Page last updated: 2024-08-08 00:09:01
Serine/threonine-protein kinase Sgk3
A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96BR1]
Synonyms
EC 2.7.11.1;
Cytokine-independent survival kinase;
Serum/glucocorticoid-regulated kinase 3;
Serum/glucocorticoid-regulated kinase-like
Research
Bioassay Publications (3)
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (69)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
staurosporine | Homo sapiens (human) | IC50 | 0.0730 | 2 | 2 |
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
imatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
staurosporine | Homo sapiens (human) | Kd | 0.0034 | 1 | 1 |
gefitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
lestaurtinib | Homo sapiens (human) | Kd | 0.0058 | 1 | 1 |
vatalanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
ruboxistaurin | Homo sapiens (human) | Kd | 1.4000 | 1 | 1 |
canertinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
birb 796 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
sb 203580 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
enzastaurin | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
erlotinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
lapatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
sorafenib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pd 173955 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
s 1033 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
bms 387032 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
tandutinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
vx-745 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
dasatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
zd 6474 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
alvocidib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
bosutinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
su 11248 | Homo sapiens (human) | Kd | 0.2200 | 1 | 1 |
vx680 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
axitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pd 184352 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
bms345541 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
midostaurin | Homo sapiens (human) | Kd | 1.4000 | 1 | 1 |
ki 20227 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pi103 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
hki 272 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
tofacitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
cediranib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
masitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pazopanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
azd 6244 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
su 14813 | Homo sapiens (human) | Kd | 0.2500 | 1 | 1 |
bibw 2992 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
tg100-115 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
pha 665752 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
brivanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
at 7519 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
bi 2536 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
nvp-ast487 | Homo sapiens (human) | Kd | 0.1500 | 1 | 1 |
kw 2449 | Homo sapiens (human) | Kd | 0.0960 | 1 | 1 |
abt 869 | Homo sapiens (human) | Kd | 1.9000 | 1 | 1 |
gw 2580 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
crizotinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
chir-265 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
motesanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
mln8054 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
GDC-0879 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
gsk 461364 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
azd 1152-hqpa | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
nvp-tae684 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
fedratinib | Homo sapiens (human) | Kd | 2.5000 | 1 | 1 |
gsk690693 | Homo sapiens (human) | Kd | 1.9000 | 1 | 1 |
gdc 0941 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
plx 4720 | Homo sapiens (human) | Kd | 7.2000 | 1 | 1 |
sgx 523 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
quizartinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
incb-018424 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
gsk 1838705a | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
gsk 1363089 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
chir 258 | Homo sapiens (human) | Kd | 0.9600 | 1 | 1 |
nintedanib | Homo sapiens (human) | Kd | 1.0000 | 1 | 1 |
pp242 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
Enables
This protein enables 10 target(s):
Target | Category | Definition |
---|---|---|
protein kinase activity | molecular function | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640] |
calcium channel regulator activity | molecular function | Modulates the activity of a calcium channel. [GOC:mah] |
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
potassium channel regulator activity | molecular function | Binds to and modulates the activity of a potassium channel. [GOC:dos, GOC:mah] |
sodium channel regulator activity | molecular function | Binds to and modulates the activity of a sodium channel. [GOC:mah] |
chloride channel regulator activity | molecular function | Binds to and modulates the activity of a chloride channel. [GOC:mah] |
phosphatidylinositol binding | molecular function | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417] |
protein serine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989] |
protein serine/threonine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] |
Located In
This protein is located in 3 target(s):
Target | Category | Definition |
---|---|---|
early endosome | cellular component | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] |
cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
recycling endosome | cellular component | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] |
Involved In
This protein is involved in 8 target(s):
Target | Category | Definition |
---|---|---|
regulation of cell growth | biological process | Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators] |
protein phosphorylation | biological process | The process of introducing a phosphate group on to a protein. [GOC:hb] |
regulation of cell migration | biological process | Any process that modulates the frequency, rate or extent of cell migration. [GOC:go_curators] |
regulation of cell population proliferation | biological process | Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl] |
regulation of DNA-binding transcription factor activity | biological process | Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai] |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis] |
peptidyl-serine phosphorylation | biological process | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037] |
intracellular signal transduction | biological process | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] |