propofol has been researched along with Necrosis in 21 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h." | 8.82 | [Propofol infusion syndrome]. ( Motsch, J; Roggenbach, J, 2004) |
| "Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups." | 7.85 | Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017) |
| "Propofol, a central-acting sedative agent, has been implicated in the development of rhabdomyolysis in children." | 7.70 | Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings. ( Apple, FS; Crosson, JT; Johari, VP; Smith, SA; Stelow, EB, 2000) |
| "Propofol has been associated with severe adverse reactions in children receiving intensive care." | 6.40 | Lactic acidemia and bradyarrhythmia in a child sedated with propofol. ( Cox, PN; Cray, SH; Robinson, BH, 1998) |
| "Propofol was added to each culture group at a concentration of 0 microM (Vehicle), 0." | 5.33 | Neuroprotective effect of propofol on necrosis and apoptosis following oxygen-glucose deprivation--relationship between mitochondrial membrane potential and mode of death. ( Akagawa, K; Iijima, T; Iwao, Y; Mishima, T, 2006) |
| "Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h." | 4.82 | [Propofol infusion syndrome]. ( Motsch, J; Roggenbach, J, 2004) |
| "Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups." | 3.85 | Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017) |
| "Propofol, a central-acting sedative agent, has been implicated in the development of rhabdomyolysis in children." | 3.70 | Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings. ( Apple, FS; Crosson, JT; Johari, VP; Smith, SA; Stelow, EB, 2000) |
| "Propofol has been associated with severe adverse reactions in children receiving intensive care." | 2.40 | Lactic acidemia and bradyarrhythmia in a child sedated with propofol. ( Cox, PN; Cray, SH; Robinson, BH, 1998) |
| "Propofol is a drug used in anesthesia that has unique antioxidant qualities that may be beneficial." | 1.36 | Apoptosis: understanding programmed cell death for the CRNA. ( Bennetts, PS; Pierce, JD, 2010) |
| "One hundred percent propofol is neither safe nor effective when administered via the IM route; presumably as a result of poor systemic uptake of the hydrophobic drug." | 1.35 | Safety and efficacy of intramuscular propofol administration in rats. ( Brosnan, RJ; Dark, MJ; Haldorson, GJ; McKune, CM, 2008) |
| "Propofol treatments were initiated at various time intervals: 1 or 24 h before ischemia, only during ischemia, or only during reperfusion." | 1.35 | The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion. ( Assad, AR; Capella, MA; Delou, JM; Fonseca, LM; Lopes, AG; Nascimento, JH; Verçosa, N; Villela, NR, 2009) |
| "Propofol was added to each culture group at a concentration of 0 microM (Vehicle), 0." | 1.33 | Neuroprotective effect of propofol on necrosis and apoptosis following oxygen-glucose deprivation--relationship between mitochondrial membrane potential and mode of death. ( Akagawa, K; Iijima, T; Iwao, Y; Mishima, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lemos, SV | 1 |
| Vianna, IG | 1 |
| Castiglia, YM | 1 |
| Golim, MA | 1 |
| Souza, AV | 1 |
| Carvalho, LR | 1 |
| Deffune, E | 1 |
| Nascimento, PD | 1 |
| Módolo, NS | 1 |
| Vianna, PT | 1 |
| Choi, SR | 1 |
| Kim, JH | 1 |
| Chae, KL | 1 |
| Lee, SC | 1 |
| Park, SY | 1 |
| Zhang, JL | 1 |
| Fei, SJ | 1 |
| Qin, X | 1 |
| Ye, HH | 1 |
| Liu, HX | 1 |
| Dai, XJ | 1 |
| Zhang, YM | 1 |
| Tang, J | 1 |
| Jiang, Y | 1 |
| Tang, Y | 1 |
| Chen, B | 1 |
| Sun, X | 1 |
| Su, L | 1 |
| Liu, Z | 1 |
| LeBlanc, JM | 1 |
| Lalonde, D | 1 |
| Cameron, K | 1 |
| Mowatt, JA | 1 |
| Chondrogiannis, K | 1 |
| Hadziyannis, E | 1 |
| Fassoulaki, A | 1 |
| Abdelmalak, BB | 1 |
| Bashour, CA | 1 |
| Yared, JP | 1 |
| McKune, CM | 1 |
| Brosnan, RJ | 1 |
| Dark, MJ | 1 |
| Haldorson, GJ | 1 |
| Assad, AR | 1 |
| Delou, JM | 1 |
| Fonseca, LM | 1 |
| Villela, NR | 1 |
| Nascimento, JH | 1 |
| Verçosa, N | 1 |
| Lopes, AG | 1 |
| Capella, MA | 1 |
| Bennetts, PS | 1 |
| Pierce, JD | 1 |
| Zangrillo, A | 1 |
| Testa, V | 1 |
| Aldrovandi, V | 1 |
| Tuoro, A | 1 |
| Casiraghi, G | 1 |
| Cavenago, F | 1 |
| Messina, M | 1 |
| Bignami, E | 1 |
| Landoni, G | 1 |
| Ohno, S | 1 |
| Kobayashi, K | 1 |
| Uchida, S | 1 |
| Amano, O | 1 |
| Sakagami, H | 1 |
| Nagasaka, H | 1 |
| Fariña Castro, R | 1 |
| Monzón Rubio, E | 1 |
| Ojeda Betancor, N | 1 |
| Rodríguez-Pérez, A | 1 |
| Motsch, J | 1 |
| Roggenbach, J | 1 |
| Iijima, T | 1 |
| Mishima, T | 1 |
| Akagawa, K | 1 |
| Iwao, Y | 1 |
| Roth, W | 1 |
| Eschertzhuber, S | 1 |
| Gardetto, A | 1 |
| Keller, C | 1 |
| Hanson, P | 1 |
| Dive, A | 1 |
| Brucher, JM | 1 |
| Bisteau, M | 1 |
| Dangoisse, M | 1 |
| Deltombe, T | 1 |
| Halestrap, AP | 1 |
| Kerr, PM | 1 |
| Javadov, S | 1 |
| Woodfield, KY | 1 |
| Cray, SH | 1 |
| Robinson, BH | 1 |
| Cox, PN | 1 |
| Stelow, EB | 1 |
| Johari, VP | 1 |
| Smith, SA | 1 |
| Crosson, JT | 1 |
| Apple, FS | 1 |
| Jevtovic-Todorovic, V | 1 |
| Wozniak, DF | 1 |
| Powell, S | 1 |
| Olney, JW | 1 |
2 reviews available for propofol and Necrosis
| Article | Year |
|---|---|
[Propofol infusion syndrome].
