Proteins > Maltase-glucoamylase, intestinal
Page last updated: 2024-08-07 12:43:51
Maltase-glucoamylase, intestinal
A maltase-glucoamylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43451]
Synonyms
Research
Bioassay Publications (32)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 19 (59.38) | 24.3611 |
| 2020's | 8 (25.00) | 2.80 |
Compounds (42)
Drugs with Inhibition Measurements
Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives.European journal of medicinal chemistry, , Nov-15, Volume: 224, 2021
Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway.Journal of natural products, , 05-28, Volume: 84, Issue:5, 2021
[no title available]European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Biological properties of D- and L-1-deoxyazasugars.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors.Bioorganic & medicinal chemistry, , 08-01, Volume: 67, 2022
Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia," against human intestinal maltase.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 33, 2021
Phloroglucinol Benzophenones and Xanthones from the Leaves of Journal of natural products, , 01-24, Volume: 83, Issue:1, 2020
Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Role of sulphur-heterocycles in medicinal chemistry: An update.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview.European journal of medicinal chemistry, , Aug-15, Volume: 176, 2019
New butenolide derivatives from the marine sponge-derived fungus Aspergillus terreus.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 28, Issue:3, 2018
[no title available]European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.Journal of natural products, , 08-25, Volume: 80, Issue:8, 2017
Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.MedChemComm, , Jul-01, Volume: 8, Issue:7, 2017
Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott.Journal of natural products, , 11-22, Volume: 80, Issue:11, 2017
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia," against human intestinal maltase.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 33, 2021
Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia," against human intestinal maltase.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 33, 2021
Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia," against human intestinal maltase.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 33, 2021
Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 57, Issue:21, 2014
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
Synthesis of a biologically active isomer of kotalanol, a naturally occurring glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-15, Volume: 18, Issue:8, 2010
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|
| catalytic activity | molecular function | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. [GOC:vw, ISBN:0198506732] |
| glucan 1,4-alpha-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. [EC:3.2.1.3] |
| alpha-1,4-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| amylase activity | molecular function | Catalysis of the hydrolysis of amylose or an amylose derivative. [GOC:ai] |
| carbohydrate binding | molecular function | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah] |
| maltose alpha-glucosidase activity | molecular function | Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose. [MetaCyc:RXN-2141] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| tertiary granule membrane | cellular component | The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] |
| ficolin-1-rich granule membrane | cellular component | The lipid bilayer surrounding a ficolin-1-rich granule. [GOC:mec, PMID:23650620] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|
| maltose catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). [GOC:jl, ISBN:0198506732] |
| starch catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants. [GOC:ai] |
| dextrin catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dextrin. [GOC:TermGenie] |