2,3-dimethoxy-1,4-naphthoquinone has been researched along with Necrosis in 3 studies
2,3-dimethoxynaphthalene-1,4-dione : A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increasing concentrations (1-100 microM) of the redox cycling quinone, 2,3-dimethoxy-1,4-naphthoquinone (DMNQ), stimulated growth, triggered apoptosis, or caused necrosis of pancreatic RINm5F cells, depending on the dose and duration of the exposure." | 3.69 | Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines. ( Ankarcrona, M; Burkitt, M; Dypbukt, JM; Nicotera, P; Orrenius, S; Sjöholm, A; Ström, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horvathova, E | 1 |
| Eckl, PM | 1 |
| Bresgen, N | 2 |
| Slamenova, D | 1 |
| Jaksch, H | 1 |
| Bauer, HC | 1 |
| Eckl, P | 1 |
| Krizbai, I | 1 |
| Tempfer, H | 1 |
| Dypbukt, JM | 1 |
| Ankarcrona, M | 1 |
| Burkitt, M | 1 |
| Sjöholm, A | 1 |
| Ström, K | 1 |
| Orrenius, S | 1 |
| Nicotera, P | 1 |
3 other studies available for 2,3-dimethoxy-1,4-naphthoquinone and Necrosis
| Article | Year |
|---|---|
Evaluation of genotoxic and cytotoxic effects of H2O2 and DMNQ on freshly isolated rat hepatocytes; protective effects of carboxymethyl chitin-glucan.
Topics: Animals; Antioxidants; Apoptosis; Cell Count; Cell Death; Cell Separation; Chitin; Comet Assay; DNA; | 2008 |
Astrocytes are more resistant than cerebral endothelial cells toward geno- and cytotoxicity mediated by short-term oxidative stress.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Death; Cells, Cultured; | 2006 |
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosylmethionine Decarboxylase; Animals; Apoptosis; Cell Division; Ce | 1994 |