A kynurenine/alpha-aminoadipate aminotransferase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N5Z0]
KAT/AadAT;
2-aminoadipate aminotransferase;
2-aminoadipate transaminase;
2.6.1.39;
Alpha-aminoadipate aminotransferase;
AadAT;
Kynurenine aminotransferase II;
Kynurenine--oxoglutarate aminotransferase II;
Kynurenine--oxogl
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,4-pyridinedicarboxylic acid | Homo sapiens (human) | IC50 | 4.2000 | 1 | 1 |
| oxalylglycine | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| pf-04859989 | Homo sapiens (human) | IC50 | 0.0230 | 2 | 2 |
| pf-04859989 | Homo sapiens (human) | Ki | 0.0141 | 2 | 2 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| kynurenine-oxoglutarate transaminase activity | molecular function | Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. [EC:2.6.1.7] |
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| kynurenine-glyoxylate transaminase activity | molecular function | Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine. [EC:2.6.1.63, RHEA:19249] |
| 2-aminoadipate transaminase activity | molecular function | Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate. [EC:2.6.1.39, RHEA:12601] |
| glycine:2-oxoglutarate aminotransferase activity | molecular function | Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate. [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN] |
| methionine-glyoxylate transaminase activity | molecular function | Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine. [EC:2.6.1.73, RHEA:22884] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| 2-oxoglutarate metabolic process | biological process | The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. [ISBN:0198506732] |
| glutamate metabolic process | biological process | The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators] |
| biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684] |
| L-lysine catabolic process to acetyl-CoA via saccharopine | biological process | The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine. [GOC:mah, MetaCyc:LYSINE-DEG1-PWY] |
| kynurenine metabolic process | biological process | The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. [CHEBI:28683, GOC:mah, GOC:rph] |
| L-kynurenine metabolic process | biological process | The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). [GOC:yaf] |
| alpha-amino acid metabolic process | biological process | The chemical reactions and pathways involving an alpha-amino acid. [GOC:TermGenie] |