Phosphatidylcholine:ceramide cholinephosphotransferase 2

A phosphatidylcholine:ceramide cholinephosphotransferase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHU3]

EC 2.7.8.27;
Sphingomyelin synthase 2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
malabaricone c	Homo sapiens (human)	IC50	1.2500	2	2
malabaricone b	Homo sapiens (human)	IC50	1.7500	2	2
malabaricone a	Homo sapiens (human)	IC50	2.5000	2	2
d 609	Homo sapiens (human)	IC50	224.0000	1	1
2-(2-methoxyanilino)-2-(2-phenylmethoxyphenyl)acetonitrile	Homo sapiens (human)	IC50	12.4000	1	1
ginkgolic acid	Homo sapiens (human)	IC50	1.5000	1	1

This protein enables 5 target(s):

Target	Category	Definition
ceramide phosphoethanolamine synthase activity	molecular function	Catalysis of the reaction: an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H+. [EC:2.7.8.48, PMID:25667419]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
kinase activity	molecular function	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]
sphingomyelin synthase activity	molecular function	Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. [EC:2.7.8.27, RHEA:18765]
ceramide cholinephosphotransferase activity	molecular function	Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin. [EC:2.7.8.3, RHEA:16273]

This protein is located in 4 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 3 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 5 target(s):

Target	Category	Definition
sphingomyelin biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]
sphingolipid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]
regulation of bone mineralization	biological process	Any process that modulates the frequency, rate or extent of bone mineralization. [GOC:go_curators]
ceramide phosphoethanolamine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of ceramide phosphoethanolamine. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419]
ceramide biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai]