A tyrosyl-DNA phosphodiesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NUW8]
Tyr-DNA phosphodiesterase 1;
EC 3.1.4.-
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 12 (80.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tyrphostin 25 | Homo sapiens (human) | IC50 | 333.0000 | 1 | 1 |
| aurintricarboxylic acid | Homo sapiens (human) | IC50 | 0.0170 | 2 | 2 |
| framycetin | Homo sapiens (human) | IC50 | 8,000.0000 | 1 | 1 |
| camptothecin | Homo sapiens (human) | IC50 | 111.0000 | 1 | 1 |
| lividomycin | Homo sapiens (human) | IC50 | 30,000.0000 | 1 | 1 |
| n,n'-dibenzoylcystine | Homo sapiens (human) | IC50 | 111.0000 | 1 | 1 |
| uvaol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| furamidine | Homo sapiens (human) | IC50 | 10.9450 | 6 | 6 |
| paromomycin | Homo sapiens (human) | IC50 | 21,000.0000 | 1 | 1 |
| nsc 88915 | Homo sapiens (human) | IC50 | 6.3660 | 5 | 5 |
| nsc 706744 | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| puromycin | Homo sapiens (human) | IC50 | 18,000.0000 | 1 | 1 |
| netilmicin | Homo sapiens (human) | IC50 | 8,000.0000 | 1 | 1 |
| (-)-usnic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| clindamycin phosphate | Homo sapiens (human) | IC50 | 9,100.0000 | 1 | 1 |
| euscaphic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| (+)-usnic acid | Homo sapiens (human) | IC50 | 75.0000 | 2 | 2 |
| isoliquiritigenin | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| ag-213 | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| ag 99 | Homo sapiens (human) | IC50 | 333.0000 | 1 | 1 |
| ag-490 | Homo sapiens (human) | IC50 | 333.0000 | 1 | 1 |
| ag 30 | Homo sapiens (human) | IC50 | 333.0000 | 1 | 1 |
| 3 beta-o-acetylursolic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| corosolic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| epi-maslinic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| double-stranded DNA binding | molecular function | Binding to double-stranded DNA. [GOC:elh, GOC:vw] |
| single-stranded DNA binding | molecular function | Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174] |
| exonuclease activity | molecular function | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. [GOC:mah, ISBN:0198547684] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| 3'-tyrosyl-DNA phosphodiesterase activity | molecular function | Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. [PMID:10521354, PMID:16751265] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| single strand break repair | biological process | The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. [PMID:18626472] |
| DNA repair | biological process | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486] |
| double-strand break repair | biological process | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh] |