Page last updated: 2024-12-10

ginkgolic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5281858
CHEMBL ID445177
CHEBI ID5354
SCHEMBL ID163525
MeSH IDM0290874

Synonyms (61)

Synonym
AC-12804
(z)-2-hydroxy-6-(8-pentadecenyl)benzoic acid
SDCCGMLS-0066799.P001
BSPBIO_002625
SPECTRUM5_000899
ginkgolic acid
ginkgoic acid
22910-60-7
NCGC00095338-01
SPECTRUM1505247
NCGC00095338-02
anacardic acid 8''z-monoene
6-[8(z)-pentadecatrienyl]salicylic acid
6-{8(z)-pentadecenyl}salicylic acid
6-(8''z-pentadecenyl)-salicylicacid
bdbm50242188
6-[8''(z)-pentadecenyl]salicylic acid
6[8''(z )-pentadecenyl]salicylic acid
CHEMBL445177 ,
chebi:5354 ,
gingkolic acid
anacardic acid 8'z-monoene
6[8'(z )-pentadecenyl]salicylic acid
BRD-K81965037-001-03-2
2-hydroxy-6-[(z)-pentadec-8-enyl]benzoic acid
anacardic acid monoene
romanicardic acid
benzoic acid, 2-hydroxy-6-(8-pentadecenyl)-, (z)-
ginkgolic acid 15:1
ginkgolic acid i
AKOS015920035
S9432
CCG-38715
6-[(8z)-pentadecenyl]-salicylic acid
AM20060557
ginkgolic acid c15:1
SCHEMBL163525
(z)-2-hydroxy-6-(pentadec-8-en-1-yl)benzoic acid
CS-3728
HY-N0077
mfcd03093717
(z)-2-(heptadec-8-en-1-yl)-6-hydroxybenzoic acid
LMPK15040003
6-((z)-heptadec-8-en-1-yl)salicylic acid
ginkgolic acid c15:1, analytical standard
6-(8z)-pentadecenylsalicylic acid
DTXSID50872875
ginkgolic acid c15:1, primary reference standard
SR-05000002608-1
sr-05000002608
(15:1)-anacardic acid
ana b
J-014896
ginkgolic acid (15:1) - cas 22910-60-7
2-hydroxy-6-(8z)-8-pentadecenylbenzoic acid
Q1525050
benzoic acid, 2-hydroxy-6-(8z)-8-pentadecenyl-
ginkgolic acid (15:1)
AS-79331
A878392
NCGC00095338-03

Research Excerpts

Overview

Ginkgolic acid (GA) is a botanical drug extracted from the seed coat of Ginkgo biloba L. It is a major toxic component in extracts obtained from GinkGo biloba (EGb) that has allergic and genotoxic effects.

ExcerptReferenceRelevance
"Ginkgolic acid (GA) is a botanical drug extracted from the seed coat of Ginkgo biloba L."( Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c‑Met signaling.
Li, H; Li, S; Li, Y; Meng, X; Xu, X; Zhang, D, 2019
)
2.68
"Ginkgolic acid (GA) is a botanical drug extracted from the seed coat of Ginkgo biloba L. "( Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis.
Chen, K; Chen, X; Duan, W; Han, L; Han, S; Huo, X; Jiang, Z; Lei, J; Li, J; Li, X; Ma, J; Nan, L; Wang, Z; Wu, E; Xu, Q, 2015
)
3.3
"Ginkgolic acid (15:1) is a major toxic component in extracts obtained from Ginkgo biloba (EGb) that has allergic and genotoxic effects. "(
Fu, YH; Hong, W; Jiang, L; Li, MH; Li, PM; Ruan, LY; Si, ZH; Wang, JS; Xing, YX; Zhao, H, 2017
)
1.9
"Ginkgolic acid is a natural herbal substance and a major component of the lipid fraction in the nutshells of the Ginkgo biloba tree."( Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro.
Chen, C; Jamaluddin, S; Liang, Z; Lü, JM; Siwak, EB; Weakley, SM; Yan, S; Yao, Q, 2012
)
2.54

Effects

Ginkgolic acid has been shown to possess allergenic as well as genotoxic and cytotoxic properties. It has strong inhibitive effect on G+-bacterium.

