porphycene: photodynamic therapy agent; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 127650 |
| CHEMBL ID | 4781333 |
| SCHEMBL ID | 12657276 |
| MeSH ID | M0146353 |
| Synonym |
|---|
| porphycene |
| 100572-96-1 |
| SCHEMBL12657276 |
| Q11824059 |
| 21,22,23,24-tetrazapentacyclo[16.2.1.12,5.18,11.112,15]tetracosa-1,3,5(24),6,8,10,12,14,16,18(21),19-undecaene |
| 133730-20-8 |
| DTXSID601108289 |
| 21,22,23,24-tetraazapentacyclo[16.2.1.12,5.18,11.112,15]tetracosa-1(21),2(24),3,5,7,9,11,13,15,17,19-undecaene |
| CHEMBL4781333 |
Porphycene is an aromatic macrocycle and a constitutional isomer of porphyrin. It constitutes an interesting new class of PS.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Porphycene is a structural isomer of porphyrin and constitutes an interesting new class of PS." | ( Porphycenes: facts and prospects in photodynamic therapy of cancer. Borrell, JI; Cañete, M; Horobin, RW; Juarranz, A; Nonell, S; Stockert, JC; Teixidó, J; Villanueva, A, 2007) | 2.5 |
| "Porphycene is an aromatic macrocycle and a constitutional isomer of porphyrin. " | ( Porphycenes: synthesis and derivatives. Sánchez-García, D; Sessler, JL, 2008) | 3.23 |
Porphycene has a complex potential energy surface with nine stationary configurations that allow a variety of tunneling paths. Porphycenes have been shown to exhibit many advantageous properties when it comes to the application of two-photon absorption (TPA)
| Excerpt | Reference | Relevance |
|---|---|---|
| "Porphycene has a complex potential energy surface with nine stationary configurations that allow a variety of tunneling paths, many of which include classically accessible regions." | ( Tunneling splitting in double-proton transfer: direct diagonalization results for porphycene. Fernández-Ramos, A; Siebrand, W; Smedarchina, Z, 2014) | 1.35 |
| "Porphycene has a complex potential energy surface with nine stationary configurations that allow a variety of tunneling paths, many of which include classically accessible regions." | ( Tunneling splitting in double-proton transfer: direct diagonalization results for porphycene. Fernández-Ramos, A; Siebrand, W; Smedarchina, Z, 2014) | 1.35 |
| "Porphycenes have been studied in different experimental regimes: molecules in condensed phases, isolated in supersonic jets and helium nanodroplets, and, recently also on the level of single molecules investigated by optical and scanning probe microscopies." | ( Spectroscopy and Tautomerization Studies of Porphycenes. Waluk, J, 2017) | 1.44 |
| "Porphycenes have been shown to exhibit many advantageous properties when it comes to the application of two-photon absorption (TPA), a technique with potential use in the area of photodynamic therapy (PDT). " | ( Two-photon absorption-molecular structure investigation using a porphycene chromophore with potential in photodynamic therapy. Bergendahl, LT; Paterson, MJ, 2012) | 2.06 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previous studies indicated pro-survival attributes of autophagy after low-dose PDT, suggesting that autophagy may be responsible for the 'shoulder' on the dose-response curve." | ( Apoptotic and autophagic responses to Bcl-2 inhibition and photodamage. Arroyo, AS; Kessel, D, 2007) | 0.34 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1739700 | Induction of singlet oxygen generation in pluronic solution in deuterated water assessed as singlet oxygen quantum yield irradiated with 635 nanometer LED light at 300 mW by spectrometric method | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| AID1739699 | Induction of singlet oxygen generation in toluene solution assessed as singlet oxygen quantum yield irradiated with 369 nanometer LED light at 300 mW by spectrometric method | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| AID1739705 | Photodynamic antibacterial activity against Enterococcus faecalis 29212 assessed as bacterial eradication at 7 uM preincubated for 30 mins in dark condition followed by 30 J/cm2 LED light irradiation | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| AID1739707 | Photodynamic anticancer activity against human HeLa cells | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| AID1739702 | Induction of peroxynitrile-anion generation in pluronic solution irradiated with 369 nanometer LED light at 6 mW by HPF fluorescence method | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| AID1739701 | Induction of hydroxy radical generation in pluronic solution irradiated with 635 nanometer LED light at 6 mW by HPF fluorescence method | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| AID1739703 | Photodynamic antibacterial activity against Enterococcus faecalis 29212 assessed as bacterial eradication at 7 uM preincubated for 30 mins in dark condition followed by 0.6 J/cm2.min LED light irradiation for 50 mins | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| AID1739708 | Absorption property in pluronic/PBS solution assessed as diode array corresponding wavelength of photodynamic inactivation by measuring electronic absorption spectra by spectrophotometry | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Photoeradication of bacteria with porphycenes: Substituent effects on the efficiency. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (1.54) | 18.7374 |
| 1990's | 6 (9.23) | 18.2507 |
| 2000's | 29 (44.62) | 29.6817 |
| 2010's | 25 (38.46) | 24.3611 |
| 2020's | 4 (6.15) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (24.57) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 5 (7.35%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 63 (92.65%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||