Page last updated: 2024-08-07 23:37:36
Smoothened homolog
A protein smoothened that is encoded in the genome of mouse. [OMA:P56726, PRO:DNx]
Synonyms
SMO
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 10 (71.43) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cyclopamine | Mus musculus (house mouse) | IC50 | 1.2710 | 4 | 4 |
| gdc 0449 | Mus musculus (house mouse) | IC50 | 0.0700 | 8 | 8 |
| glasdegib | Mus musculus (house mouse) | IC50 | 0.0050 | 1 | 1 |
| ly2940680 | Mus musculus (house mouse) | IC50 | 0.0018 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| purmorphamine | Mus musculus (house mouse) | EC50 | 0.8000 | 1 | 1 |
| sag compound | Mus musculus (house mouse) | EC50 | 0.0590 | 3 | 3 |
| gdc 0449 | Mus musculus (house mouse) | EC50 | 0.0034 | 2 | 2 |
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.Bioorganic & medicinal chemistry, , Nov-15, Volume: 20, Issue:22, 2012
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.ACS medicinal chemistry letters, , Oct-11, Volume: 3, Issue:10, 2012
Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 19, Issue:2, 2009
Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement.Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement.Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).Bioorganic & medicinal chemistry, , 01-15, Volume: 28, Issue:2, 2020
Structural optimization on a virtual screening hit of smoothened receptor.European journal of medicinal chemistry, , Jun-15, Volume: 172, 2019
Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor.European journal of medicinal chemistry, , Apr-10, Volume: 149, 2018
Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists.Journal of medicinal chemistry, , 12-22, Volume: 59, Issue:24, 2016
Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 25, Issue:17, 2015
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.Bioorganic & medicinal chemistry, , Nov-15, Volume: 20, Issue:22, 2012
Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.ACS medicinal chemistry letters, , Feb-09, Volume: 3, Issue:2, 2012
Design, synthesis and biological evaluation of novel 4-aminopiperidine derivatives as SMO/ERK dual inhibitors.Bioorganic & medicinal chemistry, , 11-15, Volume: 74, 2022
A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor.MedChemComm, , Jun-01, Volume: 8, Issue:6, 2017