ExcerptReferenceRelevance
"Ginkgolic acids have been shown to possess allergenic as well as genotoxic and cytotoxic properties. "( Structural elucidation of metabolites of ginkgolic acid in rat liver microsomes by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry and hydrogen/deuterium exchange.
Chen, J; Jiang, HD; Liu, ZH; Yao, TW; Yu, LS; Zeng, S, 2009
)
2.06
"Ginkgolic acid has strong inhibitive effect on G+-bacterium. "( [Study on anti-bacterium activity of ginkgolic acids and their momomers].
Chen, J; Qian, Z; Xie, J; Yang, X; Zhu, W, 2004
)
2.04

Actions

ExcerptReferenceRelevance
"Ginkgolic acid may inhibit HIV protease through different mechanisms than current FDA-approved HIV PI drugs."( Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro.
Chen, C; Jamaluddin, S; Liang, Z; Lü, JM; Siwak, EB; Weakley, SM; Yan, S; Yao, Q, 2012
)
2.54

Toxicity

Ginkgolic acids (GAs) are thought to be the potentially hazardous constituents corresponding to the toxic side effects of Ginkgo products. These findings suggest that HepG2 cells were more sensitive to the cytotoxicity of ginksgolic acid than primary rat hepatocytes. CYP1A and CYP3A could metabolize ginkgolics acid to more toxic compounds.

ExcerptReferenceRelevance
" As constituents with potential contact allergenic and toxic properties in crude Ginkgo extracts a group of alkylphenols (e."( Evidence for toxic effects of alkylphenols from Ginkgo biloba in the hen's egg test (HET).
Baron-Ruppert, G; Luepke, NP, 2001
)
0.31
" These findings suggest that HepG2 cells were more sensitive to the cytotoxicity of ginkgolic acid than primary rat hepatocytes, and CYP1A and CYP3A could metabolize ginkgolic acid to more toxic compounds."( Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes.
Liu, ZH; Zeng, S, 2009
)
0.92
"Ginkgolic acids (GAs) are thought to be the potentially hazardous constituents corresponding to the toxic side effects of Ginkgo products."( Metabolic profiling of the hepatotoxicity and nephrotoxicity of Ginkgolic acids in rats using ultra-performance liquid chromatography-high-definition mass spectrometry.
Duan, JA; Guo, S; Peng, Y; Qian, Y; Shang, E; Su, S; Tao, J; Yan, L; Zhao, M; Zhu, Z, 2017
)
2.14
"Pharmacological activities and adverse side effects of ginkgolic acids (GAs), major components in extracts from the leaves and seed coats of Ginkgo biloba L, have been intensively studied."( The metabolism and hepatotoxicity of ginkgolic acid (17 : 1) in vitro.
Hu, HH; Li, L; Xu, MC; Yao, QQ; Yu, LS; Zeng, S; Zhou, H, 2018
)
1

Pharmacokinetics

ExcerptReferenceRelevance
" GA (15:1) pharmacokinetic parameters C(max), T(max), t(1/2), AUC(0-12h) are 1552."( Development of high performance liquid chromatography/electrospray ionization mass spectrometry for assay of ginkgolic acid (15:1) in rat plasma and its application to pharmacokinetics study.
Guo, C; Jiang, H; Li, L; Liu, Y; Wang, S; Wang, X; Xia, H; Yu, L; Zeng, S, 2010
)
0.57
" Knowledge about the pharmacokinetic behaviour of these substances is necessary to discuss the pharmacological results on a more realistic basis."( Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients.
Schubert-Zsilavecz, M; Ude, C; Wurglics, M, 2013
)
0.39
" The proposed method is selective, precise and accurate enough of MPN and its metabolites (4-pyridoxic Acid, pyridoxal, and pyridoxine) for the pharmacokinetic study."( Interactions of pharmacokinetic profiles of Ginkgotoxin and Ginkgolic acids in rat plasma after oral administration.
Duan, JA; Guo, S; Qian, D; Qian, Y; Su, S; Tao, J; Wei, M; Yan, H; Zhu, Z, 2019
)
0.76

