( [Degradation of norfloxacin by nano-Fe3O4/H2O2]. Meng, ZF; Niu, HY; Wang, YX; Zhang, D, 2011) | 1.01 |
| " The dosage forms that remain in the stomach are referred to as gastroretentive drug delivery systems." | ( Development of sustained release floating drug delivery system for norfloxacin: in vitro and in vivo evaluation. Bomma, R; Guguloth, M; Veerabrahma, K, ) | 0.37 |
| " The combination of 2,4-difluorobenzyl benzimidazole derivative 5m and its hydrochloride 7 respectively with antibacterial Chloromycin, Norfloxacin or antifungal Fluconazole showed better antimicrobial efficiency with less dosage and broader antimicrobial spectrum than the separated use of them alone." | ( Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. Cai, GX; Damu, GL; Zhang, HZ; Zhou, CH, 2013) | 0.79 |
| " The method was successfully applied for determination of both drugs in pharmaceutical dosage forms and real human plasma." | ( Multiobjective optimization strategy based on desirability functions used for the microemulsion liquid chromatographic separation and quantification of norfloxacin and tinidazole in plasma and formulations. Abou-Taleb, NH; El-Ashry, SM; El-Sherbiny, DT; El-Wasseef, DR, 2015) | 0.62 |
| " Many antibiotics at appropriate concentrations improved the survival rate and alleviated tissue injury, while, when dosing strategies fall below subtherapeutic levels, worse therapeutic effects are seen." | ( Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. Cao, Y; Guo, J; Jin, X; Lin, T; Wang, T; Wu, D; Wu, R; Xie, X; Zhang, W, 2017) | 0.87 |
| " These changes may provide basis and new ideas to adjust the dosage and administration, so as to promote rational drug use in the high altitude." | ( Pharmacokinetic changes of norfloxacin based on expression of MRP2 after acute exposure to high altitude at 4300m. Jia, Z; Li, W; Lu, H; Luo, B; Wang, C; Wang, R; Yang, T; Zhang, J; Zhao, A, 2017) | 0.75 |
| " It has plasma half life of 3 to 4 h requiring multiple dosing in the treatment." | ( Investigation and Optimization of the Effect of Polymers on Drug Release of Norfloxacin from Floating Tablets. Gadade, DD; Sarda, K; Shahi, SR, ) | 0.36 |
| "Nine norfloxacin brands were subjected to in vitro tests associated with quality of tablet dosage form, and the tests were conducted according to procedures described in the United States Pharmacopeia (USP)." | ( In vitro comparative quality assessment of different brands of norfloxacin tablets available in Jimma, Southwest Ethiopia. Belew, S; Hambisa, S; Suleman, S, 2019) | 1.27 |
| " The removal rate of norfloxacin increased with the increase in the dosage of persulfate, but the increased ratio gradually decreased." | ( Metal-free activation of persulfates by corn stalk biochar for the degradation of antibiotic norfloxacin: Activation factors and degradation mechanism. Li, YN; Wang, B; Wang, L, 2019) | 1.05 |
| " The proposed method was successfully applied for the determination of both drugs in tablets dosage form without interference from the commonly encountered excipients." | ( Digitally enhanced thin layer chromatography for simultaneous determination of norfloxacin and tinidazole with the aid of Taguchi orthogonal array and desirability function approach: Greenness assessment by analytical Eco-Scale. Hemdan Abou-Taleb, N; Ibrahim El-Subbagh, H; Mahmoud El-Enany, N; Tawfik El-Sherbiny, D, 2020) | 0.79 |
| " Mucoretention of the drug (norfloxacin) within the eye sac is closely associated with binding interactions occurring on the ocular surface, and covalent association of the drug with the mucoadhesive polymer, poly(methylvinyl ether/maleic acid), can largely reduce dosing frequency eliciting prolonged antibacterial action much required in treating conjunctival infections." | ( In silico modeling of functionalized poly(methylvinyl ether/maleic acid) for controlled drug release in the ocular milieu. Degani, M; Gudhka, R; Khambete, M; Panchamia, S; Patravale, V; Vyas, S, 2020) | 0.85 |
| " Statistical comparisons of predictive abilities of proposed models against classical least squares CLS model and against each other was performed; whether for analysis of test set mixtures or dosage form." | ( Partial least squares and linear support vector regression chemometric models for analysis of Norfloxacin and Tinidazole with Tinidazole impurity. Abdelaleem, EA; Ali, NW; Gamal, M; Hassan, ES; Naguib, IA, 2020) | 0.78 |
| " The effects of cell voltage, initial pH, KSPEs dosage and initial NOR concentration on NOR degradation were studied in the optimization experiment of operating parameters." | ( Degradation of norfloxacin wastewater using kaolin/steel slag particle electrodes: Performance, mechanism and pathway. Li, J; Song, B; Teng, X; Wang, Z, 2021) | 0.97 |
| " elegans were more sensitive to the combined pollution that with lower Cu dosage (0." | ( Pseudo toxicity abatement effect of norfloxacin and copper combined exposure on Caenorhabditis elegans. He, S; Li, H; Lin, K; Liu, L; Sun, F; Tang, M; Wang, C; Wang, Z; Yan, Y; Zhang, M, 2022) | 1 |
| " The developed method was applied for the assay of combined pharmaceutical dosage forms of metronidazole and norfloxacin and results were found in compliance with their respective labeled claim." | ( Chemometric and DoE-Based Analytical Quality Risk Management to HPTLC Method for Simultaneous Estimation of Metronidazole and Norfloxacin. Patel, PR; Prajapati, PB; Shah, SA, 2023) | 1.33 |
| Role | Description |
|---|---|
| antibacterial drug | A drug used to treat or prevent bacterial infections. |
| DNA synthesis inhibitor | Any substance that inhibits the synthesis of DNA. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| quinolinemonocarboxylic acid | Any aromatic carboxylic acid that contains a quinoline moiety that is substituted by one carboxy substituent. |
| N-arylpiperazine | |
| quinolone | |
| quinolone antibiotic | An organonitrogen heterocyclic antibiotic whose structure contains a quinolone or quinolone-related skeleton. |
| fluoroquinolone antibiotic | An organonitrogen heterocyclic antibiotic containing a quinolone (or quinolone-like) moiety and which have a fluorine atom attached to the central ring system. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 0.0251 | 20.2376 | 39.8107 | AID893 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 0.0251 | 20.2376 | 39.8107 | AID893 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 16.2435 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 0.0316 | 37.5844 | 354.8130 | AID504865 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.8378 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.6771 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.8489 | 0.0013 | 18.0743 | 39.8107 | AID926; AID938 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 26.6032 | 0.0010 | 22.6508 | 76.6163 | AID1224838 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 19.4971 | 0.0123 | 7.9835 | 43.2770 | AID1645841 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.4850 | 0.0013 | 10.1577 | 42.8575 | AID1259256 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 4.4668 | 0.0054 | 28.0263 | 1,258.9301 | AID1346985 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.9125 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.5011 | 0.0018 | 15.6638 | 39.8107 | AID894 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 3.5481 | 0.0006 | 18.4198 | 1,122.0200 | AID1688 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 0.2512 | 15.8432 | 39.8107 | AID504327 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 7.9433 | 0.8913 | 12.0676 | 28.1838 | AID1487 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.0119 | 0.0158 | 12.3113 | 615.5000 | AID1461 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.6315 | 4.4531 | 9.3000 | AID1473740 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.2000 | 5.6774 | 10.0000 | AID1473741 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.1100 | 7.1903 | 10.0000 | AID1473738 |
| DNA gyrase subunit A | Escherichia coli K-12 | IC50 (µMol) | 9.6000 | 0.0239 | 0.5629 | 5.2300 | AID1671794; AID259173 |
| DNA gyrase subunit B | Escherichia coli K-12 | IC50 (µMol) | 9.6000 | 0.0050 | 0.4398 | 5.2300 | AID1671794; AID259173 |
| DNA topoisomerase 4 subunit A | Staphylococcus aureus | IC50 (µMol) | 3.5000 | 0.3000 | 3.5579 | 9.1600 | AID259174 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 (µMol) | 2.5600 | 0.0000 | 2.8005 | 10.0000 | AID1210069 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5057 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.4973 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.4988 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5046 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 (µMol) | 2.5600 | 0.0120 | 2.5312 | 9.4700 | AID1210069 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5065 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5057 | 10.0000 | AID71980; AID71981 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 2.4100 | 6.3433 | 10.0000 | AID1473739 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 (µMol) | 6.5100 | 0.0001 | 0.5075 | 10.0000 | AID71980; AID71981 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Multidrug resistance protein MdtK | Escherichia coli K-12 | Kd | 98.4000 | 9.8000 | 9.8000 | 9.8000 | AID572158 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID532764 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph-pTRC hisA:ramA mutant by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID200679 | Antibacterial activity against Klebsiella ozaenae Salmonella typhi | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID576111 | Antimicrobial activity against mecA-deficient Staphylococcus sciuri harboring staphylococcus aureus mecA gene assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID561323 | Antimicrobial activity against Klebsiella pneumoniae isolate 132 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID565067 | Antibacterial activity against CTX-M-15 and SHV-27 ESBL producing Escherichia coli assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID65038 | In vitro for antibacterial activity against Escherichia coli B (Ec(B)) | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID260741 | Antibacterial activity against Enterococcus faecalis 29212 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID205713 | Minimum inhibitory concentration tested against vancomycin-insensitive SA (GISA 992 strain) | 2003 | Bioorganic & medicinal chemistry letters, May-19, Volume: 13, Issue:10 | Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1907303 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID1455922 | Antibacterial activity against Staphylococcus aureus at 25 ug/ml after 24 hrs by plate colony counting method relative to control | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis and antibacterial activities of thiouracil derivatives containing acyl thiourea as SecA inhibitors. |
| AID1600095 | Antibacterial activity against Staphylococcus aureus ATCC 6538 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID586630 | Antibacterial activity against Escherichia coli ATCC 25922 harboring ParC S80R mutant by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1126760 | Antibacterial activity against multidrug-resistant 1 ug/ml Mycobacterium tuberculosis clinical isolate 930 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID322315 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID736330 | Antibacterial activity against Staphylococcus aureus XU212 overexpressing TetK tetracycline efflux pump after 18 hrs by MTT assay | 2013 | Journal of natural products, Mar-22, Volume: 76, Issue:3 | Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. |
| AID208934 | Compound was tested for inhibition of the gram-negative organism Streptococcus pneumoniae SV-1 | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID556903 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 15 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID397932 | Antimicrobial activity against Staphylococcus aureus at 64 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID151532 | Compound was tested for inhibition of the gram-negative organism Pseudomonas aeruginosa UI-18 | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID561317 | Antimicrobial activity against Enterobacter cloacae isolate 153 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID206046 | The compound was tested in vitro for antibiotic activity against Staphylococcus epidermidis 3519 | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID1765472 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID324276 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in log phase at 3 ug/ml after 10 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID556862 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 2 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID150915 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 15692 measured in Muller-Hinton (MH) liquid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID374686 | Antimicrobial activity against Escherichia coli isolate AMG1 24 hrs biofilms at 0.03 ug/ml to 0.12 ug/ml after 24 hrs by microtiter plate count method | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. |
| AID197875 | Minimum inhibition concentration against Staphylococcus aureus FDA209P strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1405063 | Antibacterial activity against Staphylococcus aureus after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID119712 | Serum concentration in mice, after oral administration at a dose of 100 mg/kg p.o. at 0.5 h | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1242643 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID565328 | Antibacterial activity against Mycoplasma genitalium M6282 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID369251 | Increase in ompX-lacZ expression in Escherichia coli JM109 assessed as increase in beta-galactosidase activity after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID285675 | Antimicrobial activity against Pseudomonas aeruginosa 24F4 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID64234 | Oral efficacy of compound after peroral administration on systemic infection by Escherichia coli KC-14 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID396035 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID556899 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 11 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID30270 | In vitro antibacterial activity against Acinetobacter CMX 669 | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID556901 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 13 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID397931 | Antimicrobial activity against Staphylococcus aureus at 16 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID544832 | Antibacterial activity against Streptococcus pneumoniae R6 by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID585423 | Antimicrobial activity against oqxAB positive Escherichia coli C600 G262-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID542148 | Antimicrobial activity against Escherichia coli DH10B harboring p2007057 by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID1326653 | Antibacterial activity against Bacillus proteus ATCC 13315 measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID285644 | Antimicrobial activity against Pseudomonas aeruginosa 15H5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID534178 | Antimicrobial activity against Escherichia coli TOP10 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID637196 | Antibacterial activity against Escherichia coli CCARM 1924 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID205531 | Minimum inhibitory concentration against Staphylococcus aureus (H-228). | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID434850 | Antibacterial activity against multidrug-resistant Staphylococcus aureus after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID1601852 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID210072 | Dose required to protect 50% of mice from lethal infection was measured on Streptococcus pyogenes C203 (p.o. administration) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID494442 | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 100 ug after 24 hrs by paper disc method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID425072 | Antimicrobial activity against Escherichia coli DH10B expressing pCRQB10 in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID1126763 | Antibacterial activity against multidrug-resistant 1 ug/ml Mycobacterium tuberculosis clinical isolate 1259 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID423083 | Antibacterial activity against Pseudomonas aeruginosa PAO1 H1105/lon+ mutant strain with lon::lux mutation assessed as fold decrease in MIC after 24 hrs by broth microdilution technique relative to wild type | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID1237613 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC62202 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1281667 | Antibacterial activity against Salmonella enterica ATCC 14028 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID133815 | Compound was evaluated for protective dose against the Streptococcus aureus UC-76 lethal infection following sc administration in mouse | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID152319 | Compound was tested for inhibition of the gram-negative organism Providencia rettgeri H1771 | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID586734 | Ratio of mutant prevention concentration to MIC for Escherichia coli ATCC 25922 harboring GyrA S83L mutant | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID585487 | Antibacterial activity against wild type Streptococcus pneumoniae M3 NCTC 7466 type 2 by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID556878 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 18 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1855821 | Antibacterial activity against Escherichia coli ATCC 25922 measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID13515 | AUC value (0-4 hr) | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1326652 | Antibacterial activity against Micrococcus luteus ATCC 4698 measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID494444 | Antibacterial activity against Escherichia coli ATCC 7839 at 100 ug after 24 hrs by paper disc method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID1516023 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID667556 | Antibacterial activity against Staphylococcus aureus KCTC 209 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID1299634 | Antibiofilm activity against Pseudomonas aeruginosa PAO1 ATCC 47085 after 24 hrs by crystal violet staining-based spectrophotometry | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID573306 | Antimicrobial activity against Escherichia coli isolate GZ14 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID495514 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4668 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID509637 | Antibacterial activity against ampicillin tetracyclin streptomycin kanamycin-resistant Escherichia coli isolate V32-1 carrying qnrB19 gene | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. |
| AID637194 | Antibacterial activity against Staphylococcus aureus RN4220 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID1374511 | Effective permeability of the compound at 200 uM after 5 hrs by PAMPA | 2018 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 28, Issue:5 | MF-8, a novel promising arylpiperazine-hydantoin based 5-HT |
| AID1652708 | Induction of Escherichia coli K12 MG1655 recN promotor measured at 30 mins interval for 20 hrs by fluorescence assay relative to control | |||
| AID255472 | Minimum inhibitory concentration against Pseudomonas aeruginosa | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. |
| AID556700 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 harboring pDrive plasmid expressing ampC gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID68537 | Minimum inhibitory concentration (MIC) of compound was measured on Enterobacter cloacae HA 2646(gram negative organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID285576 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1832280 | Antimicrobial activity against Pseudomonas aeruginosa PA01 assessed as inhibition of microbial growth measured after 24 hrs by broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents. |
| AID1402344 | Bactericidal activity against Streptococcus agalactiae WB1445 incubated for 24 hrs followed by re-plating on nutrient agar and measured after overnight incubation by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID744036 | Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID585425 | Antimicrobial activity against oqxAB positive Escherichia coli C600 G375-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID525041 | Antimicrobial activity against fluoroquinolone-resistant Escherichia coli NorE5 harboring GyrA S83L mutant, ParC S80R mutant, truncated SoxR and constitutively active SoxS by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. |
| AID1889637 | Bactericidal activity against Klebsiella pneumoniae assessed as fold increase in MIC value after 16 passages by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID285594 | Antimicrobial activity against Pseudomonas aeruginosa 1A9 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1221960 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID767450 | Antibacterial activity against Staphylococcus aureus by disc diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections. |
| AID529457 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone B expressing beta-lactamase Oxa-48, TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID1162135 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID1917492 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID586640 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1281660 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID1628393 | Antimicrobial activity against Candida mycoderma ATCC 9888 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID767451 | Antibacterial activity against enterotoxigenic Escherichia coli by disc diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections. |
| AID434852 | Antibacterial activity against multidrug-resistant Salmonella typhi after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID542141 | Antimicrobial activity against Salmonella enterica HN-GSS2007-0.056 by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID95889 | In vitro inhibition of growth of Klebsiella pneumoniae (PC-1602) | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1299590 | Bactericidal activity against Staphylococcus aureus RN4220 ATCC 35556 in exponential-phase assessed as reduction in bacterial burden at 4 times MIC99 after 2 to 6 hrs by time-kill assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID556675 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 2 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285668 | Antimicrobial activity against Pseudomonas aeruginosa 24D1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID559897 | Antimicrobial activity against Klebsiella oxytoca KO280 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID623611 | Antibacterial activity against 10'8 CFU/mL Bacillus subtilis MTCC 441 by broth microdilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. |
| AID1125381 | Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as growth inhibition at 20 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID163916 | Minimum inhibitory concentration (MIC) against gram negative bacteria Pseudomonas aeruginosa UI-18. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID162734 | Antibacterial activity against Proteus mirabilis | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1653090 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Quinolone hybrids and their anti-cancer activities: An overview. |
| AID573319 | Antimicrobial activity against Escherichia coli isolate GZ1 transconjugant harboring 16S rRNA methylase RmtB and qnrS1 by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1433841 | Antifungal activity against Candida albicans MTCC 227 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID556875 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 15 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID586635 | Antibacterial activity against qnrB gene expressing Escherichia coli ATCC 25922 harboring ParC S80R mutant and pBK-QnrB1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID665057 | Antibacterial activity against Clostridium tetani MTCC 449 after 24 hrs by micro-broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID585739 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated nikD gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID718547 | Antibacterial activity against Escherichia coli 1356 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID1415674 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID94051 | Tested in vitro against Klebsiella pneumoniae PCI-602 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1124793 | Antimicrobial activity against Escherichia coli ATCC 9637 after 24 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID379744 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 15 expressing MecA after 18 hrs by microtiter plate method | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). |
| AID423069 | Antibacterial activity against 53_F11 allele containing Pseudomonas aeruginosa PAO1 H1124 mutant strain with PA5279::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID420482 | Antibacterial activity against Escherichia coli after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents. |
| AID64046 | Compound was tested for antimicrobial activity in mice infected with Escherichia coli KC-14 after peroral administration | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1809815 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth by broth dilution method | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID556896 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 8 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID119725 | Serum concentration of the liberated Norfloxacin after oral administration (100 mg/kg) in mice after 0.5 hr | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID544861 | Antibacterial activity against Streptococcus pneumoniae U2A1413 harboring parC Ser79Tyr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID285195 | Antimicrobial activity against Escherichia coli M073 mutant with AG100 lon2::IS186 acrR::IS5 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID1444095 | Effective permeability of the compound at pH 7.4 at 25 ug/ml after 18 hrs by PAMPA-BBB assay | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. |
| AID70285 | Dose required to protect 50% of mice from lethal infection was measured on Escherichia coli vogel (subcutaneously) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID119722 | Serum concentration of the liberated Norfloxacin after oral administration 100 mg/kg in mice after the 1.0 h | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID586652 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrB gene and pBK-QnrB1 assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID324189 | Antibacterial activity against Escherichia coli K12 mutant JHU313 at 0.1 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID556670 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 25 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285641 | Antimicrobial activity against Pseudomonas aeruginosa 13E1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID397915 | Antimicrobial activity against Pseudomonas aeruginosa at 4 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID94141 | Minimum inhibitory concentration tested against Klebsiella pneumoniae PC1602 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID71033 | Compound was tested for antimicrobial activity against Escherichia coli KC-14 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID96080 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Klebsiella pneumoniae strain ATCC 10031 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1759529 | Antibacterial activity against methicillin resistant Staphylococcus aureus by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID197874 | Minimum inhibitory concentration tested against Staphylococcus aureus FDA207PJC-1 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1430045 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method | |||
| AID67684 | In vitro antibacterial activity against Enterobacter aerogenes ATCC 13048 | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID15174 | Concentration of liberated compound in serum after 30 min at the dose of 50 mg/kg (po). | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1060893 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID380477 | Antimicrobial activity against epidemic methicillin-resistant Staphylococcus aureus 15 by standard microdilution method | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Polyacylated oligosaccharides from medicinal Mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus. |
| AID523257 | Antimicrobial activity against Klebsiella pneumoniae KP63 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1299581 | Antibacterial activity against Escherichia coli ANS1 incubated overnight by microbroth dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID585749 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated acrB gene assessed as MarA-mediated multidrug resistance level by measuring fold decrease in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID621875 | Antibacterial activity against Bacillus anthracis Sterne after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID565318 | Antibacterial activity against Mycoplasma genitalium M2300 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID585432 | Antimicrobial activity against oqxAB positive Escherichia coli DH5[alpha] harboring pMD18-T::oqxAB by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1855820 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID1764067 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID586735 | Ratio of mutant prevention concentration to MIC for qnrA gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrA1 | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1890858 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID560260 | Antimicrobial activity against Salmonella enterica serovar Typhimurium transconjugant p61/9T expressing qnrB19 gene variant carried by IncL/M-like plasmid by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Characterization of the plasmid-borne quinolone resistance gene qnrB19 in Salmonella enterica serovar Typhimurium. |
| AID1221963 | Transporter substrate index ratio of permeability from apical to basolateral side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID324258 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in log phase at 3 ug/ml after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1297671 | Bactericidal activity against Escherichia coli F-50 incubated for 4 hrs | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID10961 | Compound was evaluated for area under curve doses in rat at 50 mg/kg po | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1310078 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID544835 | Antibacterial activity against Streptococcus pneumoniae U2A1686 harboring gyrA Glu85Lys mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1907307 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID1889626 | Antibacterial activity against Escherichia coli 25922 assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID207961 | In vitro antibacterial activity against Staphylococcus aureus CMX 686B | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID1242647 | Antifungal activity against Cryptococcus neoformans after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID750289 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID667558 | Antibacterial activity against Escherichia coli 1356 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID621883 | Antibacterial activity against Escherichia coli ATCC 29425 after 16 to 18 hrs by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1758078 | Antibacterial activity against Staphylococcus aureus assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID556872 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 12 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID586739 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrA gene and pBK-QnrA1 assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID40783 | In vitro inhibition of growth of Bacillus subtilis (ATCC 6633) | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1483976 | Ratio of MIC for Staphylococcus aureus ATCC 29213 after and before 15 serial passages | 2017 | Journal of medicinal chemistry, 02-23, Volume: 60, Issue:4 | Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity. |
| AID1401683 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID586729 | Antibacterial activity against qnrS gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrS1 assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1239961 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID70643 | Compound was tested for inhibition of the gram-negative organism Escherichia coli H560 | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID1759184 | Antibacterial activity against Staphylococcus aureus by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID15175 | Concentration of liberated compound in serum after 30 min at the dose of 50 mg/kg (po). | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID501423 | Antimicrobial activity against Escherichia coli K-12 after 24 hrs by microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. |
| AID589359 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by spectrophotometry | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus. |
| AID1888859 | Bactericidal activity against Staphylococcus aureus 1199B at 50 ug/mL by time-kill kinetics assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID279139 | Antibacterial activity against Streptococcus suis BB1010 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID685406 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 clinical isolate after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID119731 | Serum concentration of the liberated Norfloxacin after oral administration (100 mg/kg) in mice after 4.0h | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID405463 | Antibacterial activity against Escherichia coli TOP10 in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID324204 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 at 4 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1415677 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID151374 | Antibacterial activity was determined against gram negative organism, Providencia rettgeri. M1771 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID576022 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV A184V mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID260737 | Antibacterial activity against Bacillus subtilis BD54 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID758272 | Antibacterial activity against Clostridium tetani MTCC 449 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID550175 | Antibacterial activity against erythromycin-resistant Staphylococcus aureus RN4220 after 18 hrs by MTT assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. |
| AID560774 | Antibacterial activity against Staphylococcus aureus TS5337 harboring ddlA Pro178Ser mutation after 20 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. |
| AID584342 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID561396 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP128 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID745302 | Antifungal activity against Aspergillus fumigatus MTCC 3008 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID619393 | Cytotoxicity against human HepG2 cells measured after overnight incubation by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID1292330 | Permeability of the compound at 100 ug/ml after 18 hrs by PAMPA-BBB assay | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10 | Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1433836 | Antibacterial activity against Clostridium tetani MTCC 449 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID150924 | Oral efficacy of compound after peroral administration on systemic infection by Pseudomonas aeruginosa E-2 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1764069 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID563504 | Antimicrobial activity against Serratia marcescens ATCC 13880 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1504427 | Ratio of MIC for Staphylococcus aureus ATCC 29213 after 20 serial passages to MIC for Staphylococcus aureus ATCC 29213 | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and bioactivities study of new antibacterial peptide mimics: The dialkyl cationic amphiphiles. |
| AID585748 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated acrA gene assessed as MarA-mediated multidrug resistance level by measuring fold decrease in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1303298 | Antimicrobial activity against Escherichia coli JM109 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID285203 | Antimicrobial activity against Escherichia coli M124 mutant with AG100 lon4::IS186 acrR::IS genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID561321 | Antimicrobial activity against Escherichia coli isolate 48 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID747352 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID619388 | Antimycobacterial activity against Mycobacterium kansasii CNTC My 235/80 after 14 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID1625122 | Permeability of the compound in pH 7.4 PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA-BBB assay | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6 | Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities. |
| AID1907304 | Antibacterial activity against Staphylococcus aureus 25923 assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID206728 | Antibacterial activity was evaluated against Staphylococcus aureus | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Chemometric studies on the bactericidal activity of quinolones via an extended VolSurf approach. |
| AID406845 | Antibacterial activity against Escherichia coli TOP10 containing pS1B plasmid expressing quinolone resistance determinant QnrS1 by E-test | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Plasmid-mediated quinolone resistance determinant QnrB4 identified in France in an Enterobacter cloacae clinical isolate coexpressing a QnrS1 determinant. |
| AID556871 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 11 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID771003 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study. |
| AID1652706 | Induction of Escherichia coli K12 MG1655 recA promotor measured at 30 mins interval for 20 hrs by fluorescence assay relative to control | |||
| AID519111 | Antibacterial activity against Proteus mirabilis NP14 after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID1310117 | Binding affinity to calf thymus double stranded DNA assessed as hypochromic effect in absence of Mg2+ ion by fluorescence spectroscopic analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID113529 | In vivo inhibitory activity against Escherichia coli Juhl after peroral administration in mice | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID556657 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 12 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID556664 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 19 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID563500 | Antimicrobial activity against Serratia marcescens ATCC 13880 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID504050 | Antimicrobial activity against Bacillus subtilis MTCC 441 by broth microdilution technique | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles. |
| AID1210072 | Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID1568822 | Effective permeability of the compound at 25 ug/ml incubated for 18 hrs by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID586644 | Antibacterial activity against qnrB gene expressing Escherichia coli ATCC 25922 harboring ParC S80R mutant, ParC S80R mutant and pBK-QnrB1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1161578 | Permeability of the compound by PAMPA-BBB assay | 2014 | Bioorganic & medicinal chemistry, Oct-01, Volume: 22, Issue:19 | Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties. |
| AID556699 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 harboring pDrive plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID556885 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 25 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1600107 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID585482 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1601855 | Antibacterial activity against Staphylococcus aureus CMCC 25923 assessed as ratio of MIC after and before 16 passages at sub-MIC | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID523255 | Antimicrobial activity against Klebsiella pneumoniae KP55 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1765475 | Antibacterial activity against Pseudomonas aeruginosa by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID478526 | Antimicrobial activity against Staphylococcus aureus ATCC 11632 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID1556537 | Antibacterial activity against Acinetobacter baumannii assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID572156 | Activity of Neisseria gonorrhoeae FA19 multidrug efflux protein NorM expressed in Escherichia coli AG100AX assessed as reduction in compound accumulation in presence of 100 mM NaCl by fluorimetric assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID1334753 | Permeability of the compound at 100 ug/ml after 18 hrs by PAMPA assay | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. |
| AID96061 | Antibacterial activity against Klebsiella pneumoniae (4005) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1510759 | Antibacterial activity against Enterococcus faecalis after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1511118 | Permeability of the compound measured after compound dilution in PBS/EtOH buffer (70:30) by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. |
| AID524825 | Antibacterial activity against erythromycin susceptible Campylobacter sp. by agar plate dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID14010 | Urine conc 0-24 hours following 25 mg/kg dose | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID288185 | Permeability coefficient through artificial membrane in presence of stirred water layer | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | QSAR study on permeability of hydrophobic compounds with artificial membranes. |
| AID1294333 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by agar dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Synthesis and molecular modeling of antimicrobial active fluoroquinolone-pyrazine conjugates with amino acid linkers. |
| AID206506 | In vitro for antibacterial activity against Staphylococcus haemolyticus 75 (quinolone-resistant) | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID200853 | Antibacterial activity against Salmonella Typhimurium | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1858063 | Induction of resistant development in Staphylococcus aureus ATCC 29213 assessed as fold increase in MIC at 0.5 MIC after 12 passages by resistant development assay | |||
| AID523134 | Antimicrobial activity against Enterobacter aerogenes EA3 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID369428 | Induction of Staphylococcus aureus DNA topoisomerase 4-mediated Escherichia coli pBR322 DNA cleavage assessed as ratio of drug-induced DNA cleavage to spontaneous DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID1551299 | Antibacterial activity against Quinolone-resistant Staphylococcus aureus CCARM 3505 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID324185 | Antibacterial activity against Escherichia coli K12 mutant JHU313 at 0.5 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID203041 | Antibacterial activity against Shigella boydii | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID510321 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID750273 | Antifungal activity against Aspergillus clavatus MTCC 1323 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents. |
| AID207933 | In vitro antibacterial activity against Gram-positive, Staphylococcus aureus 209 P | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12 | Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids. |
| AID501421 | Inhibition of Escherichia coli DNA gyraseB assessed as inhibition of pBR322 supercoiling by densitometry | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. |
| AID96239 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Klebsiella pneumoniae MGH-2 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID423064 | Antibacterial activity against 31_C9 allele containing Pseudomonas aeruginosa PAO1 H1104 mutant strain with lon::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID586631 | Antibacterial activity against qnrS gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrS1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1430049 | Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 by broth microdilution method | |||
| AID498782 | Antimicrobial activity against ciprofloxacin-susceptible Streptococcus pyogenes harboring Asp91/Asn mutation in parC gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID534177 | Antimicrobial activity against armA positive Escherichia coli TOP10 producing beta lactamase CTX-M-3 with plasmid DU by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID526304 | Antimicrobial activity against Escherichia coli by agar plate disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives. |
| AID255568 | In vitro minimum inhibitory concentration against Staphylococcus aureus upon incubation at 37 degree C for 16 to 24 hr by dissolving in DMSO (1%) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID28899 | Calculated partition coefficient (clogP) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID379743 | Antibacterial activity against methicillin-resistant Staphylococcus aureus XU212 expressing TetK efflux pump and MecA after 18 hrs by microtiter plate method | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). |
| AID383144 | Inhibition of Escherichia coli H560 DNA gyrase | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8 | Tetramic and tetronic acids: an update on new derivatives and biological aspects. |
| AID1917501 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1481562 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID572147 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomeganorM plasmid containing Neisseria gonorrhoeae multidrug efflux pump NorM after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID586914 | Antibacterial activity against 5 x 10'5 CFU/ml epidemic methicillin-resistant Staphylococcus aureus EMRSA-16 after 18 hrs by MTT assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. |
| AID1294334 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 after 18 hrs by agar dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Synthesis and molecular modeling of antimicrobial active fluoroquinolone-pyrazine conjugates with amino acid linkers. |
| AID585746 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated cyaA gene assessed as MarA-mediated multidrug resistance level by measuring fold decrease in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID535911 | Antibacterial activity against Streptococcus faecalis ATCC 14506 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID74727 | Antibacterial activity against five Gram-negative bacteria | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25 | Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
| AID625497 | Antibacterial activity against Paracoccus sp. 4M6 assessed as growth inhibition at 10 uM up to 6 hrs by viability assay | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22 | Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: structure-activities relationships of polysubstituted triazoles. |
| AID775483 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1433839 | Antibacterial activity against Vibrio cholerae MTCC 3906 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID405118 | Antimicrobial activity against Escherichia coli TOP10 harbouring pS1 plasmid expressing quinolone resistant QnrS1 gene | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID1759536 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID285616 | Antimicrobial activity against Pseudomonas aeruginosa 3E2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID421761 | Antibacterial activity against tetracycline-effluxing Staphylococcus aureus XU212 after 72 hrs | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3 | Bioactive pyridine-N-oxide disulfides from Allium stipitatum. |
| AID94061 | The compound was tested for its antimicrobial activity against Klebsiella pneumoniae 8045 (Kp) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID623616 | Antibacterial activity against 10'8 CFU/mL Escherichia coli MTCC 443 by broth microdilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. |
| AID369617 | Effect on ompF-lacZ fusion translation in ompX-negative Escherichia coli mutant assessed as percent decrease in Miller units of beta-galactosidase activity after 120 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID78550 | Concentration required for 50% inhibition of gyrase. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID716248 | Antimicrobial activity against Bacillus proteus by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID585481 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID561392 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP111 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID66387 | Minimum inhibition concentration in vitro determined against Enterobacteri aerogenes ATCC 13048 | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID720953 | Antibacterial activity against Pseudomonas aeruginosa by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID95883 | Compound was tested for antimicrobial activity against Klebsiella pneumonia IFO3512 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID369426 | Induction of Escherichia coli DNA topoisomerase 4-mediated Escherichia coli pBR322 DNA cleavage assessed as ratio of drug-induced DNA cleavage to spontaneous DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID565070 | Antibacterial activity against CTX-M-14 ESBL producing Klebsiella pneumoniae assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID520638 | Antimicrobial activity against Escherichia coli MRY04-1060 expressing qepA gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID285603 | Antimicrobial activity against Pseudomonas aeruginosa 2B5 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID762013 | Bactericidal activity against Escherichia coli F-50 after 4 hrs | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID200499 | In vitro antibacterial activity against aerobically grown Salmonella choleraesuis (58B015) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID255566 | In vitro minimum inhibitory concentration against Enterococcus fecium upon incubation at 37 degree C for 16 to 24 hr by dissolving in DMSO (1%) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID324206 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid PhoU at 4 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1335835 | Antibacterial activity against Shigella dysenteriae after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID164383 | Antibacterial activity against Ps. aeruginosa RPL11+ (3350) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID637209 | Antibacterial activity against Bacillus subtilis MTCC 2063 after 24 hrs by tube dilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID1367037 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID532756 | Antimicrobial activity against Salmonella serovar Haifa 9878 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1688660 | Antibacterial activity against multidrug resistant Staphylococcus aureus ATCC 43300 assessed as diameter of inhibition zone at 0.5 mg/ml incubated for 24 hrs by agar diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID117861 | Dose required to induce phototoxic reaction in 50% of mice by probit method at different dosage forms. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID134389 | Acute toxicity on intravenous injection in in mice | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID119718 | Serum concentration in mice, after oral administration at a dose of 50 mg/kg p.o. at 2 hr | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1765492 | Potentiation of (Z)-4-((bis(2-hydroxyethyl)amino)methyl)-7-((1-(4-methoxyphenyl)-3-oxo-3-(thiazol-2-yl)prop-1-en-2-yl)oxy)-2H-chromen-2-one-induced antibacterial activity against Enterococcus faecalis assessed as (Z)-4-((bis(2-hydroxyethyl)amino)methyl)-7 | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID1413921 | Antibacterial activity against Escherichia coli after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID1649574 | Resistance index, ratio of MIC for antibacterial activity against Staphylococcus aureus ATCC 29213 passed over 19 cycles in presence of compound for period of 15 consecutive days by broth microdilution method to MIC for antibacterial activity against Stap | |||
| AID1405072 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1759194 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as reduction in bacterial growth measured after 16 passages | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID1820909 | Antibacterial activity against Enterococcus faecium assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID1126748 | Antibacterial activity against duck Escherichia coli assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID1179907 | Antimicrobial activity against Pseudomonas aeruginosa by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID198316 | Antibacterial activity was determined against gram positive organism, Streptococcus pyogenes (C203) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID285591 | Antimicrobial activity against Pseudomonas aeruginosa 65.38-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1415672 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID342999 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by MTT assay | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius. |
| AID1855827 | Antibacterial activity against Staphylococcus aureus assessed as fold increase in MIC measured after 16 passages by resistance development assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID1405073 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1563961 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial cell growth incubated for overnight by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1557282 | Antibacterial activity against Bacteroides fragilis by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID421759 | Antibacterial activity against Mycobacterium phlei after 72 hrs | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3 | Bioactive pyridine-N-oxide disulfides from Allium stipitatum. |
| AID1890871 | Induction of drug resistance in Escherichia coli ATCC 25922 assessed as fold increase in MIC measured after 16 days by CLSI protocol based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID622560 | Antimicrobial activity against Salmonella typhi MTCC 98 for 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. |
| AID1576578 | Fraction absorbed of the compound by PAMPA | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12 | Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. |
| AID1563964 | Antibacterial activity against Bacillus proteus ATCC 8427 assessed as reduction in bacterial cell growth incubated for overnight by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1557178 | Permeability of the compound at 100 ug/ml measured after compound dilution in PBS/EtOH buffer (70:30) by PAMPA-BBB assay | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID201953 | In vivo efficacy (orally) against Streptococcus pneumoniae SV-1 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1814311 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID368422 | Antimicrobial activity against Escherichia coli KAM32 pSTVqepA containing qepA gene ligated to pSTV28 plasmid by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID572520 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Virginia isolate s2219 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID200257 | In vitro minimum inhibitory concentration (MIC) against Staphylococcus aureus Smith A 9537 at 37 degrees C for 18 hr | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID368919 | Inhibition of multidrug-resistant efflux pump in methicillin-resistant Staphylococcus aureus effluxing isolate assessed as fold reduction of Norfloxacin MIC at 10 ug/ml by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus. |
| AID573307 | Antimicrobial activity against Escherichia coli isolate GZ15 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID421760 | Antibacterial activity against Staphylococcus aureus SA1199B overexpressing NorA efflux pump after 72 hrs | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3 | Bioactive pyridine-N-oxide disulfides from Allium stipitatum. |
| AID259172 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1 | Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. |
| AID1600104 | Bactericidal activity against Bacillus subtilis ATCC 6633 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID78688 | Inhibitory concentration in supercoiling inhibition Escherichia coli DNA gyrase assay | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID1814309 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID667562 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID209776 | Minimum Inhibitory concentration measured against Streptococcus pyogenes ATCC 6301 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Synthesis and antibacterial activity of some novel 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents. |
| AID1330196 | Antibacterial activity against quinolone-resistant Staphylococcus aureus 3505 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID78715 | Inhibition constant against DNA Gyrase isolated from Micrococcus luteus | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin). |
| AID1326650 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID184644 | Lethal dose was measured in rat after oral administration | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID386833 | Antibacterial activity against Escherichia coli at 50 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID1126758 | Antibacterial activity against drug-sensitive 1 ug/ml Mycobacterium tuberculosis clinical isolate 760 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID69602 | Anti-bacterial activity was tested against Gram-negative EC-1 bacterium | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. |
