Page last updated: 2024-08-07 12:43:51
Maltase-glucoamylase, intestinal
A maltase-glucoamylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43451]
Synonyms
Research
Bioassay Publications (32)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 19 (59.38) | 24.3611 |
| 2020's | 8 (25.00) | 2.80 |
Compounds (42)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,4-thiazolidinedione | Homo sapiens (human) | IC50 | 0.5400 | 1 | 1 |
| methyl acetoacetate | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| diethyl malonate | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 1-deoxynojirimycin | Homo sapiens (human) | IC50 | 34.7614 | 7 | 7 |
| acarbose | Homo sapiens (human) | IC50 | 423.9300 | 12 | 12 |
| miglustat | Homo sapiens (human) | IC50 | 5.5500 | 2 | 2 |
| (-)-catechin | Homo sapiens (human) | IC50 | 53.8000 | 1 | 1 |
| mor-14 | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| terphenyllin | Homo sapiens (human) | IC50 | 4.7900 | 1 | 1 |
| terphenyllin | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| homonojirimycin | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| valiolamine | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| migalastat | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| 3-hydroxyterphenyllin | Homo sapiens (human) | IC50 | 11.3000 | 1 | 1 |
| valienamine | Homo sapiens (human) | IC50 | 340.0000 | 1 | 1 |
| miglitol | Homo sapiens (human) | IC50 | 4.4667 | 3 | 3 |
| miglitol | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| ao 128 | Homo sapiens (human) | IC50 | 1.3000 | 2 | 2 |
| acarbose | Homo sapiens (human) | IC50 | 906.0000 | 1 | 1 |
| validamine | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| 1,4-dideoxy-1,4-imino-d-arabinitol | Homo sapiens (human) | IC50 | 55.5000 | 2 | 2 |
| 2-(Benzotriazol-1-yl)-1-(4-bromophenyl)ethanone | Homo sapiens (human) | IC50 | 2.7900 | 1 | 1 |
| trisindoline | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 9.3000 | 2 | 2 |
| genistein | Homo sapiens (human) | IC50 | 6.5050 | 2 | 2 |
| genistein | Homo sapiens (human) | Ki | 10.4000 | 1 | 1 |
| eupatoriopicrine | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| mangostin | Homo sapiens (human) | IC50 | 5.7000 | 1 | 1 |
| mangostin | Homo sapiens (human) | Ki | 7.3000 | 1 | 1 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | Ki | 1.4000 | 1 | 1 |
| beta-Mangostin | Homo sapiens (human) | IC50 | 22.6000 | 1 | 1 |
| 9-Hydroxycalabaxanthone | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| broussochalcone a | Homo sapiens (human) | Ki | 5.3000 | 1 | 1 |
| salacinol | Homo sapiens (human) | IC50 | 4.9000 | 2 | 2 |
| salacinol | Homo sapiens (human) | Ki | 0.5950 | 2 | 2 |
| n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | Homo sapiens (human) | IC50 | 3.5000 | 2 | 2 |
| papyriflavonol a | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| l-altro-1-deoxynojirimycin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| ponkoranol | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| sch 725680 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| aspernolide a | Homo sapiens (human) | IC50 | 47.3300 | 1 | 1 |
| kotalanol | Homo sapiens (human) | Ki | 0.1900 | 2 | 2 |
| neosalacinol | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| aspulvinone E | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| pinophilin b | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| catalytic activity | molecular function | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. [GOC:vw, ISBN:0198506732] |
| glucan 1,4-alpha-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. [EC:3.2.1.3] |
| alpha-1,4-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| amylase activity | molecular function | Catalysis of the hydrolysis of amylose or an amylose derivative. [GOC:ai] |
| carbohydrate binding | molecular function | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah] |
| maltose alpha-glucosidase activity | molecular function | Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose. [MetaCyc:RXN-2141] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| tertiary granule membrane | cellular component | The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] |
| ficolin-1-rich granule membrane | cellular component | The lipid bilayer surrounding a ficolin-1-rich granule. [GOC:mec, PMID:23650620] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| maltose catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). [GOC:jl, ISBN:0198506732] |
| starch catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants. [GOC:ai] |
| dextrin catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dextrin. [GOC:TermGenie] |