Dosage Studied

ExcerptRelevanceReference
" The validated method was successfully applied to investigate the pharmacokinetics of the five ginkgolic acids in rat plasma after oral administration of 3 dosage groups (900mg/kg, 300mg/kg and 100mg/kg)."( Simultaneous quantification and semi-quantification of ginkgolic acids and their metabolites in rat plasma by UHPLC-LTQ-Orbitrap-MS and its application to pharmacokinetics study.
Duan, JA; Guo, J; Guo, S; Qian, Y; Shang, E; Su, S; Tao, J; Zhu, Z, 2017
)
0.92
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxybenzoic acidAny benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (30)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency15.81140.140911.194039.8107AID2451
Chain A, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID893
Chain B, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID893
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency39.81070.177814.390939.8107AID2147
Chain A, CruzipainTrypanosoma cruziPotency39.81070.002014.677939.8107AID1476
15-lipoxygenase, partialHomo sapiens (human)Potency1.58490.012610.691788.5700AID887
USP1 protein, partialHomo sapiens (human)Potency79.43280.031637.5844354.8130AID504865
TDP1 proteinHomo sapiens (human)Potency29.09290.000811.382244.6684AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency17.78280.180013.557439.8107AID1460
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency18.99910.01237.983543.2770AID1645841
GVesicular stomatitis virusPotency0.47720.01238.964839.8107AID1645842
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency31.62280.354828.065989.1251AID504847
DNA polymerase kappa isoform 1Homo sapiens (human)Potency39.81070.031622.3146100.0000AID588579
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency8.91250.251215.843239.8107AID504327
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency25.11890.316212.765731.6228AID881
Interferon betaHomo sapiens (human)Potency0.47720.00339.158239.8107AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency0.47720.01238.964839.8107AID1645842
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency25.11890.00638.235039.8107AID881
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency0.47720.01238.964839.8107AID1645842
cytochrome P450 2C9, partialHomo sapiens (human)Potency0.47720.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TrypsinSus scrofa (pig)IC50 (µMol)200.00000.50000.50000.5000AID402793
72 kDa type IV collagenaseHomo sapiens (human)IC50 (µMol)6.30000.00001.284810.0000AID1557344
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)IC50 (µMol)40.99005.66005.66005.6600AID401414; AID401415
Coagulation factor VIIHomo sapiens (human)IC50 (µMol)32.00000.00020.83363.3000AID402795
Fatty acid synthaseGallus gallus (chicken)IC50 (µMol)17.10006.15007.63008.3700AID1803260
Tissue factorHomo sapiens (human)IC50 (µMol)32.00000.00010.734410.0000AID402795
Phosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)IC50 (µMol)1.50001.50002.57144.0000AID1600501
Phosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)IC50 (µMol)1.50001.00001.78574.0000AID1600502
SUMO-activating enzyme subunit 1Homo sapiens (human)IC50 (µMol)3.00002.20004.46678.2000AID727132
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (158)

