Proteins > Glycogen phosphorylase, muscle form
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Glycogen phosphorylase, muscle form
A glycogen phosphorylase, muscle form that is encoded in the genome of rabbit. [OMA:P00489, PRO:DNx]
Synonyms
EC 2.4.1.1;
Myophosphorylase
Research
Bioassay Publications (30)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 20 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (38)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| taxifolin | Oryctolagus cuniculus (rabbit) | IC50 | 12.8500 | 2 | 2 |
| acetazolamide | Oryctolagus cuniculus (rabbit) | Ki | 0.0410 | 1 | 1 |
| caffeine | Oryctolagus cuniculus (rabbit) | IC50 | 159.1933 | 13 | 15 |
| dichlorphenamide | Oryctolagus cuniculus (rabbit) | Ki | 0.3450 | 1 | 1 |
| ethoxzolamide | Oryctolagus cuniculus (rabbit) | Ki | 0.0250 | 1 | 1 |
| methazolamide | Oryctolagus cuniculus (rabbit) | Ki | 0.0430 | 1 | 1 |
| glycyrrhetinic acid | Oryctolagus cuniculus (rabbit) | IC50 | 66.0000 | 1 | 1 |
| oleanolic acid | Oryctolagus cuniculus (rabbit) | IC50 | 16.4465 | 6 | 7 |
| glycyrrhizic acid | Oryctolagus cuniculus (rabbit) | IC50 | 822.0000 | 1 | 1 |
| glucose, (beta-d)-isomer | Oryctolagus cuniculus (rabbit) | Ki | 7,400.0000 | 1 | 1 |
| ursolic acid | Oryctolagus cuniculus (rabbit) | IC50 | 10.5531 | 3 | 4 |
| betulinic acid | Oryctolagus cuniculus (rabbit) | IC50 | 42.9145 | 3 | 4 |
| betulin | Oryctolagus cuniculus (rabbit) | IC50 | 21.8965 | 4 | 5 |
| arjunolic acid | Oryctolagus cuniculus (rabbit) | IC50 | 102.7645 | 1 | 2 |
| maslinic acid | Oryctolagus cuniculus (rabbit) | IC50 | 28.0460 | 3 | 4 |
| glucose | Oryctolagus cuniculus (rabbit) | Ki | 1,775.0000 | 4 | 4 |
| asiatic acid | Oryctolagus cuniculus (rabbit) | IC50 | 16.9941 | 2 | 3 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Oryctolagus cuniculus (rabbit) | Ki | 0.1040 | 1 | 1 |
| 2-phenyl-2-oxazoline | Oryctolagus cuniculus (rabbit) | IC50 | 23,900.0000 | 1 | 1 |
| n-benzoyl-n'-beta-d-glucopyranosyl urea | Oryctolagus cuniculus (rabbit) | Ki | 4.6000 | 6 | 6 |
| n-acetyl-n'-beta-d-glucopyranosyl urea | Oryctolagus cuniculus (rabbit) | Ki | 321.2500 | 4 | 4 |
| isofagomine | Oryctolagus cuniculus (rabbit) | Ki | 5.2000 | 1 | 1 |
| 1,4-dideoxy-1,4-imino-d-arabinitol | Oryctolagus cuniculus (rabbit) | Ki | 0.4000 | 1 | 1 |
| 2-(beta-D-glucosyl)benzimidazole | Oryctolagus cuniculus (rabbit) | IC50 | 8.6000 | 1 | 1 |
| 2-(beta-D-glucosyl)benzimidazole | Oryctolagus cuniculus (rabbit) | Ki | 9.6000 | 10 | 10 |
| 2-(beta-D-glucosyl)benzothiazole | Oryctolagus cuniculus (rabbit) | Ki | 127.0000 | 9 | 9 |
| thiohydantoins | Oryctolagus cuniculus (rabbit) | Ki | 5.1000 | 1 | 1 |
| gl-4 | Oryctolagus cuniculus (rabbit) | Ki | 5.1000 | 4 | 4 |
| alvocidib | Oryctolagus cuniculus (rabbit) | IC50 | 1.2000 | 1 | 1 |
| 3 beta-o-acetylursolic acid | Oryctolagus cuniculus (rabbit) | IC50 | 131.4130 | 1 | 2 |
| corosolic acid | Oryctolagus cuniculus (rabbit) | IC50 | 19.9882 | 3 | 4 |
| 3-oxo-12-ursen-28-oic acid | Oryctolagus cuniculus (rabbit) | IC50 | 57.1813 | 2 | 3 |
| azd 8931 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0140 | 1 | 1 |
| 3-epioleanolic acid | Oryctolagus cuniculus (rabbit) | IC50 | 21.4624 | 2 | 3 |
| 11-deoxy glycyrrhetinic acid | Oryctolagus cuniculus (rabbit) | IC50 | 81.7610 | 2 | 3 |
| oleanonic acid | Oryctolagus cuniculus (rabbit) | IC50 | 17.8957 | 3 | 4 |
| augustic acid | Oryctolagus cuniculus (rabbit) | IC50 | 33.9615 | 2 | 3 |
| 23-hydroxybetulinic acid | Oryctolagus cuniculus (rabbit) | IC50 | 33.3698 | 4 | 5 |
| epi-maslinic acid | Oryctolagus cuniculus (rabbit) | IC50 | 144.1813 | 2 | 3 |
Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
2-Oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors: Design, synthesis and structure-activity relationship study.
European journal of medicinal chemistry, , Mar-23, Volume: 111, 2016
Synthesis, screening and docking of small heterocycles as glycogen phosphorylase inhibitors.
European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents.
Chemical biology & drug design, , Volume: 83, Issue:3, 2014
Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 22, Issue:2, 2012
Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
Journal of natural products, , Volume: 72, Issue:8, 2009
Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.
Journal of natural products, , Volume: 71, Issue:11, 2008
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
European journal of medicinal chemistry, , Mar-23, Volume: 111, 2016
Synthesis, screening and docking of small heterocycles as glycogen phosphorylase inhibitors.
European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents.
Chemical biology & drug design, , Volume: 83, Issue:3, 2014
Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 22, Issue:2, 2012
Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
Journal of natural products, , Volume: 72, Issue:8, 2009
Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.
Journal of natural products, , Volume: 71, Issue:11, 2008
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents.
Chemical biology & drug design, , Volume: 83, Issue:3, 2014
Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 22, Issue:2, 2012
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
Journal of natural products, , Volume: 72, Issue:8, 2009
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
Chemical biology & drug design, , Volume: 83, Issue:3, 2014
Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 22, Issue:2, 2012
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
Journal of natural products, , Volume: 72, Issue:8, 2009
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
Bioorganic & medicinal chemistry, , May-15, Volume: 18, Issue:10, 2010
Bioorganic & medicinal chemistry, , May-15, Volume: 18, Issue:10, 2010
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
Journal of natural products, , Volume: 72, Issue:8, 2009
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
Journal of natural products, , Volume: 72, Issue:8, 2009
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.
Journal of natural products, , Volume: 71, Issue:11, 2008
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.
Journal of natural products, , Volume: 71, Issue:11, 2008
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
Bioorganic & medicinal chemistry, , May-15, Volume: 18, Issue:10, 2010
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
Bioorganic & medicinal chemistry, , May-15, Volume: 18, Issue:10, 2010
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Synthesis, screening and docking of small heterocycles as glycogen phosphorylase inhibitors.
European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Synthesis of (benzimidazol-2-yl)aniline derivatives as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis, enzyme kinetics and computational evaluation of N-(β-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , Sep-15, Volume: 21, Issue:18, 2013
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorganic & medicinal chemistry, , Mar-01, Volume: 20, Issue:5, 2012
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis, enzyme kinetics and computational evaluation of N-(β-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , Sep-15, Volume: 21, Issue:18, 2013
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorganic & medicinal chemistry, , Mar-01, Volume: 20, Issue:5, 2012
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorganic & medicinal chemistry, , Mar-01, Volume: 20, Issue:5, 2012
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorganic & medicinal chemistry, , Mar-01, Volume: 20, Issue:5, 2012
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
Journal of medicinal chemistry, , Sep-21, Volume: 49, Issue:19, 2006
Journal of medicinal chemistry, , Sep-21, Volume: 49, Issue:19, 2006
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
Journal of medicinal chemistry, , 11-22, Volume: 60, Issue:22, 2017
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis of (benzimidazol-2-yl)aniline derivatives as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Dec-10, Volume: 6, Issue:12, 2015
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.
European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Jul-11, Volume: 4, Issue:7, 2013
Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Journal of medicinal chemistry, , 11-22, Volume: 60, Issue:22, 2017
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis of (benzimidazol-2-yl)aniline derivatives as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Dec-10, Volume: 6, Issue:12, 2015
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.
European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Jul-11, Volume: 4, Issue:7, 2013
Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis of (benzimidazol-2-yl)aniline derivatives as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Dec-10, Volume: 6, Issue:12, 2015
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.
European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Jul-11, Volume: 4, Issue:7, 2013
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis of (benzimidazol-2-yl)aniline derivatives as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Dec-10, Volume: 6, Issue:12, 2015
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.
European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
ACS medicinal chemistry letters, , Jul-11, Volume: 4, Issue:7, 2013
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorganic & medicinal chemistry, , Mar-01, Volume: 20, Issue:5, 2012
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorganic & medicinal chemistry, , Mar-01, Volume: 20, Issue:5, 2012
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.
Journal of natural products, , Volume: 71, Issue:11, 2008
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.
Journal of natural products, , Volume: 71, Issue:11, 2008
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors.
ACS medicinal chemistry letters, , Aug-08, Volume: 4, Issue:8, 2013
ACS medicinal chemistry letters, , Aug-08, Volume: 4, Issue:8, 2013
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008