Proteins > 5-hydroxytryptamine receptor 1D
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5-hydroxytryptamine receptor 1D
A 5-hydroxytryptamine receptor 1D that is encoded in the genome of rat. [OMA:P28565, PRO:DNx]
Synonyms
5-HT-1D;
5-HT1D;
Serotonin receptor 1D
Research
Bioassay Publications (34)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 16 (47.06) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (94)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.1600 | 1 | 1 |
| 1-(1-naphthyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| 1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0290 | 1 | 1 |
| 1-(3-chlorophenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| 3-nitrobenzeneboronic acid | Rattus norvegicus (Norway rat) | IC50 | 200.0000 | 1 | 1 |
| methylbufotenin | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| 5-methoxytryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| benzo(b)thiophene-2-boronic acid | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| cisapride | Rattus norvegicus (Norway rat) | IC50 | 4.4700 | 1 | 1 |
| cisapride | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| desipramine | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| amphetamine | Rattus norvegicus (Norway rat) | Ki | 7.6600 | 1 | 1 |
| doxepin | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.5090 | 2 | 2 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| metoclopramide | Rattus norvegicus (Norway rat) | IC50 | 7.8000 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 0.8400 | 2 | 2 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0199 | 2 | 2 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 15.0000 | 2 | 2 |
| pindolol | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 1 | 1 |
| prazosin | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.1053 | 2 | 3 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 0.1600 | 1 | 1 |
| sumatriptan | Rattus norvegicus (Norway rat) | IC50 | 0.0610 | 1 | 1 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| phenylpiperazine | Rattus norvegicus (Norway rat) | Ki | 0.1420 | 2 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 64.6000 | 1 | 1 |
| lysergol | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Ki | 4.5700 | 1 | 1 |
| metergoline | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Ki | 46.4000 | 1 | 1 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 79.4000 | 1 | 1 |
| indalpine | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 2 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.3850 | 1 | 1 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 1.5000 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Ki | 3.3400 | 1 | 1 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 1.0200 | 1 | 1 |
| etisulergine | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 2 | 2 |
| agroclavine | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Ki | 2.8900 | 1 | 1 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Ki | 14.1000 | 1 | 1 |
| 6-chloro-2-(1-piperazinyl)pyrazine | Rattus norvegicus (Norway rat) | Ki | 0.8440 | 1 | 1 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | Rattus norvegicus (Norway rat) | IC50 | 1.5000 | 1 | 1 |
| mosapride | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| l 687384 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| mcn 5707 | Rattus norvegicus (Norway rat) | Ki | 4.5267 | 1 | 3 |
| vb 20b7 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sc 53116 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| n-dansyl-3-aminobenzeneboronic acid | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 2.6600 | 1 | 1 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| bms 387032 | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 1 |
| mcn 5652 | Rattus norvegicus (Norway rat) | Ki | 0.9025 | 1 | 2 |
| quinagolide | Rattus norvegicus (Norway rat) | IC50 | 5.6000 | 2 | 4 |
| 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione | Rattus norvegicus (Norway rat) | Ki | 3,715,350,000,000,000.0000 | 1 | 1 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| cinanserin | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| cp 135807 | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 1 | 1 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 4.0000 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 2.2950 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 3.5500 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 4.2000 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| cirazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0126 | 1 | 1 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| naphazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0631 | 1 | 1 |
| oxymetazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| sumatriptan | Rattus norvegicus (Norway rat) | EC50 | 0.0970 | 1 | 1 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| cp 93129 | Rattus norvegicus (Norway rat) | EC50 | 10.0000 | 1 | 2 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| cp 135807 | Rattus norvegicus (Norway rat) | EC50 | 0.0013 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |
Drugs with Other Measurements
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Serotonin receptor affinity of cathinone and related analogues.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.Journal of medicinal chemistry, , May-26, Volume: 38, Issue:11, 1995
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986