Processvia Protein(s)Taxonomy
lipid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
phospholipid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
apoptotic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell population proliferationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of macrophage derived foam cell differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell migrationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
prostate gland developmentPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
regulation of epithelial cell differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of chemokine productionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of peroxisome proliferator activated receptor signaling pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of keratinocyte differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell cyclePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of growthPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
hepoxilin biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
endocannabinoid signaling pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cannabinoid biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipoxin A4 biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipid oxidationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipoxygenase pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
angiogenesis72 kDa type IV collagenaseHomo sapiens (human)
ovarian follicle development72 kDa type IV collagenaseHomo sapiens (human)
ovulation from ovarian follicle72 kDa type IV collagenaseHomo sapiens (human)
luteinization72 kDa type IV collagenaseHomo sapiens (human)
blood vessel maturation72 kDa type IV collagenaseHomo sapiens (human)
intramembranous ossification72 kDa type IV collagenaseHomo sapiens (human)
proteolysis72 kDa type IV collagenaseHomo sapiens (human)
negative regulation of cell adhesion72 kDa type IV collagenaseHomo sapiens (human)
heart development72 kDa type IV collagenaseHomo sapiens (human)
embryo implantation72 kDa type IV collagenaseHomo sapiens (human)
parturition72 kDa type IV collagenaseHomo sapiens (human)
response to xenobiotic stimulus72 kDa type IV collagenaseHomo sapiens (human)
response to mechanical stimulus72 kDa type IV collagenaseHomo sapiens (human)
peripheral nervous system axon regeneration72 kDa type IV collagenaseHomo sapiens (human)
response to activity72 kDa type IV collagenaseHomo sapiens (human)
protein metabolic process72 kDa type IV collagenaseHomo sapiens (human)
extracellular matrix disassembly72 kDa type IV collagenaseHomo sapiens (human)
protein catabolic process72 kDa type IV collagenaseHomo sapiens (human)
positive regulation of cell migration72 kDa type IV collagenaseHomo sapiens (human)
collagen catabolic process72 kDa type IV collagenaseHomo sapiens (human)
response to retinoic acid72 kDa type IV collagenaseHomo sapiens (human)
cellular response to reactive oxygen species72 kDa type IV collagenaseHomo sapiens (human)
response to nicotine72 kDa type IV collagenaseHomo sapiens (human)
endodermal cell differentiation72 kDa type IV collagenaseHomo sapiens (human)
response to hydrogen peroxide72 kDa type IV collagenaseHomo sapiens (human)
response to estrogen72 kDa type IV collagenaseHomo sapiens (human)
negative regulation of vasoconstriction72 kDa type IV collagenaseHomo sapiens (human)
ephrin receptor signaling pathway72 kDa type IV collagenaseHomo sapiens (human)
macrophage chemotaxis72 kDa type IV collagenaseHomo sapiens (human)
response to electrical stimulus72 kDa type IV collagenaseHomo sapiens (human)
response to hyperoxia72 kDa type IV collagenaseHomo sapiens (human)
face morphogenesis72 kDa type IV collagenaseHomo sapiens (human)
bone trabecula formation72 kDa type IV collagenaseHomo sapiens (human)
prostate gland epithelium morphogenesis72 kDa type IV collagenaseHomo sapiens (human)
cellular response to amino acid stimulus72 kDa type IV collagenaseHomo sapiens (human)
cellular response to interleukin-172 kDa type IV collagenaseHomo sapiens (human)
cellular response to estradiol stimulus72 kDa type IV collagenaseHomo sapiens (human)
cellular response to UV-A72 kDa type IV collagenaseHomo sapiens (human)
cellular response to fluid shear stress72 kDa type IV collagenaseHomo sapiens (human)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway72 kDa type IV collagenaseHomo sapiens (human)
response to amyloid-beta72 kDa type IV collagenaseHomo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation72 kDa type IV collagenaseHomo sapiens (human)
extracellular matrix organization72 kDa type IV collagenaseHomo sapiens (human)
response to hypoxia72 kDa type IV collagenaseHomo sapiens (human)
tissue remodeling72 kDa type IV collagenaseHomo sapiens (human)