| AID1367035 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID324259 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in stationary phase at 3 ug/ml after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1879467 | Induction of drug resistance in Acinetobacter baumannii assessed as fold increase in MIC value measured after 14 passage by resistance assay | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID559900 | Antimicrobial activity against Klebsiella pneumoniae 278 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID1237609 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC43300 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID572519 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Typhimurium isolate s2425 harboring wild type ParC gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID30557 | In vitro antibacterial activity against anaerobically grown Actinobacillus pleuropneumoniae (54B004) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID1764068 | Antibacterial activity against Klebsiella pneumonia assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID205370 | Compound was tested for antimicrobial activity against Serratia marcescens 16 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID534169 | Antimicrobial activity against armB positive Escherichia coli COP producing beta lactamase CTX-M-14 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID519106 | Antibacterial activity against Escherichia coli 10418 after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID163278 | Minimum inhibitory concentration (MIC) of compound was measured on Pseudomonas aeruginosa UI-18(gram negative organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID586725 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrS gene and pBK-QnrS1 assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1481568 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID1769963 | Antibacterial activity against Pseudomonas aeruginosa ATCC27853 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID210073 | Dose required to protect 50% of mice from lethal infection was measured on Streptococcus pyogenes C203 (s.c.) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID530052 | Antimicrobial activity against Staphylococcus aureus RN4220 expressing gyrB D437N mutant gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID693705 | Antibacterial activity against Staphylococcus aureus KCTC 503 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID523264 | Antimicrobial activity against Enterobacter cloacae Ec1194 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID586650 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID530598 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr10 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID40500 | Compound was tested for antimicrobial activity against Bacillus subtilis ATCC 6633 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1556529 | Antibacterial activity against Staphylococcus aureus assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID63887 | Inhibitory activity against ATCC 13048 strain(Enterobacter aerogenes) in the presence of ciprofloxacin fluoroquinolone at 16 ug/mL | 2001 | Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23 | New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains. |
| AID565069 | Antibacterial activity against SHV-12 ESBL producing Escherichia coli assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID1433835 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID324257 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in stationary phase at 3 ug/ml after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID162732 | Antibacterial activity against Prot. mirabilis GmR (2830) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID584334 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1162133 | Antibacterial activity against Micrococcus luteus by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID530589 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr1 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID1737525 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N. 315 | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1809816 | Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as inhibition of bacterial growth by broth dilution method | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID1310075 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID575058 | Antibacterial activity against Escherichia coli JM109 harboring plasmid ptac85-vca0421 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. |
| AID585752 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated crp gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID70099 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain ATCC 25922 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID165223 | In vitro inhibition of growth of Pseudomonas aeruginosa(E-2) | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1563955 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as reduction in bacterial cell growth incubated for overnight by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID279144 | Antibacterial activity against Streptococcus suis BB1015 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID585569 | Ratio of MIC for marA-overproducing Escherichia coli CR1000 to MIC for MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID556906 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pDrive plasmid by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID123084 | In vitro for antibacterial activity against Micrococcus luteus ATCC 8340 | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID1494124 | Antibacterial activity against Norfloxacin-resistant Staphylococcus aureus 1199B over-expressing NorA after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID534337 | Antimicrobial activity against Burkholderia pseudomallei Bp216 harboring mini-Tn7T after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID658543 | Antimycobacterial activity against Pseudomonas aeruginosa K1119 after 24 hrs | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3 | Antibacterial acylphloroglucinols from Hypericum olympicum. |
| AID674907 | Antibacterial activity against Escherichia coli MTCC 443 | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives. |
| AID405462 | Antibacterial activity against Escherichia coli TOP10 in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID720957 | Antibacterial activity against Micrococcus luteus ATCC 4698 by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID585433 | Antimicrobial activity against Escherichia coli DH5[alpha] by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1409901 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by two-fold serial dilution method | |||
| AID584332 | Antibacterial activity against tolC, gshB deficient Escherichia coli GD107 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID609221 | Antibacterial activity against 10'5 CFU/mL Escherichia coli 1356 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID15173 | Concentration of liberated compound in serum after 240 min at the dose of 50 mg/kg (po). | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID51918 | Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity) | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25 | Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
| AID1695812 | Antibacterial activity against Escherichia coli assessed as inhibition zone at 1 mg/ml measured after overnight incubation by disc diffusion method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID576014 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZN10 containing cat and bla genes by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID285664 | Antimicrobial activity against Pseudomonas aeruginosa 22D9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID405927 | Cytotoxicity against human Hep2 cells after 72 hrs | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. |
| AID1498755 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID278112 | Bactericidal activity in Escherichia coli KD2329 containing gyrA-parC mutation | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID295345 | Antibacterial activity against ciprofloxacin resistant methicillin resistant Staphylococcus aureus OC3946 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID584331 | Antibacterial activity against tolC, speE deficient Escherichia coli GD106 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID70286 | Efficacy on systematic infections against Escherichia coli A 15119 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID96422 | In vitro minimum inhibitory concentration against growth of Klebsiella pneumoniae strain 39645 | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9 | Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships. |
| AID1237606 | Antibacterial activity against Escherichia coli ATCC25922 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID542499 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA A83 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID556583 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 after 2 hrs pretreated with 250 uM bipyridyl relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID561331 | Ratio of MIC for Enterobacter cloacae isolate 101 transconjugant to MIC for azide-resistant Escherichia coli J54 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID665060 | Antibacterial activity against Vibrio cholerae MTCC 3906 after 24 hrs by micro-broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID70751 | In vitro Inhibition of growth of Escherichia coli(KC-14) | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID573302 | Antimicrobial activity against Escherichia coli isolate GZ9 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1430047 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | |||
| AID436991 | Inhibition of human A431 cell proliferation by MTT assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID524826 | Antibacterial activity against erythromycin resistant Campylobacter sp. assessed as resistance breakpoint by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID205711 | Minimum inhibitory concentration tested against Staphylococcus aureus 1199B strain | 2003 | Bioorganic & medicinal chemistry letters, May-19, Volume: 13, Issue:10 | Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. |
| AID535912 | Antibacterial activity against Staphylococcus aureus ATCC 11632 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID585418 | Antimicrobial activity against Escherichia coli C600 by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID63898 | Antibacterial activity was determined against gram negative organism, Enterobacter cloacae MA2646 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID1666751 | Antibacterial activity against Escherichia coli ATCC 25922 by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID510324 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID209298 | In vitro antibacterial activity against Streptococcus pyogenes 930 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID556889 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 1 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID519121 | Antibacterial activity against Proteus mirabilis M 17 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID207173 | Antibacterial activity against Staphylococcus aureus | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID464584 | Antibacterial activity against Methicillin-Resistant Staphylococcus aureus subsp. aureus N315 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID556879 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 19 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID260739 | Antibacterial activity against Staphylococcus aureus smith | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID1917500 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID520698 | Antimicrobial activity against Escherichia coli isolate DH10B by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID585491 | Antibacterial activity against wild type Streptococcus pneumoniae M3 NCTC 7466 type 2 by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID279136 | Antibacterial activity against Streptococcus suis BB1007 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID585427 | Antimicrobial activity against oqxAB positive Escherichia coli C600 XT11-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID544841 | Antibacterial activity against Streptococcus pneumoniae U2A1053 harboring parC Ser79Phe mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID205588 | In vitro antibacterial activity against Staphylococcus epidermidis 3519 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID15883 | Calculated partition coefficient (clogP) | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. |
| AID255567 | In vitro minimum inhibitory concentration against Enterococcus faecalis upon incubation at 37 degree C for 16 to 24 hr by dissolving in DMSO (1%) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID1628382 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1890853 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID585430 | Antimicrobial activity against oqxAB positive Escherichia coli C600 SP8-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID556565 | Antimicrobial activity against katG gene-deficient Escherichia coli K-12 3157 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1319973 | Permeability of the compound by PAMPA assay | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21 | Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. |
| AID1850946 | Antibacterial activity against Pseudomonas aeruginosa assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID1125397 | Antibacterial activity against Escherichia coli DH5alpha assessed as growth inhibition at 1.5 ug/ml after 16 hrs by spectrophotometric method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1221956 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID660265 | Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID96233 | Compound was tested in vitro for antibiotic activity against the bacteria Klebsiella pneumoniae 8045 | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID369432 | Induction of Staphylococcus aureus DNA topoisomerase 4 ParC E48K mutant-mediated Escherichia coli pBR322 DNA cleavage assessed as ratio of drug-induced DNA cleavage to spontaneous DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID619392 | Antimycobacterial activity against Mycobacterium kansasii CNTC 6509/96 after 21 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID548131 | Antibacterial activity against Escherichia coli 1924 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID1551297 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus CCARM 3167 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID285622 | Antimicrobial activity against Pseudomonas aeruginosa 8A12 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID758162 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID67408 | In vitro antimicrobial activity against Enterococcus faecalis (vancomycin-resistant) was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID343000 | Antibacterial activity against methicillin-resistant Staphylococcus aureus XU212 expressing TetK efflux pump after 18 hrs by MTT assay | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius. |
| AID1481565 | Antibacterial activity against Shigella dysenteriae after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID38470 | Minimum inhibitory concentration tested against Bacillus subtilis ATCC 6633 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1510767 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID255575 | In vitro minimum inhibitory concentration against Vancomycin resistant Enterococci faecium upon incubation at 37 degree C for 16 to 24 hr by dissolving in DMSO (1%) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID1671803 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID572061 | Ratio of MIC for Acinetobacter baumannii AC0037 to MIC for abeS-deficient Acinetobacter baumannii AC0037 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID1243364 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies. |
| AID94069 | Efficacy on systematic infections against Klebsiella pneumoniae A 9664 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID1237612 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC513045 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1310079 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID1820915 | Antibacterial activity against Pseudomonas aeruginosa assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID285583 | Antimicrobial activity against Pseudomonas aeruginosa 65.33-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID603362 | Antibacterial activity against vancomycin resistant Enterococcus FN-1 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID544836 | Antibacterial activity against Streptococcus pneumoniae U2A1050 harboring gyrA Ser81Phe mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1413925 | Antibacterial activity against Acinetobacter baumannii after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID1465314 | Effective permeability of the compound by PAMPA | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1496041 | Effective permeability of the compound by PAMPA-BBB assay | 2018 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 28, Issue:11 | Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold. |
| AID556575 | Bactericidal activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 at 0.4 ug/ml relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID556561 | Antimicrobial activity against sodB gene-deficient Escherichia coli K-12 DKsodB by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID285190 | Antimicrobial activity against Escherichia coli AG100 mutant with argE3 thi-3 rpsL xyl mtl supE44 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID397922 | Antimicrobial activity against Escherichia coli at 64 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID523263 | Antimicrobial activity against Enterobacter cloacae Ec07769 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID200856 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Salmonella Typhimurium MTCC 98 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID565074 | Antibacterial activity against CTX-M-14 ESBL producing Proteus mirabilis assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID285627 | Antimicrobial activity against Pseudomonas aeruginosa 9A7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID279135 | Antibacterial activity against Streptococcus suis BB1006 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID386835 | Antibacterial activity against Bacillus cirrhosis at 100 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID405457 | Antibacterial activity against Escherichia coli C600Rif in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1415676 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID397936 | Antimicrobial activity against Escherichia coli after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1402100 | Antibacterial activity against Staphylococcus epidermidis after 18 hrs by agar dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | 4-Quinolone derivatives and their activities against Gram positive pathogens. |
| AID436994 | Inhibition of human KB cell proliferation by MTT assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID534345 | Antimicrobial activity against Burkholderia pseudomallei Bp175 harboring mini-Tn7T-P1-bpeR+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1486827 | Antimicrobial activity against Streptococcus pyogenes MTCC 442 incubated for overnight by broth micro dilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. |
| AID613572 | Antibacterial activity against Escherichia coli ATCC 8099 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID573308 | Antimicrobial activity against Escherichia coli isolate GZ16 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID197881 | In vivo efficacy in systemic infection due to Staphylococcus aureus Smith (A 9537) in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID523115 | Antimicrobial activity against Escherichia coli AG100 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID542512 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, Y87 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID397928 | Antimicrobial activity against Klebsiella pneumoniae at 128 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID556883 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 23 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1638915 | Antimicrobial activity against penicillin-resistant Staphylococcus aureus ATCC 29213 assessed as ratio of MIC after and before 15 serial passages preincubated followed by replating and measured after 24 hrs | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action. |
| AID362546 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 16 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID1183255 | Antimicrobial activity against Clostridium tetani MTCC 449 assessed as absence of visible growth after 24 to 48 hrs by broth micro dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Design, synthesis and characterization of fluoro substituted novel pyrazolylpyrazolines scaffold and their pharmacological screening. |
| AID310529 | Antibacterial activity against Escherichia coli ATCC 25922 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Synthesis and antimicrobial evaluation of guanylsulfonamides. |
| AID1126670 | Antibacterial activity against Salmonella typhi MTCC 98 assessed as growth inhibition after 24 to 48 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, characterization and pharmacological screening of some novel 5-imidazopyrazole incorporated polyhydroquinoline derivatives. |
| AID523169 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC4222 harboring gyrA S84L and parC S80F mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID1177547 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus EMRSA-16 assessed as absence of growth after 18 hrs by MTT assay | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. |
| AID122563 | Dose which has no effect to induce phototoxic reaction in 50% of mice by probit method. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID448074 | Antifungal activity against Rhizoctonia solani at 200 mg/L by plate growth rate method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID771176 | Antibacterial activity against Staphylococcus aureus EMRSA-15 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID1310077 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID548327 | Antibacterial activity against Staphylococcus aureus QRSA CCARM 3519 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID1730945 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as bacterial growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 36 | Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme. |
| AID561401 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP121 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID1462723 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 1688 | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities. |
| AID255469 | Minimum inhibitory concentration against Escherichia coli | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. |
| AID41277 | Minimum Inhibitory concentration measured against Bacteroides fragilis ATCC 25285 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Synthesis and antibacterial activity of some novel 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents. |
| AID1360741 | Antibacterial activity against Staphylococcus aureus SA1199B over-expressing NorA by MTT dye based assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. |
| AID560775 | Antibacterial activity against Staphylococcus aureus TS10007 harboring ddlA Asp39Asn mutation after 20 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. |
| AID1755824 | Antibacterial activity against Enterococcus faecalis by microbroth dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID565326 | Antibacterial activity against Mycoplasma genitalium M6090 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID441339 | Antibacterial activity against Escherichia coli ATCC 8739 by turbidity method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis of 6-aminomethyl derivatives of benzopyran-4-one with dual biological properties: anti-inflammatory-analgesic and antimicrobial. |
| AID497759 | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Calu3 cells | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. |
| AID448075 | Antifungal activity against Gibberella zeae at 200 mg/L by plate growth rate method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID498784 | Antimicrobial activity against mild ciprofloxacin-resistant Streptococcus pyogenes assessed as 1 fold decrease in compound MIC by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID1755826 | Antibacterial activity against Acinetobacter baumannii by microbroth dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID557084 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 harboring pDrive plasmid expressing ampC gene by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1564352 | Antibacterial activity against Staphylococcus aureus ATCC 6538 incubated for 24 hrs by resazurin dye based fluorimetric assay | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. |
| AID556654 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 9 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID667132 | Antibacterial activity against Bacillus subtilis MTCC 441 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles. |
| AID1850940 | Antibacterial activity against Staphylococcus aureus assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID163963 | In vitro antibacterial activity against Pseudomonas aeruginosa IFO 3445,Pa(I),(gram-negative) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID423082 | Antibacterial activity against 24_A2 allele containing Pseudomonas aeruginosa PAO1 H1106 mutant strain with lon::lux mutation assessed as fold decrease in MIC after 24 hrs by broth microdilution technique relative to wild type | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID556573 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 3145 at 0.4 ug/ml | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1349983 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus EMRSA-15 after 18 hrs by MTT based broth dilution assay | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. |
| AID405468 | Antibacterial activity against Escherichia coli TOP10 containing pAT851 in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1428538 | Antibacterial activity against Bacillus amyloliquefaciens at 25 ug/ml after overnight incubation by plate colony counting method relative to control | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors. |
| AID1737630 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by agar dilution method | 2020 | European journal of medicinal chemistry, Jun-15, Volume: 196 | Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates. |
| AID1546134 | Antimicrobial activity against Escherichia coli JM 109 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1494123 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NCTC 13373 after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID324275 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in log phase at 3 ug/ml after 10 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID559896 | Antimicrobial activity against Klebsiella oxytoca KO279 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID208906 | In vitro antibacterial activity against Streptococcus aureus IID 803 - | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID256236 | Serum effect on MIC of compound was measured against Enterococcus faecalis as ratio of MIC value in presence and absence of 50% fetal calf serum | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID209413 | Compound was tested for inhibition of the gram-negative organism Streptococcus faecalis MGH-2 | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID560259 | Antimicrobial activity against Salmonella enterica serovar Typhimurium STYM61/9 expressing qnrB19 gene variant carried by IncL/M-like plasmid by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Characterization of the plasmid-borne quinolone resistance gene qnrB19 in Salmonella enterica serovar Typhimurium. |
| AID1409893 | Antimicrobial activity against Enterococcus faecalis after 24 hrs by two-fold serial dilution method | |||
| AID117084 | Lethal dose of compound in OF1-strain female swiss mice after oral administration | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID1600116 | Bactericidal activity against Streptococcus pneumoniae cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID216568 | Antibacterial activity against Vibrio cholerae 0139 | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID230838 | MIC ratio measured as the mean MICs of gram-negative bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID64237 | Minimum inhibitory concentration tested against Escherichia coli KC-14 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID586733 | Ratio of mutant prevention concentration to MIC for Escherichia coli ATCC 25922 expressing qnrS gene and pBK-QnrS1 | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID369618 | Effect on ompF-lacZ fusion translation in wild type Escherichia coli AG100 assessed as percent decrease in Miller units of beta-galactosidase activity after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID556876 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 16 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID279143 | Antibacterial activity against Streptococcus suis BB1014 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID65235 | In vivo efficacy in mouse protection test in Escherichia coli Vogel dose administered orally by gavage. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID266674 | Antibacterial activity against Streptococcus faecalis | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 | Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives. |
| AID524824 | Antibacterial activity against erythromycin resistant Campylobacter sp. by agar plate dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID637228 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID718546 | Antibacterial activity against multidrug-resistant Staphylococcus aureus CCARM 3167 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID405454 | Antibacterial activity against Escherichia coli C600Rif by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID10959 | Compound was evaluated for area under curve doses in rat at 100 mg/kg po | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID542521 | Antimicrobial activity against fluoroquinolone-resistant Escherichia coli clinical isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. |
| AID669972 | Resistance ratio, MIC for methicillin-resistant Staphylococcus aureus ATCC 33592 grown on half-MIC concentration for 3 passages to MIC for methicillin-resistant Staphylococcus aureus ATCC 33592 after 24 hrs | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8 | Lipo-γ-AApeptides as a new class of potent and broad-spectrum antimicrobial agents. |
| AID1557285 | Antibacterial activity against Streptococcus pneumoniae by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID133823 | In vivo activity against Escherichia coli (po) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID519123 | Antibacterial activity against Proteus mirabilis M 35 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID1367038 | Antibacterial activity against drug-resistant Pseudomonas aeruginosa after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID70458 | Biological activity against Escherichia coli N1HJ JC-2 relative to Norfloxacin. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Three-dimensional structure-activity relationships and receptor mapping of N1-substituents of quinolone antibacterials. |
| AID613569 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID556692 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pACM204 plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID731206 | Antibacterial activity against Bacillus subtilis MTCC 441 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | An efficient domino reaction in ionic liquid: synthesis and biological evaluation of some pyrano- and thiopyrano-fused heterocycles. |
| AID1601854 | Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa ATCC BAA-2111 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID585743 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated yibLp gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1600100 | Bactericidal activity against Staphylococcus epidermidis ATCC 14990 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID207943 | In vitro antibacterial activity against Staphylococcus aureus ATCC 6538P | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID1401689 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID1759182 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID1666752 | Antibacterial activity against Pseudomonas aeruginosa by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID406846 | Antibacterial activity against Escherichia coli TOP10 containing pS1A plasmid expressing quinolone resistance determinant QnrB4 by E-test | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Plasmid-mediated quinolone resistance determinant QnrB4 identified in France in an Enterobacter cloacae clinical isolate coexpressing a QnrS1 determinant. |
| AID682302 | TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.010? uM, Norfloxacin: 500 uM) in OCTN2-expressing HEK293 cells | 1999 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 291, Issue:2 | Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. |
| AID1125387 | Antibacterial activity against Bacillus subtilis 168 assessed as growth inhibition at 20 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID526303 | Antimicrobial activity against Streptococcus pyogenes by agar plate disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives. |
| AID467613 | Volume of distribution at steady state in human | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID515780 | Intrinsic solubility of the compound in water | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19 | QSAR-based solubility model for drug-like compounds. |
| AID209577 | The compound was tested for its antimicrobial activity against Streptococcus faecium ATCC 8043 (Sf) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID1335829 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID1551787 | Antifungal activity against Candida albicans | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID561333 | Ratio of MIC for Escherichia coli isolate 17 transconjugant to MIC for azide-resistant Escherichia coli J56 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1177545 | Antimicrobial activity against Staphylococcus aureus ATCC25943 assessed as absence of growth after 18 hrs by MTT assay | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. |
| AID561313 | Antimicrobial activity against Enterobacter cloacae isolate 37 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1124796 | Antimicrobial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID1367033 | Antibacterial activity against drug-resistant Staphylococcus aureus after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID322313 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID285654 | Antimicrobial activity against Pseudomonas aeruginosa 19D9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1917494 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID209922 | The compound was tested for its antimicrobial activity against Streptococcus pyogenes 930 (Sp) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID386842 | Antifungal activity against Rhizoctonia bataticola at 50 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID151048 | Minimum inhibitory concentration against Pseudomonas aeruginosa IAI, measured in Muller-Hinton (MH) liquid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID397923 | Antimicrobial activity against Escherichia coli at 128 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID747350 | Antibacterial activity against Escherichia coli DH52 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1413924 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID366954 | Antibacterial activity against Bacillus subtilis ATCC 60511 after 18 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. |
| AID565327 | Antibacterial activity against Mycoplasma genitalium M6151 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1628381 | Antimicrobial activity against Eberthella typhosa ATCC 14028 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1060939 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID448697 | Antimicrobial activity against Escherichia coli ATCC 10145 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID285201 | Antimicrobial activity against Escherichia coli M104 mutant with AG100 dupIS3 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID405461 | Antibacterial activity against Escherichia coli TOP10 by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID397916 | Antimicrobial activity against Pseudomonas aeruginosa at 16 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID720958 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID1680074 | Resistance ratio of compound MIC for Staphylococcus aureus ATCC 29213 after 20 passages to compound MIC for Staphylococcus aureus ATCC 29213 after 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID621879 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1737633 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by agar dilution assay | 2020 | European journal of medicinal chemistry, Jun-15, Volume: 196 | Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates. |
| AID556873 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 13 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1413922 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID556562 | Antimicrobial activity against sodA gene-deficient Escherichia coli K-12 3144 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID519115 | Antibacterial activity against Proteus mirabilis NP37 after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID1319976 | Permeability of the compound at 25 ug/ml at 7.4 pH after 18 hrs by PAMPA | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21 | Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. |
| AID1510769 | Antibacterial activity against drug-resistant Escherichia coli after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1183257 | Antimicrobial activity against Streptococcus pneumoniae MTCC 1936 assessed as absence of visible growth after 24 to 48 hrs by broth micro dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Design, synthesis and characterization of fluoro substituted novel pyrazolylpyrazolines scaffold and their pharmacological screening. |
| AID1374214 | Effective permeability of the compound in pH 7.4 buffer after 18 hrs by PAMPA-BBB assay | 2018 | Bioorganic & medicinal chemistry, 03-01, Volume: 26, Issue:5 | Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. |
| AID1889629 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID1907308 | Antibacterial activity against Escherichia coli 25922 assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID20677 | Serum level of compound (50 mg/kg) after 1.0 hr of peroral administration in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID151049 | Minimum inhibitory concentration against Pseudomonas aeruginosa IAI, measured in Muller-Hinton (MH) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID1809826 | Antimicrobial activity against methicilin- resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of bacterial growth by broth dilution method | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID285635 | Antimicrobial activity against Pseudomonas aeruginosa 12A3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1391388 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1759532 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID397938 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID542140 | Antimicrobial activity against Salmonella enterica HN-GSS2007-0.033 by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID565073 | Antibacterial activity against CTX-M-14 ESBL producing Morganella morganii assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID1879459 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID556687 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 14 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID436987 | Inhibition of human NCI-H460 cell proliferation by sulphorodhamine B assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID478527 | Antimicrobial activity against Streptococcus faecalis ATCC 14506 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID556560 | Antimicrobial activity against Escherichia coli K-12 BW25113 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1221965 | Transporter substrate index of efflux ratio in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1600108 | Bactericidal activity against Pseudomonas aeruginosa ATCC 9027 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID494440 | Antibacterial activity against Bacillus subtilis ATCC 6633 at 100 ug after 24 hrs by paper disc method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID720955 | Antibacterial activity against Escherichia coli DH52 by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID556895 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 7 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID584343 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID586750 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrS gene and pBK-QnrS1 assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID430966 | Antibacterial activity against Escherichia coli SKM9 containing gyrA L83, Y87 and parC L80 mutants assessed as increase in MIC by Etest relative to MIC for Escherichia coli 1596 containing gyrA L83 and parC I80 mutants | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. |
| AID542502 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID495513 | Antibacterial activity against Acinetobacter baumannii BM4467 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1126761 | Antibacterial activity against multidrug-resistant 1 ug/ml Mycobacterium tuberculosis clinical isolate 1237 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID585568 | Antibacterial activity against MarA-overexpressing Escherichia coli CR1000 after 20 hrs by Etest method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1060896 | Antibacterial activity against methicillin-resistant staphylococcus aureus N315 after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID151051 | Minimum inhibitory concentration against Pseudomonas aeruginosa K690, measured in succinate (SC) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID1820917 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID1221979 | Transporter substrate index ratio of permeability from basolateral to apical side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID637227 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID762020 | Antibacterial activity against Bacillus cereus 8035 measured every 24 hrs for 5 days by conventional dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID501419 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus COL after 24 hrs by microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. |
| AID322318 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID520700 | Ratio of MIC for Escherichia coli DH10B harboring p05283 carrying qepA and rmtB gene to MIC for Escherichia coli isolate DH10B | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID1390040 | Effective permeability of the compound at 100 ug/ml after 18 hrs by PAMPA-BBB assay | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. |
| AID324279 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in stationary phase at 3 ug/ml after 10 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID565316 | Antibacterial activity against Mycoplasma genitalium UTMB-10G by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID198160 | Minimum inhibitory concentration tested against Serratia marcescens LAM 1184 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1740330 | Antifungal activity against Fusarium solani ATCC 36031 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID609219 | Antibacterial activity against 10'5 CFU/mL Staphylococcus aureus RN4220 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID758273 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID397926 | Antimicrobial activity against Klebsiella pneumoniae at 16 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID573299 | Antimicrobial activity against Escherichia coli isolate GZ5 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1759189 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID324184 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 at 0.5 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID771171 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID202106 | Minimum inhibition concentration against Streptococcus pneumoniae Type I strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID102698 | Inhibitory activity against Lycopus europeus; no inhibitory activity | 2004 | Bioorganic & medicinal chemistry letters, Feb-23, Volume: 14, Issue:4 | Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates. |
| AID386843 | Antifungal activity against Rhizoctonia bataticola at 25 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID556905 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID137611 | Serum levels in mice after 1 hr Oral administration of 50 mg/kg | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1481566 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID366956 | Antibacterial activity against Escherichia coli ATCC 10536 after 18 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. |
| AID532583 | Antimicrobial activity against Salmonella serovar Binza 8269 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID565320 | Antibacterial activity against Mycoplasma genitalium M2341 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID206488 | The compound was tested in vitro for antibiotic activity against Staphylococcus aureus 686B | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID425070 | Antimicrobial activity against multidrug-resistant Escherichia coli M7943-TC2 bearing qnrB10 gene with aac(6)-Ib-cr-blaOXA-30 catB3-arr-3 integron in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID544866 | Antibacterial activity against Streptococcus pneumoniae U2A1056 harboring gyrA Ser81Tyr parC Asp83His mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID520697 | Antimicrobial activity against Escherichia coli DH10B harboring p05283 carrying qepA and rmtB gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID1091955 | Dissociation constant, pKa of the compound at pH 7.3 | 2011 | Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7 | Importance of physicochemical properties for the design of new pesticides. |
| AID1818878 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID285588 | Antimicrobial activity against Pseudomonas aeruginosa 65.36-3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID501417 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OM584 after 24 hrs by microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. |
| AID621874 | Antibacterial activity against Bacillus subtilis BD54 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID565317 | Antibacterial activity against Mycoplasma genitalium M2282 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1769953 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 52056 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID523122 | Antimicrobial activity against Enterobacter aerogenes ATCC 13048 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID285582 | Antimicrobial activity against Pseudomonas aeruginosa 65.33-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1564351 | Antibacterial activity against Enterococcus faecium ATCC 19434 incubated for 24 hrs by resazurin dye based fluorimetric assay | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. |
| AID324271 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in stationary phase at 3 ug/ml after 1 week | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID750291 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID71793 | Percentage of GABA-induced chloride currents with 10 e-5 M 4-biphenylacetic acid | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID561320 | Antimicrobial activity against Escherichia coli isolate 17 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1254077 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID1310085 | Cytotoxicity against rat PC12 cells assessed as reduction in cell viability at 256 ug/mL after 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID561327 | Antimicrobial activity against Klebsiella pneumoniae isolate 202 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1671809 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID285206 | Antimicrobial activity against Escherichia coli AG112 mutant with marR genotype after 125 generations in absence of tetracycline | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID585745 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated hns gene assessed as MarA-mediated multidrug resistance level by measuring fold decrease in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1556528 | Antibacterial activity against Enterococcus faecalis assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID586728 | Antibacterial activity against qnrB gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrB1 assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID206012 | Minimum inhibitory concentration (MIC) of compound was measured on Staphylococcus aureus H228 (gram positive organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID369419 | Induction of Escherichia coli DNA gyrase-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID200502 | Antibacterial activity against Salmonella enteritidis | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1349979 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after 18 hrs by MTT based broth dilution assay | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. |
| AID70100 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain ATCC 35218 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID532034 | Antimicrobial activity against Citrobacter freundii S008 expressing PMQR determinant qnrB23 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID279134 | Antibacterial activity against Streptococcus suis BB1005 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID563502 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID165047 | In vitro antibacterial activity against Pseudomonas aeruginosa IFO 3445 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID429851 | Antibacterial activity against Staphylococcus aureus 1199B overexpressing NorA after 24 hrs | 2009 | Journal of natural products, Jun, Volume: 72, Issue:6 | Antibacterial diterpenes from Plectranthus ernstii. |
| AID1162137 | Antibacterial activity against Pseudomonas aeruginosa by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID448698 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID586643 | Antibacterial activity against qnrA gene expressing Escherichia coli ATCC 25922 harboring ParC S80R mutant, ParC S80R mutant and pBK-QnrA1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1764065 | Antibacterial activity against Staphylococcus aureus assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID523114 | Antimicrobial activity against Escherichia coli AG100 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1576576 | Effective permeability of compound by PAMPA | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12 | Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. |
| AID1907305 | Antibacterial activity against Staphylococcus aureus 29213 assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID1242645 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID530588 | Antimicrobial activity against Escherichia coli TOP10 by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID532754 | Antimicrobial activity against Salmonella serovar Hadar by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1769954 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC513045 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID22114 | Concentrations in serum after 30 minutes at 50 mg / kg oral administration | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID267739 | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID1557184 | Permeability of the compound at 25 ug/ml by PAMPA-BBB assay | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19 | The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID203199 | Antibacterial activity against Shigella sonnei | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID542519 | Antimicrobial activity against fluoroquinolone-sensitive Escherichia coli clinical isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. |
| AID419586 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. |
| AID542144 | Antimicrobial activity against Escherichia coli DH10B harboring pBR322 by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID736331 | Antibacterial activity against Staphylococcus aureus 1199B overexpressing NorA pump after 18 hrs by MTT assay | 2013 | Journal of natural products, Mar-22, Volume: 76, Issue:3 | Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. |
| AID534339 | Antimicrobial activity against Burkholderia pseudomallei 1026b after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID556647 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 2 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1890859 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID1444094 | Permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA-BBB assay | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. |
| AID67532 | Minimum inhibitory concentration (MIC) against gram negative bacteria Enterobacter cloacae MA-2646. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID662990 | Antibacterial activity against Salmonella typhi MTCC 98 by macrobroth dilution assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID206368 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Staphylococcus faecalis MGH-2 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID1486828 | Antimicrobial activity against Staphylococcus aureus MTCC 96 incubated for overnight by broth micro dilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. |
| AID666961 | Antibacterial activity against Escherichia coli MTCC 443 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID586745 | Antibacterial activity against qnrS gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrS1 assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1769964 | Antibacterial activity against Enterococcus faecalis ATCC29212 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID586651 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrA gene and pBK-QnrA1 assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID155925 | In vivo protective dose was evaluated against Pasteurella multocida (59A006) in mouse(po) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID207257 | In vitro antibacterial activity against aerobically grown Staphylococcus aureus (54B004) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID209256 | Minimum inhibitory concentration (MIC) of compound was measured on Streptococcus faecalis MGH-2(gram positive organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID96409 | In vitro antimicrobial activity against Klebsiella pneumoniae was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID1494127 | Antibacterial activity against tetracycline/methicillin-resistant Staphylococcus aureus XU212 after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID1242642 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID70409 | In vitro antibacterial activity against Escherichia coli Juhl | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID1546137 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID529161 | FIC index, ratio of MIC for Pseudomonas aeruginosa 100609 in presence of 250 ug/ml polyethylenimine to MIC for Pseudomonas aeruginosa 100609 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID197850 | Efficacy on systematic infections against Staphylococcus aureus Smith A 9537 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID209257 | Minimum Inhibitory concentration measured against Streptococcus faecalis ATCC 29212 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Synthesis and antibacterial activity of some novel 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents. |
| AID1557295 | Cmax in human at 0.4 g, po bid | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID759325 | Antibacterial activity against Escherichia coli CCARM 1356 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID585681 | Antibacterial activity against dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1889625 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID1335850 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 5 passages | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID775482 | Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1571582 | Bactericidal activity against Bacillus cereus ATCC 8035 measured after 4 hrs | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID619389 | Antimycobacterial activity against Mycobacterium kansasii CNTC My 235/80 after 21 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID119713 | Serum concentration in mice, after oral administration at a dose of 100 mg/kg p.o. at 1 hr | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID604023 | Ratio of total drug level in brain to plasma in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID560261 | Antimicrobial activity against Escherichia coli CSH26RifR receiving qnrB19 gene variant carried by IncL/M-like plasmid from Salmonella enterica serovar Typhimurium STYM61/9 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Characterization of the plasmid-borne quinolone resistance gene qnrB19 in Salmonella enterica serovar Typhimurium. |
| AID324264 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in log phase at 3 ug/ml after 5 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1390042 | Effective permeability of the compound at 25 ug/ml after 18 hrs by PAMPA-BBB assay | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8 | Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. |
| AID621868 | Antibacterial activity against Escherichia coli 700 expressing TolC after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID216567 | Antibacterial activity against Vibrio cholerae 01 | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1183256 | Antimicrobial activity against Bacillus subtilis MTCC 441 assessed as absence of visible growth after 24 to 48 hrs by broth micro dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Design, synthesis and characterization of fluoro substituted novel pyrazolylpyrazolines scaffold and their pharmacological screening. |
| AID563515 | Cellular uptake at cetylpyridinium chloride-resistant Serratia marcescens 01 at 50 ug/ml after 60 mins by spectrofluorometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID519119 | Antibacterial activity against Proteus mirabilis NP43 after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID434849 | Antibacterial activity against multidrug-resistant Streptococcus pyogenes after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID324255 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in stationary phase at 3 ug/ml after 1 day | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID164530 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Pseudomonas aeruginosa strain DRCC 131 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1402343 | Bactericidal activity against Escherichia coli ATCC 35150 incubated for 24 hrs followed by re-plating on nutrient agar and measured after overnight incubation by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID369427 | Induction of Staphylococcus aureus DNA gyrase-mediated Escherichia coli pBR322 DNA cleavage assessed as ratio of drug-induced DNA cleavage to spontaneous DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID585684 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID509638 | Antibacterial activity against Escherichia coli HB101 | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. |
