An aldo-keto reductase family 1 member C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42330]
EC 1.1.1.-; This protein enables 23 target(s): This protein is located in 4 target(s): This protein is active in 1 target(s): This protein is involved in 30 target(s):
EC 1.1.1.210;
EC 1.1.1.53;
EC 1.1.1.62;
17-beta-hydroxysteroid dehydrogenase type 5;
17-beta-HSD 5;
3-alpha-HSD type II, brain;
3-alpha-hydroxysteroid dehydrogenase type 2;
3-alpha-HSD type 2;
1.1.1.357;Research
Bioassay Publications (25)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 4 (16.00) 29.6817 2010's 19 (76.00) 24.3611 2020's 2 (8.00) 2.80 Compounds (34)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) berberine Homo sapiens (human) IC50 4.9900 2 2 flufenamic acid Homo sapiens (human) IC50 1.4901 7 7 flufenamic acid Homo sapiens (human) Ki 1.6200 2 2 flurbiprofen Homo sapiens (human) IC50 1.5600 1 1 gliclazide Homo sapiens (human) IC50 19.6200 1 1 glimepiride Homo sapiens (human) IC50 0.8500 1 1 ibuprofen Homo sapiens (human) IC50 21.5000 2 2 indomethacin Homo sapiens (human) IC50 3.4486 7 7 indomethacin Homo sapiens (human) Ki 1.1850 2 2 meclofenamic acid Homo sapiens (human) IC50 0.5307 3 3 mefenamic acid Homo sapiens (human) IC50 0.5600 1 1 mefenamic acid Homo sapiens (human) Ki 0.3000 1 1 fenamic acid Homo sapiens (human) IC50 1.5100 2 2 medroxyprogesterone acetate Homo sapiens (human) IC50 1.4059 2 2 benzoic anhydride Homo sapiens (human) IC50 70.0000 1 1 3,5-dichlorosalicylic acid Homo sapiens (human) Ki 23.9210 2 9 3,5-dibromosalicylic acid Homo sapiens (human) Ki 23.0000 1 1 3-phenoxybenzoic acid Homo sapiens (human) IC50 0.6800 1 1 6-methoxy-2-naphthylacetic acid Homo sapiens (human) IC50 0.6500 1 1 dexibuprofen Homo sapiens (human) IC50 32.7000 1 1 octyl gallate Homo sapiens (human) IC50 2.5600 1 1 4-methoxybenzophenone Homo sapiens (human) IC50 180.0000 1 1 5-methoxy-methylindoleacetic acid Homo sapiens (human) IC50 100.0000 1 1 naproxen Homo sapiens (human) IC50 0.5867 3 3 2'-hydroxyflavanone Homo sapiens (human) IC50 0.2333 3 3 tolfenamic acid Homo sapiens (human) Ki 0.0080 1 1 diclofenac sodium Homo sapiens (human) IC50 2.6000 1 1 linoleic acid Homo sapiens (human) IC50 0.6900 2 2 jasmonic acid Homo sapiens (human) Ki 93.0000 2 2 caffeic acid phenethyl ester Homo sapiens (human) IC50 2.7050 2 2 tazettine Homo sapiens (human) IC50 15.8000 1 1 artepillin c Homo sapiens (human) IC50 1.0000 1 1 artepillin c Homo sapiens (human) Ki 0.6800 2 2 drupanin Homo sapiens (human) IC50 15.2830 3 3 mf63 compound Homo sapiens (human) IC50 50.0000 1 1 buparlisib Homo sapiens (human) IC50 8.7000 2 2 buparlisib Homo sapiens (human) Ki 14.0000 1 1 dinaciclib Homo sapiens (human) IC50 0.2300 1 1 dinaciclib Homo sapiens (human) Ki 0.0700 1 1 Drugs with Other Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide Homo sapiens (human) Km 43.5500 1 1 Enables
Target Category Definition retinal dehydrogenase activity molecular function Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. [EC:1.2.1.36] aldose reductase (NADPH) activity molecular function Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21] aldo-keto reductase (NADPH) activity molecular function Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. [GOC:ai] estradiol 17-beta-dehydrogenase [NAD(P)] activity molecular function Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62] all-trans-retinol dehydrogenase (NAD+) activity molecular function Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. [RHEA:21284] oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor molecular function Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai] phenanthrene 9,10-monooxygenase activity molecular function Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. [UM-BBD_reactionID:r0495] dihydrotestosterone 17-beta-dehydrogenase activity molecular function Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755] prostaglandin H2 endoperoxidase reductase activity molecular function Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate). [GOC:mw, KEGG_REACTION:R02264, PMID:10622721, PMID:14979715, PMID:16475787] prostaglandin D2 11-ketoreductase activity molecular function Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+. [EC:1.1.1.188, GOC:mw, KEGG_REACTION:R02799, PMID:1504718, PMID:3862115] geranylgeranyl reductase activity molecular function Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. [PMID:9492312] ketoreductase activity molecular function Catalysis of the reduction of a ketone group to form the corresponding alcohol. [GOC:curators] prostaglandin-F synthase activity molecular function Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN] 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity molecular function Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN] androsterone dehydrogenase activity molecular function Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] 5alpha-androstane-3beta,17beta-diol dehydrogenase