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Mu-type opioid receptor
A mu-type opioid receptor that is encoded in the genome of mouse. [OMA:P42866, PRO:DNx]
Synonyms
M-OR-1;
MOR-1
Research
Bioassay Publications (61)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 10 (16.39) | 18.7374 |
| 1990's | 12 (19.67) | 18.2507 |
| 2000's | 9 (14.75) | 29.6817 |
| 2010's | 23 (37.70) | 24.3611 |
| 2020's | 7 (11.48) | 2.80 |
Compounds (55)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.ACS medicinal chemistry letters, , Aug-14, Volume: 5, Issue:8, 2014
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 24, Issue:20, 2014
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Antipodal alpha-N-(methyl through decyl)-N-normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans): in vitro and in vivo properties.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.ACS medicinal chemistry letters, , Aug-09, Volume: 3, Issue:8, 2012
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.Bioorganic & medicinal chemistry, , Sep-01, Volume: 17, Issue:17, 2009
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.Journal of medicinal chemistry, , Sep-26, Volume: 40, Issue:20, 1997
Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.ACS medicinal chemistry letters, , Aug-14, Volume: 5, Issue:8, 2014
Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide.Journal of medicinal chemistry, , Volume: 34, Issue:6, 1991
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators.Journal of medicinal chemistry, , 12-26, Volume: 62, Issue:24, 2019
Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime.Journal of medicinal chemistry, , Aug-04, Volume: 38, Issue:16, 1995
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.Journal of medicinal chemistry, , Volume: 32, Issue:5, 1989
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.Journal of medicinal chemistry, , 02-10, Volume: 65, Issue:3, 2022
Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception.MedChemComm, , Jan-01, Volume: 8, Issue:1, 2017
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 23, Issue:17, 2013
Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans.Bioorganic & medicinal chemistry, , May-15, Volume: 18, Issue:10, 2010
Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.Bioorganic & medicinal chemistry, , Apr-15, Volume: 16, Issue:8, 2008
Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 14, Issue:22, 2004
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.Journal of medicinal chemistry, , 06-10, Volume: 64, Issue:11, 2021
Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry.ACS medicinal chemistry letters, , Nov-12, Volume: 11, Issue:11, 2020
Design and synthesis of a bivalent probe targeting the putative mu opioid receptor and chemokine receptor CXCR4 heterodimer.RSC medicinal chemistry, , Jan-01, Volume: 11, Issue:1, 2020
Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opioBioorganic & medicinal chemistry, , Nov-01, Volume: 21, Issue:21, 2013
Structure activity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinBioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.ACS medicinal chemistry letters, , Aug-09, Volume: 3, Issue:8, 2012
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.Journal of medicinal chemistry, , Mar-26, Volume: 52, Issue:6, 2009
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluatiJournal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Isolation and Pharmacological Characterization of Six Opioidergic Journal of natural products, , 01-22, Volume: 84, Issue:1, 2021
Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.Journal of medicinal chemistry, , 11-25, Volume: 63, Issue:22, 2020
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators.Journal of medicinal chemistry, , 12-26, Volume: 62, Issue:24, 2019
Chemical space screening around PheBioorganic & medicinal chemistry letters, , 07-15, Volume: 28, Issue:13, 2018
Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception.MedChemComm, , Jan-01, Volume: 8, Issue:1, 2017
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.Journal of medicinal chemistry, , 09-22, Volume: 59, Issue:18, 2016
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 24, Issue:20, 2014
Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 23, Issue:17, 2013
Novel 6β-acylaminomorphinans with analgesic activity.European journal of medicinal chemistry, , Volume: 69, 2013
Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands.Bioorganic & medicinal chemistry, , Oct-01, Volume: 20, Issue:19, 2012
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.Journal of medicinal chemistry, , Sep-26, Volume: 40, Issue:20, 1997
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 22, Issue:8, 2012
Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands.Bioorganic & medicinal chemistry, , Oct-01, Volume: 20, Issue:19, 2012
Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 20, Issue:21, 2010