| AID1060934 | Antimicrobial activity against Escherichia coli DH52 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID467612 | Fraction unbound in human plasma | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID369252 | Increase in ompX-lacZ expression in Enterobacter aerogenes ATCC 15038 assessed as ompX upregulation after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID434851 | Antibacterial activity against multidrug-resistant Staphylococcus aureus after 20 hrs by cylinder and well method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID523168 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC8530 harboring gyrA S84L and parC I143V mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpin | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID65202 | In vitro antibacterial activity against Escherichia coli KC-14, Ec(K), (gram-negative) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID207679 | Minimum inhibitory concentration (MIC) against Staphylococcus aureus K2068; Range 12.5 1.6 ug/mL | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps. |
| AID716254 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID210022 | Antibacterial activity against Streptococcus pneumoniae (SV-1) | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID585493 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1601851 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID529309 | Antimicrobial activity against QnrS2-positive Aeromonas veronii A272 harboring GyrA Ile83 and ParC Ile80 mutant gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate. |
| AID1401691 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID1516029 | Antibacterial activity against Staphylococcus aureus 11011 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID563512 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 011 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID386837 | Antibacterial activity against Bacillus cirrhosis at 25 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID285649 | Antimicrobial activity against Pseudomonas aeruginosa 19B6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1722536 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as ratio of MIC after and before 10 serial passages at 0.5 times MIC passaged daily for 10 days | |||
| AID1850938 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID1601848 | Antibacterial activity against Escherichia coli CMCC 44568 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1601845 | Antibacterial activity against Enterococcus faecalis CMCC 29212 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID586726 | Antibacterial activity against Escherichia coli ATCC 25922 harboring GyrA S83L mutant assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID267736 | Antibacterial activity against Bacillus subtilis ATCC 6633 by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID495511 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4665 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID1530021 | Antibacterial activity against glycopeptide-intermediate Staphylococcus aureus | 2019 | European journal of medicinal chemistry, Jan-01, Volume: 161 | Quinoline and quinolone dimers and their biological activities: An overview. |
| AID285665 | Antimicrobial activity against Pseudomonas aeruginosa 22E1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID572522 | Antimicrobial activity against qnrA-positive Salmonella enterica serovar Mbandaka isolate s2093 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID1755825 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microbroth dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID1436575 | Antibacterial activity against Escherichia coli MTCC 443 by broth microdilution assay method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives. |
| AID1917498 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID324163 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid vector after 16 hrs by serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID78706 | Minimum effective dose required for the inhibition of Escherichia coli gyrase | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID559904 | Antimicrobial activity against Escherichia coli TF-KP278 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID745303 | Antibacterial activity against Vibrio cholerae MTCC 3906 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID1557286 | Antibacterial activity against Streptococcus pyogenes by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID69597 | Antibacterial activity was evaluated against Escherichia coli | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Chemometric studies on the bactericidal activity of quinolones via an extended VolSurf approach. |
| AID1126764 | Antibacterial activity against multidrug-resistant 1 ug/ml Mycobacterium tuberculosis clinical isolate 1288 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID1832283 | Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents. |
| AID1740333 | Cytotoxicity against rat L6 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1764071 | Antibacterial activity against Acinetobacter baumannii assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID662992 | Antibacterial activity against Escherichia coli MTCC 443 by macrobroth dilution assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID285678 | Antimicrobial activity against Pseudomonas aeruginosa 29G6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285680 | Antimicrobial activity against Pseudomonas aeruginosa 29G8 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID151052 | Antibacterial activity was determined against gram negative organism, Pseudomonas aeruginosa UI-18 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID133810 | Compound was evaluated for protective dose against the Escherichia coli vogel lethal infection following peroral administration in mouse | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID200361 | Antibacterial activity against Ser. marcescens (2840) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID396001 | Antimicrobial activity against Mycoplasma putrefaciens Jordanian isolates after 24 hrs by twofold serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibilities of Mycoplasma putrefaciens field isolates. |
| AID65234 | In vivo efficacy in mouse protection test in Escherichia coli Vogel administered by subcutaneous injection. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1290442 | Antibacterial activity against Salmonella typhi MTCC 98 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID544860 | Antibacterial activity against Streptococcus pneumoniae U2A1053 harboring parC Ser79Phe mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID556671 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 26 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285199 | Antimicrobial activity against Escherichia coli M093 mutant with AG100 lon3::IS186 acrR::IS1 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID523259 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID260738 | Antibacterial activity against Staphylococcus aureus 25293 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID575169 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 1000 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID549144 | Antimicrobial activity against Cryptococcus neoformans ATCC 14116 after 18 to 24 hrs by microbroth dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives. |
| AID421756 | Antibacterial activity against Mycobacterium fortuitum after 72 hrs | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3 | Bioactive pyridine-N-oxide disulfides from Allium stipitatum. |
| AID144438 | Anti-bacterial activity tested against Mycobacterium smegmatis (ATCG 19420) | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. |
| AID747355 | Antifungal activity against Candida albicans by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1292332 | Permeability of the compound at 25 ug/ml after 18 hrs by PAMPA-BBB assay | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10 | Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1239964 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1237614 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC51033 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID544868 | Antibacterial activity against Streptococcus pneumoniae U2A1414 harboring gyrA Glu85Lys parC Ser79Phe mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID285577 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556685 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 12 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1764072 | Antibacterial activity against Escherichia coli assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID137613 | Serum levels in mice after 4 hr Oral administration of 50 mg/kg | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID95878 | In vitro for antibacterial activity against Klebsiella oxytoca 1082E | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID666962 | Antibacterial activity against Salmonella typhi MTCC 98 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID523123 | Antimicrobial activity against Enterobacter aerogenes ATCC 13048 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID572523 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Corvallis isolate s2052 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID1524626 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID1740320 | Antimicrobial activity against Escherichia coli ATCC 8739 assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID283088 | Antibacterial activity against Staphylococcus aureus SA1199B overexpressing NorA at 5 ug by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus. |
| AID572058 | Ratio of MIC for Escherichia coli KAM32 harboring plasmid pUC18 to MIC for Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID206293 | In vitro antibacterial activity against Staphylococcus aureus FDA 209P JC-1 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID563516 | Cellular uptake at Serratia marcescens ATCC 13880 at 50 ug/ml after 60 mins by spectrofluorometry in presence of 10 mM proteon conductor CCCP | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID70714 | Antibacterial activity against Escherichia coli DC2 (4353) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID51018 | In vitro antibacterial activity against anaerobically grown Clostridium perfringens (10A009) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID1290439 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID117064 | In vivo acute toxicity against Escherichia coli (KC-14) was determined for the compound administered orally | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID1879457 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID736326 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus EMRSA-16 after 18 hrs by MTT assay | 2013 | Journal of natural products, Mar-22, Volume: 76, Issue:3 | Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. |
| AID200232 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus H228 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID285619 | Antimicrobial activity against Pseudomonas aeruginosa 5G3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID559899 | Antimicrobial activity against Klebsiella pneumoniae 101A harboring beta-lactamase CMY-2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID745305 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID285196 | Antimicrobial activity against Escherichia coli M074 mutant with AG100 lon2::IS186 acrR::IS genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID209075 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Streptococcus faecalis strain ATCC 29212 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID255474 | Minimum inhibitory concentration against Staphylococcus epidermidis | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. |
| AID1585652 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after overnight incubation by micro broth dilution analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID1818875 | Antibacterial activity against Escherichia coli assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID65384 | Minimum inhibition concentration against Enterococcus faecalis LS-101 strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1391383 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1737532 | Antibacterial activity against Bacillus proteus ATCC 8427 | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID586754 | Antibacterial activity against qnrS gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrS1 assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID556900 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 12 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID198021 | Antibacterial activity was determined against gram positive organism, Streptococcus faecalis MGH-2 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID565309 | Antibacterial activity against Mycoplasma genitalium by quantitative TaqMan PCR method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID586637 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrA gene and pBK-QnrA1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID585496 | Antibacterial activity against dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID464586 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID1557042 | Antibacterial activity against Pseudomonas aeruginosa incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID369420 | Induction of Staphylococcus aureus DNA gyrase-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID560777 | Antibacterial activity against Staphylococcus aureus TS2921 harboring ddlA Asp102Asn mutation in presence of 100 mM D-Ala-D-Ala, which complements temperature sensitivity after 20 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. |
| AID563507 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 harboring plasmid STV29 expressing hasF gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID693706 | Antibacterial activity against Staphylococcus aureus RN4220 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID1415673 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID150908 | Antibacterial activity was determined against gram negative organism, Pseudomonas aeruginosa (UI-18) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID1391381 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID658536 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3 | Antibacterial acylphloroglucinols from Hypericum olympicum. |
| AID1759535 | Antibacterial activity against Escherichia coli by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID216703 | Antibacterial activity against Vibrio parahaemolyticus | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1585571 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as zone of inhibition at 25 ug/ml by agar well diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Benzofuran derivatives and their anti-tubercular, anti-bacterial activities. |
| AID667555 | Antibacterial activity against Staphylococcus aureus KCTC 4220 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID396000 | Antimicrobial activity against Mycoplasma putrefaciens French isolates after 24 hrs by twofold serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibilities of Mycoplasma putrefaciens field isolates. |
| AID572513 | Antimicrobial activity against Salmonella enterica serovar Mbandaka isolate s2159 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID557077 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pDrive plasmid expressing ampC gene by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID207944 | In vitro antibacterial activity against Staphylococcus aureus CMX 686B | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID1601842 | Antibacterial activity against Staphylococcus aureus CMCC 25923 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID544847 | Antibacterial activity against Streptococcus pneumoniae U2A1056 harboring gyrA Ser81Tyr parC Asp83His mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID96264 | In vitro antibacterial activity against clinical isolates of Klebsiella pneumoniae-4 (gram negative) by agar dilution assay. | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids. |
| AID267741 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1 by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID530594 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr6 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID150917 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 15692 measured in succinate (SC) liquid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID288184 | Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | QSAR study on permeability of hydrophobic compounds with artificial membranes. |
| AID1809825 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth by broth dilution method | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID30568 | In vitro antibacterial activity against anaerobically grown Actinomyces pyogenes (14D002) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID565072 | Antibacterial activity against SHV-12 ESBL producing Klebsiella pneumoniae assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID1401688 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID750277 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents. |
| AID621878 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1239962 | Antibacterial activity against Salmonella enterica ATCC 14028 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1889620 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID70735 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Escherichia coli Vogel | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID753248 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID544851 | Antibacterial activity against Streptococcus pneumoniae R6 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID613570 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID419587 | Antimicrobial activity against Bacillus subtilis after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. |
| AID1498759 | Antibacterial activity against Bacillus typhi after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID1601847 | Antibacterial activity against Escherichia coli CMCC 25922 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1209582 | Unbound volume of distribution in Sprague-Dawley rat brain slices at 100 nM after 5 hrs | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3 | Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. |
| AID563517 | Cellular uptake at cetylpyridinium chloride-resistant Serratia marcescens 01 at 50 ug/ml after 60 mins by spectrofluorometry in presence of 10 mM proteon conductor CCCP | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID285677 | Antimicrobial activity against Pseudomonas aeruginosa 29F6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID603462 | Inhibition of Staphylococcus aureus DNA Topoisomerase 4-mediated decatenation of kDNA after 30 mins by densitometry | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID1695897 | Antibacterial activity against Klebsiella pneumoniae MTCC 618 incubated for 24 hrs by microdilution method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID523131 | Antimicrobial activity against Enterobacter aerogenes EA298 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID163214 | Antibacterial activity against Prot. vulgaris (2829) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1383912 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID542509 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87, gyrB T471 and parC I80, G84 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID744032 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition after 24 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1242651 | Antifungal activity against Candida parapsilosis ATCC 22019 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID216697 | Antibacterial activity against Vibrio mimicus | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID563510 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens HMS011 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID561397 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP58 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID1907306 | Antibacterial activity against Klebsiella pneumonia assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID542504 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87 and parC I80 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID1401684 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID584333 | Antibacterial activity against wild type Escherichia coli BW25113 absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1405068 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1427527 | Effective permeability of the compound at pH 7.4 after 18 hrs by PAMPA | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. |
| AID523124 | Antimicrobial activity against Enterobacter aerogenes EA-CM64 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID544857 | Antibacterial activity against Streptococcus pneumoniae U2A1266 harboring gyrA Ser81Cys mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID206264 | Compound was tested for antimicrobial activity against Staphylococcus aureus FDA207PJC-1 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID68793 | Minimum concentration of compound needed to produce linear DNA at an intensity relative to oxolinic acid at 10 ug/mL was measured on Escherichia coli for gyrase-drug induced cleavage. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID1726684 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID448696 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID573304 | Antimicrobial activity against Escherichia coli isolate GZ12 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1281664 | Antibacterial activity against Escherichia coli JM109 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID556682 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 9 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1126751 | Antibacterial activity against Staphylococcus aureus assessed as zone of inhibition at 2 ug/ml | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID561334 | Ratio of MIC for Escherichia coli isolate 48 transconjugant to MIC for azide-resistant Escherichia coli J57 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1730950 | Antibacterial activity against Streptococcus pyogenes MTCC 442 assessed as bacterial growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 36 | Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme. |
| AID1537801 | Antimicrobial activity against carbapenem-resistant Escherichia coli K12 W3110 at sub-MIC treated by resistant development assay | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes. |
| AID758275 | Antibacterial activity against Bacillus subtilis MTCC 441 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID532035 | Antimicrobial activity against azide-resistant Escherichia coli J53 TrcPS012 harboring PMQR determinant qnrB22 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID285657 | Antimicrobial activity against Pseudomonas aeruginosa 19E2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID586751 | Antibacterial activity against Escherichia coli ATCC 25922 harboring GyrA S83L mutant assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID542501 | Antimicrobial activity against Escherichia coli K-12 harboring parE A458 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID544862 | Antibacterial activity against Streptococcus pneumoniae U2A1693 harboring parC Asp83Asn mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID200230 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus (H228) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID529670 | Antimicrobial activity against Escherichia coli J53 transconjugate by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli. |
| AID716252 | Antimicrobial activity against Micrococcus luteus ATCC 4698 by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID200349 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Salmonella abony strain NCIM 2257 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID397920 | Antimicrobial activity against Escherichia coli at 4 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID637226 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID1374215 | Effective permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA-BBB assay | 2018 | Bioorganic & medicinal chemistry, 03-01, Volume: 26, Issue:5 | Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. |
| AID604025 | Unbound CSF to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID206205 | Minimum inhibition concentration in vitro determined against Staphylococcus epidermidis 3519 | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID1600097 | Antibacterial activity against methicillin resistant Staphylococcus aureus N315 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID201090 | Minimum inhibitory concentration against Staphylococcus aureus Smith | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID548130 | Antibacterial activity against Streptococcus mutans KCTC 3289 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID495510 | Antibacterial activity against Acinetobacter baumannii BM4454 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID609224 | Antibacterial activity against 10'5 CFU/mL methicillin-resistant Staphylococcus aureus CCARM 3506 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID758274 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID621832 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1570001 | Permeability of compound at 100 ug/ml measured after dilution with PBS/EtOH (70:30) at pH 7.4 after 18 hrs by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. |
| AID324244 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in log phase at 3 ug/ml after 5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID572516 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Montevideo isolate s2944 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID504047 | Antimicrobial activity against Escherichia coli MTCC 443 by broth microdilution technique | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles. |
| AID133813 | Compound was evaluated for protective dose against the Streptococcus aureus UC-76 lethal infection following po administration in mouse | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID205944 | Minimum inhibitory concentration (MIC) against gram positive bacteria Streptococcus faecalis MGH-2. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID17991 | Bioavailability | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | Search compounds with antimicrobial activity by applying molecular topology to selected quinolones. |
| AID584337 | Antibacterial activity against tolC deficient Escherichia coli GD100 absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID164728 | Compound was tested in vitro for antibiotic activity against the bacteria Pseudomonas aeruginosa 5007 | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID522872 | Antibacterial activity against uropathogenic Escherichia coli UTI89 infected in human 5637 cells assessed as decrease in intracellular bacterial level at 300 to 500 ug/ml after 12 hrs by serial dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID1917522 | Induction of drug resistance in Pseudomonas aeruginosa assessed as fold increase in MIC measured after 11 passages | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID585420 | Antimicrobial activity against oqxAB positive Escherichia coli C600 W191-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1726688 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID561315 | Antimicrobial activity against Enterobacter cloacae isolate 101 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID753246 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID556674 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 1 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1889621 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID200520 | Antibacterial activity against Salmonella paratyphi A | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1335836 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID1504253 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1199B after 24 hrs by MTT dye based broth microdilution method | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis. |
| AID1126669 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition after 24 to 48 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, characterization and pharmacological screening of some novel 5-imidazopyrazole incorporated polyhydroquinoline derivatives. |
| AID744035 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID585573 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated degP gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID95881 | In vitro antibacterial activity against Klebsiella pneumoniae 8045 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID324272 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in log phase at 3 ug/ml after 1 week | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID209294 | In vitro antibacterial activity against Streptococcus pyogenes 930 | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID1516086 | Resistance index, ratio of MIC for antibacterial activity against ciprofloxacin-resistant Escherichia coli to MIC for Escherichia coli ATCC 25922 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID164115 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Pseudomonas fluorescence strain NCIMB 10586 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID368424 | Ratio of MIC for Escherichia coli KAM32 pSTVqepA mutant to MIC for Escherichia coli KAM32 pSTV28 mutant | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID324205 | Antibacterial activity against Escherichia coli K12 mutant JHU313 at 4 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID731203 | Antibacterial activity against Escherichia coli MTCC 443 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | An efficient domino reaction in ionic liquid: synthesis and biological evaluation of some pyrano- and thiopyrano-fused heterocycles. |
| AID1855812 | Antibacterial activity against Enterococcus faecalis measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID585424 | Antimicrobial activity against oqxAB positive Escherichia coli C600 G062-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1368747 | Antibacterial activity against Pseudomonas aeruginosa MTCC 424 at 1 ug/ml under overnight incubation condition by paper disc method | 2018 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2 | Synthesis and biological evaluation of 1-amino isochromans from 2-bromoethyl benzaldehyde and amines in acid medium. |
| AID1601841 | Antibacterial activity against Staphylococcus aureus CMCC(B) 26003 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID556661 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 16 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1192731 | Permeability of the compound in PBS/EtOH buffer at 100 ug/ml by PAMPA | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. |
| AID586645 | Antibacterial activity against qnrS gene expressing Escherichia coli ATCC 25922 harboring ParC S80R mutant, ParC S80R mutant and pBK-QnrS1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID134390 | Acute toxicity on oral administration in mice | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1758082 | Antibacterial activity against Klebsiella pneumonia assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID95879 | Antibacterial activity against Klebsiella ozaenae | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID498781 | Antimicrobial activity against mild ciprofloxacin-resistant Streptococcus pyogenes by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID202110 | In vivo efficacy (s.c.) against Streptococcus pyogenes C-203 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1367032 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID542503 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87 and parC K84 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID67692 | Compound was tested in vitro for antibiotic activity against bacteria Enterobacter aerogenes ATCC 13048 | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID322316 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID497916 | Binding affinity to Escherichia coli K-12 MC1061 acrB assessed as susceptibility to compound efflux at 0.01 to 1 ug/ml after 16 hrs by plate reader assay | 2009 | Nature chemical biology, Nov, Volume: 5, Issue:11 | Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. |
| AID369253 | Increase in ompX-lacZ expression in Enterobacter aerogenes ATCC 15038 assessed as increase in beta-galactosidase activity after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID753251 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID1221964 | Transporter substrate index ratio of permeability from basolateral to apical side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1177542 | Antimicrobial activity against multi-drug-resistant Staphylococcus aureus SA-1199B expressing NorA efflux pump assessed as absence of growth after 18 hrs by MTT assay | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. |
| AID1855819 | Antibacterial activity against Acinetobacter baumannii measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID362542 | Antibacterial activity against macrolide-resistant Staphylococcus aureus RN4220 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID1510723 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 18 hrs by two fold serial dilution | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID619386 | Antimycobacterial activity against Mycobacterium avium CNTC 330/88 after 21 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID589361 | Antibacterial activity against methicillin- resistant and vancomycin resistant Staphylococcus aureus ATCC 29213 after 24 hrs by spectrophotometry | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus. |
| AID1335830 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID1868913 | Inhibition of wild type full length miR-21 in human HeLa cells co-expressing firefly luciferase and renilla luciferase gene assessed as fold change in Luc/Rlu by measuring relative fluorescence intensity at 20 uM by Dual-Luciferase reporter based luminome | 2022 | Bioorganic & medicinal chemistry, 07-15, Volume: 66 | Identification of benzamides derivatives of norfloxacin as promising microRNA-21 inhibitors via repressing its transcription. |
| AID534174 | Antimicrobial activity against armA positive Enterobacter cloacae BEH producing beta lactamase CTX-M-3 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID1352415 | Antibacterial activity against Escherichia coli DH52 after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID523129 | Antimicrobial activity against Enterobacter aerogenes EA294 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID781330 | pKa (acid-base dissociation constant) as determined by potentiometric titration | 2014 | Pharmaceutical research, Apr, Volume: 31, Issue:4 | Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. |
| AID1462721 | Antimicrobial activity against Streptococcus pyogenes MTCC 442 | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities. |
| AID520639 | Antimicrobial activity against Escherichia coli MRY05-3283 expressing qepA and rmtB gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID63899 | Antibacterial activity against gram negative organism, Escherichia cloacae (MA2646) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID64551 | Inhibition of growth of Escherichia coli (KC-14) upon oral administration in mice(95%CL) | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID609220 | Antibacterial activity against 10'5 CFU/mL Staphylococcus aureus KCTC 503 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID425071 | Antimicrobial activity against Escherichia coli J53-AzR in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID285624 | Antimicrobial activity against Pseudomonas aeruginosa 8B11 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID530597 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr9 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID397937 | Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID119715 | Serum concentration in mice, after oral administration at a dose of 100 mg/kg p.o. at 5 hr | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1814302 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID1557283 | Antibacterial activity against Haemophilus influenzae with horse blood by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID379741 | Antibacterial activity against multidrug-resistant Staphylococcus aureus SA-1199B overexpressing NorA efflux transporter after 18 hrs by microtiter plate method | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID423071 | Antibacterial activity against Pseudomonas aeruginosa PAO1 H1105/lon+c mutant strain with lon::lux/lon+ mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID200881 | Tested in vitro against Salmonella Typhimurium IID971 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID421757 | Antibacterial activity against Mycobacterium smegmatis after 72 hrs | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3 | Bioactive pyridine-N-oxide disulfides from Allium stipitatum. |
| AID205965 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Staphylococcus aureus UC-76 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID405924 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus XU212 | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. |
| AID758168 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID584339 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID396038 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP2 plasmid containing Enterobacter cloacae acrA gene by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID405117 | Antimicrobial activity against Escherichia coli TOP10 harbouring pVS2 expressing quinolone resistant Vibrio splendidus LGP32 QnrVS2 gene | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID529308 | Antimicrobial activity against QnrS2-negative Aeromonas veronii CECT 4260 harboring GyrA Ser83 and ParC Ser80 mutant gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate. |
| AID420480 | Antibacterial activity against Staphylococcus aureus after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents. |
| AID758270 | Antibacterial activity against Pseudomonas aeruginosa MTCC 1688 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID206812 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Staphylococcus pyogenes C203 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID1740325 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID573297 | Antimicrobial activity against Escherichia coli isolate GZ3 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID163915 | In vivo efficacy (orally) against Pseudomonas aeruginosa in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID133946 | In vivo activity against Pseudomonas aeruginosa (po) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID206477 | The compound was tested for its antimicrobial activity against Staphylococcus aureus CMX 68613 (Sa) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID571885 | Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method in presence of 25 ug/ml efflux pump inhibitor CCCP | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID260743 | Antibacterial activity against Vancomycin resistant Enterococcus faecium VRE 700802 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID556690 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1600111 | Antibacterial activity against methicillin resistant Staphylococcus aureus 6347 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1907310 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID207771 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Staphylococcus aureus strain ATCC 29213 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1758085 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID70586 | Compound was tested in vitro for antibiotic activity against the bacteria Escherichia coli juhl | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID1297666 | Bacteriostatic activity against Escherichia coli F-50 measured every 24 hrs for 5 days by broth dilution method | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID279141 | Antibacterial activity against Streptococcus suis BB1012 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID496819 | Antimicrobial activity against Plasmodium falciparum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID206489 | The compound was tested in vitro for antibiotic activity against Staphylococcus aureus ATCC 6538P | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID565308 | Antibacterial activity against Mycoplasma genitalium by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1405070 | Antibacterial activity against Acinetobacter baumannii after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID586740 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrB gene and pBK-QnrB1 assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1814305 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID1124795 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID78690 | Supercoiling inhibition activity DNA gyrase isolated from Escherichia coli H560 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Asymmetric synthesis and properties of the enantiomers of the antibacterial agent 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-6- fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride. |
| AID207773 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Staphylococcus aureus strain ATCC 33592 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID565231 | Antimicrobial activity against Mycobacterium chelonae 9917 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID65383 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2,(gram-negative) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID1600110 | Bactericidal activity against Proteus vulgaris NCTC 4635 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID14008 | Serum conc at 3 hours following 25 mg/kg dose | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1758080 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID64383 | In vitro minimum inhibitory concentration (MIC) against Enterococcus faecium A 24885 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID1493765 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by agar dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates. |
| AID125423 | Antibacterial activity against Morganella morganii | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1281658 | Antibacterial activity against Shigella dysenteriae by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID585566 | Antibacterial activity against wild-type Escherichia coli BW25113 after 20 hrs by Etest method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID150927 | Minimum inhibitory concentration against Pseudomonas aeruginosa IAI measured in succinate (SC) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID207152 | Antibacterial activity against Staphylococcus aureus (2865) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID637208 | Antibacterial activity against Staphylococcus aureus MTCC 2901 after 24 hrs by tube dilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID565329 | Antibacterial activity against Mycoplasma genitalium M6283 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID93905 | Minimum inhibitory concentration (MIC) of compound was measured on Klebsiella pneumoniae MGH-2(gram negative organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID207573 | Minimum inhibition concentration in vitro determined against Staphylococcus aureus CMX 686B | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID572509 | Antimicrobial activity against Salmonella enterica serovar Typhimurium isolate SL1344 harboring wild type ParC gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID1737631 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 incubated for 18 hrs by agar dilution method | 2020 | European journal of medicinal chemistry, Jun-15, Volume: 196 | Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates. |
| AID464585 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID674909 | Antibacterial activity against Staphylococcus aureus MTCC 96 | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives. |
| AID481442 | Transcellular permeability at pH 6.5 calculated from in vitro P app values in Caco-2 and/or MDCK cells | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID1221980 | Transporter substrate index of efflux ratio in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID523166 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC11696 assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID1481561 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID208310 | Minimum inhibitory concentration against Streptococcus pneumoniae (SV-1). | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID1221982 | Fraction absorbed in human | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1126762 | Antibacterial activity against multidrug-resistant 1 ug/ml Mycobacterium tuberculosis clinical isolate 1256 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID573321 | Antimicrobial activity against Escherichia coli isolate CQ22 transconjugant harboring 16S rRNA methylase RmtB and qnrS1 by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1436573 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth microdilution assay method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives. |
| AID386832 | Antibacterial activity against Escherichia coli at 100 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID685407 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 clinical isolate after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID1504252 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate XU2120 after 24 hrs by MTT dye based broth microdilution method | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis. |
| AID1221970 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID324161 | Antibacterial activity against Escherichia coli K12 mutant JHU313 after 16 hrs by serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID720959 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID1855813 | Antibacterial activity against Staphylococcus aureus measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID586727 | Antibacterial activity against qnrA gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrA1 assessed as mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID379742 | Antibacterial activity against Staphylococcus aureus RN4220 expressing MsrA efflux transporter after 18 hrs by microtiter plate method | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). |
| AID532040 | Antimicrobial activity against azide-resistant Escherichia coli DH5alpha by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID448070 | Antibacterial activity against Xanthomonas axonopodis at 50 mg/L after 24 hrs by agar well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID586633 | Antibacterial activity against qnrA gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrA1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1465293 | Effective permeability of the compound at 100 ug/ml by PAMPA-BBB assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease. |
| AID1730947 | Antibacterial activity against Pseudomonas aeruginosa MTCC 1688 assessed as bacterial growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 36 | Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme. |
| AID532758 | Antimicrobial activity against Salmonella serovar Mbandaka 7892 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID685408 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 clinical isolate after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID197878 | Oral efficacy of compound after peroral administration on systemic infection by Staphylococcus aureus IID803 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID201952 | In vivo efficacy (s.c.) against Streptococcus pneumoniae SV-1 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1433840 | Antibacterial activity against Escherichia coli MTCC 443 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID563513 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 011 harboring plasmid STV28 expressing sdeB gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1809817 | Antimicrobial activity against Klebsiella pneumoniae ATCC 27736 assessed as inhibition of bacterial growth by broth dilution method | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID324262 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in log phase at 3 ug/ml after 5 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID448069 | Antibacterial activity against Xanthomonas oryzae at 50 mg/L after 24 hrs by agar well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID1496040 | Effective permeability of the compound in PBS/EtOH at 50 ug/mL after 18 hrs by PAMPA-BBB assay | 2018 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 28, Issue:11 | Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold. |
| AID206476 | The compound was tested for its antimicrobial activity against Staphylococcus aureus ATCC 6538P (Sa(A)) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID436997 | Inhibition of mouse NIH/3T3 cell proliferation by MTT assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID523258 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1304601 | Antibacterial activity against methicillin-resistant Staphylococcus aureus EMRSA-16 after 18 hrs by MTT assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3 | Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID758271 | Antibacterial activity against Salmonella typhi MTCC 98 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID1850948 | Antibacterial activity against Acinetobacter baumannii assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID585494 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1571581 | Bactericidal activity against Staphylococcus aureus 209p measured after 4 hrs | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID285595 | Antimicrobial activity against Pseudomonas aeruginosa 1B9 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID67922 | Antibacterial activity evaluated against Enterococcus faecalis | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Chemometric studies on the bactericidal activity of quinolones via an extended VolSurf approach. |
| AID69917 | Antibacterial activity against Escherichia coli NCTC 10418 | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID542147 | Antimicrobial activity against Escherichia coli DH10B harboring pBR322 with Salmonella enterica HN-GSS-2007-057 qnrD gene by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID96419 | In vitro minimum inhibitory concentration (MIC) against Klebsiella pneumoniae A 9664 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID285596 | Antimicrobial activity against Pseudomonas aeruginosa 1C9 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID324190 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid PhoU at 0.1 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID565310 | Antibacterial activity against Mycoplasma genitalium G37 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID386841 | Antifungal activity against Rhizoctonia bataticola at 100 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1546140 | Antifungal activity against Saccharomyces cerevisiae after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID406847 | Antibacterial activity against Enterobacter cloacae S1 isolate expressing quinolone resistance determinant QnrB4 by E-test | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Plasmid-mediated quinolone resistance determinant QnrB4 identified in France in an Enterobacter cloacae clinical isolate coexpressing a QnrS1 determinant. |
| AID1383908 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID70775 | In vivo antibacterial activity against Escherichia coli KC-14 (po) | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID164235 | Anti-bacterial activity tested against Gram-negative PA-7 bacterium | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. |
| AID20680 | Serum level of compound (50 mg/kg) after 4.0h of peroral administration in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID526305 | Antimicrobial activity against Pseudomonas aeruginosa by agar plate disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives. |
| AID771177 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID544856 | Antibacterial activity against Streptococcus pneumoniae U2A1051 harboring gyrA Ser81Tyr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID512994 | Antimicrobial activity against Staphylococcus aureus | 2006 | Nature chemical biology, Nov, Volume: 2, Issue:11 | An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. |
| AID775484 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID573314 | Antimicrobial activity against Escherichia coli isolate CQ20 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID69469 | Minimum inhibitory concentration against Escherichia coli (H560) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID429855 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs | 2009 | Journal of natural products, Jun, Volume: 72, Issue:6 | Antibacterial diterpenes from Plectranthus ernstii. |
| AID1666747 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID520699 | Ratio of MIC for Escherichia coli DH10B harboring p041060 carrying qepA gene to MIC for Escherichia coli isolate DH10B | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID362541 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1199B after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID70947 | In vitro antibacterial activity against clinical isolates of Escherichia coli 15 (gram negative) by agar dilution assay. | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids. |
| AID150921 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 27853 measured in Muller-Hinton (MH) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID1125379 | Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as growth inhibition at 10 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1551300 | Antibacterial activity against Quinolone-resistant Staphylococcus aureus CCARM 3519 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID366952 | Antibacterial activity against Staphylococcus aureus ATCC 11632 after 18 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. |
| AID622558 | Antimicrobial activity against Clostridium tetani MTCC 449 for 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. |
| AID1820910 | Antibacterial activity against Staphylococcus aureus assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID497761 | Apparent permeability across basolateral to apical side in human Calu3 cells in presence of 3 uM PSC-833 P-gp inhibitor | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. |
| AID69826 | Tested in vitro against Escherichia coli NIHJ JC-2 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1437175 | Permeability of the compound by PAMPA | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. |
| AID1199294 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 at 0.5 times MIC measured after 17 passages by multistep passage drug resistance selection study relative to wild type Staphylococcus aureus ATCC 29213 before passage | 2015 | Journal of medicinal chemistry, Jan-22, Volume: 58, Issue:2 | Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections. |
| AID529311 | Antimicrobial activity against Escherichia coli J53 harboring QnrS2 and GyrA Ile83 and ParC Ile80 mutant gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate. |
| AID1125388 | Antibacterial activity against Bacillus subtilis 168 assessed as growth inhibition at 10 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID771001 | Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study. |
| AID266675 | Antibacterial activity against Klebsiella pneumoniae | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 | Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives. |
| AID131701 | Effective dose against Staphylococcus aureus smith strain in mouse | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1210070 | Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID1765476 | Antibacterial activity against Acinetobacter baumannii by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID1272237 | Antibacterial activity against Staphylococcus aureus by broth micro-dilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors. |
| AID561336 | Ratio of MIC for Klebsiella pneumoniae isolate 135 transconjugant to MIC for azide-resistant Escherichia coli J59 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID405114 | Antimicrobial activity against Vibrio splendidus 12B01 expressing plasmid-mediated QnrS-like quinolone resistance determinants | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID557082 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID386834 | Antibacterial activity against Escherichia coli at 25 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID532573 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID565063 | Antibacterial activity against CTX-M-15 ESBL producing Enterobacter cloacae assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID716251 | Antimicrobial activity against Escherichia coli DH52 by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID1239966 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1890861 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID571882 | Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID619387 | Antimycobacterial activity against Mycobacterium kansasii CNTC My 235/80 after 7 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID285631 | Antimicrobial activity against Pseudomonas aeruginosa 10A6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID534341 | Antimicrobial activity against Burkholderia pseudomallei Bp227 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID395102 | Inhibition of DNA replication in wild type Trypanosoma brucei brucei s427 assessed as kinetoplast disintegrate at IC50 after 24 hrs by DAPI staining visualized by fluorescence microscopy | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. |
| AID556758 | Bactericidal activity against katE gene-deficient Escherichia coli K-12 3202 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID205725 | In vitro antibacterial activity against Staphylococcus epidermidis IAM 1576 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID523128 | Antimicrobial activity against Enterobacter aerogenes EA294 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID324277 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in stationary phase at 3 ug/ml after 10 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID519109 | Antibacterial activity against Proteus mirabilis M 48 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID753250 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID523265 | Antimicrobial activity against Enterobacter cloacae Ec1194 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID285200 | Antimicrobial activity against Escherichia coli M103 mutant with AG100 lon3::IS186 acrR-acrAB genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID1546141 | Antifungal activity against Candida mycoderma after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID203106 | Minimum inhibitory concentration (MIC) against gram positive bacteria Staphylococcus aureus H-228. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID164555 | In vitro antibacterial activity against Pseudomonas aeruginosa K799/WT | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID561399 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP117 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID603475 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus 209P after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID1507051 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID1764070 | Antibacterial activity against Pseudomonas aeruginosa assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID532759 | Antimicrobial activity against Salmonella serovar Montevideo 5747 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID94135 | In vivo efficacy in systemic infection due to Klebsiella pneumoniae (A 9664) in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID1671794 | Inhibition of Escherichia coli DNA gyrase holoenzyme assessed as reduction in pBR322 DNA supercoiling using pBR322 plasmid DNA as substrate incubated for 90 mins in presence of ATP by ethidium bromide staining based agarose gel electrophoresis analysis | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID556902 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 14 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID310530 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Synthesis and antimicrobial evaluation of guanylsulfonamides. |
