A coiled-coil domain-containing protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16204]
Papillary thyroid carcinoma-encoded protein;
Protein H4
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| staurosporine | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| zd 6474 | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| lenvatinib | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| ponatinib | Homo sapiens (human) | IC50 | 0.1804 | 1 | 1 |
| cabozantinib | Homo sapiens (human) | GI50 | 0.0290 | 1 | 1 |
| cabozantinib | Homo sapiens (human) | IC50 | 0.4615 | 2 | 2 |
| cep-32496 | Homo sapiens (human) | IC50 | 0.0037 | 2 | 2 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| structural constituent of cytoskeleton | molecular function | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| SH3 domain binding | molecular function | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cytoskeleton | cellular component | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah] |
| biological_process | biological process | A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt] |