in utero embryonic development1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
epidermal growth factor receptor signaling pathway1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
phospholipid catabolic process1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
positive regulation of epithelial cell migration1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
cellular response to vascular endothelial growth factor stimulus1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
phosphatidylinositol metabolic process1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
cellular response to epidermal growth factor stimulus1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
response to hypoxiaCoagulation factor VIIHomo sapiens (human)
positive regulation of leukocyte chemotaxisCoagulation factor VIIHomo sapiens (human)
blood coagulationCoagulation factor VIIHomo sapiens (human)
circadian rhythmCoagulation factor VIIHomo sapiens (human)
response to carbon dioxideCoagulation factor VIIHomo sapiens (human)
positive regulation of platelet-derived growth factor receptor signaling pathwayCoagulation factor VIIHomo sapiens (human)
protein processingCoagulation factor VIIHomo sapiens (human)
positive regulation of blood coagulationCoagulation factor VIIHomo sapiens (human)
positive regulation of cell migrationCoagulation factor VIIHomo sapiens (human)
animal organ regenerationCoagulation factor VIIHomo sapiens (human)
positive regulation of TOR signalingCoagulation factor VIIHomo sapiens (human)
response to estradiolCoagulation factor VIIHomo sapiens (human)
response to vitamin KCoagulation factor VIIHomo sapiens (human)
response to genisteinCoagulation factor VIIHomo sapiens (human)
response to estrogenCoagulation factor VIIHomo sapiens (human)
positive regulation of positive chemotaxisCoagulation factor VIIHomo sapiens (human)
response to growth hormoneCoagulation factor VIIHomo sapiens (human)
response to cholesterolCoagulation factor VIIHomo sapiens (human)
response to thyroxineCoagulation factor VIIHomo sapiens (human)
response to Thyroid stimulating hormoneCoagulation factor VIIHomo sapiens (human)
response to 2,3,7,8-tetrachlorodibenzodioxineCoagulation factor VIIHomo sapiens (human)
response to astaxanthinCoagulation factor VIIHomo sapiens (human)
response to thyrotropin-releasing hormoneCoagulation factor VIIHomo sapiens (human)
lactate metabolic processFatty acid synthaseGallus gallus (chicken)
fatty acid biosynthetic processFatty acid synthaseGallus gallus (chicken)
positive regulation of appetiteFatty acid synthaseGallus gallus (chicken)
positive regulation of gene expressionTissue factorHomo sapiens (human)
positive regulation of interleukin-8 productionTissue factorHomo sapiens (human)
positive regulation of endothelial cell proliferationTissue factorHomo sapiens (human)
activation of plasma proteins involved in acute inflammatory responseTissue factorHomo sapiens (human)
activation of blood coagulation via clotting cascadeTissue factorHomo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processTissue factorHomo sapiens (human)
blood coagulationTissue factorHomo sapiens (human)
positive regulation of platelet-derived growth factor receptor signaling pathwayTissue factorHomo sapiens (human)
protein processingTissue factorHomo sapiens (human)
positive regulation of cell migrationTissue factorHomo sapiens (human)
positive regulation of TOR signalingTissue factorHomo sapiens (human)
positive regulation of angiogenesisTissue factorHomo sapiens (human)
positive regulation of positive chemotaxisTissue factorHomo sapiens (human)
cytokine-mediated signaling pathwayTissue factorHomo sapiens (human)
ceramide biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
sphingomyelin biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
apoptotic processPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
sphingolipid biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathwayPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
ceramide biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
sphingomyelin biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
sphingolipid biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
regulation of bone mineralizationPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
ceramide phosphoethanolamine biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
ceramide biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
protein ubiquitinationSUMO-activating enzyme subunit 1Homo sapiens (human)
protein sumoylationSUMO-activating enzyme subunit 1Homo sapiens (human)
positive regulation of protein sumoylationSUMO-activating enzyme subunit 1Homo sapiens (human)
positive regulation of protein targeting to mitochondrionSUMO-activating enzyme subunit 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (62)

