Page last updated: 2024-08-07 16:12:22
Aromatase
An aromatase that is encoded in the genome of rat. [OMA:P22443, PRO:DNx]
Synonyms
EC 1.14.14.14;
CYPXIX;
Cytochrome P-450AROM;
Cytochrome P450 19A1;
Estrogen synthase
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aminoglutethimide | Rattus norvegicus (Norway rat) | EC50 | 0.2600 | 1 | 1 |
| miconazole | Rattus norvegicus (Norway rat) | EC50 | 0.4000 | 1 | 1 |
| ancymidol | Rattus norvegicus (Norway rat) | EC50 | 2.0000 | 1 | 1 |
| fenarimol | Rattus norvegicus (Norway rat) | EC50 | 4.1000 | 1 | 1 |
| ly 56110 | Rattus norvegicus (Norway rat) | EC50 | 0.0550 | 2 | 2 |
| octotiamine | Rattus norvegicus (Norway rat) | EC50 | 0.1400 | 1 | 1 |
Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives.Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Mechanism and inhibition of cytochrome P-450 aromatase.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987