| AID573329 | Antimicrobial activity against Escherichia coli isolate CQ1 transconjugant harboring 16S rRNA methylase RmtB and qnrB6 by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1290440 | Antibacterial activity against Clostridium tetani MTCC 449 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID586632 | Antibacterial activity against qnrB gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrB1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1585695 | Toxicity in po dosed CF mouse measured after 1 week | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Fluoroquinolone-isatin hybrids and their biological activities. |
| AID731202 | Antibacterial activity against Salmonella typhi MTCC 98 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | An efficient domino reaction in ionic liquid: synthesis and biological evaluation of some pyrano- and thiopyrano-fused heterocycles. |
| AID510325 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID397927 | Antimicrobial activity against Klebsiella pneumoniae at 64 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1628391 | Antimicrobial activity against beer yeast ATCC 9763 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID450457 | Antibacterial activity against Staphylococcus aureus after 24 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Interaction of drug based binuclear mixed-ligand complexes with DNA. |
| AID747357 | Antifungal activity against Aspergillus flavus by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1769955 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC515992 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID1818869 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID523250 | Antimicrobial activity against Enterobacter aerogenes EA5 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID164554 | In vitro antibacterial activity against Pseudomonas aeruginosa 5007 | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID561400 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP118 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID621870 | Antibacterial activity against Pseudomonas aeruginosa PAO1 ATCC BAA-47 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1740331 | Antifungal activity against Stachybotrys chartarum IBT 7711 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID123073 | The compound was tested for inhibition constant against DNA gyrase isolated from micrococcus luteus | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID395097 | Antitrypanosomal activity against wild type Trypanosoma brucei brucei s427 after 48 hrs by alamar blue assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6 | Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. |
| AID623614 | Antibacterial activity against 10'8 CFU/mL Salmonella typhi MTCC 98 by broth microdilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. |
| AID1179906 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID1636268 | Permeability of the compound at pH 7.4 after 18 hrs by PAMPA-BBB assay | 2016 | Bioorganic & medicinal chemistry, 10-15, Volume: 24, Issue:20 | Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors. |
| AID565330 | Antibacterial activity against Mycoplasma genitalium M6284 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1402341 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID1628383 | Antimicrobial activity against Escherichia coli JM109 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1239959 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID622561 | Antimicrobial activity against Vibrio cholerae MTCC 3906 for 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. |
| AID556580 | Bactericidal activity against katG,katE gene-deficient Escherichia coli K-12 3201 after 2 hrs relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID78705 | Inhibition constant against DNA Gyrase isolated from Escherichia coli | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin). |
| AID133807 | Compound was evaluated for protective dose against Streptococcus pneumoniae SV-1 lethal infection following sc administration | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID285681 | Antimicrobial activity against Pseudomonas aeruginosa 29H1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID523256 | Antimicrobial activity against Klebsiella pneumoniae KP63 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1600112 | Bactericidal activity against methicillin resistant Staphylococcus aureus 6347 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1510761 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID324270 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in log phase at 3 ug/ml after 1 week | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID523251 | Antimicrobial activity against Enterobacter aerogenes EA5 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID621871 | Antibacterial activity against Pseudomonas aeruginosa PAO1 harboring oprM deltamexAB after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID267740 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID370046 | Induction of Escherichia coli DNA topoisomerase 4-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID164231 | Antibacterial activity was evaluated against Pseudomonas aeruginosa | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Chemometric studies on the bactericidal activity of quinolones via an extended VolSurf approach. |
| AID397917 | Antimicrobial activity against Pseudomonas aeruginosa at 64 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID498786 | Antimicrobial activity against strong ciprofloxacin-resistant Streptococcus pyogenes at 10 ug by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID525040 | Antimicrobial activity against fluoroquinolone-susceptible Escherichia coli PS5 harboring GyrA S83L mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. |
| AID155926 | In vivo protective dose was evaluated against Pasteurella multocida (59A006) in mouse(sc) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID137605 | Serum levels in Mice 1 hr after Oral administration of 50 mg/kg | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID665058 | Antibacterial activity against Bacillus subtilis MTCC 441 after 24 hrs by micro-broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID324181 | Antibacterial activity against Escherichia coli K12 mutant JHU313 at 2 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID397924 | Antimicrobial activity against Escherichia coli at 512 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1510720 | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 after 18 hrs by two fold serial dilution | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID534338 | Antimicrobial activity against Burkholderia pseudomallei Bp250 harboring mini-Tn7T-bpeA+B+ -oprB+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID666960 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID544850 | Antibacterial activity against Streptococcus pneumoniae CIP104485 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID556865 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 5 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285651 | Antimicrobial activity against Pseudomonas aeruginosa 19C5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID369423 | Induction of Staphylococcus aureus DNA topoisomerase 4-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage assessed as amount of linear DNA generated per unit amount of enzyme at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID1436079 | Permeability of compound at 25 ug/ml after 18 hrs by PAMPA | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. |
| AID1516085 | Antibacterial activity against ciprofloxacin-resistant Escherichia coli ATCC 25922 incubated for 18 to 24 hrs | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1303299 | Antimicrobial activity against Bacillus proteus ATCC 13315 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID556884 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 24 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID68843 | In vitro minimum inhibitory concentration (MIC) against Escherichia coli A 15119 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID781326 | pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/047145026X | 2014 | Pharmaceutical research, Apr, Volume: 31, Issue:4 | Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. |
| AID750274 | Antifungal activity against Aspergillus niger MTCC 282 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents. |
| AID20922 | Compound was evaluated for aqueous solubility at pH 7.2 | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID380476 | Antimicrobial activity against NorA multidrug efflux pump overexpressing Staphylococcus aureus 1199B by ethidium efflux assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Polyacylated oligosaccharides from medicinal Mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus. |
| AID534170 | Antimicrobial activity against armA positive Escherichia coli TOP10 harboring plasmid COP1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID322314 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID1652707 | Induction of Escherichia coli K12 MG1655 lexA promotor measured at 30 mins interval for 20 hrs by fluorescence assay relative to control | |||
| AID1853140 | Effect on DNA damage repair in Caulobacter vibrioides lacking uvrA expression assessed as decrease in cell survival rate upto 1 ug/ml and measured after 2 days by agar dilution method | 2022 | RSC medicinal chemistry, Dec-14, Volume: 13, Issue:12 | Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage. |
| AID285608 | Antimicrobial activity against Pseudomonas aeruginosa 3B1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID448695 | Antimicrobial activity against Bacillus subtilis ATCC 60511 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID64256 | In vitro minimum inhibitory concentration (MIC) against Enterococcus faecalis A 9808 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID1870751 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16 | |
| AID1453097 | Effective permeability of the compound at 100 ug/ml incubated for 18 hrs by PAMPA-BBB assay | 2017 | Bioorganic & medicinal chemistry, 06-15, Volume: 25, Issue:12 | Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease. |
| AID1498756 | Antibacterial activity against Shigella dysenteriae after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID324187 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid vector at 0.5 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1335831 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID523260 | Antimicrobial activity against Pseudomonas aeruginosa PA124 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID556880 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 20 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID585490 | Antibacterial activity against wild type Streptococcus pneumoniae M4 NCTC 7465 type 1 by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID523253 | Antimicrobial activity against Klebsiella pneumoniae ATCC 11296 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1405067 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID295339 | Inhibition of bacterial DNA gyrase | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID523252 | Antimicrobial activity against Klebsiella pneumoniae ATCC 11296 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1365603 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | Recently reported biological activities of pyrazole compounds. |
| AID1557038 | Antibacterial activity against Enterococcus faecalis incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID534344 | Antimicrobial activity against Burkholderia pseudomallei Bp174 harboring mini-Tn7T-bpeR+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID208765 | Dose required to protect 50% of mice from lethal infection was measured on Streptococcus pneumoniae SV-1 (subcutaneously) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID1310076 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID295342 | Antibacterial activity against Staphylococcus aureus ATCC 13709 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID206684 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Staphylococcus pneumoniae SV-1 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID150925 | Minimum inhibitory concentration tested against Pseudomonas aeruginosa E-2 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID745304 | Antibacterial activity against Salmonella typhi MTCC 98 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID324261 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in stationary phase at 3 ug/ml after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID216690 | Antibacterial activity against Vibrio fluvialis | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID586639 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrS gene and pBK-QnrS1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID285579 | Antimicrobial activity against Pseudomonas aeruginosa IA5 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID369264 | Effect on ompF-lacZ fusion transcription in wild type Escherichia coli AG100 assessed as percent decrease in Miller units of beta-galactosidase activity after 120 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID1556534 | Antibacterial activity against Escherichia coli assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID163937 | In vitro for antibacterial activity against Pseudomonas aeruginosa 799/61 | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID266673 | Antibacterial activity against Staphylococcus aureus | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 | Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives. |
| AID1666749 | Antibacterial activity against Klebsiella pneumoniae by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID588219 | FDA HLAED, gamma-glutamyl transferase (GGT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID603367 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID1409905 | Antimicrobial activity against Enterococcus faecalis assessed as ratio of MIC after and before 7 serial passages measured at 24 hrs interval for 16 days by two-fold serial dilution method | |||
| AID1764063 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID556660 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 15 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1726686 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID693710 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID622557 | Antimicrobial activity against Streptococcus pneumoniae MTCC 1936 for 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. |
| AID1183278 | Permeability of the compound by PAMPA | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID207776 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Staphylococcus aureus strain MTCC 737 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID731204 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | An efficient domino reaction in ionic liquid: synthesis and biological evaluation of some pyrano- and thiopyrano-fused heterocycles. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID604020 | Unbound drug concentration in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID133806 | Compound was evaluated for antibacterial activity in mice after peroral administration with 0.5 mL of Escherichia coli Vogel inoculum | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9 | Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships. |
| AID78708 | Inhibitory activity against Escherichia coli DNA gyrase (represented as MNEC) | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID1237610 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC523512 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID565071 | Antibacterial activity against CTX-M-15 ESBL producing Klebsiella pneumoniae assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID1737632 | Antibacterial activity against Salmonella typhimurium ATCC 19430 incubated for 18 hrs by agar dilution assay | 2020 | European journal of medicinal chemistry, Jun-15, Volume: 196 | Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates. |
| AID210392 | Compound was tested for inhibition of the gram-negative organism Streptococcus pyogenes C203. | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID1546131 | Antibacterial activity against methicillin resistant Staphylococcus aureus N315 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID396039 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pACYC184 plasmid by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID227416 | Fold reduction in minimum inhibitory concentration of antibiotic in presence of Reserpine | 2004 | Bioorganic & medicinal chemistry letters, Feb-23, Volume: 14, Issue:4 | Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates. |
| AID42650 | In vitro antibacterial activity against aerobically grown Bordetella bronchiseptica (73A009) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID1557287 | Antibacterial activity against Enterococcus by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID1383910 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID1551298 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus CCARM 3506 assessed as reduction in bacterial cell growth incubated for 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Jun-15, Volume: 172 | Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents. |
| AID556651 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 6 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID585489 | Antibacterial activity against wild type Streptococcus pneumoniae R6 by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID150926 | Minimum inhibitory concentration against Pseudomonas aeruginosa IAI measured in succinate (SC) liquid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID119714 | Serum concentration in mice, after oral administration at a dose of 100 mg/kg p.o. at 2 hr | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1601850 | Antibacterial activity against Pseudomonas aeruginosa CMCC 10104 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID434853 | Antibacterial activity against multidrug-resistant Salmonella typhi after 20 hrs by cylinder and well method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID666964 | Antifungal activity against Aspergillus fumigatus MTCC 3008 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID762426 | Stabilization of reversible Escherichia coli DNA gyrase-pBR322 DNA complex at 20 uM after 15 mins by AFM image analysis | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Confirmation of quinolone-induced formation of gyrase-DNA conjugates using AFM. |
| AID310531 | Antibacterial activity against Bacillus subtilis ATCC 6033 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Synthesis and antimicrobial evaluation of guanylsulfonamides. |
| AID556676 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 3 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID585737 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated ynfE gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID666965 | Antifungal activity against Candida albicans MTCC 227 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID165055 | In vitro antibacterial activity against clinical isolates of Pseudomonas aeruginosa 2437 (gram negative) by agar dilution assay. | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids. |
| AID662987 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 by macrobroth dilution assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID726490 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA). |
| AID771172 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Ig5 clinical isolate after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID1585572 | Antibacterial activity against Streptococcus pyogenes MTCC 442 assessed as zone of inhibition at 25 ug/ml by agar well diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Benzofuran derivatives and their anti-tubercular, anti-bacterial activities. |
| AID665056 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 after 24 hrs by micro-broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID758268 | Antifungal activity against Trichophyton rubrum MTCC 296 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID1507054 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID279131 | Antibacterial activity against Streptococcus suis BB1002 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID1221973 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1879460 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID544839 | Antibacterial activity against Streptococcus pneumoniae H548 clinical isolate harboring gyrA Ser81Phe mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID666959 | Antibacterial activity against Clostridium tetani MTCC 449 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID94123 | Antibacterial activity was determined against gram negative organism, K. pneumoniae (MGH-2) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID1510766 | Antibacterial activity against Escherichia coli after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID163100 | Minimum inhibitory concentration against Pseudomonas aeruginosa. (UI-18) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID573303 | Antimicrobial activity against Escherichia coli isolate GZ11 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1507049 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID519124 | Antibacterial activity against Proteus mirabilis M 40 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID565230 | Antimicrobial activity against Mycobacterium chelonae 9917 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID324250 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in log phase at 3 ug/ml after 1 day | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID775477 | Antibacterial activity against Escherichia coli ATCC 8099 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1888252 | Permeability of the compound in PBS/EtOH buffer (7:3) incubated for 16 hrs by PAMPA-BBB assay | 2022 | European journal of medicinal chemistry, Jan-05, Volume: 227 | Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects. |
| AID237034 | Dissociation constant (pKa) was determined | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID198020 | Antibacterial activity was determined against gram positive organism, Streptococcus faecalis (MGH-2) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID1695811 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition zone at 1 mg/ml measured after overnight incubation by disc diffusion method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID529671 | Antimicrobial activity against azide-resistant Escherichia coli J53 by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli. |
| AID1695810 | Antibacterial activity against Staphylococcus aureus assessed as inhibition zone at 1 mg/ml measured after overnight incubation by disc diffusion method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID324245 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in stationary phase at 3 ug/ml after 5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1764064 | Antibacterial activity against Enterococcus faecalis assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID1890857 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID310532 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Synthesis and antimicrobial evaluation of guanylsulfonamides. |
| AID163921 | Minimum inhibition concentration in vitro determined against Pseudomona aeruginosa 5007 | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID396041 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pBGS18 plasmid by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID119719 | Serum concentration in mice, after oral administration at a dose of 50 mg/kg p.o. at 4 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID135327 | BBB penetration classification | 2000 | Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11 | Predicting blood-brain barrier permeation from three-dimensional molecular structure. |
| AID1368174 | Antibacterial activity against Staphylococcus aureus measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID1237617 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC510019 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1436577 | Antibacterial activity against Vibrio cholerae MTCC 3906 by broth microdilution assay method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives. |
| AID586738 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1907311 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID542139 | Antimicrobial activity against Salmonella enterica HN-GSS2006-142 by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID758160 | Antibacterial activity against Proteus vulgaris after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID279142 | Antibacterial activity against Streptococcus suis BB1013 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID1242650 | Antifungal activity against Aspergillus fumigatus after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID448694 | Antimicrobial activity against Streptococcus faecalis ATCC 14506 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID285629 | Antimicrobial activity against Pseudomonas aeruginosa 9B2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID519107 | Antibacterial activity against Proteus mirabilis B2 after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID1299592 | Bactericidal activity against Staphylococcus aureus RN4220 ATCC 35556 in stationary-phase assessed as reduction in bacterial burden at 4 times MIC99 after 4 hrs by time-kill assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID285574 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID66393 | The compound was tested for its antimicrobial activity against Enterobacter aerogenes ATCC 13048 (Ea) strain. | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID1237604 | Antibacterial activity against Staphylococcus epidermidis ATCC12228 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1455921 | Antibacterial activity against Bacillus amyloliquefaciens at 25 ug/ml after 24 hrs by plate colony counting method relative to control | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis and antibacterial activities of thiouracil derivatives containing acyl thiourea as SecA inhibitors. |
| AID279133 | Antibacterial activity against Streptococcus suis BB1004 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID1628388 | Antimicrobial activity against Micrococcus luteus ATCC 4698 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID267738 | Antibacterial activity against Escherichia coli ATCC 8739 by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID40940 | In vitro for antibacterial activity against Bacillus subtilis ATCC 585369 | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID1855816 | Antibacterial activity against Klebsiella pneumoniae measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID532039 | Antimicrobial activity against azide-resistant Escherichia coli DH5alpha TrfS008 harboring PMQR determinant qnrB23 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID40476 | Antibacterial activity against Bacillus megatherium | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID637214 | Antibacterial activity against Bacillus subtilis MTCC 2063 after 24 hrs by tube dilution method hrs followed by subculturing | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID1759537 | Antibacterial activity against Pseudomonas aeruginosa by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID573327 | Antimicrobial activity against Escherichia coli isolate GZ10 transconjugant harboring 16S rRNA methylase RmtB and qepA, aac(6')-Ib-cr gene by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1239965 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID523120 | Antimicrobial activity against tetracycline-resistant Escherichia coli AG102 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID585486 | Antibacterial activity against wild type Streptococcus pneumoniae R6 by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585683 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID324247 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in stationary phase at 3 ug/ml after 5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1850942 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID556755 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID759326 | Antibacterial activity against Staphylococcus aureus KCTC 503 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID603457 | Antibacterial activity against Streptococcus pneumoniae R6 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID621869 | Antibacterial activity against TolC deficient Escherichia coli 701 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID278109 | Bactericidal activity against Escherichia coli DM4100 in the presence of chloramphenicol | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID1769962 | Antibacterial activity against Escherichia coli ATCC25922 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID1415680 | Antibacterial activity against Proteus vulgaris ATCC 13315 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID1556545 | Antibacterial activity against methicillin resistant Staphylococcus aureus assessed as fold change after 16 serial passages at 0.5 times of MIC incubated for 12 hrs by sequential passaging method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID256237 | Serum effect on MIC against Staphylococcus aureus (Smith) as ratio of MIC value in presence and absence of 50% fetal calf serum | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID556694 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1551811 | Antibacterial activity against methicillin-resistant Staphylococcus aureus incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID762427 | Induction of Escherichia coli DNA gyrase-mediated pBR322 DNA cleavage at 5 to 20 uM after 30 mins by agarose gel electrophoresis | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Confirmation of quinolone-induced formation of gyrase-DNA conjugates using AFM. |
| AID324274 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in log phase at 3 ug/ml after 10 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1162138 | Antibacterial activity against Escherichia coli DH52 by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID1405069 | Antibacterial activity against Escherichia coli after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1765471 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID586642 | Antibacterial activity against Escherichia coli ATCC 25922 harboring GyrA S83L mutant and ParC S80R mutant by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID622559 | Antimicrobial activity against Bacillus subtilis MTCC 441 for 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. |
| AID1126757 | Antibacterial activity against drug-sensitive 1 ug/ml Mycobacterium tuberculosis clinical isolate 758 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID576024 | Activity of antiseptic efflux protein QacBIII expressed in Staphylococcus aureus RDN1 assessed as decrease in compound accumulation | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID1391378 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID534175 | Antimicrobial activity against armA positive Escherichia coli TOP10 producing beta lactamase CTX-M-3 with plasmid BEH by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID151050 | Minimum inhibitory concentration against Pseudomonas aeruginosa K690, measured in Muller-Hinton (MH) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID1765478 | Antibacterial activity against Escherichia coli ATCC 25922 by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID1404016 | Permeability of the compound by PAMPA | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. |
| AID584341 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID285637 | Antimicrobial activity against Pseudomonas aeruginosa 12B2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID69987 | Escherichia coli DNA cleavage endpoint value which is the minimum amount required (in micro g/mL) to induce detectable cleavage of supercoiled pBR322 substrate to linear form (gyrase) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID1352416 | Antibacterial activity against drug-resistant Escherichia coli after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID573305 | Antimicrobial activity against Escherichia coli isolate GZ13 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID603368 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID110153 | Percentage of mice with convulsion with compound alone at 400 mg/kg | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID586742 | Antibacterial activity against Escherichia coli ATCC 25922 harboring GyrA S83L mutant assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID523170 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC17042 harboring gyrA S84L/G106D, parC S80F and parE D732N mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID1299593 | Bactericidal activity against Pseudomonas aeruginosa PAO1 ATCC 47085 in exponential-phase assessed as reduction in bacterial burden at 4 times MIC99 upto 6 hrs by time-kill assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID1568812 | Permeability of the compound in pH 7.4 PBS/EtOH at 100 ug/ml by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID324186 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid PhoU at 0.5 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1413920 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID532036 | Antimicrobial activity against azide-resistant Escherichia coli J53 TrcS008 harboring PMQR determinant qnrB23 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID759327 | Antibacterial activity against Staphylococcus aureus KCTC 209 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID1413923 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID324278 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in log phase at 3 ug/ml after 10 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID548127 | Antibacterial activity against Staphylococcus aureus KCTC 503 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID285662 | Antimicrobial activity against Pseudomonas aeruginosa 22D2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556566 | Antimicrobial activity against ahpC gene-deficient Escherichia coli K-12 3200 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1360746 | Antibacterial activity against methicillin-resistant Staphylococcus aureus EMRSA16 by MTT dye based assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. |
| AID205581 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Staphylococcus epidermidis strain ATCC 12228 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID279129 | Antibacterial activity against Streptococcus suis ATCC 43765 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID530591 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr3 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID693708 | Antibacterial activity against Escherichia coli CCARM 1356 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID619395 | Cytotoxicity against human SH-SY5Y cells measured after overnight incubation by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID1585851 | Effective permeability of the compound by PAMPA | 2018 | Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24 | Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID523110 | Antimicrobial activity against Escherichia coli ATCC 10536 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID285648 | Antimicrobial activity against Pseudomonas aeruginosa 19B3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1600113 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis ATCC 13199 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID613568 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID1326655 | Antibacterial activity against Pseudomonas aeruginosa measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID1688664 | Antibacterial activity against multidrug resistant Staphylococcus aureus ATCC 43300 assessed as reduction in bacterial growth incubated for 1 day by paper disk diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID563503 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID775476 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1404017 | Permeability of the compound at 500 uM after 8 hrs by PAMPA | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. |
| AID1814303 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID295346 | Antibacterial activity against ciprofloxacin resistant methicillin resistant Staphylococcus aureus OC4159 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID556570 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 DKsodB after 2 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID405466 | Antibacterial activity against Escherichia coli TOP10 containing pIP1206 plasmid in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID205710 | Minimum inhibitory concentration tested against Staphylococcus aureus 1199-3 strain | 2003 | Bioorganic & medicinal chemistry letters, May-19, Volume: 13, Issue:10 | Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. |
| AID163962 | In vitro antibacterial activity against Pseudomonas aeruginosa IFO 3445 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID279132 | Antibacterial activity against Streptococcus suis BB1003 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID285601 | Antimicrobial activity against Pseudomonas aeruginosa 2A3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID510322 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID69663 | Minimum inhibitory concentration (MIC) of compound was measured on Escherichia coli H560 (gram negative organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID1557041 | Antibacterial activity against Escherichia coli incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID1585671 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID278111 | Bactericidal activity in Escherichia coli KD2750 containing gyrA resistant mutation in anerobic condition | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID532761 | Antimicrobial activity against Salmonella serovar Virchow 5742 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1890855 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID530050 | Antimicrobial activity against Staphylococcus aureus 286607-R1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1907309 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID565191 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 expressing open reading frame orf3 encoded efflux pump CraA by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. |
| AID1413915 | Antibacterial activity against methicillin resistant Staphylococcus aureus after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID603365 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OM481 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID585741 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated metV gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1809828 | Hemolytic activity in human RBC measured after 40 mins | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID572157 | Binding affinity to Neisseria gonorrhoeae FA19 multidrug efflux protein NorM expressed in Escherichia coli AG100AX in presence of 0.02% DDM surfactant by fluorescence polarization assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID771170 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID423081 | Antibacterial activity against 74_D9 allele containing Pseudomonas aeruginosa PAO1 H1105 mutant strain with lon::lux mutation assessed as fold decrease in MIC after 24 hrs by broth microdilution technique relative to wild type | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID1299580 | Antibacterial activity against Pseudomonas aeruginosa PAO1 ATCC 47085 incubated overnight by microbroth dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID1557281 | Antibacterial activity against Klebsiella by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID556563 | Antimicrobial activity against sodB gene-deficient Escherichia coli K-12 3145 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID266676 | Antibacterial activity against Escherichia coli | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 | Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives. |
| AID685405 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 clinical isolate after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID619382 | Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis A8 241 after 28 days by colony forming unit determination | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID556590 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 DK after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID133947 | In vivo activity against Pseudomonas aeruginosa (sc) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID285584 | Antimicrobial activity against Pseudomonas aeruginosa 65.33-3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID396037 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1310107 | Antibacterial activity against Bacillus proteus ATCC 13315 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID68989 | Concentration of compound needed to produce linear DNA at an intensity relative to oxolinic acid at 10 ug/mL was measured on Escherichia coli for gyrase-drug induced cleavage,. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID1666750 | Antibacterial activity against Escherichia coli by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID556655 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 10 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1433838 | Antibacterial activity against Salmonella typhi MTCC 98 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID436995 | Inhibition of human SK-MEL cell proliferation by MTT assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID1494122 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus NCTC 12981 after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID1688665 | Antibacterial activity against multidrug resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacterial growth incubated for 1 day by paper disk diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID324260 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in log phase at 3 ug/ml after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID523113 | Antimicrobial activity against Escherichia coli ATCC 8739 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID163580 | In vitro antibacterial activity against Proteus vulgaris OX-19 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1557040 | Antibacterial activity against Klebsiella pneumoniae incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID1303295 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID21488 | Solubility in citrate buffer (0.1 M) at 25 degree centigrade(pH 5) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID556589 | Bactericidal activity against Escherichia coli K-12 BW25113 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID586629 | Antibacterial activity against qnrS gene expressing Escherichia coli ATCC 25922 harboring ParC S80R mutant and pBK-QnrS1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID386836 | Antibacterial activity against Bacillus cirrhosis at 50 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID556568 | Antimicrobial activity against katE gene-deficient Escherichia coli K-12 3202 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID133951 | In vivo activity against Streptococcus pyogenes (sc) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID556658 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 13 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1688669 | Bactericidal activity against Staphylococcus aureus ATCC 33591 incubated for 24 hrs followed by transferring to freshly prepared broth medium and measured after 24 hrs by broth microdilution assay | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID112501 | In vivio inhibitory activity against Escherichia coli Juhl after subcutaneous administration in mice | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID425073 | Antimicrobial activity against Escherichia coli DH10B expressing pCR2.1 in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID556893 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 5 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID667563 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID227855 | In vitro antibacterial activity against staphylococcus epidermidis IAM 1296, (gram-positive) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID285599 | Antimicrobial activity against Pseudomonas aeruginosa 2A2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID119723 | Serum concentration of the liberated Norfloxacin after oral administration 100 mg/kg in mice after the 2.0 h | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID285589 | Antimicrobial activity against Pseudomonas aeruginosa 65.36-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285609 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID571884 | Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID1564348 | Antibacterial activity against Escherichia coli ATCC 8739 incubated for 24 hrs by resazurin dye based fluorimetric assay | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. |
| AID10958 | Compound was evaluated for Area under curve in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID573312 | Antimicrobial activity against Escherichia coli isolate CQ5 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1326649 | Antibacterial activity against Staphylococcus aureus ATCC 25923 measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID637225 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID762014 | Bactericidal activity against Bacillus cereus 8035 after 4 hrs | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID1237607 | Antibacterial activity against Proteus vulgaris ATCC49101 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID736328 | Antibacterial activity against Staphylococcus aureus RN4220 overexpressing MsrA macrolide efflux protein after 18 hrs by MTT assay | 2013 | Journal of natural products, Mar-22, Volume: 76, Issue:3 | Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. |
| AID285633 | Antimicrobial activity against Pseudomonas aeruginosa 10B1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID322317 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID342997 | Antibacterial activity against Staphylococcus aureus RN42209 expressing MsrA macrolide efflux pump after 18 hrs by MTT assay | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius. |
| AID164550 | In vitro antibacterial activity against Gram-negative Pseudomonas aeruginosa V-1. | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12 | Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids. |
| AID1870752 | Hemolytic activity in rabbit erythrocytes incubated for 1 hr | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16 | |
| AID1516027 | Antibacterial activity against Acinetobacter baumannii AB1902 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID559905 | Antimicrobial activity against Escherichia coli DH5alpha by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID753249 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1600102 | Bactericidal activity against Enterococcus hirae ATCC 1052 cultured in BHI medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID573323 | Antimicrobial activity against Escherichia coli isolate CQ6 transconjugant harboring 16S rRNA methylase RmtB and qepA, qnrS2, aac(6')-Ib-cr gene by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID604026 | Unbound CSF to plasma concentration ratio in human | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID637215 | Antibacterial activity against Escherichia coli MTCC 1652 after 24 hrs by tube dilution method hrs followed by subculturing | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID565325 | Antibacterial activity against Mycoplasma genitalium M6328 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID603463 | Inhibition of Escherichia coli DNA topoisomerase 4 subunit ParC/DNA topoisomerase 4 subunit ParE-mediated decatenation of kDNA by densitometry | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID565064 | Antibacterial activity against SHV-12 ESBL producing Enterobacter cloacae assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID448073 | Antibacterial activity against Ralstonia solanacearum at 50 mg/L after 24 hrs by agar well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID324248 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in log phase at 3 ug/ml after 5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID718545 | Antibacterial activity against multidrug-resistant Staphylococcus aureus CCARM 3506 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID30551 | Minimum inhibition concentration in vitro determined against Acinetobacter sp CMX669 | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID584328 | Antibacterial activity against gshB deficient Escherichia coli JW2914-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID497762 | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Calu3 cells in presence of 3 uM PSC-833 P-gp inhibitor | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. |
| AID573320 | Antimicrobial activity against Escherichia coli isolate GZ2 transconjugant harboring 16S rRNA methylase RmtB and qnrS1 by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID731201 | Antibacterial activity against Vibrio cholerae MTCC 3906 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | An efficient domino reaction in ionic liquid: synthesis and biological evaluation of some pyrano- and thiopyrano-fused heterocycles. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID509636 | Antibacterial activity against ampicillin sulfamethoxazole streptomycin kanamycin-resistant Escherichia coli isolate V6-9 carrying qnrB19 gene | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. |
| AID210401 | Minimum inhibition concentration in vitro determined against Streptococcus pyogenes 930 | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID556571 | Bactericidal activity against sodA gene-deficient Escherichia coli K-12 3144 at 0.4 ug/ml | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1335837 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID1455924 | Antibacterial activity against Bacillus amyloliquefaciens after 24 hrs by plate colony counting method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis and antibacterial activities of thiouracil derivatives containing acyl thiourea as SecA inhibitors. |
| AID1126753 | Antibacterial activity against duck Escherichia coli assessed as zone of inhibition at 2 ug/ml | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID544859 | Antibacterial activity against Streptococcus pneumoniae R6 Tr1 harboring parC Ser79Tyr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1759190 | Antibacterial activity against Pseudomonas aeruginosa by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID119717 | Serum concentration in mice, after oral administration at a dose of 50 mg/kg p.o. at 1 hr | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID623612 | Antibacterial activity against 10'8 CFU/mL Streptococcus pyogenes MTCC 442 by broth microdilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. |
| AID207405 | In vitro for antibacterial activity against Staphylococcus aureus 887 | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID573326 | Antimicrobial activity against Escherichia coli isolate CQ16 transconjugant harboring 16S rRNA methylase RmtB and qepA, qnrS2, aac(6')-Ib-cr gene by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1192730 | Permeability of the compound by PAMPA | 2015 | Bioorganic & medicinal chemistry, Feb-15, Volume: 23, Issue:4 | Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. |
| AID70103 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain DRCC 134 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1814308 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID202111 | In vivo efficacy (orally) against Streptococcus pyogenes C-203 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID209068 | Antibacterial activity against Strep. faecalis (2864) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1391379 | Antibacterial activity against Enterococcus faecalis after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID396040 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP3 plasmid containing Enterobacter aerogenes acrR gene by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1494126 | Antibacterial activity against Staphylococcus aureus EMRSA-15 after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID542507 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87 and parC I80, G84 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID586913 | Antibacterial activity against 5 x 10'5 CFU/ml epidemic methicillin-resistant Staphylococcus aureus EMRSA-15 after 18 hrs by MTT assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. |
| AID565322 | Antibacterial activity against Mycoplasma genitalium M6280 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID759322 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID1433837 | Antibacterial activity against Bacillus subtilis MTCC 441 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID1850945 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID1879461 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID532033 | Antimicrobial activity against Citrobacter werkmanii PS012 expressing PMQR determinant qnrB22 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID386840 | Antifungal activity against Aspergillus niger at 25 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID1486831 | Antifungal activity against Candida albicans MTCC 227 incubated for overnight by broth micro dilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. |
| AID1628392 | Antimicrobial activity against Candida albicans ATCC 76615 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID163435 | The compound was tested evaluated for its antimicrobial activity against Pseudomonas aeruginosa A5007 (Pa(5)) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID586641 | Antibacterial activity against Escherichia coli ATCC 25922 harboring GyrA S83L mutant by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID70101 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain DRCC 091 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1060938 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID586737 | Ratio of mutant prevention concentration to MIC for qnrS gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrS1 | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID201381 | In vitro antibacterial activity against Salmonella Typhimurium IID 971 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1303296 | Antimicrobial activity against Micrococcus luteus ATCC 4698 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID548132 | Antibacterial activity against Escherichia coli 1356 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID1820911 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID758165 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID529310 | Antimicrobial activity against Escherichia coli J53 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate. |
| AID561329 | Antimicrobial activity against azide-resistant Escherichia coli J53 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID532755 | Antimicrobial activity against Salmonella serovar Heidelberg 5171 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1516024 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1855818 | Antibacterial activity against Pseudomonas aeruginosa measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID405458 | Antibacterial activity against Escherichia coli C600Rif containing pIP1206 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID585426 | Antimicrobial activity against oqxAB positive Escherichia coli C600 X1B1-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1242641 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1504255 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate EMRSA-15 after 24 hrs by MTT dye based broth microdilution method | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis. |
| AID1820918 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID665061 | Antibacterial activity against Escherichia coli MTCC 443 after 24 hrs by micro-broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID556667 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 22 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID573309 | Antimicrobial activity against Escherichia coli isolate CQ15 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1820914 | Antibacterial activity against Escherichia coli assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID556684 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 11 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1352418 | Antibacterial activity against drug-resistant Pseudomonas aeruginosa after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID523004 | Antibacterial activity against uropathogenic Escherichia coli UTI89 assessed as degradation of preexisting biofilm after 24 hrs by microscopy | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID421762 | Antibacterial activity against Staphylococcus aureus EMRSA15 after 72 hrs | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3 | Bioactive pyridine-N-oxide disulfides from Allium stipitatum. |
| AID1652709 | Induction of Escherichia coli K12 MG1655 sulA promotor measured at 30 mins interval for 20 hrs by fluorescence assay relative to control | |||
| AID557083 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 harboring pDrive plasmid by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID770998 | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study. |
| AID369013 | Resistance of Staphylococcus aureus isolated from lactating Holstein bovine subclinical mastitis model at 5 ug/disk after 20 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Therapeutic effect of nisin Z on subclinical mastitis in lactating cows. |
| AID510328 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID585571 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated ompR gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID556891 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 3 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID56595 | Number of mice which show positive phototoxic reaction in 5 mice at subcutaneous dose | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID448693 | Antimicrobial activity against Staphylococcus aureus ATCC 11632 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. |
| AID556698 | Antimicrobial activity against multidrug resistant Escherichia coli ATCC 35218 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1210071 | Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID1481567 | Antibacterial activity against Bacillus typhi after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID255470 | Minimum inhibitory concentration against Bacillus subtilis | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. |
