Page last updated: 2024-08-07 12:49:04
Proto-oncogene tyrosine-protein kinase Src
A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of chicken. [OMA:P00523, PRO:DNx]
Synonyms
EC 2.7.10.2;
Proto-oncogene c-Src;
pp60c-src;
p60-Src
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
Compounds (24)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| pd 173074 | Gallus gallus (chicken) | IC50 | 20.0000 | 1 | 1 |
| cl 387785 | Gallus gallus (chicken) | IC50 | 13.5005 | 2 | 2 |
| pd168393 | Gallus gallus (chicken) | IC50 | 4.7744 | 6 | 7 |
| 1-NA-PP1 | Gallus gallus (chicken) | IC50 | 0.3400 | 1 | 1 |
| ag 1879 | Gallus gallus (chicken) | IC50 | 0.0360 | 1 | 1 |
| imatinib | Gallus gallus (chicken) | IC50 | 2.7840 | 1 | 1 |
| staurosporine | Gallus gallus (chicken) | IC50 | 0.0063 | 1 | 1 |
| erlotinib | Gallus gallus (chicken) | IC50 | 7.9950 | 3 | 4 |
| pd 166326 | Gallus gallus (chicken) | IC50 | 0.0060 | 1 | 1 |
| Src Inhibitor-1 | Gallus gallus (chicken) | IC50 | 0.1800 | 1 | 1 |
| dasatinib | Gallus gallus (chicken) | IC50 | 0.1922 | 4 | 5 |
| 1-tert-butyl-3-naphthalen-1-ylmethyl-1h-pyrazolo(3,4-d)pyrimidin-4-ylemine | Gallus gallus (chicken) | IC50 | 0.6200 | 1 | 1 |
| pd 166285 | Gallus gallus (chicken) | IC50 | 0.0090 | 2 | 2 |
| su 6656 | Gallus gallus (chicken) | IC50 | 0.1000 | 1 | 1 |
| pd 089828 | Gallus gallus (chicken) | IC50 | 0.2200 | 1 | 1 |
| pd 166866 | Gallus gallus (chicken) | IC50 | 50.0000 | 2 | 2 |
| pd 161570 | Gallus gallus (chicken) | IC50 | 0.0152 | 2 | 2 |
| su 11248 | Gallus gallus (chicken) | IC50 | 0.5550 | 1 | 1 |
| vx680 | Gallus gallus (chicken) | IC50 | 0.3400 | 1 | 1 |
| ponatinib | Gallus gallus (chicken) | IC50 | 0.0009 | 1 | 1 |
| chir 258 | Gallus gallus (chicken) | IC50 | 0.0808 | 1 | 1 |
| pp242 | Gallus gallus (chicken) | IC50 | 2.6263 | 1 | 8 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ag 1879 | Gallus gallus (chicken) | Kd | 0.2960 | 1 | 1 |
| imatinib | Gallus gallus (chicken) | Kd | 0.0128 | 2 | 2 |
| s 1033 | Gallus gallus (chicken) | Kd | 0.0130 | 2 | 2 |
| dasatinib | Gallus gallus (chicken) | Kd | 0.0037 | 2 | 3 |
| ponatinib | Gallus gallus (chicken) | Kd | 0.0007 | 2 | 2 |
| dcc-2036 | Gallus gallus (chicken) | Kd | 0.0091 | 2 | 2 |