activity molecular function Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH. [EC:1.1.1.210, RHEA:16297] testosterone dehydrogenase (NAD+) activity molecular function Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. [EC:1.1.1.239] androstan-3-alpha,17-beta-diol dehydrogenase activity molecular function Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] testosterone 17-beta-dehydrogenase (NADP+) activity molecular function Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] ketosteroid monooxygenase activity molecular function Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] Delta4-3-oxosteroid 5beta-reductase activity molecular function Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates. [EC:1.3.1.3] all-trans-retinol dehydrogenase (NADP+) activity molecular function Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. [RHEA:25033] bile acid binding molecular function Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph] Located In
Target Category Definition nucleus cellular component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] cytoplasm cellular component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] extracellular exosome cellular component A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] Active In
Target Category Definition cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] Involved In
Target Category Definition retinoid metabolic process biological process The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [ISBN:0198506732] prostaglandin metabolic process biological process The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [ISBN:0198506732] G protein-coupled receptor signaling pathway biological process The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] response to nutrient biological process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators] steroid metabolic process biological process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684] positive regulation of cell population proliferation biological process Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] male gonad development biological process The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid] cellular response to starvation biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl] farnesol catabolic process biological process The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. [GOC:go_curators] cyclooxygenase pathway biological process The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. [PMID:19854273] keratinocyte differentiation biological process The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] progesterone metabolic process biological process The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/] retinol metabolic process biological process The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] retinal metabolic process biological process The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. [ISBN:0198506732] macromolecule metabolic process biological process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah] daunorubicin metabolic process biological process The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. [PMID:20837989] doxorubicin metabolic process biological process The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. [PMID:10200167] regulation of retinoic acid receptor signaling pathway biological process Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. [GOC:dgh] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction biological process Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai] testosterone biosynthetic process biological process The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5. [GOC:dph, GOC:yaf] renal absorption biological process A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). [GOC:dph, GOC:mah, GOC:yaf] cellular response to calcium ion biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:mah] cellular response to prostaglandin stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. [GOC:mah] cellular response to corticosteroid stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. [GOC:mah] cellular response to jasmonic acid stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. [GOC:mah] cellular response to prostaglandin D stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. [GOC:sl] negative regulation of retinoic acid biosynthetic process biological process Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process. [GOC:TermGenie, GOC:yaf] regulation of testosterone biosynthetic process biological process Any process that modulates the frequency, rate or extent of testosterone biosynthetic process. [GOC:obol, GOC:yaf] positive regulation of endothelial cell apoptotic process biological process Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] positive regulation of reactive oxygen species metabolic process biological process Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]