| AID1162161 | Binding affinity to calf thymus DNA by UV-vis spectroscopy | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID1281666 | Antibacterial activity against Bacillus proteus ATCC 13315 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID758163 | Antibacterial activity against Shigella dysenteriae after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID519113 | Antibacterial activity against Proteus mirabilis M 21 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID405460 | Antibacterial activity against Escherichia coli C600Rif containing pIP1206 plasmid in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID529160 | Antibacterial activity against Pseudomonas aeruginosa 100609 after 20 hrs by broth microdilution assay in presence of 250 ug/ml polyethylenimine | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID1383909 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID1688661 | Antibacterial activity against multidrug resistant Staphylococcus aureus ATCC 33591 assessed as diameter of inhibition zone at 0.5 mg/ml incubated for 24 hrs by agar diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID1889622 | Antibacterial activity against Staphylococcus aureus 25923 assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID1671802 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID1601844 | Antibacterial activity against Streptococcus pneumoniae CMCC 31968 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1600109 | Antibacterial activity against Proteus vulgaris NCTC 4635 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID529885 | Antibacterial activity against Staphylococcus aureus RN4220 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID621881 | Antibacterial activity against Burkholderia cepacia ATCC 55792 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1221962 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1060892 | Antibacterial activity against Bacillus typhi after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID70475 | In vivo protective dose was evaluated against Escherichia coli (51A266) in mouse(po) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID753245 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID119716 | Serum concentration in mice, after oral administration at a dose of 50 mg/kg p.o. at 0.5 hr | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID255576 | In vitro minimum inhibitory concentration against Methicillin-resistant Staphylococcus aureus upon incubation at 37 degree C for 16 to 24 hr by dissolving in DMSO (1%) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID1814310 | Antibacterial activity against Acinetobacter baumanii assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID405116 | Antimicrobial activity against Escherichia coli TOP10 harbouring pVS1 expressing quinolone resistant Vibrio splendidus 12B01 QnrVS1 gene | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID1585551 | Antibacterial activity against Proteus vulgaris after 24 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Benzofuran derivatives and their anti-tubercular, anti-bacterial activities. |
| AID504048 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 1688 by broth microdilution technique | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles. |
| AID542517 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, Y87, parC I80, G84 and parE A458 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID1726690 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID1091956 | Apparent hydrophobicity, log D of the compound in Octanol-buffer | 2011 | Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7 | Importance of physicochemical properties for the design of new pesticides. |
| AID1758084 | Antibacterial activity against Escherichia coli assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID1383913 | Antibacterial activity against Shigella dysenteriae after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID1855829 | Antibacterial activity against Pseudomonas aeruginosa assessed as fold increase in MIC measured after 16 passages by resistance development assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID324160 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 after 16 hrs by serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID534171 | Antimicrobial activity against beta lactamase CTX-M-14 producing Escherichia coli TOP10 harboring plasmid COP2 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID572518 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Typhimurium isolate s2705 harboring wild type ParC gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID758166 | Antibacterial activity against Bacillus subtilis after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID572515 | Antimicrobial activity against Salmonella enterica serovar Stanley isolate s2043 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID68183 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Enterobacter cloacae HA 2646 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID1765493 | Potentiation of(Z)-4-((bis(2-hydroxyethyl)amino)methyl)-7-((1-(4-methoxyphenyl)-3-oxo-3-(thiazol-2-yl)prop-1-en-2-yl)oxy)-2H-chromen-2-one-induced antibacterial activity against Klebsiella pneumoniae assessed as (Z)-4-((bis(2-hydroxyethyl)amino)methyl)-7- | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID1297668 | Bacteriostatic activity against Staphylococcus aureus 209p measured every 24 hrs for 5 days by broth dilution method | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID285605 | Antimicrobial activity against Pseudomonas aeruginosa 2F6 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1221978 | Transporter substrate index ratio of permeability from apical to basolateral side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1125398 | Antibacterial activity against Escherichia coli DH5alpha assessed as growth inhibition at 0.75 ug/ml after 16 hrs by spectrophotometric method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1530018 | Antibacterial activity against Staphylococcus aureus 1199 | 2019 | European journal of medicinal chemistry, Jan-01, Volume: 161 | Quinoline and quinolone dimers and their biological activities: An overview. |
| AID565323 | Antibacterial activity against Mycoplasma genitalium M6285 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1765469 | Antibacterial activity against Enterococcus faecalis by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID10729 | Area under the curve in concentration/ time | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1310082 | Cytotoxicity against human LO2 cells assessed as cell viability at 512 ug/mL after 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID535908 | Antibacterial activity against Escherichia coli ATCC 10536 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID133824 | In vivo activity against Escherichia coli (sc) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID260740 | Antibacterial activity against methicillin resistant Staphylococcus aureus MRSA 1094 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID285666 | Antimicrobial activity against Pseudomonas aeruginosa 22E3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1060894 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID556753 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 3145 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID572521 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Montevideo isolate s2209 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID200518 | In vitro antibacterial activity against Salmonella paratyphi 1015 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID1818889 | Induction of bacterial resistance in Escherichia coli assessed as fold increase in MIC measured after 16 days by resistance development assay | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID1430046 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 by broth microdilution method | |||
| AID1889627 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID1221976 | Transporter substrate index ratio of permeability from basolateral to apical side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID548129 | Antibacterial activity against Streptococcus mutans KCTC 3065 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID207161 | Antibacterial activity against Staphylococcus aureus GmR Meth (4310) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID563514 | Cellular uptake at Serratia marcescens ATCC 13880 at 50 ug/ml after 60 mins by spectrofluorometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID28832 | Solubility in bicarbonate buffer (0.05 M) at 25 degree centigrade(pH 8.5) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID386838 | Antifungal activity against Aspergillus niger at 100 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID1818870 | Antibacterial activity against Enterococcus faecalis assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID1758077 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID65381 | In vitro antibacterial activity against Enterococcus faecalis IID 682,Ec (N),(gram-positive) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID22111 | Concentrations in serum after 120 minutes at 50 mg / kg oral administration | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID561388 | Antibacterial activity against quinolone-susceptible Bordetella pertussis CCUG 30837 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID1352417 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID209569 | In vitro antibacterial activity against Streptococcus faecium ATCC 8043 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID369422 | Induction of Escherichia coli DNA gyrase-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage assessed as amount of linear DNA generated per unit amount of enzyme at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID448071 | Antibacterial activity against Erwinia aroideae at 50 mg/L after 24 hrs by agar well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID559902 | Antimicrobial activity against Escherichia coli TF-KO279 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID1516026 | Antibacterial activity against Acinetobacter baumannii AB1901 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1557288 | Antibacterial activity against Clostridium perfringens by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID285623 | Antimicrobial activity against Pseudomonas aeruginosa 8C4 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1759545 | Antibacterial activity against Escherichia coli ATCC 25922 measured after 6 passages by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID550176 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 15 after 18 hrs by MTT assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. |
| AID556756 | Bactericidal activity against ahpC gene-deficient Escherichia coli K-12 3200 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID534343 | Antimicrobial activity against Burkholderia pseudomallei Bp173 harboring mini-Tn7T after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID285642 | Antimicrobial activity against Pseudomonas aeruginosa 15G2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID223835 | In vitro antibacterial activity against Pseudomonas aeruginosa E-2,Pa(E),(gram-negative) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID434858 | Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID368419 | Antimicrobial activity against Escherichia coli KAM32 expressing deltaacrB ydhE hsd gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID397929 | Antimicrobial activity against Klebsiella pneumoniae at 512 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1879453 | Antibacterial activity against methicillin resistant Staphylococcus aureus N315 assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID163052 | Minimum inhibitory concentration against Providencia rettgeri. (M1771) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID397935 | Antimicrobial activity against Pseudomonas aeruginosa after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1401690 | Antibacterial activity against Bacillus typhi after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID362545 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 15 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID565321 | Antibacterial activity against Mycoplasma genitalium M6257 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID467611 | Dissociation constant, pKa of the compound | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID1601843 | Antibacterial activity against Streptococcus pyogenes CMCC 32067 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID1237616 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC515992 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1360743 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by MTT dye based assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. |
| AID586636 | Antibacterial activity against qnrA gene expressing Escherichia coli ATCC 25922 harboring ParC S80R mutant and pBK-QnrA1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID478529 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID151055 | In vitro antibacterial activity against Pseudomonas aeruginosa (A 9843) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID1600101 | Antibacterial activity against Enterococcus hirae ATCC 1052 cultured in BHI medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID556668 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 23 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID429854 | Antibacterial activity against Staphylococcus aureus EMRSA-15 after 24 hrs | 2009 | Journal of natural products, Jun, Volume: 72, Issue:6 | Antibacterial diterpenes from Plectranthus ernstii. |
| AID771000 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study. |
| AID523167 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC12501 assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID368418 | Antimicrobial activity against multidrug-resistant Escherichia coli C316 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID621884 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 to 18 hrs by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1242648 | Antifungal activity against Sporothrix schenckii after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID112793 | Compound was tested for antimicrobial activity in mice infected with Staphylococcus aureus smith. po | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1853134 | Effect on DNA damage repair in Caulobacter vibrioides expressing Gam-GFP reporter system assessed as increase in double stranded break by measuring Gam localization in cells at 25 to 50 ug/ml and measured after 2 hrs by fluorescence analysis | 2022 | RSC medicinal chemistry, Dec-14, Volume: 13, Issue:12 | Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage. |
| AID535697 | Antimicrobial activity against Azide-resistant Escherichia coli J53 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID585421 | Antimicrobial activity against oqxAB positive Escherichia coli C600 W322-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1759534 | Antibacterial activity against Klebsiella pneumonia by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID22116 | Total serum concentrations at 0 to 4 hours interval was determined by 50 mg / kg oral administration | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID285630 | Antimicrobial activity against Pseudomonas aeruginosa 9B5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID244930 | In vitro antibacterial activity against Streptococcus pneumoniae type III | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9 | Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent. |
| AID69782 | Antibacterial activity against Escherichia coli (H560) | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID150922 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 27853 measured in succinate (SC) liquid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID1310086 | Cytotoxicity against human LO2 cells assessed as reduction in cell viability at 256 ug/mL after 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID565312 | Antibacterial activity against Mycoplasma genitalium R32 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1759186 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID534340 | Antimicrobial activity against Burkholderia pseudomallei Bp50 harboring deleted (amrRAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID70800 | Minimum inhibition concentration in vitro determined against Escherichia coli juhl | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID1060889 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID759324 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID1889619 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID397934 | Antimicrobial activity against Staphylococcus aureus at 512 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID504049 | Antimicrobial activity against Staphylococcus aureus MTCC 96 by broth microdilution technique | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles. |
| AID556656 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 11 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1401685 | Antibacterial activity against Bacillus subtilis after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID285621 | Antimicrobial activity against Pseudomonas aeruginosa 8A2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1600115 | Antibacterial activity against Streptococcus pneumoniae cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1405071 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID556564 | Antimicrobial activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID70807 | In vitro antibacterial activity against Escherichia coli NHJ JC-2 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID572060 | Antibacterial activity against abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID1546133 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1546136 | Antimicrobial activity against Shigella dysenteriae after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID556665 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 20 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID137603 | Serum levels in Mice 0.5 hr after Oral administration of 50 mg/kg | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1671801 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID526302 | Antimicrobial activity against Staphylococcus aureus by agar plate disk diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives. |
| AID529456 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone A expressing beta-lactamase Oxa-48, TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID530051 | Antimicrobial activity against Staphylococcus aureus 286607-R1 harboring wild type gyrB by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1349982 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus RN4220 after 18 hrs by MTT based broth dilution assay | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. |
| AID1402338 | Antibacterial activity against Flavobacterium columnare FC-G1 after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID163216 | Antibacterial activity against Proteus vulgaris | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID572514 | Antimicrobial activity against Salmonella enterica serovar Corvallis isolate s2064 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID197880 | In vitro antibacterial activity against Staphylococcus aureus Smith (A9537) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID95885 | Antibacterial activity against Klebsiella pneumonia (MGH-2) | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID198343 | Tested in vitro against Staphylococcus aureus FDA209P JC-1 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID571883 | Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method in presence of 25 ug/ml efflux pump inhibitor CCCP | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID623615 | Antibacterial activity against 10'8 CFU/mL Klebsiella pneumoniae MTCC 109 by broth microdilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. |
| AID1726687 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID1601853 | Antibacterial activity against multidrug-resistant Escherichia coli ATCC BAA-196 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID450460 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Interaction of drug based binuclear mixed-ligand complexes with DNA. |
| AID743656 | Antibacterial activity against Escherichia coli EB2120 conditional lolA strain with lolA deletion and complementing copy placed at araBAD locus at 1 to 256 ug/mL after 18 hrs in presence of 0.00002 to 0.2% of arabinose | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. |
| AID1209593 | Dissociation constant, pKa of the acidic compound by capillary electrophoresis-mass spectrometry analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3 | Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. |
| AID324251 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in stationary phase at 3 ug/ml after 1 day | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID94133 | In vitro antibacterial activity against Klebsiella pneumoniae (A 9664) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID285672 | Antimicrobial activity against Pseudomonas aeruginosa 24E5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1335838 | Antibacterial activity against Bacillus typhi after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID208451 | Minimum inhibitory concentration (MIC) of compound was measured on Streptococcus pneumoniae SV-1(gram positive organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID260736 | Binding affinity to Bacillus subtilis DNA polymerase3C | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID523117 | Antimicrobial activity against Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID151056 | In vivo efficacy in systemic infection due to Pseudomonas aeruginosa (A 9843) in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID548324 | Antibacterial activity against Staphylococcus aureus MRSA CCARM 3167 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID1769950 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID70705 | Minimum inhibitory concentration (MIC) against gram negative bacteria Escherichia coli Vogel. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID430963 | Antibacterial activity against Escherichia coli 1608 containing gyrA L83, L87 mutants assessed as increase in MIC by Etest relative to MIC for wild type Escherichia coli 1609 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. |
| AID1850943 | Antibacterial activity against Klebsiella pneumoniae assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID1126756 | Antibacterial activity against drug-sensitive 1 ug/ml Mycobacterium tuberculosis clinical isolate 753 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID285586 | Antimicrobial activity against Pseudomonas aeruginosa 65.36-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID119724 | Serum concentration of the liberated Norfloxacin after oral administration 100 mg/kg in mice after the 4.0 h | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID1507048 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID1546132 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID572517 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Braenderup isolate s2856 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID1564354 | Antibacterial activity against Mycobacterium tuberculosis H37Ra ATCC 25177 incubated for 7 days by resazurin dye based fluorimetric assay | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. |
| AID1585850 | Effective permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA | 2018 | Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24 | Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
| AID584338 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID324162 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid PhoU after 16 hrs by serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID40943 | In vitro antibacterial activity against Bacillus subtilis ATCC 6633 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID68687 | In vitro antimicrobial activity against Escherichia coli was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID1628390 | Antimicrobial activity against Aspergillus flavus ATCC 204304 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1556535 | Antibacterial activity against Pseudomonas aeruginosa assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID585429 | Antimicrobial activity against Escherichia coli C600 ST2-T transconjugant harboring oqxAB, qnrB6 and aac(6')-Ib-cr genes by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID530347 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M carrying blaCTX-M-15 and pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID205709 | Minimum inhibitory concentration tested against Staphylococcus aureus 1199 strain | 2003 | Bioorganic & medicinal chemistry letters, May-19, Volume: 13, Issue:10 | Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. |
| AID1221972 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1294335 | Antibacterial activity against Salmonella typhi ATCC 19430 after 18 hrs by agar dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Synthesis and molecular modeling of antimicrobial active fluoroquinolone-pyrazine conjugates with amino acid linkers. |
| AID1571575 | Antimicrobial activity against Bacillus cereus ATCC 8035 measured every 24 hrs for 5 days by two-fold serial dilution method | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID1765470 | Antibacterial activity against Staphylococcus aureus by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID556579 | Bactericidal activity against katG,katE gene-deficient Escherichia coli K-12 3201 at 10 times MIC relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1628386 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID227851 | In vitro antibacterial activity against staphylococcus aureus IID 803,(gram-positive) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID604024 | Unbound brain to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID1820912 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID718544 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID561337 | Ratio of MIC for Klebsiella pneumoniae isolate 202 transconjugant to MIC for azide-resistant Escherichia coli J60 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1125390 | Antibacterial activity against Escherichia coli DH5alpha assessed as growth inhibition at 3 ug/ml after 16 hrs by spectrophotometric method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID267742 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 2 by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID556869 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 9 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID770999 | Antibacterial activity against Escherichia coli ATCC 8739 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study. |
| AID255471 | Minimum inhibitory concentration against Klebsiella pneumoniae | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. |
| AID64899 | In vitro for antibacterial activity against Escherichia coli 1527E (Ec(C)) | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID54107 | Minimum inhibitory concentration required to inhibit DNA gyrase supercoiling. | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID1769952 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 62202 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID561330 | Ratio of MIC for Enterobacter cloacae isolate 37 transconjugant to MIC for azide-resistant Escherichia coli J53 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID163281 | Minimum Inhibitory concentration measured against Pseudomonas aeruginosa ATCC 27853 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Synthesis and antibacterial activity of some novel 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents. |
| AID1507050 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID198174 | Antibacterial activity was determined against gram positive organism, Streptococcus pneumoniae (SV-1) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID285600 | Antimicrobial activity against Pseudomonas aeruginosa 2C2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID586917 | Antibacterial activity against 5 x 10'5 CFU/ml multi-drug-resistant Staphylococcus aureus XU212 expressing TetK tetracycline efflux protein after 18 hrs by MTT assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID1888884 | Up regulation of NorA gene expression in Staphylococcus aureus 1199B at 1.55 ug/ml measured after 2 hrs by qRT-PCR analysis relative to control | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID425074 | Antimicrobial activity against Escherichia coli DH10B in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID1430050 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 by broth microdilution method | |||
| AID1349584 | Antimicrobial activity against Acinetobacter baumannii after 24 hrs by two fold serial dilution method | |||
| AID209289 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Streptococcus pyogenes strain DRCC 092 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID619391 | Antimycobacterial activity against Mycobacterium kansasii CNTC 6509/96 after 14 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID1671806 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID208904 | Compound was tested for inhibition of the gram-negative organism Streptococcus aureus H228. | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID573318 | Antimicrobial activity against Escherichia coli isolate GZ7 transconjugant harboring 16S rRNA methylase RmtB and qepA and qnrS1 by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID573310 | Antimicrobial activity against Escherichia coli isolate CQ18 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID137609 | Serum levels in mice 2 hr after Oral administration of 50 mg/kg | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1126759 | Antibacterial activity against drug-sensitive 1 ug/ml Mycobacterium tuberculosis clinical isolate 821 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID1510768 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1125374 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as growth inhibition at 30 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1564349 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 incubated for 24 hrs by resazurin dye based fluorimetric assay | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. |
| AID559903 | Antimicrobial activity against Escherichia coli TF-KO281 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID497760 | Apparent permeability across apical to basolateral side in human Calu3 cells in presence of 3 uM PSC-833 P-gp inhibitor | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. |
| AID205946 | Minimum inhibitory concentration (MIC) against gram positive bacteria Streptococcus pyogenes C-203. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID279146 | Antibacterial activity against Streptococcus suis BB1017 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID209583 | Minimum inhibition concentration in vitro determined against Streptococcus faecium ATCC 8043 | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID1330194 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 3167 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID693707 | Antibacterial activity against Escherichia coli CCARM 1924 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID556881 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 21 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1688670 | Bactericidal activity against Escherichia coli ATCC BAA-196 incubated for 24 hrs followed by transferring to freshly prepared broth medium and measured after 24 hrs by broth microdilution assay | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID584344 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID693712 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID1304600 | Antibacterial activity against methicillin-resistant Staphylococcus aureus EMRSA-15 after 18 hrs by MTT assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3 | Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis. |
| AID572150 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBAD plasmid after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID70476 | In vivo protective dose was evaluated against Escherichia coli (51A266) in mouse(sc) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID1162136 | Antibacterial activity against Bacillus subtilis ATCC 6633 by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID556689 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 16 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1755823 | Antibacterial activity against Escherichia coli by microbroth dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID556864 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 4 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID324182 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid PhoU at 2 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID144301 | In vitro antimicrobial activity against Mycobacterium ranae was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID15176 | Concentration of liberated compound in serum after 60 min at the dose of 50 mg/kg (po). | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID621876 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID69470 | Minimum inhibitory concentration against Escherichia coli (vogel) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID565193 | Antimicrobial activity against efflux pump CraA deficient Acinetobacter baumannii JVAB01 receiving pJV103 harboring open reading frame orf3 encoded efflux pump CraA by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. |
| AID1740326 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 9253 assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID209122 | Anti-bacterial activity tested against Gram-positive SP1-1 bacterium | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. |
| AID1455925 | Antibacterial activity against Staphylococcus aureus after 24 hrs by plate colony counting method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis and antibacterial activities of thiouracil derivatives containing acyl thiourea as SecA inhibitors. |
| AID519110 | Antibacterial activity against Proteus mirabilis M 55 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID267737 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID324253 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in stationary phase at 3 ug/ml after 1 day | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID110152 | Percentage of mice with convulsion (400 mg/kg fenbufen) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1367039 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID1585677 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus planktonic biofilm assessed as optical density at 492 nm at MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID405925 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. |
| AID693711 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID208907 | Compound was tested for inhibition of the gram-negative organism Streptococcus aureus UC-76. | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID565324 | Antibacterial activity against Mycoplasma genitalium M6286 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1585672 | Antibacterial activity against methicillin-resistant Staphylococcus haemolyticus assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID1814312 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID70716 | Antibacterial activity against Escherichia coli TEM 2+ DC2 (4352) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID572512 | Antimicrobial activity against Salmonella enterica serovar Montevideo isolate s2317 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID556672 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 27 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1221975 | Transporter substrate index ratio of permeability from apical to basolateral side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1303293 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID1737529 | Antibacterial activity against Bacillus subtilis ATCC 6633 | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID324207 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid vector at 4 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID557079 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pDrive plasmid by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1060936 | Antimicrobial activity against Micrococcus luteus ATCC 4698 after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID63893 | Inhibitory activity against p9- (derivative of ATCC )13048 strain(Enterobacter aerogenes) in the presence of Norfloxacin and fluoroquinolone at 16 ug/mL | 2001 | Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23 | New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains. |
| AID1183260 | Antimicrobial activity against Vibrio cholerae MTCC 3906 assessed as absence of visible growth after 24 to 48 hrs by broth micro dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Design, synthesis and characterization of fluoro substituted novel pyrazolylpyrazolines scaffold and their pharmacological screening. |
| AID498789 | Antimicrobial activity against ciprofloxacin-susceptible Streptococcus pyogenes harboring Asp91/Asn mutation in parC gene assessed as 1 fold decrease in compound MIC by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID519252 | Antibacterial activity against Proteus mirabilis M 26 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID556666 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 21 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1430048 | Antibacterial activity against Escherichia coli ATCC 9637 by broth microdilution method | |||
| AID1242639 | Antibacterial activity against Escherichia coli ATCC 9637 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID133948 | In vivo activity against Streptococcus pneumoniae (po) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID585570 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated cspGp gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1336731 | Permeability of compound at 100 ug/ml after 18 hrs by PAMPA | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3 | Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID205712 | Minimum inhibitory concentration tested against methicillin resistant Staphylococcus aureus 494 strain (MRSA 494) | 2003 | Bioorganic & medicinal chemistry letters, May-19, Volume: 13, Issue:10 | Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. |
| AID563505 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 01 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID586731 | Ratio of mutant prevention concentration to MIC for Escherichia coli ATCC 25922 expressing qnrA gene and pBK-QnrA1 | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID556693 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pDrive plasmid expressing ampC gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID585431 | Antimicrobial activity against oqxAB positive Escherichia coli C600 D83-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1290444 | Antibacterial activity against Escherichia coli MTCC 443 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID1625123 | Permeability of the compound in pH 7.4 PBS at 200 uL after 18 hrs by PAMPA-BBB assay | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6 | Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities. |
| AID285597 | Antimicrobial activity against Pseudomonas aeruginosa 2A1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID542511 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83,N87,gyrB V456, parC I80 and parE A458 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID1517867 | Permeability of compound by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease. |
| AID576016 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2182-encoded QacBII gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID1737531 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1415681 | Antibacterial activity against Bacillus typhi after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID534166 | Antimicrobial activity against rmtB positive Escherichia coli VOG producing beta lactamase CTX-M-14 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID497757 | Apparent permeability across apical to basolateral side in human Calu3 cells | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. |
| AID560773 | Antibacterial activity against Staphylococcus aureus TS2921 harboring ddlA Asp102Asn mutation after 20 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. |
| AID288192 | Partition coefficient, log P of the compound | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | QSAR study on permeability of hydrophobic compounds with artificial membranes. |
| AID206209 | In vitro antibacterial activity against Staphylococcus epidermidis IAM 1296 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID324246 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in log phase at 3 ug/ml after 5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID530593 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr5 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID1221968 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID69664 | Minimum inhibitory concentration (MIC) of compound was measured on Escherichia coli Vogel(gram negative organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID585572 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated appA gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID220994 | In vitro antibacterial activity against klebsiella pneumoniae B54,Kp,(gram-negative) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID519125 | Antibacterial activity against Proteus mirabilis M 42 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID255565 | In vitro minimum inhibitory concentration against Bacillus subtilis upon incubation at 37 degree C for 16 to 24 h | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID436988 | Inhibition of human HeLa cell proliferation | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID585567 | Antibacterial activity against MarA-deficient Escherichia coli CR2000 after 20 hrs by Etest method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1524629 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID41564 | In vitro antibacterial activity against anaerobically grown Bacteroides vulgatus (78D029) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID1360744 | Antibacterial activity against Staphylococcus aureus RN4220 harboring MsrA macrolide efflux protein by MTT dye based assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. |
| AID1628387 | Antimicrobial activity against Bacillus subtilis ATCC 6633 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1290443 | Antibacterial activity against Vibrio cholerae MTCC 3906 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID565315 | Antibacterial activity against Mycoplasma genitalium TW48-5G by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID556663 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 18 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID556874 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 14 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID366953 | Antibacterial activity against Streptococcus faecalis ATCC 14506 after 18 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. |
| AID285578 | Antimicrobial activity against Pseudomonas aeruginosa P21.23 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID20678 | Serum level of compound (50 mg/kg) after 2.0 hr of peroral administration in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID285646 | Antimicrobial activity against Pseudomonas aeruginosa 16D5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1368175 | Antibacterial activity against Bacillus subtilis measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID1402339 | Antibacterial activity against Escherichia coli ATCC 35150 after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID542518 | Antimicrobial activity against Escherichia coli ATCC 25922 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. |
| AID747353 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID366957 | Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 after 18 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. |
| AID573322 | Antimicrobial activity against Escherichia coli isolate CQ13 transconjugant harboring 16S rRNA methylase RmtB and qnrS1 by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID718549 | Antibacterial activity against Staphylococcus aureus KCTC 209 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID1916102 | Induction of drug resistance in Staphylococcus aureus ATCC 29213 assessed as fold change in MIC measured after 19 passages by CLSI based broth dilution method | |||
| AID203331 | In vitro inhibition of growth of Serratia marcescens (IAM1184) | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1267221 | Antibacterial activity against Escherichia coli after 18 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties. |
| AID1888847 | Antibacterial activity against Staphylococcus aureus 1199 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID1405065 | Antibacterial activity against Enterococcus faecalis after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1557037 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID1917493 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID386839 | Antifungal activity against Aspergillus niger at 50 ug/mL after 48 hrs by cup-plate method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. |
| AID324191 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid vector at 0.1 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1281695 | Binding affinity to calf thymus DNA by UV-visible spectroscopy | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID1304596 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1199B over expressing NorA MDR efflux pump after 18 hrs by MTT assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3 | Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis. |
| AID572151 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomegaydhE plasmid containing Escherichia coli multidrug efflux pump YdhE after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID278104 | Bacteriostatic activity against Escherichia coli DM4100 in aerobic condition | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID586741 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrS gene and pBK-QnrS1 assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID750290 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID368915 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus effluxing isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus. |
| AID498783 | Antimicrobial activity against strong ciprofloxacin-resistant Streptococcus pyogenes assessed as 1 fold decrease in compound MIC by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID1179908 | Antimicrobial activity against Bacillus subtilis by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID501418 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. |
| AID1237611 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC425055 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID200850 | Antibacterial activity against Sal. Typhimurium (3860) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1546139 | Antifungal activity against Aspergillus flavus after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1889386 | Permeability of compound at 100 ug/mL by PAMPA-BBB assay | 2022 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 60 | Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease. |
| AID423073 | Antibacterial activity against 63_H5 allele containing Pseudomonas aeruginosa PAO1 H1133 mutant strain with nfxB::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID603364 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID419588 | Antimicrobial activity against Escherichia coli after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. |
| AID665059 | Antibacterial activity against Salmonella typhi MTCC 98 after 24 hrs by micro-broth dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones. |
| AID1888848 | Antibacterial activity against Staphylococcus aureus K1758 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID1557068 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 at 0.5 times MIC measured after 6 to 16 passages | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID523171 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC11521 harboring gyrA S84L/S85P, parC E84G mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserp | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID285585 | Antimicrobial activity against Pseudomonas aeruginosa 65.33-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285626 | Antimicrobial activity against Pseudomonas aeruginosa 9A3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1243366 | Antimicrobial activity against Salmonella typhimurium ATCC 19430 incubated for 18 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies. |
| AID619385 | Antimycobacterial activity against Mycobacterium avium CNTC 330/88 after 14 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID1815189 | Induction of drug resistance in Staphylococcus aureus ATCC29213 assessed as reduction in bacterial growth at 0.5 times MIC measured after 24 hr | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria. |
| AID1546135 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two-fold broth serial dilution method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1125384 | Antibacterial activity against Bacillus subtilis 168 assessed as growth inhibition at 5 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID621885 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 16 to 18 hrs by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID523119 | Antimicrobial activity against tetracycline-resistant Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID405120 | Antimicrobial activity against Escherichia coli TOP10 harbouring p0 plasmid expressing pCR-BluntII-TOPO | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID586746 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1551813 | Antibacterial activity against Pseudomonas aeruginosa | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID1855815 | Antibacterial activity against Staphylococcus aureus ATCC 29213 measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID1740319 | Antimicrobial activity against Escherichia coli NCTC 11954 producing penicillinase assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID285202 | Antimicrobial activity against Escherichia coli M114 mutant with AG100 lon4::IS186 marR::IS2 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID556887 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 27 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID227415 | Fold reduction in minimum inhibitory concentration of antibiotic in presence of GG918 | 2004 | Bioorganic & medicinal chemistry letters, Feb-23, Volume: 14, Issue:4 | Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates. |
| AID1281661 | Antibacterial activity against Micrococcus luteus ATCC 4698 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID1740902 | Effective permeability of the compound at 200 uM incubated for 5 hrs by PAMPA based UPLC/MS analysis | |||
| AID556678 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 5 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1237608 | Antibacterial activity against Pseudomonas aeruginosa ATCC2785 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1557039 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID1210073 | Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID1895487 | Antibacterial activity against methicillin resistant Staphylococcus aureus incubated for 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic access to thiolane-based therapeutics and biological activity studies. |
| AID369249 | Increase in ompX-lacZ expression in Escherichia coli deltaompX mutant assessed as increase in beta-galactosidase activity after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID1759187 | Antibacterial activity against Klebsiella pneumonia by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID561332 | Ratio of MIC for Enterobacter cloacae isolate 153 transconjugant to MIC for azide-resistant Escherichia coli J55 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID133812 | Compound was evaluated for protective dose against the Escherichia coli vogel lethal infection following sc administration in mouse | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID744038 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID1917497 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1067072 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3167 after 20 hrs by two-fold serial dilution technique | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives. |
| AID1239960 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1726681 | Antibacterial activity against methicillin resistant Staphylococcus aureus assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID585742 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated yfdG gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID747356 | Antifungal activity against Saccharomyces cerevisiae by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID56591 | Days of the first positive reaction in depleted mice. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID259171 | Antibacterial activity against Escherichia coli ATCC 25922 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1 | Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. |
| AID441341 | Antibacterial activity against Staphylococcus aureus ATCC 29737 by turbidity method | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis of 6-aminomethyl derivatives of benzopyran-4-one with dual biological properties: anti-inflammatory-analgesic and antimicrobial. |
| AID556659 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 14 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1628389 | Antimicrobial activity against Candida utilis ATCC 9950 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID66736 | Antibacterial activity against Ent. cloacae P99- (2647) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1671804 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID423070 | Antibacterial activity against 16_G12 allele containing Pseudomonas aeruginosa PAO1 H1125 mutant strain with recG::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID1585574 | Antibacterial activity against Pseudomonas aeruginosa MTCC 424 assessed as zone of inhibition at 25 ug/ml by agar well diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Benzofuran derivatives and their anti-tubercular, anti-bacterial activities. |
| AID556653 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 8 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1126746 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID523249 | Antimicrobial activity against Enterobacter aerogenes EA3 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1524627 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID1124794 | Antimicrobial activity against Pseudomonas aeruginosa ATCC BAA-427 after 24 hrs by standard broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents. |
| AID576019 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID434855 | Antibacterial activity against multidrug-resistant Streptococcus agalactiae after 20 hrs by cylinder and well method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID405121 | Antimicrobial activity against Escherichia coli TOP10 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID1272236 | Antibacterial activity against Pseudomonas aeruginosa by broth micro-dilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors. |
| AID1367034 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID530346 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M plasmid carrying blaCTX-M-15 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID70715 | Antibacterial activity against Escherichia coli TEM 2+ (4351) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1402342 | Bactericidal activity against Flavobacterium columnare FC-G1 incubated for 24 hrs followed by re-plating on nutrient agar and measured after overnight incubation by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID509635 | Antibacterial activity against tetracycline trimethoprim sulfamethoxazole kanamycin-resistant Escherichia coli isolate C14-9 carrying qnrB19 gene | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. |
| AID1498752 | Antibacterial activity against Bacillus subtilis after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID775478 | Antibacterial activity against Bacillus cereus ATCC 14579 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID604022 | Fraction unbound in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID1818872 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID70102 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Escherichia coli strain DRCC 133 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID584340 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID151670 | Minimum inhibition concentration against Pseudomonas aeruginosa U-31 strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1850947 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID589360 | Antibacterial activity against methicillin- resistant Staphylococcus aureus ATCC 25923 after 24 hrs by spectrophotometry | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus. |
| AID1402345 | Bactericidal activity against Staphylococcus aureus ATCC 29213 incubated for 24 hrs followed by re-plating on nutrient agar and measured after overnight incubation by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID1653162 | Cytotoxicity against human EJ cells assessed as reduction in cell viability by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Quinolone hybrids and their anti-cancer activities: An overview. |
| AID405115 | Antimicrobial activity against Vibrio splendidus LGP32 expressing plasmid-mediated QnrS-like quinolone resistance determinants | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID519112 | Antibacterial activity against Proteus mirabilis M 19 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID1436078 | Permeability of compound at 100 ug/ml after 18 hrs by PAMPA | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. |
| AID151536 | Tested in vitro against Pseudomonas aeruginosa IFO3445 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID369616 | Effect on ompF-lacZ fusion translation in ompX-negative Escherichia coli mutant assessed as percent decrease in Miller units of beta-galactosidase activity after 90 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID572525 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Corvallis isolate s2017 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID255473 | Minimum inhibitory concentration against Staphylococcus aureus | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. |
| AID1436572 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 by broth microdilution assay method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives. |
| AID1524628 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by microtiter ELISA | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents. |
| AID285663 | Antimicrobial activity against Pseudomonas aeruginosa 22D6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID133761 | Maximum tolerance dose was measured for phototoxic skin reaction by po administration | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID151373 | Antibacterial activity was determined against gram negative organism, Providencia rettgeri. (M1771) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID544838 | Antibacterial activity against Streptococcus pneumoniae U2A1266 harboring gyrA Ser81Cys mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID206916 | In vitro antimicrobial activity against Staphylococcus aureus (methicillin-resistant) was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID556691 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pDrive plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1740322 | Antimicrobial activity against fluoroquinolone-resistant Escherichia coli assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1557280 | Antibacterial activity against Pseudomonas aeruginosa by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID1415675 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID662989 | Antibacterial activity against Bacillus subtilis MTCC 441 by macrobroth dilution assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID767453 | Antibacterial activity against Pseudomonas aeruginosa by disc diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections. |
