A sialidase-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQ49]
EC 3.2.1.18;
Ganglioside sialidasedis;
Membrane sialidase;
N-acetyl-alpha-neuraminidase 3
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| carzenide | Homo sapiens (human) | IC50 | 2,500.0000 | 1 | 1 |
| zanamivir | Homo sapiens (human) | IC50 | 5.6617 | 6 | 5 |
| zanamivir | Homo sapiens (human) | Ki | 0.6200 | 3 | 2 |
| oseltamivir | Homo sapiens (human) | IC50 | 5,250.0000 | 4 | 4 |
| 2-deoxy-2,3-dehydro-n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 34.4632 | 18 | 17 |
| 2-deoxy-2,3-dehydro-n-acetylneuraminic acid | Homo sapiens (human) | Ki | 1.7500 | 4 | 3 |
| bcx 1812 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| 4-amino-2-deoxy-2,3-didehydro-n-acetylneuraminic acid | Homo sapiens (human) | IC50 | 180.0000 | 1 | 1 |
| bana 113 | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| exo-alpha-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. [EC:3.2.1.18] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| alpha-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. [GOC:mah] |
| exo-alpha-(2->3)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
| exo-alpha-(2->6)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
| exo-alpha-(2->8)-sialidase activity | molecular function | Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| caveola | cellular component | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| early endosome membrane | cellular component | The lipid bilayer surrounding an early endosome. [GOC:pz] |
| recycling endosome membrane | cellular component | The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| ganglioside catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. [ISBN:0198547684] |
| oligosaccharide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732] |
| positive regulation of epidermal growth factor receptor signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators] |
| glycosphingolipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198506732] |
| negative regulation of clathrin-dependent endocytosis | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis. [GOC:TermGenie] |