Processvia Protein(s)Taxonomy
iron ion bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
calcium ion bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
protein bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipid bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleate 13S-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonate 8(S)-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonate 15-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleate 9S-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
fibronectin binding72 kDa type IV collagenaseHomo sapiens (human)
endopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
metalloendopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
serine-type endopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
protein binding72 kDa type IV collagenaseHomo sapiens (human)
metallopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
zinc ion binding72 kDa type IV collagenaseHomo sapiens (human)
phosphatidylinositol phospholipase C activity1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
guanyl-nucleotide exchange factor activity1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
calcium ion binding1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
protein binding1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
calcium-dependent phospholipase C activity1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
serine-type endopeptidase activityCoagulation factor VIIHomo sapiens (human)
signaling receptor bindingCoagulation factor VIIHomo sapiens (human)
calcium ion bindingCoagulation factor VIIHomo sapiens (human)
protein bindingCoagulation factor VIIHomo sapiens (human)
serine-type peptidase activityCoagulation factor VIIHomo sapiens (human)
single-stranded DNA bindingFatty acid synthaseGallus gallus (chicken)
fatty acid synthase activityFatty acid synthaseGallus gallus (chicken)
[acyl-carrier-protein] S-acetyltransferase activityFatty acid synthaseGallus gallus (chicken)
[acyl-carrier-protein] S-malonyltransferase activityFatty acid synthaseGallus gallus (chicken)
3-oxoacyl-[acyl-carrier-protein] synthase activityFatty acid synthaseGallus gallus (chicken)
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activityFatty acid synthaseGallus gallus (chicken)
(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activityFatty acid synthaseGallus gallus (chicken)
(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activityFatty acid synthaseGallus gallus (chicken)
(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activityFatty acid synthaseGallus gallus (chicken)
fatty acyl-[ACP] hydrolase activityFatty acid synthaseGallus gallus (chicken)
phosphopantetheine bindingFatty acid synthaseGallus gallus (chicken)
(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activityFatty acid synthaseGallus gallus (chicken)
(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activityFatty acid synthaseGallus gallus (chicken)
enoyl-[acyl-carrier-protein] reductase (NADPH) activityFatty acid synthaseGallus gallus (chicken)
serine-type endopeptidase activityTissue factorHomo sapiens (human)
protease bindingTissue factorHomo sapiens (human)
protein bindingTissue factorHomo sapiens (human)
phospholipid bindingTissue factorHomo sapiens (human)
cytokine receptor activityTissue factorHomo sapiens (human)
ceramide phosphoethanolamine synthase activityPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
kinase activityPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
sphingomyelin synthase activityPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
ceramide cholinephosphotransferase activityPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
ceramide phosphoethanolamine synthase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
protein bindingPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
kinase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
sphingomyelin synthase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
ceramide cholinephosphotransferase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
SUMO activating enzyme activitySUMO-activating enzyme subunit 1Homo sapiens (human)
ubiquitin activating enzyme activitySUMO-activating enzyme subunit 1Homo sapiens (human)
protein bindingSUMO-activating enzyme subunit 1Homo sapiens (human)
enzyme activator activitySUMO-activating enzyme subunit 1Homo sapiens (human)
ATP-dependent protein bindingSUMO-activating enzyme subunit 1Homo sapiens (human)
small protein activating enzyme bindingSUMO-activating enzyme subunit 1Homo sapiens (human)
protein heterodimerization activitySUMO-activating enzyme subunit 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (38)