| AID585735 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated recD gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1850941 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID556894 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 6 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID556866 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 6 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID21514 | Solubility in water at 25 degree Centigrade | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID718550 | Antibacterial activity against Staphylococcus aureus RN 4220 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID532581 | Antimicrobial activity against Salmonella serovar Typhimurium LT2 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1162140 | Antibacterial activity against Eberthella typhosa by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID209567 | In vitro antibacterial activity against Streptococcus faecium ATCC 8043 | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID369250 | Increase in ompX-lacZ expression in Escherichia coli JM109 assessed as ompX upregulation after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID70418 | In vitro antibacterial activity against Escherichia coli Juhl | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID285573 | Antimicrobial activity against Pseudomonas aeruginosa P21.21 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID227850 | In vitro antibacterial activity against staphylococcus aureus FDA 209P JC-1,Sa(F)(gram-positive) | 1992 | Journal of medicinal chemistry, Jan, Volume: 35, Issue:1 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. |
| AID1666753 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID1666761 | Antibacterial activity against Enterococcus faecalis measured after 16 passages by microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID572158 | Binding affinity to Escherichia coli K-12 multidrug efflux protein YdhE expressed in Escherichia coli AG100AX in presence of 0.02% DDM surfactant by fluorescence polarization assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID666958 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID556897 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 9 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1310074 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID369620 | Effect on ompF-lacZ fusion translation in wild type Escherichia coli AG100 assessed as percent decrease in Miller units of beta-galactosidase activity after 120 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID1162134 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID1494121 | Antibacterial activity against Bacillus subtilis NCTC 10400 after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID1530019 | Antibacterial activity against Staphylococcus aureus 1199-3 | 2019 | European journal of medicinal chemistry, Jan-01, Volume: 161 | Quinoline and quinolone dimers and their biological activities: An overview. |
| AID586730 | Ratio of mutant prevention concentration to MIC for Escherichia coli ATCC 25922 | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1585693 | Antibacterial activity against Escherichia coli NCTC 10418 infected in po dosed CF mouse measured after 1 week | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Fluoroquinolone-isatin hybrids and their biological activities. |
| AID1510719 | Antibacterial activity against Bacillus subtilis PTCC 1023 after 18 hrs by two fold serial dilution | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1855817 | Antibacterial activity against Escherichia coli measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID405464 | Antibacterial activity against Escherichia coli TOP10 containing pIP1206 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID556669 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 24 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID563508 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID573298 | Antimicrobial activity against Escherichia coli isolate GZ4 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID70801 | The compound was tested for its antimicrobial activity against Escherichia coli juhl (Ec) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID609222 | Antibacterial activity against 10'5 CFU/mL Escherichia coli 1682 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID548126 | Antibacterial activity against Staphylococcus aureus RN 4220 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID674910 | Antibacterial activity against Streptococcus pyogenes MTCC 442 | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives. |
| AID767452 | Antibacterial activity against Salmonella typhi by disc diffusion method | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections. |
| AID585428 | Antimicrobial activity against oqxAB positive Escherichia coli C600 SW8-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID498785 | Antimicrobial activity against mild ciprofloxacin-resistant Streptococcus pyogenes at 10 ug by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID1297670 | Bactericidal activity against Staphylococcus aureus 209p incubated for 4 hrs | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID759323 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID208764 | Dose required to protect 50% of mice from lethal infection was measured on Streptococcus pneumoniae SV-1(peroral administration) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID267735 | Antibacterial activity against Staphylococcus aureus ATCC 6538p by agar-dilution method | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. |
| AID736329 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by MTT assay | 2013 | Journal of natural products, Mar-22, Volume: 76, Issue:3 | Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. |
| AID1261214 | Bacteriostatic activity against Staphylococcus aureus Mu50 after 24 hrs | 2015 | Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21 | Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus. |
| AID430964 | Antibacterial activity against Escherichia coli 1596 containing gyrA L83 and parC I80, G84 mutants assessed as increase in MIC by Etest relative to MIC for Escherichia coli 1608 containing gyrA mutant | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. |
| AID556696 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pDrive plasmid expressing ampC gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1126668 | Antibacterial activity against Clostridium tetani MTCC 449 assessed as growth inhibition after 24 to 48 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, characterization and pharmacological screening of some novel 5-imidazopyrazole incorporated polyhydroquinoline derivatives. |
| AID1888892 | Bactericidal activity against Staphylococcus aureus 1199B infected in human THP-1 cells assessed as reduction in bacterial count at 0.015 to 8 ug/ml measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID1759185 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID324267 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in stationary phase at 3 ug/ml after 5 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID131700 | Effective dose against Escherichia coli KC14 strain in mouse | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1585670 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID685404 | Antibacterial activity against Escherichia coli CCARM 1356 after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID565192 | Antimicrobial activity against Acinetobacter baumannii JVAB01 expressing disrupted open reading frame orf3 mutant deficient in efflux pump CraA by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. |
| AID1126667 | Antibacterial activity against Bacillus subtilis MTCC 441 assessed as growth inhibition after 24 to 48 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, characterization and pharmacological screening of some novel 5-imidazopyrazole incorporated polyhydroquinoline derivatives. |
| AID1571574 | Antimicrobial activity against Staphylococcus aureus 209p measured every 24 hrs for 5 days by two-fold serial dilution method | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID198156 | In vitro minimum inhibitory concentration (MIC) against Serratia marcescens A 20019 at 37 degrees C for 18 hr | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID209763 | Minimum inhibitory concentration against Streptococcus pyogenes (C203). | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID544831 | Antibacterial activity against Streptococcus pneumoniae CIP104485 by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1303294 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID380474 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by standard microdilution method | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Polyacylated oligosaccharides from medicinal Mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus. |
| AID1576577 | Effective permeability of compound incubated for 8 hrs by PAMPA | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12 | Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. |
| AID586747 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrA gene and pBK-QnrA1 assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1352419 | Antibacterial activity against drug-resistant Klebsiella pneumoniae after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID556683 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 10 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID586744 | Antibacterial activity against qnrB gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrB1 assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1600098 | Bactericidal activity against methicillin resistant Staphylococcus aureus N315 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1517838 | Permeability of the compound in pH 7.4 PBS/EtOH at 25 ug/ml after 18 hrs by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease. |
| AID1653065 | In vivo antibacterial activity against Escherichia coli infected in po dosed mouse | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID1237605 | Antibacterial activity against Bacillus subtilis ATCC6633 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID244878 | In vitro antibacterial activity against Staphylococcus aureus Smith | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9 | Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent. |
| AID544858 | Antibacterial activity against Streptococcus pneumoniae H548 clinical isolate harboring gyrA Ser81Phe mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID556888 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae ATCC 11296 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID609223 | Antibacterial activity against 10'5 CFU/mL methicillin-resistant Staphylococcus aureus CCARM 3167 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID1360742 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate XU212 harboring TetK tetracycline efflux pump by MTT dye based assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. |
| AID1405064 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID369261 | Effect on ompF-lacZ fusion transcription in ompX-negative Escherichia coli mutant assessed as percent decrease in Miller units of beta-galactosidase activity after 120 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID584329 | Antibacterial activity against gspS deficient Escherichia coli JW2956-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1126752 | Antibacterial activity against Escherichia coli assessed as zone of inhibition at 2 ug/ml | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID1162132 | Antibacterial activity against Streptococcus pneumoniae by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID1507055 | Antibacterial activity against Bacillus typhi after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID1326656 | Antibacterial activity against Salmonella typhi measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID1304599 | Antibacterial activity against MsrA macrolide-resistant Staphylococcus aureus RN4220 after 18 hrs by MTT assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3 | Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis. |
| AID405465 | Antibacterial activity against Escherichia coli TOP10 containing pIP1206 plasmid in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1571577 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 9027 measured every 24 hrs for 5 days by two-fold serial dilution method | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID209076 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Streptococcus faecalis strain ATCC 49384 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1409895 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by two-fold serial dilution method | |||
| AID542516 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, Y87 and parC I80, G84 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID544852 | Antibacterial activity against Streptococcus pneumoniae CP1000 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID573324 | Antimicrobial activity against Escherichia coli isolate CQ7 transconjugant harboring 16S rRNA methylase RmtB and qepA, qnrS2, aac(6')-Ib-cr gene by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID556581 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 at 10 times MIC pretreated with 250 uM bipyridyl relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID716255 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID667565 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID758164 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID200231 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus (UC76) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID1299579 | Antibacterial activity against Staphylococcus aureus RN4220 ATCC 35556 incubated overnight by microbroth dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID1437174 | Permeability of the compound in PBS/EtOH at 100 ug/ml after 18 hrs by PAMPA | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. |
| AID1427528 | Permeability of the compound at 100 ug/ml after 18 hrs by PAMPA | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. |
| AID164385 | Antibacterial activity against Pseudomonas aeruginosa (UI-18) | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID425069 | Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae M7943 bearing qnrB10 gene with aac(6)-Ib-cr-blaOXA-30 catB3-arr-3 integron in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID1290441 | Antibacterial activity against Bacillus subtilis MTCC 441 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID1862975 | Antibacterial activity against Staphylococcus aureus ATCC 43300 assessed as resistance development by measuring fold increase in MIC | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents. |
| AID57389 | Minimum inhibitory concentration against Escherichia coli DNA-gyrase supercoiling assay | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID781329 | pKa (acid-base dissociation constant) as determined by other workers | 2014 | Pharmaceutical research, Apr, Volume: 31, Issue:4 | Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. |
| AID1600099 | Antibacterial activity against Staphylococcus epidermidis ATCC 14990 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID423072 | Antibacterial activity against 70_H3 allele containing Pseudomonas aeruginosa PAO1 H1129 mutant strain with rnt::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID1383915 | Antibacterial activity against Salmonella typhi after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID164381 | Antibacterial activity against Ps. aeruginosa (2835) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID534173 | Antimicrobial activity against armA positive Escherichia coli TOP10 producing beta lactamase CTX-M-3 with plasmid MEZ by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID95531 | Minimum inhibitory concentration (MIC) against gram negative bacteria Klebsiella pneumoniae MGH-2. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1310081 | Cytotoxicity against rat PC12 cells assessed as cell viability at 512 ug/mL after 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID285204 | Antimicrobial activity against Escherichia coli AG112 mutant with AG100 marR genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID674908 | Antibacterial activity against Bacillus subtilis MTCC 441 | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives. |
| AID557076 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes ATCC 15038 harboring pACM204 plasmid by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID530345 | Antimicrobial activity against Escherichia coli BicA expressing blaTEM-1, blaCTX-M-15 and qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID572511 | Antimicrobial activity against Salmonella enterica serovar Typhimurium isolate s2878 harboring wild type ParC gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID530595 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr7 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID1784750 | Permeability coefficient of the compound in PBS buffer incubated for 5 hrs by PAMPA-based LC-MS analysis | 2021 | European journal of medicinal chemistry, Dec-05, Volume: 225 | Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT |
| AID1242649 | Antifungal activity against Trichophyton mentagrophytes after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID542500 | Antimicrobial activity against Escherichia coli K-12 harboring by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID1221957 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID556679 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 6 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID369258 | Effect on ompF-lacZ fusion transcription in wild type Escherichia coli MC1061 assessed as percent decrease in Miller units of beta-galactosidase activity after 120 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID1183258 | Antimicrobial activity against Escherichia coli MTCC 443 assessed as absence of visible growth after 24 to 48 hrs by broth micro dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Design, synthesis and characterization of fluoro substituted novel pyrazolylpyrazolines scaffold and their pharmacological screening. |
| AID1126745 | Antibacterial activity against Pseudomonas aeruginosa assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID207027 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Synthesis and antibacterial evaluation of certain quinolone derivatives. |
| AID1486832 | Antifungal activity against Aspergillus clavatus MTCC 1323 incubated for overnight by broth micro dilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. |
| AID573311 | Antimicrobial activity against Escherichia coli isolate CQ2 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID481439 | Absolute bioavailability in human | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID64233 | Effective dose of compound against Escherichia coli KC-14 in rats after oral administration | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1814304 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID1330195 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 3506 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID207772 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Staphylococcus aureus strain ATCC 33591 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID369614 | Effect on ompF-lacZ fusion translation in wild type Escherichia coli MC1061 assessed as percent decrease in Miller units of beta-galactosidase activity after 120 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID310533 | Antibacterial activity against Streptococcus faecalis ATCC 29212 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Synthesis and antimicrobial evaluation of guanylsulfonamides. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID775479 | Bactericidal activity against Staphylococcus aureus ATCC 6538 after 18 to 24 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID150916 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 15692 measured in Muller-Hinton (MH) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID534176 | Antimicrobial activity against armA positive Klebsiella pneumoniae DU producing beta lactamase CTX-M-3 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID548326 | Antibacterial activity against Staphylococcus aureus QRSA CCARM 3505 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID78687 | Lowest concentration necessary to induce DNA gyrase-mediated cleavage of DNA | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID1768864 | Antibacterial activity against Staphylococcus aureus SA-1199B overexpressing NorA incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 50 | Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach. |
| AID745308 | Antibacterial activity against Bacillus subtilis MTCC 441 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID1326651 | Antibacterial activity against Bacillus subtilis measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID434860 | Antibacterial activity against multidrug-resistant Escherichia coli after 20 hrs by cylinder and well method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID586753 | Antibacterial activity against qnrB gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrB1 assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1832297 | Resistance index, ratio of IC50 for antitumor activity against human MCF7 cells to IC50 for antitumour activity against dox resistant human MCF7/ADR cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents. |
| AID561314 | Antimicrobial activity against Enterobacter cloacae isolate 37 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1556533 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID575054 | Antibacterial activity against Vibrio cholerae O1 569B harboring gyrA and parC genes by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. |
| AID720952 | Antibacterial activity against Proteus vulgaris by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID1814307 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID556882 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 22 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1737530 | Antibacterial activity against Campylobacter coli JM 109 | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID572524 | Antimicrobial activity against qnrS-positive Salmonella enterica serovar Stanley isolate s2018 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID1740329 | Antifungal activity against Aspergillus flavus ATCC 9643 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID206685 | In vitro antimicrobial activity against Staphylococcus pneumoniae (erythromycin and ampicillin-resistant) was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID1281659 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID535910 | Antibacterial activity against Bacillus subtilis ATCC 60511 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID1060891 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID529669 | Antimicrobial activity against Escherichia coli R4525 expressing gyrA S83L and D87Y and parC S80I and E84G mutant gene by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli. |
| AID1221961 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1402340 | Antibacterial activity against Streptococcus agalactiae WB1445 after 24 hrs by two fold serial dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. |
| AID762012 | Bactericidal activity against Pseudomonas aeruginosa 9027 after 4 hrs | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID1415678 | Antibacterial activity against Shigella dysenteriae after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID544849 | Antibacterial activity against Streptococcus pneumoniae U2A1414 harboring gyrA Glu85Lys parC Ser79Phe mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID532038 | Antimicrobial activity against azide-resistant Escherichia coli DH5alpha TrfPS012 harboring PMQR determinant qnrB22 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID1907301 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID1556532 | Antibacterial activity against Klebsiella pneumoniae assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID423066 | Antibacterial activity against 24_A2 allele containing Pseudomonas aeruginosa PAO1 H1106 mutant strain with lon::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID586736 | Ratio of mutant prevention concentration to MIC for qnrB gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrB1 | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1368176 | Antibacterial activity against Escherichia coli measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID64076 | In vitro antibacterial activity against Escherichia coli (A 15119) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID285611 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID117062 | In vivo acute toxicity against Escherichia coli (KC-14) was determined for the compound administered intravenously | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID1758081 | Antibacterial activity against Enterococcus faecalis assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID544844 | Antibacterial activity against Streptococcus pneumoniae U2A1411 harboring parC Asp83Gly mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1310084 | Cytotoxicity against human LO2 cells assessed as reduction in cell viability at 128 ug/mL after 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID1758086 | Antibacterial activity against Pseudomonas aeruginosa assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID563506 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID609225 | Antibacterial activity against 10'5 CFU/mL quinolone-resistant Staphylococcus aureus CCARM 3505 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID244871 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2 | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9 | Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent. |
| AID423074 | Antibacterial activity against 75_F11 allele containing Pseudomonas aeruginosa PAO1 H1136 mutant strain with PA5455::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID762021 | Antibacterial activity against Staphylococcus aureus 209p measured every 24 hrs for 5 days by conventional dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID1401701 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 16 serial passages by two-fold serial dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID534342 | Antimicrobial activity against Burkholderia pseudomallei Bp58 harboring deleted bpeR::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID133805 | Antibacterial activity in mice after intraperitoneal administration with 0.5 mL of Escherichia coli Vogel inoculum | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9 | Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships. |
| AID1428539 | Antibacterial activity against Staphylococcus aureus at 25 ug/ml after overnight incubation by plate colony counting method relative to control | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors. |
| AID405469 | Antibacterial activity against Escherichia coli TOP10 containing pAT851 in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1391382 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID716249 | Antimicrobial activity against Pseudomonas aeruginosa by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID22115 | Concentrations in serum after 60 minutes at 50 mg / kg oral administration | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID585744 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated yniDp gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID324183 | Antibacterial activity against Escherichia coli K12 mutant JHU313 containing plasmid vector at 2 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID658544 | Antimycobacterial activity against Pseudomonas aeruginosa K767 after 24 hrs | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3 | Antibacterial acylphloroglucinols from Hypericum olympicum. |
| AID68850 | In vitro minimum inhibitory concentration against growth of Escherichia coli Vogel | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9 | Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships. |
| AID1272235 | Antibacterial activity against Escherichia coli by broth micro-dilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors. |
| AID623617 | Antibacterial activity against 10'8 CFU/mL Pseudomonas aeruginosa MTCC 1688 by broth microdilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. |
| AID119721 | Serum concentration of the liberated Norfloxacin after oral administration 100 mg/kg in mice after the 0.5 h | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID285634 | Antimicrobial activity against Pseudomonas aeruginosa 10B3 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID544837 | Antibacterial activity against Streptococcus pneumoniae U2A1051 harboring gyrA Ser81Tyr mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID68447 | Antibacterial activity against Edwardsiella tarda | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID436993 | Inhibition of human SW480 cell proliferation by MTT assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID64898 | In vitro for antibacterial activity against Escherichia coli 1346 (Ec(A)) | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID163554 | Tested in vitro against Proteus vulgaris OX-19 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID66734 | Antibacterial activity against Ent. cloacae 99+ (2646) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID67545 | Activity against Enterobacter aerogenes | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | Search compounds with antimicrobial activity by applying molecular topology to selected quinolones. |
| AID406844 | Antibacterial activity against Escherichia coli TOP10 by E-test | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Plasmid-mediated quinolone resistance determinant QnrB4 identified in France in an Enterobacter cloacae clinical isolate coexpressing a QnrS1 determinant. |
| AID556567 | Antimicrobial activity against katG,katE gene-deficient Escherichia coli K-12 3201 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID576112 | Antimicrobial activity against mecA-positive Staphylococcus sciuri harboring staphylococcus aureus mecA gene assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID206857 | Anti-bacterial activity was tested against Gram-positive SA-13 bacterium | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. |
| AID64394 | In vitro antibacterial activity against Enterobacter cloacae (A 9656) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID1498758 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID1818873 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID771178 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID285587 | Antimicrobial activity against Pseudomonas aeruginosa 65.36-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID324265 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in stationary phase at 3 ug/ml after 5 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID40925 | Tested in vitro against Bacillus subtilis ATCC 6633 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID198342 | Tested in vivo against Staphylococcus aureus IID803 in mice after peroral dose of drug with 0.5% sodium carboxy methyl cellulose | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID112791 | Compound was tested for antimicrobial activity in mice infected with Pseudomonas aeruginosa E2,po | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1348992 | Ratio of MIC for Staphylococcus aureus ATCC 29213 after 20 passages to MIC for Staphylococcus aureus ATCC 29213 before 20 passages | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antibacterial evaluation of novel cationic chalcone derivatives possessing broad spectrum antibacterial activity. |
| AID133763 | Maximum tolerance dose was measured for phototoxic skin reaction by sc administration | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID603458 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID397933 | Antimicrobial activity against Staphylococcus aureus at 128 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID434848 | Antibacterial activity against multidrug-resistant Streptococcus pyogenes after 20 hrs by cylinder and well method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID369260 | Effect on ompF-lacZ fusion transcription in ompX-negative Escherichia coli mutant assessed as percent decrease in Miller units of beta-galactosidase activity after 90 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID1726689 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID324254 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in log phase at 3 ug/ml after 1 day | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1666748 | Antibacterial activity against Enterococcus faecalis by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID1879454 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID667564 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID1820916 | Antibacterial activity against Acinetobacter baumannii assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID278106 | Bactericidal activity against Escherichia coli DM4100 in aerobic condition | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID532766 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph-pTRC hisA:ramA mutant by broth dilution method in presence of chlorpromzine | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID285618 | Antimicrobial activity against Pseudomonas aeruginosa 5F8 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID96082 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Klebsiella pneumoniae strain DRCC 136 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID96064 | Antibacterial activity against Klebsiella pneumoniae K1+ (4354) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1917491 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1391387 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1630580 | Antibacterial activity against multidrug resistant Escherichia coli 1137 after 24 hrs by two fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | Synthesis and antibacterial evaluation of hamacanthin B analogues. |
| AID295340 | Inhibition of bacterial DNA topoisomerase 4 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID561325 | Antimicrobial activity against Klebsiella pneumoniae isolate 135 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1067069 | Antimicrobial activity against quinolone-resistant Staphylococcus aureus clinical isolate 3519 after 20 hrs by two-fold serial dilution technique | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives. |
| AID1428540 | Antibacterial activity against Bacillus subtilis at 25 ug/ml after overnight incubation by plate colony counting method relative to control | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors. |
| AID70411 | In vitro for antibacterial activity against Gram-negative Escherichia coli NIJH JC-2. | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12 | Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids. |
| AID1769960 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC49008 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID207153 | Antibacterial activity against Staphylococcus aureus (2868) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID63901 | In vitro minimum inhibitory concentration (MIC) against Enterobacter cloacae A 9656 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID1281662 | Antibacterial activity against Bacillus subtilis ATCC 6633 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID523133 | Antimicrobial activity against Enterobacter aerogenes EA27 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID542142 | Antimicrobial activity against Salmonella enterica HN-GSS-2007-057 by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID1737528 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2020 | European journal of medicinal chemistry, Jun-01, Volume: 195 | Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID745307 | Antibacterial activity against Clostridium tetani MTCC 449 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID69639 | Minimum inhibitory concentration against Escherichia coli | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods. |
| AID544853 | Antibacterial activity against Streptococcus pneumoniae R6 Tr6 harboring gyrA Ser81Phe mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1630579 | Antibacterial activity against methicillin resistant Staphylococcus aureus 3089 after 24 hrs by two fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20 | Synthesis and antibacterial evaluation of hamacanthin B analogues. |
| AID1297667 | Bacteriostatic activity against Bacillus cereus 8035 measured every 24 hrs for 5 days by broth dilution method | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID576015 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2396-encoded QacA gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID1765491 | Potentiation of (Z)-4-((bis(2-hydroxyethyl)amino)methyl)-7-((1-(4-methoxyphenyl)-3-oxo-3-(thiazol-2-yl)prop-1-en-2-yl)oxy)-2H-chromen-2-one-induced antibacterial activity against methicillin resistant Staphylococcus aureus N315 assessed as (Z)-4-((bis(2-h | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID1758087 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID1368748 | Antibacterial activity against Staphylococcus aureus MTCC 96 at 1 ug/ml under overnight incubation condition by paper disc method | 2018 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2 | Synthesis and biological evaluation of 1-amino isochromans from 2-bromoethyl benzaldehyde and amines in acid medium. |
| AID1352410 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID750276 | Antibacterial activity against Streptococcus pyogenes MTCC 442 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents. |
| AID369421 | Induction of Escherichia coli DNA topoisomerase 4-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage assessed as amount of linear DNA generated per unit amount of enzyme at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID260742 | Antibacterial activity against Enterococcus faecium 19434 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID603459 | Antibacterial activity against Escherichia coli K-12 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID490648 | Antibacterial activity against Escherichia coli at 50 ug after 48 hrs by agar well diffusion assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: inhibitory activity against bacteria and fungi. |
| AID519108 | Antibacterial activity against Proteus mirabilis M 44 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID64077 | In vivo efficacy in systemic infection due to Escherichia coli (A 15119) in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID1564350 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 incubated for 24 hrs by resazurin dye based fluorimetric assay | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. |
| AID150918 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 15692 measured in succinate (SC) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID494446 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 at 100 ug after 24 hrs by paper disc method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID207960 | In vitro antibacterial activity against Staphylococcus aureus ATCC 6538P | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID509634 | Antibacterial activity against ampicillin tetracycline trimethoprim sulfamethoxazole streptomycin-resistant Escherichia coli isolate Y6-7 carrying qnrB19 gene | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. |
| AID561393 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP112 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID621873 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID532765 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph-pTRC hisA:ramA mutant by broth dilution method in presence of IPTG | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID544854 | Antibacterial activity against Streptococcus pneumoniae U2A1686 harboring gyrA Glu85Lys mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID561395 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP115 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID544864 | Antibacterial activity against Streptococcus pneumoniae U2A1681 harboring parC Ser79Tyr Asp83Ala mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID434859 | Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa after 20 hrs by cylinder and well method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID556574 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 3145 after 2 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID66227 | In vitro for antibacterial activity against Enterobacter cloacae P99 | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8 | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. |
| AID542143 | Antimicrobial activity against Escherichia coli DH10B by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID1832282 | Cytotoxicity against human WH1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents. |
| AID771002 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study. |
| AID424879 | Antimicrobial activity against multidrug-resistant Enterobacter cloacae E705 bearing qnrB10 gene with aac(6)-IId-aadA1a integron in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID1435640 | Antibacterial activity against Escherichia coli after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors. |
| AID1445729 | Ratio of MIC for Staphylococcus aureus ATCC 29213 after 15 passages to MIC for Staphylococcus aureus ATCC 29213 | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA). |
| AID586638 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrB gene and pBK-QnrB1 by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID586916 | Antibacterial activity against 5 x 10'5 CFU/ml multi-drug-resistant Staphylococcus aureus SA1199B expressing NorA quinolone efflux protein after 18 hrs by MTT assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. |
| AID1759533 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID575056 | Antibacterial activity against Vibrio cholerae O1 mTn-321 harboring Ser to Ile mutation at 83 position in gyrA and parC genes by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. |
| AID206013 | Minimum inhibitory concentration (MIC) of compound was measured on Staphylococcus aureus UC-76(gram positive organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID1564353 | Antibacterial activity against Streptococcus pneumoniae ATCC BAA-334 incubated for 24 hrs by resazurin dye based fluorimetric assay | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. |
| AID1671795 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID556867 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 7 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID747348 | Antibacterial activity against Eberthella typhosa by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID530592 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr4 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID1671790 | Antibacterial activity against Klebsiella pneumoniae measured every 24 hrs after several passages by serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID285628 | Antimicrobial activity against Pseudomonas aeruginosa 9A10 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID523118 | Antimicrobial activity against tetracycline-resistant Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID207383 | Inhibition of growth of Staphylococcus aureus (FDA207PJC-1) after incubation at 37 degree Centigrade | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID366955 | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 after 18 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. |
| AID745306 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID1809818 | Antimicrobial activity against Pseudomonas aeruginosa ATCC BAA-427 assessed as inhibition of bacterial growth by broth dilution method | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID623613 | Antibacterial activity against 10'8 CFU/mL Staphylococcus aureus MTCC 96 by broth microdilution method | 2011 | European journal of medicinal chemistry, Nov, Volume: 46, Issue:11 | 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. |
| AID1281692 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 at MIC measured after 6 passages | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID544865 | Antibacterial activity against Streptococcus pneumoniae R6 Tr10 harboring gyrA Ser81Tyr parC Ser79Tyr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID259173 | Inhibition of DNA gyrase supercoiling in Escherichia coli ATCC 25922 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1 | Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. |
| AID450459 | Antibacterial activity against Serratia marcescens after 24 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Interaction of drug based binuclear mixed-ligand complexes with DNA. |
| AID1585654 | Antibacterial activity against methicillin-resistant Staphylococcus haemolyticus after overnight incubation by micro broth dilution analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID151535 | Tested in vitro against Pseudomonas aeruginosa E-2 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID436989 | Inhibition of human MCF7 cell proliferation by MTT assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID556646 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 1 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1889623 | Antibacterial activity against Staphylococcus aureus 29213 assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID495512 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4666 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID1367036 | Antibacterial activity against drug-resistant Escherichia coli after 24 hrs by micro broth dilution method | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. |
| AID1688662 | Antibacterial activity against multidrug resistant Escherichia coli ATCC BAA-196 assessed as diameter of inhibition zone at 0.5 mg/ml incubated for 24 hrs by agar diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID162778 | In vitro minimum inhibitory concentration against growth of Pseudomonas aeruginosa MGH-2 | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9 | Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships. |
| AID285192 | Antimicrobial activity against Escherichia coli M043 mutant with AG100 lon4::IS186 marR::IS2 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID1126750 | Antibacterial activity against Pseudomonas aeruginosa assessed as zone of inhibition at 2 ug/ml | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID450461 | Antibacterial activity against Escherichia coli after 24 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Interaction of drug based binuclear mixed-ligand complexes with DNA. |
| AID561398 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP99 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID369433 | Sensitivity ratio for induction of Escherichia coli DNA topoisomerase 4 over DNA gyrase-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID523130 | Antimicrobial activity against Enterobacter aerogenes EA298 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1726691 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID164382 | Antibacterial activity against Ps. aeruginosa (4279) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID162912 | Antibacterial activity against Prot. morganii SmR (2833) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID207175 | Antibacterial activity against Staphylococcus aureus (H228) | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID1436574 | Antibacterial activity against Clostridium tetani MTCC 449 by broth microdilution assay method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives. |
| AID380475 | Antimicrobial activity against TetK multidrug efflux pump possessing Staphylococcus aureus XU-212 by standard microdilution method | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Polyacylated oligosaccharides from medicinal Mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus. |
| AID285580 | Antimicrobial activity against Pseudomonas aeruginosa IC7 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1391380 | Antibacterial activity against Staphylococcus aureus after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID67685 | In vitro antibacterial activity against Enterobacter aerogenes ATCC 13048 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID497758 | Apparent permeability across basolateral to apical side in human Calu3 cells | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. |
| AID1688668 | Bactericidal activity against Staphylococcus aureus ATCC 43300 incubated for 24 hrs followed by transferring to freshly prepared broth medium and measured after 24 hrs by broth microdilution assay | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID1516022 | Antibacterial activity against Escherichia coli UB1005 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1060895 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID448076 | Antifungal activity against Valsa mali at 200 mg/L by plate growth rate method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID1917496 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID535694 | Antimicrobial activity against Azide-resistant Escherichia coli J53 transconjugant harboring Escherichia coli DH5alpha-5825 qnrB2 gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID369257 | Effect on ompF-lacZ fusion transcription in wild type Escherichia coli MC1061 assessed as percent decrease in Miller units of beta-galactosidase activity after 90 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID285625 | Antimicrobial activity against Pseudomonas aeruginosa 9A1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID163244 | In vitro antibacterial activity against Proteus vulgaris HX-19 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID1486830 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 1688 incubated for overnight by broth micro dilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. |
| AID70284 | Dose required to protect 50% of mice from lethal infection was measured on Escherichia coli vogel(peroral administration) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID69999 | The compound was tested for inhibition constant against DNA gyrase isolated from Escherichia coli | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID1391384 | Antibacterial activity against Escherichia coli after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1493766 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 after 18 hrs by agar dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates. |
| AID205964 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Staphylococcus aureus H228 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID1303297 | Antimicrobial activity against Escherichia coli DH52 after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID1769951 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 43300 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID207676 | Minimum inhibitory concentration (MIC) against Staphylococcus aureus 1199B; Range 50 - 6.3 ug/mL | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps. |
| AID716246 | Antimicrobial activity against Eberthella typhosa by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID1267220 | Antibacterial activity against Staphylococcus aureus after 18 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties. |
| AID1628385 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID342998 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 15 after 18 hrs by MTT assay | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius. |
| AID285193 | Antimicrobial activity against Escherichia coli M044 mutant with AG100 lon4::IS186 marR::IS genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID324252 | Antibacterial activity against Escherichia coli K12 containing PhoU mutant assessed as cell count in log phase at 3 ug/ml after 1 day | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID556861 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 1 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID534168 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid VOG2 expressing CTX-M-14 and AAC(6 )-Ib gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID534172 | Antimicrobial activity against armA positive Escherichia coli MEZ producing beta lactamase CTX-M-3 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID1201796 | Antibacterial activity against fluoroquinolone-resistant Staphylococcus aureus 1199B overexpressing NorA after 24 hrs by two fold microdilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: study of 6-substituted pyridine-3-boronic acid derivatives. |
| AID1335832 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID119729 | Serum concentration of the liberated Norfloxacin after oral administration (100 mg/kg) in mice after 2.0 hr | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID14009 | Urine conc 0-5 hours following 25 mg/kg dose | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID556673 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae ATCC 11296 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID556680 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 7 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID658533 | Antibacterial activity against Staphylococcus aureus SA-1199B overexpressing NorA MDR efflux pump after 24 hrs | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3 | Antibacterial acylphloroglucinols from Hypericum olympicum. |
| AID1765477 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID67076 | Antibacterial activity tested against vancomycin-resistant Enterococcus faecalis | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Synthesis and antibacterial evaluation of certain quinolone derivatives. |
| AID497756 | Distribution coefficient, log D of the compound | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. |
| AID1349583 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold serial dilution method | |||
| AID1221977 | Transporter substrate index of efflux ratio in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID498780 | Antimicrobial activity against strong ciprofloxacin-resistant Streptococcus pyogenes by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID163078 | Compound was tested for antimicrobial activity against Proteus vulgaris OX-19 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID206373 | The compound was tested in vitro for antibiotic activity against Staphylococcus faecium ATCC 8043 | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID556648 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 3 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285652 | Antimicrobial activity against Pseudomonas aeruginosa 19C7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID586732 | Ratio of mutant prevention concentration to MIC for Escherichia coli ATCC 25922 expressing qnrB gene and pBK-QnrB1 | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID585750 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated tolC gene assessed as MarA-mediated multidrug resistance level by measuring fold decrease in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1310106 | Antibacterial activity against Eberthella typhosa ATCC 14028 after 18 to 24 hrs | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID397918 | Antimicrobial activity against Pseudomonas aeruginosa at 128 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID556870 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 10 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID65221 | Minimum inhibition concentration against Escherichia coli NIHJ JC-2 strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID586743 | Antibacterial activity against qnrA gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrA1 assessed as earliest time required to resistant colonies visible one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID67536 | Antibacterial activity against Enterobacter | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID285636 | Antimicrobial activity against Pseudomonas aeruginosa 12A7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID495516 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii AYE by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID523127 | Antimicrobial activity against Enterobacter aerogenes EA289 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID542506 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87, parC I80 and parE A548 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID165215 | In vitro antimicrobial activity against Pseudomonas aeruginosa was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID556649 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 4 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285612 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1126747 | Antibacterial activity against Escherichia coli assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID556892 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 4 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID584330 | Antibacterial activity against ygiBC, yjfMC, gspS deficient Escherichia coli GD108 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID96067 | Antibacterial activity against Klebsiella pneumoniae | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1759531 | Antibacterial activity against Staphylococcus aureus by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID556754 | Bactericidal activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID324256 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in log phase at 3 ug/ml after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1290445 | Antifungal activity against Candida albicans MTCC 227 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID1402093 | Antibacterial activity against Staphylococcus aureus | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | 4-Quinolone derivatives and their activities against Gram positive pathogens. |
| AID184639 | Lethal dose of compound after peroral administration in rats | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID753244 | Antibacterial activity against Bacillus typhi after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID64063 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID285632 | Antimicrobial activity against Pseudomonas aeruginosa 10A9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1890872 | Induction of drug resistance in Enterococcus faecalis assessed as fold increase in MIC measured after 16 days by CLSI protocol based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID621877 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1094 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID343001 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 16 expressing mecA after 18 hrs by MTT assay | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius. |
| AID210028 | Antibacterial activity tested against ampicillin and erythromycin-resistant Streptococcus pneumoniae | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Synthesis and antibacterial evaluation of certain quinolone derivatives. |
| AID572059 | Antibacterial activity against Acinetobacter baumannii AC0037 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID207550 | Minimum inhibition concentration in vitro determined against Staphylococcus aureus ATCC 6538P | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID523001 | Cytotoxicity against human 5637 cells assessed as mild induction of cell death by trypan blue exclusion assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID556752 | Bactericidal activity against sodA gene-deficient Escherichia coli K-12 3144 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID295343 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID405456 | Antibacterial activity against Escherichia coli C600Rif in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID573301 | Antimicrobial activity against Escherichia coli isolate GZ8 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1243365 | Antimicrobial activity against Streptococcus pyogenes ATCC 19615 incubated for 18 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies. |
