A rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35913]
GMP-PDE beta;
EC 3.1.4.35
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| dipyridamole | Homo sapiens (human) | Ki | 0.1250 | 1 | 1 |
| tadalafil | Homo sapiens (human) | IC50 | 2.9280 | 5 | 5 |
| sildenafil | Homo sapiens (human) | IC50 | 0.0188 | 4 | 4 |
| sildenafil | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| zaprinast | Homo sapiens (human) | Ki | 0.4000 | 1 | 1 |
| vardenafil | Homo sapiens (human) | IC50 | 0.0077 | 3 | 3 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| 3',5'-cyclic-GMP phosphodiesterase activity | molecular function | Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957] |
| 3',5'-cyclic-AMP phosphodiesterase activity | molecular function | Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| photoreceptor disc membrane | cellular component | Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane. [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| photoreceptor outer segment membrane | cellular component | The membrane surrounding the outer segment of a vertebrate photoreceptor. [GOC:jl] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| visual perception | biological process | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai] |
| phototransduction, visible light | biological process | The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. [GOC:go_curators, ISBN:0198506732] |
| entrainment of circadian clock by photoperiod | biological process | The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). [GOC:jl] |
| retinal cell apoptotic process | biological process | Any apoptotic process in a retinal cell. [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675] |
| retina development in camera-type eye | biological process | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. [GOC:bf, GOC:dph, ISBN:0815340729] |
| cAMP-mediated signaling | biological process | An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling] |