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Alpha-2B adrenergic receptor
An alpha-2B adrenergic receptor that is encoded in the genome of mouse. [OMA:P30545, PRO:DNx]
Synonyms
Alpha-2B adrenoreceptor;
Alpha-2B adrenoceptor;
Alpha-2BAR
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| oxymetazoline | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| prazosin | Mus musculus (house mouse) | Ki | 0.2828 | 5 | 8 |
| terazosin | Mus musculus (house mouse) | Ki | 0.0069 | 1 | 2 |
| yohimbine | Mus musculus (house mouse) | Ki | 0.0281 | 3 | 4 |
| niguldipine | Mus musculus (house mouse) | Ki | 0.0002 | 1 | 2 |
| rauwolscine | Mus musculus (house mouse) | Ki | 0.0138 | 4 | 4 |
| sb-224289 | Mus musculus (house mouse) | Ki | 1.0000 | 1 | 1 |
| harmine | Mus musculus (house mouse) | Ki | 10.0000 | 1 | 1 |
| dexniguldipine | Mus musculus (house mouse) | Ki | 0.0047 | 1 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| clonidine | Mus musculus (house mouse) | IC40 | 0.0037 | 1 | 1 |
| phenylephrine | Mus musculus (house mouse) | IC40 | 0.0780 | 1 | 1 |
Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.Journal of medicinal chemistry, , Dec-17, Volume: 41, Issue:26, 1998
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function bJournal of medicinal chemistry, , Apr-09, Volume: 41, Issue:8, 1998