| AID1455926 | Antibacterial activity against Bacillus subtilis after 24 hrs by plate colony counting method | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis and antibacterial activities of thiouracil derivatives containing acyl thiourea as SecA inhibitors. |
| AID434856 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae after 20 hrs by cylinder and well method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID1764078 | Antibacterial activity against methicillin-resistant Staphylococcus aureus measured after 13 passages by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID542513 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, Y87 and parC K84 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID771174 | Antibacterial activity against Staphylococcus aureus XU212 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID1264447 | Permeability of the compound by PAMPA method | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. |
| AID278107 | Bactericidal activity against Escherichia coli DM4100 in saline | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID379740 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after 18 hrs by microtiter plate method | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). |
| AID1209592 | Dissociation constant, pKa of the basic compound by capillary electrophoresis-mass spectrometry analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3 | Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. |
| AID1888846 | Antibacterial activity against Staphylococcus aureus 1199B measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID529307 | Antimicrobial activity against QnrS2-negative Aeromonas veronii CECT 4258 harboring GyrA Ser83 and ParC Ser80 mutant gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate. |
| AID625495 | Antibacterial activity against Pseudoalteromonas sp. D41 assessed as growth inhibition at 10 uM up to 6 hrs by viability assay | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22 | Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: structure-activities relationships of polysubstituted triazoles. |
| AID1563962 | Antibacterial activity against methicillin resistant Staphylococcus aureus N 315 assessed as reduction in bacterial cell growth incubated for overnight by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1401687 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID1769958 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC48073 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID1671810 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID1335833 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID561328 | Antimicrobial activity against Klebsiella pneumoniae isolate 202 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID678911 | TP_TRANSPORTER: increase in Doxorubicin intracellular accumulation (Doxorubicin: 5 uM, Norfloxacin: 500 uM) in P388/ADR cells | 2002 | Clinical and experimental pharmacology & physiology, Mar, Volume: 29, Issue:3 | Possible involvement of P-glycoprotein in the biliary excretion of grepafloxacin. |
| AID150902 | In vitro minimum inhibitory concentration (MIC) against Pseudomonas aeruginosa A 9843 at 37 degree C for 18 h | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID478531 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID397939 | Octanol-phosphate buffer partition coefficient, log D at pH 7.4 by spectrophotometry | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID573300 | Antimicrobial activity against Escherichia coli isolate GZ6 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1695809 | Antibacterial activity against Bacillus subtilis assessed as inhibition zone at 1 mg/ml measured after overnight incubation by disc diffusion method | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID1557298 | Protein binding in human at 0.4 g, po bid | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID369431 | Induction of Staphylococcus aureus DNA topoisomerase 4 ParC S80L mutant-mediated Escherichia coli pBR322 DNA cleavage assessed as ratio of drug-induced DNA cleavage to spontaneous DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID1764073 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID544855 | Antibacterial activity against Streptococcus pneumoniae U2A1050 harboring gyrA Ser81Phe mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID565066 | Antibacterial activity against CTX-M-15 ESBL producing Escherichia coli assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID1091958 | Hydrophobicity, log P of the compound in octanol-water by shaking-flask method | 2011 | Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7 | Importance of physicochemical properties for the design of new pesticides. |
| AID70721 | Evaluated for minimum concentration needed to produce linear DNA at an intensity relative to oxolinic acid at 10 mg/mL. by gyrase mediated cleavage of DNA in Escherichia coli 560. | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID559898 | Antimicrobial activity against Klebsiella oxytoca KO281 harboring beta-lactamase OXY-1 and CMY-2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID396036 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID575057 | Antibacterial activity against Escherichia coli JM109 harboring plasmid ptac85 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. |
| AID222084 | Minimum inhibitory concentration as geometric mean calculated for the gram-negative enterobacteriaceae. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID1759538 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID1832286 | Antitumor activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents. |
| AID1304598 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after 18 hrs by MTT assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3 | Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis. |
| AID423068 | Antibacterial activity against 6_G1 allele containing Pseudomonas aeruginosa PAO1 H1121 mutant strain with PA4961::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID556757 | Bactericidal activity against katG,katE gene-deficient Escherichia coli K-12 3201 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID685401 | Antibacterial activity against Staphylococcus aureus KCTC 209 after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID560776 | Antibacterial activity against Staphylococcus aureus TS2921 harboring ddlA Asp102Asn mutation and coexpressing pSddlA which complements temperature sensitivity after 20 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. |
| AID621880 | Antibacterial activity against Burkholderia cepacia ATCC 39277 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID685402 | Antibacterial activity against Staphylococcus aureus KCTC 503 after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID91481 | Binding constant against human serum albumin (HSA) | 2001 | Journal of medicinal chemistry, Dec-06, Volume: 44, Issue:25 | Cheminformatic models to predict binding affinities to human serum albumin. |
| AID342996 | Antibacterial activity against Staphylococcus aureus 1199B overexpressing NorA efflux pump after 18 hrs by MTT assay | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius. |
| AID585488 | Antibacterial activity against wild type Streptococcus pneumoniae M4 NCTC 7465 type 1 by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID421758 | Antibacterial activity against Mycobacterium smegmatis mc2 2700 after 72 hrs | 2009 | Journal of natural products, Mar-27, Volume: 72, Issue:3 | Bioactive pyridine-N-oxide disulfides from Allium stipitatum. |
| AID1666746 | Antibacterial activity against Staphylococcus aureus by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID369430 | Induction of Escherichia coli DNA topoisomerase 4 ParC E48K mutant-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage assessed as amount of linear DNA generated per unit amount of enzyme at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID295348 | Antibacterial activity against ciprofloxacin resistant methicillin resistant Staphylococcus aureus OC5273 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID573317 | Antimicrobial activity against Escherichia coli isolate CQ14 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID163384 | In vitro antimicrobial activity against Proteus vulgaris was determined | 2000 | Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20 | Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives. |
| AID1297673 | Hemolytic activity against human RBC at 0.19 to 3.9 mg/L after 1 hr relative to control | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID585740 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated alx gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1653161 | Cytotoxicity against human A431 cells assessed as reduction in cell viability by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Quinolone hybrids and their anti-cancer activities: An overview. |
| AID726491 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA). |
| AID69668 | Minimum Inhibitory concentration measured against Escherichia coli ATCC 1-25922 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Synthesis and antibacterial activity of some novel 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents. |
| AID306326 | Antimicrobial activity against fluoroquinolone-resistant Staphylococcus aureus SA1199B | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. |
| AID244897 | In vitro antibacterial activity against Pseudomonas aeruginosa IID1210 | 2005 | Journal of medicinal chemistry, May-05, Volume: 48, Issue:9 | Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent. |
| AID1486829 | Antimicrobial activity against Escherichia coli MTCC 443 incubated for overnight by broth micro dilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. |
| AID544863 | Antibacterial activity against Streptococcus pneumoniae U2A1411 harboring parC Asp83Gly mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID206034 | Tested in vitro against Staphylococcus epidermidis IAM12896 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID535909 | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID1413916 | Antibacterial activity against Staphylococcus aureus after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID523002 | Cytotoxicity against human 5637 cells assessed as mild induction of cell death by LDH release assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID1510721 | Antibacterial activity against Escherichia coli ATCC 8739 after 18 hrs by two fold serial dilution | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID775473 | Bactericidal activity against Bacillus cereus ATCC 14579 after 18 to 24 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID161378 | Minimum inhibitory concentration (MIC) against gram negative bacteria Prot. rettgeri M-1771. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1177543 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus RN4220 assessed as absence of growth after 18 hrs by MTT assay | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. |
| AID556662 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 17 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1126666 | Antibacterial activity against Streptococcus pneumoniae MTCC 1936 assessed as growth inhibition after 24 to 48 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, characterization and pharmacological screening of some novel 5-imidazopyrazole incorporated polyhydroquinoline derivatives. |
| AID30422 | In vitro antibacterial activity against Acinetobacter species CMX669 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID556584 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 after 2 hrs pretreated with 100 mM thiourea relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1666754 | Antibacterial activity against Acinetobacter baumannii by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID164729 | Compound was tested in vitro for antibiotic activity against the bacteria Pseudomonas aeruginosa K799/WT | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID70862 | Compound was tested for inhibition of the gram-negative organism Escherichia cloacae HA 2646 | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID726492 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA). |
| AID1507053 | Antibacterial activity against Escherichia coli ATCC 8099 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID164268 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Pseudomonas rettgeri H1771 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID285607 | Antimicrobial activity against Pseudomonas aeruginosa 2A9 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID556652 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 7 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1177544 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus XU212 assessed as absence of growth after 18 hrs by MTT assay | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. |
| AID278108 | Bactericidal activity against Escherichia coli DM4100 in anaerobic condition | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID619384 | Selectivity index, ratio of IC50 for human HepG2 cells to MIC for multidrug-resistant Mycobacterium tuberculosis A8 241 | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID74853 | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25 | Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
| AID279140 | Antibacterial activity against Streptococcus suis BB1011 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID1067070 | Antimicrobial activity against quinolone-resistant Staphylococcus aureus clinical isolate 3505 after 20 hrs by two-fold serial dilution technique | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives. |
| AID22112 | Concentrations in serum after 240 minutes at 50 mg / kg oral administration | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID1814331 | Antibacterial activity against Pseudomonas aeruginosa assessed as drug resistance by measuring fold change in MIC treated for 16 serial passages and measured every 24 hrs | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID30271 | Compound was tested in vitro for antibiotic activity against the bacteria Acinetobacter sp. CMX669 | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID1879455 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID1600103 | Antibacterial activity against Bacillus subtilis ATCC 6633 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID207698 | In vitro antibacterial activity against Staphylococcus aureus FDA 2029P JC-1 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID285659 | Antimicrobial activity against Pseudomonas aeruginosa 19E9 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID542505 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87, parC I80 and parE M464 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID20676 | Serum level of compound (50 mg/kg) after 0.50 hr of peroral administration in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1870749 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16 | |
| AID1600117 | Antibacterial activity against Serratia marcescens ATCC 12795 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1242646 | Antifungal activity against Candida albicans after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1726685 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID576023 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV E377G mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID586912 | Antibacterial activity against 5 x 10'5 CFU/ml Staphylococcus aureus ATCC 25923 expressing TetK tetracycline efflux protein after 18 hrs by MTT assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. |
| AID164070 | Compound was tested for antimicrobial activity against Pseudomonas aeruginosa PAO1 | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID1820913 | Antibacterial activity against Klebsiella pneumoniae assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID203167 | Tested in vitro against Serratia marcescens IAM1184 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID519117 | Antibacterial activity against Proteus mirabilis M 29 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID534167 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid VOG1 expressing RmtB, TEM-1, and QepA gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID369613 | Effect on ompF-lacZ fusion translation in wild type Escherichia coli MC1061 assessed as percent decrease in Miller units of beta-galactosidase activity after 90 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID397919 | Antimicrobial activity against Pseudomonas aeruginosa at 512 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1765473 | Antibacterial activity against Klebsiella pneumonia by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID1551783 | Antibacterial activity against Staphylococcus aureus | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID203107 | Minimum inhibitory concentration (MIC) against gram positive bacteria Staphylococcus aureus UC-76. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1601846 | Antibacterial activity against Bacillus subtilis CMCC 63501 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID198317 | Antibacterial activity was determined against gram positive organism, Streptococcus pyogenes C203 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID163386 | In vitro inhibition of growth of Proteus vulgaris(OX-19) | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID30420 | The compound was tested for its antimicrobial activity against Acinetobacter sp. CMX 669 (A) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID550018 | Antibacterial activity against multi drug-resistant Staphylococcus aureus 1199B after 18 hrs by MTT assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. |
| AID96263 | In vitro antibacterial activity against Klebsiella pneumoniae PCI-602 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID550174 | Antibacterial activity against Staphylococcus aureus ATCC 25943 after 18 hrs by MTT assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. |
| AID324268 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in log phase at 3 ug/ml after 1 week | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID556904 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 16 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1600094 | Lipophilicity, log k of the compound at 100 ug/ml by micellar electrokinetic chromatography | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID464588 | Antibacterial activity against Proteus vulgaris ATCC 49027 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID70774 | In vivo antibacterial activity against Escherichia coli KC-14 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID495509 | Antibacterial activity against Acinetobacter baumannii BM4587 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID681772 | TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, Norfloxacin: 2000 uM) in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 290, Issue:2 | The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. |
| AID622562 | Antimicrobial activity against Escherichia coli MTCC 443 for 24 hrs by microdilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20 | Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. |
| AID285669 | Antimicrobial activity against Pseudomonas aeruginosa 24D5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID230840 | MIC ratio measured as the mean MICs of gram-positive bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID1571087 | Permeability of the compound by PAMPA | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11 | Search for a 5-CT alternative. |
| AID279145 | Antibacterial activity against Streptococcus suis BB1016 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID534346 | Antimicrobial activity against Burkholderia pseudomallei Bp207 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1462724 | Antimicrobial activity against Candida albicans MTCC 227 | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities. |
| AID362543 | Antibacterial activity against tetracycline-resistant Staphylococcus aureus XU212 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID1396071 | Dark toxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay | 2018 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 28, Issue:10 | Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria. |
| AID1557043 | Antibacterial activity against Acinetobacter baumannii incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. |
| AID498787 | Antimicrobial activity against ciprofloxacin-susceptible Streptococcus pyogenes harboring Asp91/Asn mutation in parC gene at 10 ug by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. |
| AID448072 | Antibacterial activity against Bacillus subtilis at 50 mg/L after 24 hrs by agar well diffusion method | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. |
| AID771173 | Antibacterial activity against Staphylococcus aureus RN4220 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID532760 | Antimicrobial activity against Salmonella serovar Newport 129 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID576025 | Activity of antiseptic efflux protein QacBIII expressed in Staphylococcus aureus RDN1 assessed as decrease in compound accumulation in presence of CCCP | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID1820908 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as bacterial growth inhibition measured after 24 hrs by two fold serial dilution technique | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID164533 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Pseudomonas aeruginosa strain MTCC 1688 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID561391 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP109 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID510323 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by micro-broth dilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. |
| AID561322 | Antimicrobial activity against Escherichia coli isolate 48 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID279130 | Antibacterial activity against Streptococcus suis BB1001 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID1334754 | Permeability of the compound at 25 ug/ml after 18 hrs by PAMPA assay | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. |
| AID1221958 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID163914 | In vivo efficacy (s.c.) against Pseudomonas aeruginosa in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID1537802 | Antibacterial activity against Staphylococcus aureus FDA 209P at sub-MIC by resistant development assay | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes. |
| AID548128 | Antibacterial activity against Staphylococcus aureus KCTC 209 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID1510760 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID556572 | Bactericidal activity against sodA gene-deficient Escherichia coli K-12 3144 after 2 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID523165 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC8525 harboring wild type quinolone resistance-determining region assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 u | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID445446 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. |
| AID1126749 | Antibacterial activity against Salmonella assessed as zone of inhibition at 2 ug/ml | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID1676002 | Permeability of the compound at 100 uM measured after 40 mins by PAMPA | |||
| AID71981 | Inhibition of [3H]muscimol binding to GABA A receptor with compound alone at 10 e-4 M | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID161920 | Antibacterial activity against Plesiomonas shigelloides | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID70569 | Compound was tested for inhibition of target enzyme DNA gyrase obtained from Escherichia coli H560 cells | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID521967 | Antibacterial activity against Campylobacter coli assessed as resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID604021 | Unbound volume of distribution in Sprague-Dawley rat brain measured per gram of brain tissue administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr b | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID521966 | Antibacterial activity against Campylobacter jejuni assessed as resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID621882 | Antibacterial activity against Escherichia coli ATCC 29425 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID1481564 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID478528 | Antimicrobial activity against Bacillus subtilis ATCC 60511 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID565065 | Antibacterial activity against CTX-M-14 ESBL producing Escherichia coli assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID285598 | Antimicrobial activity against Pseudomonas aeruginosa 2C1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID619390 | Antimycobacterial activity against Mycobacterium kansasii CNTC 6509/96 after 7 days | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID405930 | Antimicrobial activity against multidrug-resistant Staphylococcus aureus over expressing NorA MDR efflux pump | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. |
| AID434861 | Antibacterial activity against multidrug-resistant Escherichia coli broth after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID1199292 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 by broth macrodilution method | 2015 | Journal of medicinal chemistry, Jan-22, Volume: 58, Issue:2 | Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections. |
| AID1557296 | AUC in human at 0.4 g, po bid | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID1126671 | Antibacterial activity against Vibrio cholerae MTCC 3906 assessed as growth inhibition after 24 to 48 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, characterization and pharmacological screening of some novel 5-imidazopyrazole incorporated polyhydroquinoline derivatives. |
| AID747354 | Antibacterial activity against Micrococcus luteus ATCC 4698 by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID20675 | Serum level of compound (50 mg/kg) after 0.25 hr of peroral administration in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID762015 | Bactericidal activity against Staphylococcus aureus 209p after 4 hrs | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID1391385 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID1516028 | Antibacterial activity against Pseudomonas aeruginosa 25349 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID557078 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID285593 | Antimicrobial activity against Pseudomonas aeruginosa 65.38-4 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1511119 | Permeability of the compound at 25 ug/ml by PAMPA-BBB assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. |
| AID28851 | The compound was evaluated for the solubility in water at 25 degrees Centigrade | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1759191 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID1759530 | Antibacterial activity against Enterococcus faecalis by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID731205 | Antibacterial activity against Clostridium tetani MTCC 449 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | An efficient domino reaction in ionic liquid: synthesis and biological evaluation of some pyrano- and thiopyrano-fused heterocycles. |
| AID762022 | Antibacterial activity against Pseudomonas aeruginosa 9027 measured every 24 hrs for 5 days by conventional dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID476929 | Human intestinal absorption in po dosed human | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Neural computational prediction of oral drug absorption based on CODES 2D descriptors. |
| AID1759183 | Antibacterial activity against Enterococcus faecalis by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID1595156 | Permeability of compound at pH 7.4 by PAMPA | |||
| AID1653193 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Quinolone hybrids and their anti-cancer activities: An overview. |
| AID1888860 | Bactericidal activity against Staphylococcus aureus 1199B assessed as bacterial count at 3.1 ug/mL measured after 24 hrs by time-kill kinetics assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID1814306 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth measured after 24 hrs by two-fold serial dilution method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID572510 | Antimicrobial activity against Salmonella enterica serovar Braenderup isolate s2906 harboring ParC QRDR mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. |
| AID1091957 | Apparent permeability of the compound by PAMPA | 2011 | Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7 | Importance of physicochemical properties for the design of new pesticides. |
| AID155922 | In vitro antibacterial activity against aerobically grown Pasteurella multocida (59A006) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID512995 | Antimicrobial activity against Staphylococcus aureus expressing mgrA C12S mutant gene | 2006 | Nature chemical biology, Nov, Volume: 2, Issue:11 | An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. |
| AID1601856 | Antibacterial activity against Escherichia coli CMCC 44568 assessed as ratio of MIC after and before 16 passages at sub-MIC | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID519122 | Antibacterial activity against Proteus mirabilis NP55 after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID1507052 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by NCCLS two fold broth microdilution method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. |
| AID310528 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Synthesis and antimicrobial evaluation of guanylsulfonamides. |
| AID495515 | Antibacterial activity against Acinetobacter baumannii CIP70-10 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID1209581 | Fraction unbound in Sprague-Dawley rat brain homogenates at 5 uM by equilibrium dialysis analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3 | Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. |
| AID209077 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Streptococcus faecalis strain ATCC 51299 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1494120 | Antibacterial activity against Enterococcus faecalis NCTC 12697 after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID285679 | Antimicrobial activity against Pseudomonas aeruginosa 29G7 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID164532 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Pseudomonas aeruginosa strain DRCC 137 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID603363 | Antibacterial activity against vancomycin resistant Enterococcus NCTC 12201 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID163741 | Minimum inhibitory concentration (MIC) of compound was measured on Providencia rettgeri H1771 (gram negative organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID1221969 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID565331 | Antibacterial activity against Mycoplasma genitalium M6287 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID1436576 | Antibacterial activity against Salmonella typhi MTCC 98 by broth microdilution assay method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives. |
| AID1850939 | Antibacterial activity against Enterococcus faecalis assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID1071344 | Permeability of the compound by BBB-PAMPA | 2014 | European journal of medicinal chemistry, Feb-12, Volume: 73 | 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies. |
| AID1462720 | Antimicrobial activity against Staphylococcus aureus MTCC 96 | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities. |
| AID1585675 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus at 2 times MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID561326 | Antimicrobial activity against Klebsiella pneumoniae isolate 135 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1162139 | Antibacterial activity against Shigella dysenteriae by two-fold serial dilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin. |
| AID260744 | Antibacterial activity against Escherichia coli J53 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID759328 | Antibacterial activity against Staphylococcus aureus RN4220 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID206021 | Minimum Inhibitory concentration measured against Staphylococcus aureus ATCC 29213 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Synthesis and antibacterial activity of some novel 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents. |
| AID1917499 | Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID436992 | Inhibition of human EJ cell proliferation by MTT assay | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
| AID1294336 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by agar dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Synthesis and molecular modeling of antimicrobial active fluoroquinolone-pyrazine conjugates with amino acid linkers. |
| AID285676 | Antimicrobial activity against Pseudomonas aeruginosa 24G1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID519118 | Antibacterial activity against Proteus mirabilis M 31 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID420481 | Antibacterial activity against Bacillus subtilis after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents. |
| AID405459 | Antibacterial activity against Escherichia coli C600Rif containing pIP1206 plasmid in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1740321 | Antimicrobial activity against Escherichia coli O157:H7 assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1764066 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | A facile reaction to access novel structural sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. |
| AID259174 | Inhibition of topoisomerase 4 decatenation in Staphylococcus aureus ATCC 29213 | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1 | Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. |
| AID324273 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in stationary phase at 3 ug/ml after 1 week | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID544842 | Antibacterial activity against Streptococcus pneumoniae U2A1413 harboring parC Ser79Tyr mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1600105 | Antibacterial activity against Escherichia coli ATCC 8739 cultured in MH medium assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID362544 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID585734 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated metL gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1239963 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu(2+) mediated DNA-targeting antibacterial agents. |
| AID1126755 | Antibacterial activity against drug-sensitive 1 ug/ml Mycobacterium tuberculosis clinical isolate 741 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID210971 | In vitro evaluation for antibacterial activity against anaerobically grown Treponema hyodysenteriae (94A007) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID573316 | Antimicrobial activity against Escherichia coli isolate CQ10 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1889636 | Bactericidal activity against Acinetobacter baumannii assessed as fold increase in MIC value after 16 passages by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID464583 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID1494125 | Antibacterial activity against erythromycin-resistant Staphylococcus aureus RN4220 after 16 hrs by microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains. |
| AID765040 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by MTT assay | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | 3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. |
| AID96081 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Klebsiella pneumoniae strain DRCC 132 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID556578 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 after 2 hrs relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1352413 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1242640 | Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID1688667 | Antibacterial activity against multidrug resistant Pseudomonas aeruginosa ATCC BAA-2111 assessed as reduction in bacterial growth incubated for 1 day by paper disk diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID1563963 | Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as reduction in bacterial cell growth incubated for overnight by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID155754 | In vitro antibacterial activity against Aerobically grown Pasteurella haemolytica (59B018) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID573328 | Antimicrobial activity against Escherichia coli isolate CQ19 transconjugant harboring 16S rRNA methylase RmtB and qepA, aac(6')-Ib-cr gene by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1653194 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Quinolone hybrids and their anti-cancer activities: An overview. |
| AID1237615 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC52056 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID285575 | Antimicrobial activity against Pseudomonas aeruginosa 65.18-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1498753 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID586749 | Antibacterial activity against Escherichia coli ATCC 25922 expressing qnrB gene and pBK-QnrB1 assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID573313 | Antimicrobial activity against Escherichia coli isolate CQ4 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1352412 | Antibacterial activity against Bacillus subtilis ATCC 21216 after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID285191 | Antimicrobial activity against Escherichia coli M013 mutant with AG100 delta-(lon-hupB-ppiD) dupIS5 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID544867 | Antibacterial activity against Streptococcus pneumoniae U2A1060 harboring gyrA Ser81Phe parC Asp83His mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID509633 | Antibacterial activity against tetracycline sulfamethoxazole streptomycin kanamycin-resistant Escherichia coli isolate M66-6 carrying qnrB19 gene | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. |
| AID576018 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2162-encoded QacBIII E320A mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID387376 | Antimicrobial activity against Pseudomonas aeruginosa | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18 | Antimicrobial and cytotoxic arylazoenamines. Part III: antiviral activity of selected classes of arylazoenamines. |
| AID94140 | Compound was tested for inhibition of the gram-negative organism Klebsiella pneumoniae MGH-2 | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID285602 | Antimicrobial activity against Pseudomonas aeruginosa 2A5 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID133817 | Compound was evaluated for protective dose against the Streptococcus pneumoniae SV-1 lethal infection following po administration | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID1890860 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID21498 | Solubility in phosphate buffer (0.1 M) at 25 degree centigrade(pH 7.4) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID585574 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated maoC gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID662991 | Antibacterial activity against Vibrio cholerae MTCC 3906 by macrobroth dilution assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID94001 | Antibacterial activity was determined against gram negative organism, Klebsiella pneumoniae MGH-2 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID1765494 | Potentiation of (Z)-4-((bis(2-hydroxyethyl)amino)methyl)-7-((1-(4-methoxyphenyl)-3-oxo-3-(thiazol-2-yl)prop-1-en-2-yl)oxy)-2H-chromen-2-one-induced antibacterial activity against Escherichia coli assessed as (Z)-4-((bis(2-hydroxyethyl)amino)methyl)-7-((1- | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID726565 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 assessed as bacterial growth inhibition measured during 24 hrs incubation at 37 degC by two-fold serial dilution technique | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA). |
| AID397921 | Antimicrobial activity against Escherichia coli at 16 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1415679 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two-fold serial dilution based spectrophotometric analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID68201 | In vitro antibacterial activity against clinical isolates of Enterobacter cloacae 041 (gram negative) by agar dilution assay. | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids. |
| AID1556527 | Antibacterial activity against methicillin resistant Staphylococcus aureus N315 assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID434854 | Antibacterial activity against multidrug-resistant Streptococcus agalactiae after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID1697194 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as ratio of MIC after and before 13 serial passages | 2020 | Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 | Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents. |
| AID164534 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Pseudomonas aeruginosa strains ATCC 27853 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID285613 | Antimicrobial activity against Pseudomonas aeruginosa 2A5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1769956 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC49800 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID207212 | In vitro minimum inhibitory concentration against growth of Staphylococcus aureus Smith | 1984 | Journal of medicinal chemistry, Sep, Volume: 27, Issue:9 | Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1666767 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID445445 | Permeability at pH 6.5 by PAMPA method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. |
| AID1310087 | Inhibition of Escherichia coli DNA gyrase assessed as reduction in enzyme-mediated supercoiling of pBR322 DNA after 1.5 hrs by agarose gel electrophoresis method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID1310100 | Binding affinity to methicillin-resistant Staphylococcus aureus double stranded genomic DNA by spectroscopic analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID80632 | pD2 value (pD2 = -log EC50) was calculated using guinea pig trachea; ND means not determined | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | New bronchodilators selected by molecular topology. |
| AID619381 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 28 days by colony forming unit determination | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID666963 | Antibacterial activity against Vibrio cholerae MTCC 3906 by broth microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | New N-arylamino biquinoline derivatives: synthesis, antimicrobial, antituberculosis, and antimalarial evaluation. |
| AID1303300 | Antimicrobial activity against Bacillus typhi after 24 hrs by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11 | Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. |
| AID150920 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 27853 measured in Muller-Hinton (MH) liquid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID1671805 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID542515 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, Y87, parC I80 and parE A458 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID209775 | Minimum inhibitory concentration (MIC) of compound was measured on Streptococcus pyogenes C203 (gram positive organism) | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10 | Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity. |
| AID1879451 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID137612 | Serum levels in mice after 2 hr Oral administration of 50 mg/kg | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID1571576 | Antimicrobial activity against Escherichia coli CDC F-50 measured every 24 hrs for 5 days by two-fold serial dilution method | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID295341 | Antibacterial activity against Escherichia coli KL16 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID556650 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 5 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1126744 | Antibacterial activity against Salmonella assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID66730 | Antibacterial activity against Ent. aerogenes (2828) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1504254 | Antibacterial activity against methicillin-resistant Staphylococcus aureus RN4220 after 24 hrs by MTT dye based broth microdilution method | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis. |
| AID565313 | Antibacterial activity against Mycoplasma genitalium TW10-5G by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID495517 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4675 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID70479 | In vitro antibacterial activity against aerobically grown Escherichia coli (51A538) | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. |
| AID1297672 | Bactericidal activity against Pseudomonas aeruginosa 9027 incubated for 4 hrs | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID1326654 | Antibacterial activity against Escherichia coli JM109 measured after 24 hrs by two-fold serial dilution method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents. |
| AID557081 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pACM204 plasmid by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID586752 | Antibacterial activity against qnrA gene expressing Escherichia coli ATCC 25922 harboring GyrA S83L mutant and pBK-QnrA1 assessed as resistant colonies recovered one step below mutant prevention concentration | 2011 | Antimicrobial agents and chemotherapy, Mar, Volume: 55, Issue:3 | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| AID1067071 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3506 after 20 hrs by two-fold serial dilution technique | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives. |
| AID1769959 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC48966 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID198175 | Antibacterial activity was determined against gram positive organism, Streptococcus pneumoniae SV-1 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID530349 | Antimicrobial activity against Escherichia coli TOP10 harboring pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID1557297 | Half life in human at 0.4 g, po bid | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID230837 | MIC ratio measured as the mean MICs of gram-negative bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID586915 | Antibacterial activity against 5 x 10'5 CFU/ml macrolide-resistant Staphylococcus aureus RN4220 expressing MsrA macrolide efflux protein after 18 hrs by MTT assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. |
| AID65203 | Minimum inhibitory concentration against Escherichia coli KC14 strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID80624 | Percent relaxation using isolated guinea pig trachea. | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | New bronchodilators selected by molecular topology. |
| AID1688666 | Antibacterial activity against multidrug resistant Escherichia coli ATCC BAA-196 assessed as reduction in bacterial growth incubated for 1 day by paper disk diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID1814330 | Antibacterial activity against Escherichia coli assessed as drug resistance by measuring fold change in MIC treated for 16 serial passages and measured every 24 hrs | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors. |
| AID1179910 | Antimicrobial activity against Escherichia coli JM109 by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID548325 | Antibacterial activity against Staphylococcus aureus MRSA CCARM 3506 after 20 hrs by twofold serial dilution technique | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. |
| AID542146 | Antimicrobial activity against Escherichia coli DH10B harboring pBR322 with Salmonella enterica HN-GSS-2007-057 qnrS1 gene by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID1352420 | Antibacterial activity against drug-resistant Acinetobacter baumannii after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID434857 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae after 24 hrs by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID1850944 | Antibacterial activity against Escherichia coli assessed as bacterial growth inhibition by serial dilution method | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID369425 | Induction of Escherichia coli DNA gyrase-mediated Escherichia coli pBR322 DNA cleavage assessed as ratio of drug-induced DNA cleavage to spontaneous DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID609226 | Antibacterial activity against 10'5 CFU/mL quinolone-resistant Staphylococcus aureus CCARM 3519 assessed as inhibition of bacterial growth after 24 hrs by microtiter enzyme-linked immunosorbent assay | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. |
| AID523111 | Antimicrobial activity against Escherichia coli ATCC 10536 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine beta-naphthylamide | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID523116 | Antimicrobial activity against Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID561390 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP106 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID285620 | Antimicrobial activity against Pseudomonas aeruginosa 5H6 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID585738 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated mhpT gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1628384 | Antimicrobial activity against Bacillus proteus ATCC13315 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12 | Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1557279 | Antibacterial activity against Escherichia coli by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID576021 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV S151I mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID94370 | In vitro antibacterial activity against Klebsiella pneumoniae PCI-602 | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID151381 | Minimum inhibitory concentration tested against Proteus vulgaris OX-19 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1879458 | Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID237037 | Dissociation constant (pKa) was determined | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. |
| AID1510765 | Antibacterial activity against Acinetobacter baumannii after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1769957 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC49025 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID285667 | Antimicrobial activity against Pseudomonas aeruginosa 22C5 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID163433 | The compound was tested evaluated for its antimicrobial activity against Pseudomonas aeruginosa ( Pa(K)) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID565229 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID1281665 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID1855814 | Antibacterial activity against Staphylococcus aureus ATCC 25923 measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID1546138 | Antifungal activity against Candida utilis after 24 hrs | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID530596 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr8 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID10503 | Area under curve value of compound per hour after oral administration | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID1243367 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies. |
| AID603461 | Inhibition of Escherichia coli DNA gyrase assessed as inhibition of pBR322 supercoiling by densitometry | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID203315 | In vitro antibacterial activity against Serratia | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1413918 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID542514 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, Y87 and parC I80 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID1493767 | Antibacterial activity against Salmonella typhi ATCC 19430 after 18 hrs by agar dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates. |
| AID561402 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP122 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID771179 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID1740323 | Antimicrobial activity against Salmonella enterica ATCC 13312 assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1879456 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID1060890 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by twofold serial dilution method | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. |
| AID1177546 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus EMRSA-15 assessed as absence of growth after 18 hrs by MTT assay | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. |
| AID561389 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP101 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID255570 | In vitro minimum inhibitory concentration against Staphylococcus aureus (Smith) upon incubation at 37 degree C for 16 to 24 hr by dissolving in DMSO (1%) | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. |
| AID519114 | Antibacterial activity against Proteus mirabilis M 23 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID52924 | Antibacterial activity against Citrobacter ferundii | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID70704 | Minimum inhibitory concentration (MIC) against gram negative bacteria Escherichia coli H-560. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID556576 | Bactericidal activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 after 2 hrs relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID324249 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in stationary phase at 3 ug/ml after 5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1510763 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID200680 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Salmonella typhi strain MTCC 531 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1917521 | Induction of drug resistance in Pseudomonas aeruginosa assessed as reduction in susceptibility measured after 6 passages | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID64251 | Antibacterial activity was determined against gram negative organism, Escherichia coli vogel | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID621872 | Antibacterial activity against Stenotrophomonas maltophilia ATCC 13637 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID64254 | Antibacterial activity was determined against gram negative organism, E. coli(vogel) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID556695 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pDrive plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1686923 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as bacterial killing by measuring reduction in bacterial colony count at 64 times MIC incubated for 2 hrs by time-kill kinetics method | 2018 | Journal of medicinal chemistry, 04-12, Volume: 61, Issue:7 | Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents. |
| AID1556531 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID1516019 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1879462 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. |
| AID584335 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID744033 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 24 hrs by microbroth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID164560 | In vitro antibacterial activity against Pseudomonas aeruginosa 5007 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID71795 | Percentage of GABA-induced chloride currents with compound alone at 10 e-4 M | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID1510715 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 18 hrs by two fold serial dilution | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1210074 | Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID1601849 | Antibacterial activity against Pseudomonas aeruginosa CMCC 27853 measured after 24 hrs by ELISA | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. |
| AID368423 | Antimicrobial activity against Escherichia coli KAM32 pSTVdeltaqepA containing disrupted qepA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID206826 | The compound was tested in vitro for antibiotic activity against Staphylococcus pyogenes 930 | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents. |
| AID563511 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens HMS011 harboring plasmid STV28 expressing sdeB gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1349981 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus SA1199B after 18 hrs by MTT based broth dilution assay | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. |
| AID1310083 | Cytotoxicity against rat PC12 cells assessed as reduction in cell viability at 128 ug/mL after 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism. |
| AID637213 | Antibacterial activity against Staphylococcus aureus MTCC 2901 after 24 hrs followed by subculturing | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID1895485 | Antibacterial activity against vancomycin resistant Enterococcus incubated for 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic access to thiolane-based therapeutics and biological activity studies. |
| AID1179905 | Antimicrobial activity against Micrococcus luteus ATCC 4698 by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID1125368 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as growth inhibition at 60 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID544834 | Antibacterial activity against Streptococcus pneumoniae R6 Tr6 harboring gyrA Ser81Phe mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID556569 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 DKsodB at 0.4 ug/ml | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1481563 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID285590 | Antimicrobial activity against Pseudomonas aeruginosa 65.38-1 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID423063 | Antibacterial activity against wild type Pseudomonas aeruginosa PAO1 H103 after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID603366 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OM584 after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, Jun-09, Volume: 54, Issue:11 | Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. |
| AID501416 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OM481 after 24 hrs by microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. |
| AID744037 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion method | 2013 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8 | Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives. |
| AID660264 | Ratio of MIC for wild type Escherichia coli HS414 to MIC for acrB-deficient Escherichia coli HS832 by agar dilution method | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID565314 | Antibacterial activity against Mycoplasma genitalium TW10-6G by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID524827 | Antibacterial activity against erythromycin susceptible Campylobacter sp. assessed as resistance breakpoint by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID1759192 | Antibacterial activity against Acinetobacter baumannii by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID1183259 | Antimicrobial activity against Salmonella typhi MTCC 98 assessed as absence of visible growth after 24 to 48 hrs by broth micro dilution method | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Design, synthesis and characterization of fluoro substituted novel pyrazolylpyrazolines scaffold and their pharmacological screening. |