Topics: Acid-Base Imbalance; Acidosis, Lactic; Anesthesia, Intravenous; Anesthetics, Intravenous; Chemistry, | 2004 |
Lactic acidemia and bradyarrhythmia in a child sedated with propofol.
Topics: Acidosis, Lactic; Bradycardia; Conscious Sedation; Fatty Liver; Humans; Hyperlipidemias; Hypnotics a | 1998 |
1 trial available for propofol and Necrosis
| Article | Year |
|---|---|
Volatile agents for cardiac protection in noncardiac surgery: a randomized controlled study.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2011 |
18 other studies available for propofol and Necrosis
| Article | Year |
|---|---|
Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apoptosis; Cell Survival; Cyclosporine; | 2017 |
Anesthetic considerations during surgical intervention in Woake's syndrome -a case report.
Topics: Adolescent; Anesthesia, Intravenous; Anesthetics, Intravenous; Ethmoid Sinus; Humans; Infusions, Int | 2019 |
Propofol inhibits hypoxia/reoxygenation-induced human gastric epithelial cell injury by suppressing the Toll-like receptor 4 pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Cell Hypoxia; Cell Line; Cell Survival; Epithelial Cells; Flo | 2013 |
Effects of propofol on damage of rat intestinal epithelial cells induced by heat stress and lipopolysaccharides.
Topics: Anesthetics, Intravenous; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Survival; Ep | 2013 |
Tissue necrosis after propofol extravasation.
Topics: Anesthetics, Intravenous; Aneurysm; Comorbidity; Diabetes Mellitus; Extravasation of Diagnostic and | 2014 |
Propofol or sevoflurane anaesthesia does not affect hepatic integrity as assessed by the M30 & M65 cell death markers & liver enzymes.
Topics: Aged; Alanine Transaminase; Anesthesia; Apoptosis; Aspartate Aminotransferases; Female; Humans; Kera | 2014 |
Skin infection and necrosis after subcutaneous infiltration of propofol in the intensive care unit.
Topics: Aged; Anesthetics, Intravenous; Drug Contamination; Humans; Injections, Subcutaneous; Intensive Care | 2008 |
Safety and efficacy of intramuscular propofol administration in rats.
Topics: Anesthesia; Animals; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Inflammation | 2008 |
The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Apoptosis; Cell Survival; Cytoprotection; Decanoic Aci | 2009 |
Apoptosis: understanding programmed cell death for the CRNA.
Topics: Anesthetics; Animals; Antioxidants; Apoptosis; Comorbidity; Disease Models, Animal; Drug Monitoring; | 2010 |
Cytotoxicity and type of cell death induced by midazolam in human oral normal and tumor cells.
Topics: Anesthetics, Intravenous; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Diazepam; DNA Frag | 2012 |
[Necro-hemorrhagic pancreatitis after prolonged propofol perfusion].
Topics: Adult; Hemorrhage; Humans; Hypnotics and Sedatives; Male; Necrosis; Pancreatic Diseases; Pancreatiti | 2002 |
Neuroprotective effect of propofol on necrosis and apoptosis following oxygen-glucose deprivation--relationship between mitochondrial membrane potential and mode of death.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Dose-Res | 2006 |
Extravasation of propofol is associated with tissue necrosis in small children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Intravenous; Extravasation of Diagnostic and Therapeuti | 2006 |
Acute corticosteroid myopathy in intensive care patients.
Topics: Acute Disease; Aged; Aged, 80 and over; Biopsy; Critical Care; Electromyography; Female; Humans; Hyp | 1997 |
Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Calcium; Calcium Channels; Cell Death; Deoxyglucose; Fre | 1998 |
Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings.
Topics: Adult; Biomarkers; Cardiomyopathies; Creatine Kinase; Female; Humans; Hypnotics and Sedatives; Kidne | 2000 |
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.
Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Inter | 2001 |