| AID1688663 | Antibacterial activity against multidrug resistant Pseudomonas aeruginosa ATCC BAA-2111 assessed as diameter of inhibition zone at 0.5 mg/ml incubated for 24 hrs by agar diffusion method | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID285198 | Antimicrobial activity against Escherichia coli M084 mutant AG100 lon4::IS186 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID565311 | Antibacterial activity against Mycoplasma genitalium M30 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID584325 | Antibacterial activity against wild type Escherichia coli BW25113 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1498754 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID771175 | Antibacterial activity against Staphylococcus aureus SA1199B after 18 hrs by MTT assay | 2013 | Journal of natural products, Sep-27, Volume: 76, Issue:9 | Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. |
| AID544846 | Antibacterial activity against Streptococcus pneumoniae R6 Tr10 harboring gyrA Ser81Tyr parC Ser79Tyr mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID285592 | Antimicrobial activity against Pseudomonas aeruginosa 65.38-3 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID585422 | Antimicrobial activity against oqxAB positive Escherichia coli C600 W245-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID1551812 | Antibacterial activity against Bacillus anthracis incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID1726683 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID1758079 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID520696 | Antimicrobial activity against Escherichia coli DH10B harboring p041060 carrying qepA gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID78707 | MIC at which cleaved DNA (linear) is observed at an intensity relative to oxolinic acid at 10 ug/mL by using Gyrase Induced DNA-Cleavage assay | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID550173 | Antibacterial activity against multi drug-resistant Staphylococcus aureus XU212 after 18 hrs by MTT assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. |
| AID532580 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph mutant by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID369254 | Increase in ompX-lacZ expression in marA-negative Escherichia coli CH164 mutant assessed as beta-galactosidase activity after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID1125380 | Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as growth inhibition at 40 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID297186 | Antibacterial activity against multidrug resistant Staphylococcus aureus 49589 | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. |
| AID15172 | Concentration of liberated compound in serum after 120 min at the dose of 50 mg/kg (po). | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID164384 | Antibacterial activity against Pseudomonas aeruginosa | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. |
| AID1433842 | Antifungal activity against Aspergillus fumigatus MTCC 3008 after 24 to 48 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs. |
| AID747349 | Antibacterial activity against Pseudomonas aeruginosa by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID237457 | Partition coefficient (logD2.0) | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. |
| AID544840 | Antibacterial activity against Streptococcus pneumoniae R6 Tr1 harboring parC Ser79Tyr mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID324269 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in stationary phase at 3 ug/ml after 1 week | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1462725 | Antimicrobial activity against Aspergillus clavatus MTCC 1323 | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities. |
| AID397925 | Antimicrobial activity against Klebsiella pneumoniae at 4 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID1510764 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1758083 | Antibacterial activity against Acinetobacter baumannii assessed as reduction in microbial growth by two fold microdilution method | 2021 | European journal of medicinal chemistry, May-05, Volume: 217 | Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. |
| AID1401692 | Antibacterial activity against Shigella dysenteriae after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID762019 | Antibacterial activity against Escherichia coli F-50 measured every 24 hrs for 5 days by conventional dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Antimicrobial activity of imidazo[1,5-a]quinoxaline derivatives with pyridinium moiety. |
| AID1125375 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as growth inhibition at 15 ug/ml after 16 hrs by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7 | Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. |
| AID1666745 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by two fold serial microbroth dilution method | 2020 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 30, Issue:6 | Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. |
| AID775475 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition after 24 hrs by liquid dilution method | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID584327 | Antibacterial activity against speE deficient Escherichia coli JW0117-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID324266 | Antibacterial activity against Escherichia coli K12 containing deletion deltaphoU mutant assessed as cell count in log phase at 3 ug/ml after 5 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID396002 | Antimicrobial activity against Mycoplasma putrefaciens KS1 after 24 hrs by twofold serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibilities of Mycoplasma putrefaciens field isolates. |
| AID556681 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 8 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID324180 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 at 2 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID576017 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2162-encoded QacBIII gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID720954 | Antibacterial activity against Shigella dysenteriae by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID561316 | Antimicrobial activity against Enterobacter cloacae isolate 101 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID164114 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Pseudomonas fluorescence strain DRCC 008 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID758269 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. |
| AID759321 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15 | Synthesis and biological evaluation of rhodanine derivatives bearing a quinoline moiety as potent antimicrobial agents. |
| AID542510 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87, parC I80, K84 and parE D460 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID1820907 | Antibacterial activity against methicillin resistant Staphylococcus aureus treated over 10 serial passages measured after 24 hrs by resistance development assay | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID1765474 | Antibacterial activity against Escherichia coli by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID530590 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr2 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID637210 | Antibacterial activity against Escherichia coli MTCC 1652 after 24 hrs by tube dilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. |
| AID285614 | Antimicrobial activity against Pseudomonas aeruginosa 3D1 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID285610 | Antimicrobial activity against Pseudomonas aeruginosa 65.68-2 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID544848 | Antibacterial activity against Streptococcus pneumoniae U2A1060 harboring gyrA Ser81Phe parC Asp83His mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID205543 | Minimum inhibitory concentration against Staphylococcus aureus (UC76). | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID198344 | Tested in vitro against Staphylococcus aureus IID803 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1462722 | Antimicrobial activity against Escherichia coli MTCC 443 | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities. |
| AID1909448 | Permeability of the compound by PAMPA-BBB assay | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. |
| AID1209583 | Unbound drug partitioning coefficient, Kp of the compound assessed as ratio of unbound concentration in Sprague-Dawley rat brain to unbound concentration in plasma | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 39, Issue:3 | Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. |
| AID585736 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated treC gene assessed as MarA-mediated multidrug resistance level by measuring fold change in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID369429 | Induction of Escherichia coli DNA topoisomerase 4-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage assessed as amount of linear DNA generated per unit amount of enzyme at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID40779 | In vitro antibacterial activity against Bacillus subtilis ATCC 6633 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID1516021 | Antibacterial activity against Salmonella enterica serovar typhimurium C77-31 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1481559 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID1516020 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1600118 | Bactericidal activity against Serratia marcescens ATCC 12795 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID549143 | Antimicrobial activity against Candida albicans ATCC 90028 after 18 to 24 hrs by microbroth dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives. |
| AID206437 | In vitro antibacterial activity against clinical isolates of Staphylococcus aureus 18773 (gram-positive) by agar dilution assay. | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids. |
| AID1360745 | Antibacterial activity against methicillin-resistant Staphylococcus aureus EMRSA15 by MTT dye based assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. |
| AID523132 | Antimicrobial activity against Enterobacter aerogenes EA27 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID369434 | Sensitivity ratio for induction of Staphylococcus aureus DNA topoisomerase 4 over DNA gyrase-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID69784 | Antibacterial activity against Escherichia coli (vogel) | 1986 | Journal of medicinal chemistry, Mar, Volume: 29, Issue:3 | New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. |
| AID1759188 | Antibacterial activity against Escherichia coli by broth microdilution assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. |
| AID405929 | Antimicrobial activity against epidemic methicillin-resistant Staphylococcus aureus 15 containing mecA gene | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. |
| AID133950 | In vivo activity against Streptococcus pyogenes (po) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID1680071 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1510741 | Antibacterial activity against Escherichia coli infected in mouse | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID556890 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 2 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID532762 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 by broth dilution method in presence of chlorpromazine | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID718548 | Antibacterial activity against Staphylococcus aureus KCTC 503 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID1498757 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID1297669 | Bactericidal activity against Bacillus cereus 8035 incubated for 4 hrs | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID585747 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated pcnB gene assessed as MarA-mediated multidrug resistance level by measuring fold decrease in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID1820936 | Binding affinity to Staphylococcus aureus PBP2a measured after 6 hrs by ELISA | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. |
| AID200233 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus UC76 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID1600106 | Bactericidal activity against Escherichia coli ATCC 8739 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1818879 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID753247 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. |
| AID556863 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 3 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID95882 | Minimum inhibition concentration in vitro determined against Klebsiella pneumoniae 8045 | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID1330197 | Antibacterial activity against quinolone-resistant Staphylococcus aureus 3519 measured after 24 hrs by two-fold serial dilution method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24 | Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties. |
| AID576020 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV A19T mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID285197 | Antimicrobial activity against Escherichia coli M083 mutant with AG100 lon4::IS186 acrR::IS1 genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID405119 | Antimicrobial activity against Escherichia coli TOP10 harbouring pS2 plasmid expressing quinolone resistant QnrS2 gene | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. |
| AID1818877 | Antibacterial activity against Acinetobacter baumannii assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1413919 | Antibacterial activity against Enterococcus faecalis after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID530599 | Antimicrobial activity against Escherichia coli TOP10 harboring pSmQnr11 carrying Smqnr gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. |
| AID237458 | Partition coefficient (logD7.4) | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. |
| AID523112 | Antimicrobial activity against Escherichia coli ATCC 8739 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1126754 | Antibacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 7 days by microtiter plate assay | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. |
| AID750279 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents. |
| AID1571583 | Bactericidal activity against Escherichia coli CDC F-50 measured after 4 hrs | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID1272238 | Antibacterial activity against Streptococcus pyogenes by broth micro-dilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors. |
| AID1297665 | Bacteriostatic activity against Pseudomonas aeruginosa 9027 measured every 24 hrs for 5 days by broth dilution method | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones. |
| AID1730946 | Antibacterial activity against Escherichia coli MTCC 443 assessed as bacterial growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 36 | Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme. |
| AID576110 | Antimicrobial activity against mecA-positive Staphylococcus sciuri assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID150907 | Efficacy on systematic infections against Pseudomonas aeruginosa A 9843 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID1254080 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID613567 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID556677 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 4 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1391386 | Antibacterial activity against Acinetobacter baumannii after 24 hrs by two fold serial dilution method | 2018 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9 | Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove. |
| AID556577 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 at 10 times MIC relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID563501 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 01 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID103832 | In vitro antibacterial activity against Morganella morganii (A 15153) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID1600096 | Bactericidal activity against Staphylococcus aureus ATCC 6538 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID747351 | Antibacterial activity against Shigella dysenteriae by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID1383914 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID1060932 | Antimicrobial activity against Shigella dysenteriae after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID150923 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 27853 measured in succinate (SC) solid media | 2001 | Journal of medicinal chemistry, Jun-21, Volume: 44, Issue:13 | Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific Therapy against Pseudomonas aeruginosa. |
| AID144009 | Anti-bacterial activity tested against Mycobacterium fortuitum (ATCG 6841) | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. |
| AID1299591 | Bactericidal activity against Staphylococcus aureus RN4220 ATCC 35556 in stationary-phase assessed as reduction in bacterial burden at 4 times MIC99 after 2 to 6 hrs by time-kill assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID164531 | Compound was evaluated for in vitro antibacterial activity against gram negative organism Pseudomonas aeruginosa strain DRCC 135 | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID561319 | Antimicrobial activity against Escherichia coli isolate 17 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID745301 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition after overnight incubation by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents. |
| AID1557284 | Antibacterial activity against Staphylococcus aureus by agar diffusion method | 2019 | MedChemComm, Oct-01, Volume: 10, Issue:10 | Quinolone antibiotics. |
| AID397930 | Antimicrobial activity against Staphylococcus aureus at 4 ug/ml after 24 hrs by agar diffusion technique | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11 | Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. |
| AID775480 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1290446 | Antifungal activity against Aspergillus fumigatus MTCC 3008 after 24 to 48 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities. |
| AID1493764 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by agar dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates. |
| AID556868 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 8 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID575055 | Antibacterial activity against Vibrio cholerae O1 CIP0.25-1 harboring Ser to Ile mutation at 83 position in gyrA and parC genes by 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. |
| AID685403 | Antibacterial activity against Staphylococcus aureus RN4220 after 24 hrs by broth microdilution method | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone. |
| AID750278 | Antibacterial activity against Pseudomonas aeruginosa MTCC 441 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents. |
| AID1832281 | Antitumour activity against dox resistant human MCF7/ADR cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents. |
| AID478530 | Antimicrobial activity against Escherichia coli ATCC 10536 after 24 hrs by broth microdilution assay | 2010 | European journal of medicinal chemistry, May, Volume: 45, Issue:5 | Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. |
| AID295347 | Antibacterial activity against ciprofloxacin resistant methicillin resistant Staphylococcus aureus OC4222 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID556688 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 15 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID230839 | MIC ratio measured as the mean MICs of gram-positive bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID1889628 | Antibacterial activity against Pseudomonas aeruginosa 27853 assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID1383916 | Antibacterial activity against Bacillus proteus ATCC 13315 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID279137 | Antibacterial activity against Streptococcus suis BB1008 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID285615 | Antimicrobial activity against Pseudomonas aeruginosa 3D10 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID523262 | Antimicrobial activity against Enterobacter cloacae Ec07769 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1556530 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID1740332 | Antifungal activity against Penicillium chrysogenum ATCC 10106 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1907302 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth incubated for 24 hrs by CLSI protocol based two fold serial dilution method | |||
| AID311990 | Antibacterial activity against multidrug-resistant Staphylococcus aureus 1199B overexpressing NorA after 18 hrs | 2007 | Journal of natural products, Nov, Volume: 70, Issue:11 | Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. |
| AID279138 | Antibacterial activity against Streptococcus suis BB1009 isolate after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | First characterization of fluoroquinolone resistance in Streptococcus suis. |
| AID423065 | Antibacterial activity against 74_D9 allele containing Pseudomonas aeruginosa PAO1 H1105 mutant strain with lon::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID1809827 | Antimicrobial activity against multidrug-resistant Staphylococcus aureus ATCC BAA-44 assessed as inhibition of bacterial growth by broth dilution method | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities. |
| AID1179909 | Antimicrobial activity against Shigella dysenteriae by two-fold serial dilution technique | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Synthesis and bioactive evaluation of a novel series of coumarinazoles. |
| AID573315 | Antimicrobial activity against Escherichia coli isolate CQ26 transconjugant harboring 16S rRNA methylase RmtB and qepA by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID1765468 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 by microbroth dilution method | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. |
| AID1653160 | Cytotoxicity against human SK-MEL-3 cells assessed as reduction in cell viability by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Quinolone hybrids and their anti-cancer activities: An overview. |
| AID285606 | Antimicrobial activity against Pseudomonas aeruginosa 2A7 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1493768 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar dilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates. |
| AID561324 | Antimicrobial activity against Klebsiella pneumoniae isolate 132 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID368421 | Antimicrobial activity against Escherichia coli KAM32 pSTV28 containing chloramphenicol-resistant vector by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1653067 | Toxicity in po dosed mouse | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID70803 | Compound was tested for inhibition of the gram-negative organism Escherichia coli vogel | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4 | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid. New quinolone antibacterial with potent gram-positive activity. |
| AID119727 | Serum concentration of the liberated Norfloxacin after oral administration (100 mg/kg) in mice after 1.0 hr | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups. |
| AID1556536 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial cell viability incubated for 24 hrs by two fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV. |
| AID1818871 | Antibacterial activity against Staphylococcus aureus assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID556697 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pACM204 plasmid by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID207774 | Compound was evaluated for in vitro antibacterial activity against gram positive organism Staphylococcus aureus strain ATCC 6538P | 1998 | Bioorganic & medicinal chemistry letters, Mar-03, Volume: 8, Issue:5 | Novel quinolone derivatives as potent antibacterials. |
| AID1516025 | Antibacterial activity against Escherichia coli 20411 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID285194 | Antimicrobial activity against Escherichia coli M064 mutant with AG100 lon1::IS186 acrR::IS genotype | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID164873 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Pseudomonas aeruginosa UI-18 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships. |
| AID324188 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 at 0.1 ug/ml after 48 hrs by disc diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1304597 | Antibacterial activity against methicillin-resistant Staphylococcus aureus XU212 expressing TetK efflux pump after 18 hrs by MTT assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3 | Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis. |
| AID450458 | Antibacterial activity against Bacillus subtilis after 24 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Interaction of drug based binuclear mixed-ligand complexes with DNA. |
| AID667557 | Antibacterial activity against Staphylococcus aureus KCTC 503 after 24 hrs by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID585751 | Antibacterial activity against marA-overproducing Escherichia coli CR1000 harboring inactivated damX gene assessed as MarA-mediated multidrug resistance level by measuring fold decrease in MIC relative to MarA-deficient Escherichia coli CR2000 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. |
| AID561394 | Antibacterial activity against quinolone-susceptible Bordetella pertussis BP113 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Emergence of quinolone-resistant Bordetella pertussis in Japan. |
| AID1818874 | Antibacterial activity against Klebsiella pneumoniae assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID464587 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6 | Synthesis, antibacterial and antifungal activities of some carbazole derivatives. |
| AID521968 | Antibacterial activity against Campylobacter sp. assessed as resistance breakpoint by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID550177 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 16 after 18 hrs by MTT assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. |
| AID747358 | Antifungal activity against Candida utilis by NCCLS method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. |
| AID556582 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 at 10 times MIC pretreated with 100 mM thiourea relative to wild-type | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID70713 | Antibacterial activity against Escherichia coli (2891) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID1682598 | Antibacterial activity against Staphylococcus aureus SA-1199B | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Inhibition of the NorA efflux pump of S. aureus by (Z)-5-(4-Fluorobenzylidene)-Imidazolidines. |
| AID532763 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph mutant by broth dilution method in presence of chlorpromazine | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID278110 | Bactericidal activity in Escherichia coli KD1373 containing parC mutation in anerobic condition | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID369010 | Sensitivity of Staphylococcus aureus isolated from lactating Holstein bovine subclinical mastitis model at 5 ug/disk after 20 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Therapeutic effect of nisin Z on subclinical mastitis in lactating cows. |
| AID619383 | Selectivity index, ratio of IC50 for human HepG2 cells to MIC for Mycobacterium tuberculosis H37Rv ATCC 27294 | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID125278 | In vitro minimum inhibitory concentration (MIC) against Morganella morganii A 15153 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
| AID1498750 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID1740328 | Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in fungal growth incubated for 48 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID584336 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID544845 | Antibacterial activity against Streptococcus pneumoniae U2A1681 harboring parC Ser79Tyr Asp83Ala mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID584326 | Antibacterial activity against tolC deficient Escherichia coli GD100 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID278105 | Bacteriostatic activity against Escherichia coli DM4100 in anaerobic condition | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Effect of anaerobic growth on quinolone lethality with Escherichia coli. |
| AID565319 | Antibacterial activity against Mycoplasma genitalium M2321 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. |
| AID63885 | Inhibitory activity against ATCC 13048 strain(Enterobacter aerogenes) in the presence of Norfloxacin and fluoroquinolone at 16 ug/mL | 2001 | Journal of medicinal chemistry, Nov-08, Volume: 44, Issue:23 | New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains. |
| AID285617 | Antimicrobial activity against Pseudomonas aeruginosa 5F2 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID201400 | Minimum inhibition concentration against Staphylococcus aureus MRSA strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID324263 | Antibacterial activity against Escherichia coli K12 PhoU wild type W3110 assessed as cell count in stationary phase at 3 ug/ml after 5 days | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. |
| AID1237603 | Antibacterial activity against Staphylococcus aureus ATCC25923 assessed as bacterial growth inhibition after 24 hrs by broth dilution method | 2015 | European journal of medicinal chemistry, Jul-15, Volume: 100 | Novel cajaninstilbene acid derivatives as antibacterial agents. |
| AID1349980 | Antimicrobial activity against tetracycline/methicillin-resistant Staphylococcus aureus XU212 after 18 hrs by MTT based broth dilution assay | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. |
| AID1368177 | Antibacterial activity against Pseudomonas fluorescens measured after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24 | Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity. |
| AID1415694 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 5 passages | 2017 | MedChemComm, May-01, Volume: 8, Issue:5 | Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents. |
| AID1850962 | Induction of drug resistance in Enterococcus faecalis assessed as fold increase in MIC measured for 16 passages relative to control | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. |
| AID561335 | Ratio of MIC for Klebsiella pneumoniae isolate 132 transconjugant to MIC for azide-resistant Escherichia coli J58 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID369262 | Effect on ompF-lacZ fusion transcription in wild type Escherichia coli AG100 assessed as percent decrease in Miller units of beta-galactosidase activity after 60 mins relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. |
| AID209248 | Minimum inhibitory concentration against Streptococcus faecalis (MGH-2). | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID1383911 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID1264455 | Permeability of the compound by high throughput PAMPA method | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. |
| AID369424 | Induction of Staphylococcus aureus DNA gyrase-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage assessed as amount of linear DNA generated per unit amount of enzyme at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID530348 | Antimicrobial activity against azide-resistant Escherichia coli J53 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID1173449 | Effective permeability of the compound by PAMPA assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23 | Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. |
| AID133949 | In vivo activity against Streptococcus pneumoniae (sc) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID621886 | Antibacterial activity against Klebsiella pneumoniae ATCC 13882 after 18 hrs by broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19 | Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. |
| AID637195 | Antibacterial activity against Staphylococcus aureus KCTC 503 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID1916449 | Induction of drug resistance in Staphylococcus aureus ATCC 29213 assessed as fold change in MIC incubated for 17 days | |||
| AID396034 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID96096 | In vitro antibacterial activity against Klebsiella pneumoniae 8045 | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID1686931 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 grown under presence of test compound at 1/2 MIC assessed as inhibition of bacterial growth measured after 14 passages by broth microdilution method relative to wild typ | 2018 | Journal of medicinal chemistry, 04-12, Volume: 61, Issue:7 | Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents. |
| AID557080 | Antimicrobial activity against multidrug resistant Escherichia coli DH5[alpha] harboring pDrive plasmid expressing ampC gene by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1740324 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 9627 assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID1855811 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 measured by Muller-Hinton broth based microdilution assay | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members. |
| AID750275 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents. |
| AID1401686 | Antibacterial activity against Micrococcus luteus ATCC4698 after 24 hrs by micro broth dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. |
| AID1759539 | Antibacterial activity against Acinetobacter baumannii by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. |
| AID56594 | Number of mice which show positive phototoxic reaction in 5 mice at peroral dose | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID532757 | Antimicrobial activity against Salmonella serovar Kedougou by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1571584 | Bactericidal activity against Pseudomonas aeruginosa ATCC 9027 measured after 4 hrs | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group. |
| AID137610 | Serum levels in mice after 0.5 hr Oral administration of 50 mg/kg | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1 | Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives. |
| AID560772 | Antibacterial activity against Staphylococcus aureus RN4220 after 20 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. |
| AID561318 | Antimicrobial activity against Enterobacter cloacae isolate 153 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID295344 | Antibacterial activity against quinolone susceptible methicillin resistant Staphylococcus aureus OC2878 | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10 | Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. |
| AID573325 | Antimicrobial activity against Escherichia coli isolate CQ12 transconjugant harboring 16S rRNA methylase RmtB and qepA, qnrS2, aac(6')-Ib-cr gene by agar dilution method relative to recipient strain | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. |
| AID495518 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4676 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID1221971 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1402099 | Antibacterial activity against Staphylococcus aureus ATCC 6538P after 18 hrs by agar dilution assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | 4-Quinolone derivatives and their activities against Gram positive pathogens. |
| AID523125 | Antimicrobial activity against Enterobacter aerogenes EA-CM64 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID619394 | Cytotoxicity against human PBMC measured after overnight incubation by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | New fluorine-containing hydrazones active against MDR-tuberculosis. |
| AID565228 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID184643 | Lethal dose was measured in rat after iv administration | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Studies on prodrugs. 5. Synthesis and antimicrobial activity of N-(oxoalkyl)norfloxacin derivatives. |
| AID563509 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 harboring plasmid STV29 expressing hasF gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID285205 | Antimicrobial activity against Escherichia coli AG112 mutant with marR genotype after 250 generations in 5 ug/ml presence of tetracycline | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. |
| AID1726682 | Antibacterial activity against Enterococcus faecalis assessed as inhibition of bacterial growth after 24 hrs by microbroth dilution method | 2021 | RSC medicinal chemistry, Apr-28, Volume: 12, Issue:4 | Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase. |
| AID532582 | Antimicrobial activity against Salmonella serovar Typhimurium 14028S by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1769961 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC48706 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms. |
| AID1671807 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID576109 | Antimicrobial activity against mecA-deficient Staphylococcus sciuri assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID163922 | Minimum inhibition concentration in vitro determined against Pseudomona aeruginosa K799/WT | 1985 | Journal of medicinal chemistry, Nov, Volume: 28, Issue:11 | Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents. |
| AID1818876 | Antibacterial activity against Pseudomonas aeruginosa assessed as decrease in bacterial growth incubated for 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant |
| AID207869 | The compound was tested for its antimicrobial activity against Staphylococcus epidermidis 3519 (Se) strain | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10 | Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. |
| AID1242644 | Antibacterial activity against methicillin/gentamicin-resistant Staphylococcus aureus ATCC 33592 after 16 hrs by microtiter broth dilution method | 2015 | ACS medicinal chemistry letters, Jul-09, Volume: 6, Issue:7 | Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus. |
| AID164561 | In vitro antibacterial activity against Pseudomonas aeruginosa K799/WT | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents. |
| AID736327 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus EMRSA-15 after 18 hrs by MTT assay | 2013 | Journal of natural products, Mar-22, Volume: 76, Issue:3 | Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. |
| AID1585573 | Antibacterial activity against Escherichia coli MTCC 443 assessed as zone of inhibition at 25 ug/ml by agar well diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Benzofuran derivatives and their anti-tubercular, anti-bacterial activities. |
| AID285640 | Antimicrobial activity against Pseudomonas aeruginosa 13D11 tracheal isolates from mechanically ventilated chronic respiratory insufficiency patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID1653163 | Cytotoxicity against human SW480 cells assessed as reduction in cell viability by MTT assay | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Quinolone hybrids and their anti-cancer activities: An overview. |
| AID71980 | Inhibition of [3H]muscimol binding to GABA A receptor 4-biphenylacetic acid at 10 e-4 M | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID637224 | Antibacterial activity against Escherichia coli CCARM 1356 after 20 hrs by twofold serial dilution technique | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. |
| AID585419 | Antimicrobial activity against oqxAB positive Escherichia coli C600 W281-T transconjugant by CLSI agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. |
| AID667133 | Antibacterial activity against Escherichia coli MTCC 7443 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles. |
| AID532584 | Antimicrobial activity against Salmonella serovar Enteritidis 5188 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID716253 | Antimicrobial activity against Bacillus subtilis by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID112677 | In vivo antibacterial activity against Escherichia coli (KC-14) was determined for the compound administered perorally; Value ranges from 4.8-9.4 | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12 | Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones. |
| AID208905 | In vitro antibacterial activity against Streptococcus aureus IID 803 (po) | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID1060937 | Antimicrobial activity against Bacillus subtilis after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID556877 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 17 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID556898 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 10 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1510762 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 24 hrs | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID535691 | Antimicrobial activity against beta-lactamase CTX-M-15-producing fluoroquinolone-resistant Escherichia coli FMV5825 expressing qnrB2 and aac(6')-Ib-cr and harboring gyrA Ser83Ile and Asp87Asn mutant gene and ParC Ser80Ile and Glu84Val mutant gene obtained | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID758167 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14 | Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1481560 | Antibacterial activity against Bacillus subtilis after 24 hrs by two-fold serial dilution assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8 | Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. |
| AID542520 | Antimicrobial activity against fluoroquinolone-resistant Escherichia coli clinical isolate by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. |
| AID1504251 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after 24 hrs by MTT dye based broth microdilution method | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis. |
| AID1740327 | Antimicrobial activity against Listeria monocytogenes ATCC 19115 assessed as inhibition of microbial growth incubated for 24 hrs by microbroth dilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. |
| AID368420 | Antimicrobial activity against Escherichia coli KAM32 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1498751 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by micro broth dilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton. |
| AID205945 | Minimum inhibitory concentration (MIC) against gram positive bacteria Streptococcus pneumoniae SV-1. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2 | New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID530350 | Antimicrobial activity against Escherichia coli TOP10 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID535907 | Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by broth microdilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. |
| AID1530020 | Antibacterial activity against Staphylococcus aureus 1199B | 2019 | European journal of medicinal chemistry, Jan-01, Volume: 161 | Quinoline and quinolone dimers and their biological activities: An overview. |
| AID206215 | In vitro antibacterial activity against Staphylococcus epidermis 3519 | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents. |
| AID20679 | Serum level of compound (50 mg/kg) after 3.0 hh of peroral administration in mice | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin . |
| AID718543 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3519 incubated for 24 hrs serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents. |
| AID1890852 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID572062 | Antibacterial activity against abeS sigma abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID542145 | Antimicrobial activity against Escherichia coli DH10B harboring pBR322 with Salmonella enterica HN-GSS-2007-057 qnrA1 gene by broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. |
| AID1352411 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID1060935 | Antimicrobial activity against Bacillus proteus after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID575170 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 200 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID1889624 | Antibacterial activity against Klebsiella pneumoniae assessed as inhibition of bacterial growth by two fold serial dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens. |
| AID529159 | Antibacterial activity against Pseudomonas aeruginosa 100609 after 20 hrs by broth microdilution assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID716250 | Antimicrobial activity against Shigella dysenteriae by microbroth dilution method | 2012 | European journal of medicinal chemistry, Sep, Volume: 55 | Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. |
| AID423080 | Antibacterial activity against 31_C9 allele containing Pseudomonas aeruginosa PAO1 H1104 mutant strain with lon::lux mutation assessed as fold decrease in MIC after 24 hrs by broth microdilution technique relative to wild type | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID662988 | Antibacterial activity against Clostridium tetani MTCC 449 by macrobroth dilution assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12 | An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. |
| AID1890854 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID1281663 | Antibacterial activity against Escherichia coli DH52 by micro broth dilution method | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents. |
| AID556886 | Antimicrobial activity against multidrug resistant Enterobacter aerogenes isolate 26 by broth dilution method in presence of 26.3 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID559901 | Antimicrobial activity against Klebsiella pneumoniae 278sp by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID1352414 | Antibacterial activity against drug-resistant Enterococcus faecalis after 18 to 24 hrs by CLSI two fold serial dilution method | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. |
| AID162914 | In vitro antibacterial activity against clinical isolates of Proteus morganii 27 (gram negative) by agar dilution assay. | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3 | Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids. |
| AID556686 | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 13 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. |
| AID1688671 | Bactericidal activity against Pseudomonas aeruginosa ATCC BAA-2111 incubated for 24 hrs followed by transferring to freshly prepared broth medium and measured after 24 hrs by broth microdilution assay | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor. |
| AID565068 | Antibacterial activity against CTX-M-15 and SHV-12 ESBL producing Escherichia coli assessed as resistant isolates by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. |
| AID775481 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition at 1000 ug/mL after 24 hrs by disk diffusion assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives. |
| AID1254079 | Antibacterial activity against quinolone-resistant Staphylococcus aureus CCARM 3505 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID1455923 | Antibacterial activity against Bacillus subtilis at 25 ug/ml after 24 hrs by plate colony counting method relative to control | 2017 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 27, Issue:10 | Design, synthesis and antibacterial activities of thiouracil derivatives containing acyl thiourea as SecA inhibitors. |
| AID151530 | Tested in vivo against Pseudomonas aeruginosa E-2 in mice after peroral dose of drug with 0.5% sodium carboxy methyl cellulose | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID532037 | Antimicrobial activity against azide-resistant Escherichia coli J53 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. |
| AID1563965 | Antibacterial activity against Escherichia coli JM109 assessed as reduction in bacterial cell growth incubated for overnight by two-fold serial dilution method | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents. |
| AID1870750 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16 | |
| AID544833 | Antibacterial activity against Streptococcus pneumoniae CP1000 by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID1671808 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth after 24 hrs by CLSI protocol based two fold serial dilution method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation. |
| AID542508 | Antimicrobial activity against Escherichia coli K-12 harboring gyrA L83, N87 and parC R80, V84 mutant gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. |
| AID490647 | Antibacterial activity against Bacillus subtilis at 50 ug after 48 hrs by agar well diffusion assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: inhibitory activity against bacteria and fungi. |
| AID693709 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3167 after 20 hrs by two fold serial dilution assay | 2012 | European journal of medicinal chemistry, Dec, Volume: 58 | Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. |
| AID1405066 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by micro broth dilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. |
| AID1600114 | Bactericidal activity against methicillin resistant Staphylococcus epidermidis ATCC 13199 cultured in MH medium assessed as reduction in bacterial survival incubated for 48 hrs by microbroth dilution method | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
| AID1254078 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3506 after 24 hrs by two-fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. |
| AID544843 | Antibacterial activity against Streptococcus pneumoniae U2A1693 harboring parC Asp83Asn mutant gene by agar disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. |
| AID93887 | Minimum inhibitory concentration against Klebsiella pneumoniae (MGH-2) | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID1768863 | Antibacterial activity against wild-type Staphylococcus aureus SA-1199 incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 50 | Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach. |
| AID501420 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 209P after 24 hrs by microdilution assay | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. |
| AID126320 | % dose recovered in urine | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | (Acyloxy)alkyl carbamate prodrugs of norfloxacin. |
| AID423067 | Antibacterial activity against 69_C12 allele containing Pseudomonas aeruginosa PAO1 H1109 mutant strain with recA::lux mutation after 24 hrs by broth microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. |
| AID1890856 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth measured after 24 hrs by CLSI based broth microdilution method | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. |
| AID1917495 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth by CLSI based continuous dilution method | 2022 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 76 | Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. |
| AID1413917 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microbroth dilution method | 2018 | MedChemComm, Sep-01, Volume: 9, Issue:9 | Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant |
| AID405467 | Antibacterial activity against Escherichia coli TOP10 containing pAT851 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1435639 | Antibacterial activity against Staphylococcus aureus after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors. |
| AID523126 | Antimicrobial activity against Enterobacter aerogenes EA289 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID1551789 | Antifungal activity against Aspergillus niger | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID285604 | Antimicrobial activity against Pseudomonas aeruginosa 2A6 tracheal isolates from mechanically ventilated tuberculosis patient | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. |
| AID266677 | Antibacterial activity against Pseudomonas aeruginosa | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 | Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives. |
| AID370047 | Induction of Staphylococcus aureus DNA topoisomerase 4-mediated negatively supercoiled Escherichia coli pBR322 DNA cleavage at 50 uM after 10 mins by gel electrophoresis | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. |
| AID613960 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by twofold serial dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. |
| AID523121 | Antimicrobial activity against tetracycline-resistant Escherichia coli AG102 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID523254 | Antimicrobial activity against Klebsiella pneumoniae KP55 after 18 hrs by rapid INT colorimetric assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID720956 | Antibacterial activity against Bacillus subtilis by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 | Novel berberine triazoles: synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin. |
| AID1335834 | Antibacterial activity against Escherichia coli JM109 after 24 hrs by two fold serial dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. |
| AID1210069 | Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID1060933 | Antimicrobial activity against Pseudomonas aeruginosa after 24 hrs by two-fold serial dilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin. |
| AID1383907 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by NCCLS micro broth dilution method | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents. |
| AID523261 | Antimicrobial activity against Pseudomonas aeruginosa PA124 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. |
| AID519120 | Antibacterial activity against Proteus mirabilis M 12 mutant after 18 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Reduced Susceptibility of Proteus mirabilis to triclosan. |
| AID1585653 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis after overnight incubation by micro broth dilution analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID68506 | Minimum inhibitory concentration against Enterobacter cloacae. (MA2446). | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588461 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588460 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, Validation Compound Set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588459 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, Validation compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1224864 | HCS microscopy assay (F508del-CFTR) | 2016 | PloS one, , Volume: 11, Issue:10 | Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 748 (25.63) | 18.7374 |
| 1990's | 656 (22.47) | 18.2507 |
| 2000's | 525 (17.99) | 29.6817 |
| 2010's | 664 (22.75) | 24.3611 |
| 2020's | 326 (11.17) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (106.65) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 280 (9.10%) | 5.53% |
| Reviews | 129 (4.19%) | 6.00% |
| Case Studies | 124 (4.03%) | 4.05% |
| Observational | 2 (0.06%) | 0.25% |
| Other | 2,542 (82.61%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Balanced, Randomized, Two Treatment, Two Sequence, Two Period, Two Way Crossover, Single Oral Dose Comparative Pharmacokinetic Study of Amlodipine Besylate Controlled-release Tablets, EQ 5mg Base of Overseas Pharmaceuticals Ltd., China and [NCT05667818] | Phase 1 | 16 participants (Anticipated) | Interventional | 2023-01-28 | Not yet recruiting | ||
| Comparison of the Efficacy of Granulocyte - Macrophage Colony Stimulating Factor (GM-CSF) and Norfloxacin in Secondary Prophylaxis for Spontaneous Bacterial Peritonitis - A Randomised Controlled Trial [NCT03702426] | 120 participants (Actual) | Interventional | 2018-07-23 | Completed | |||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| Randomized Control Trial of Rifaximin and Norfloxacin in Primary and Secondary Prophylaxis of Spontaneous Bacterial Peritonitis(SBP) in Cirrhotic Patients [NCT03695705] | Phase 3 | 142 participants (Actual) | Interventional | 2016-01-01 | Completed | ||
| COMPARATIVE STUDY OF NORFLOXACIN AND PROBIOTICS ON PORTAL PRESSURE IN PATIENTS WITH CIRRHOSIS AND LARGE VARICES WHO HAVE NEVER BLED IN THE PAST [NCT01134692] | Phase 3 | 0 participants | Interventional | Recruiting | |||
| Comparative Study of Rifaximin Versus Norfloxacin in the Secondary Prophylaxis of Spontaneous Bacterial Peritonitis [NCT02120196] | Phase 3 | 100 participants (Anticipated) | Interventional | 2014-01-31 | Recruiting | ||
| Noroxin Efficacy and Safety Trial [NCT03506256] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2018-05-10 | Not yet recruiting | ||
| [NCT00678613] | Phase 2/Phase 3 | 250 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| Evaluation of Safety and Efficacy of Synbiotic on the Incidence and Recurrence of Spontaneous Bacterial Peritonitis in Cirrhotics: A Randomized, Double Blind Placebo Controlled Trial [NCT00947336] | Phase 3 | 110 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| Comparative Study of Norfloxacin Versus Norfloxacin With Itopride in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis [NCT04161768] | Phase 3 | 80 participants (Anticipated) | Interventional | 2018-12-01 | Recruiting | ||
| Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting. A Randomized, Double Blind Trial [NCT01039545] | Phase 4 | 253 participants (Actual) | Interventional | 2012-02-29 | Terminated(stopped due to New power calculation (reduction of necessary patient number)) | ||
| Randomized, Double-Blind, Placebo-Controlled Trial Assessing Norfloxacin in the Prevention of Complications in Patients With Cirrhosis and Severe Liver Failure [NCT01037959] | Phase 3 | 291 participants (Actual) | Interventional | 2010-04-30 | Terminated(stopped due to lack of recruitement) | ||
| Rifaximin Versus Norfloxacin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis [NCT04159870] | Phase 3 | 322 participants (Anticipated) | Interventional | 2019-11-05 | Active, not recruiting | ||
| [NCT00163982] | 0 participants | Interventional | Recruiting | ||||
| A Phase III Non-Inferiority Open-label Multicenter Randomized Clinical Trial to Compare CEPHALOSPORIN to NORFLOXACIN in the Treatment of Acute Cystitis [NCT01527019] | Phase 3 | 0 participants (Actual) | Interventional | 2012-10-31 | Withdrawn(stopped due to the company suspended the persecution of this combination) | ||
| Comparison of Daily Norfloxacin Versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients [NCT01542801] | Phase 4 | 124 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Randomized Double-Blid Placebo Controlled Trial Assessing Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis In Advanced Cirrhosis [NCT00359853] | Phase 4 | 70 participants | Interventional | 2000-09-30 | Completed | ||
| Antibiotic Profile of Pathogenic Bacteria Isolated From Postsurgical Site Infections in Public Hospitals in Northern Jordan [NCT05106803] | 24 participants (Actual) | Observational | 2019-08-01 | Completed | |||
| Clinical Study to Evaluate the Possible Efficacy and Safety of Nitazoxanide in Secondary Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients [NCT04746937] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-03-31 | Not yet recruiting | ||
| A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome [NCT00362752] | Phase 2 | 9 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||