Processvia Protein(s)Taxonomy
nucleusPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cytosolPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cytoskeletonPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
plasma membranePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
adherens junctionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
focal adhesionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
membranePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
extracellular exosomePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
collagen-containing extracellular matrix72 kDa type IV collagenaseHomo sapiens (human)
extracellular region72 kDa type IV collagenaseHomo sapiens (human)
extracellular space72 kDa type IV collagenaseHomo sapiens (human)
nucleus72 kDa type IV collagenaseHomo sapiens (human)
mitochondrion72 kDa type IV collagenaseHomo sapiens (human)
plasma membrane72 kDa type IV collagenaseHomo sapiens (human)
sarcomere72 kDa type IV collagenaseHomo sapiens (human)
collagen-containing extracellular matrix72 kDa type IV collagenaseHomo sapiens (human)
extracellular space72 kDa type IV collagenaseHomo sapiens (human)
plasma membrane1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
ruffle1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
cytoplasm1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
lamellipodium1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
COP9 signalosome1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
extracellular regionCoagulation factor VIIHomo sapiens (human)
endoplasmic reticulum lumenCoagulation factor VIIHomo sapiens (human)
Golgi lumenCoagulation factor VIIHomo sapiens (human)
plasma membraneCoagulation factor VIIHomo sapiens (human)
vesicleCoagulation factor VIIHomo sapiens (human)
collagen-containing extracellular matrixCoagulation factor VIIHomo sapiens (human)
serine-type peptidase complexCoagulation factor VIIHomo sapiens (human)
extracellular spaceCoagulation factor VIIHomo sapiens (human)
cytoplasmFatty acid synthaseGallus gallus (chicken)
extracellular spaceTissue factorHomo sapiens (human)
plasma membraneTissue factorHomo sapiens (human)
external side of plasma membraneTissue factorHomo sapiens (human)
cell surfaceTissue factorHomo sapiens (human)
membraneTissue factorHomo sapiens (human)
collagen-containing extracellular matrixTissue factorHomo sapiens (human)
serine-type peptidase complexTissue factorHomo sapiens (human)
plasma membraneTissue factorHomo sapiens (human)
Golgi trans cisternaPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
Golgi membranePhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
nucleusPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
endoplasmic reticulumPhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
plasma membranePhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
membranePhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
plasma membranePhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
endoplasmic reticulum membranePhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
Golgi membranePhosphatidylcholine:ceramide cholinephosphotransferase 1 Homo sapiens (human)
Golgi membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
nucleoplasmPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
Golgi apparatusPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
plasma membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
Golgi membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
endoplasmic reticulum membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
plasma membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusSUMO-activating enzyme subunit 1Homo sapiens (human)
nucleoplasmSUMO-activating enzyme subunit 1Homo sapiens (human)
SUMO activating enzyme complexSUMO-activating enzyme subunit 1Homo sapiens (human)
cytoplasmSUMO-activating enzyme subunit 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID1859350Inhibition of His-tagged SUMO1/GST-tagged Aos1/Uba2/His-tagged Ubc9 (unknown origin)-mediated recombinant His/T7-tagged RanGAP1-C-terminal fragment SUMOylation expressed in Escherichia coli BL21 (DE3) assessed as reduction in Ubc9-SUMO level in presence o2022European journal of medicinal chemistry, Apr-05, Volume: 233Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.
AID401418Growth inhibition of human A549 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID402795Inhibition of amidolytic activity of human tissue factor/human factor 7a1998Journal of natural products, Nov, Volume: 61, Issue:11
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
AID767038Inhibition of SUMO E1 (unknown origin)-biotinylated SUMO-1 thioester complex formation at 10 uM after 20 mins by SDS-PAGE analysis in presence of ATP2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors.
AID1557344Inhibition of recombinant human MMP2 using fluorescently conjugated gelatin as substrate2019MedChemComm, Dec-01, Volume: 10, Issue:12
Recent insights into natural product inhibitors of matrix metalloproteinases.
AID348950Antibacterial activity against Streptococcus mutans ATCC 25175 after 2 days by twofold broth dilution method2008European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
Design and evaluation of anacardic acid derivatives as anticavity agents.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1082437Inhibition of fruit-infesting behavior of Cydia pomonella (codling moth) neonates infested in apple fruit plugs assessed as feeding deterrence index at 10 mg/mL2011Journal of agricultural and food chemistry, Oct-26, Volume: 59, Issue:20
Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
AID401423Growth inhibition of human CCD-18Co cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID1082427Inhibition of fruit-infesting behavior of Cydia pomonella (codling moth) neonates infested in apple fruit plugs assessed as feeding deterrence index at 0.5 mg/mL2011Journal of agricultural and food chemistry, Oct-26, Volume: 59, Issue:20
Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
AID332456Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA1994Journal of natural products, Apr, Volume: 57, Issue:4
Tyrosinase inhibitors from Anacardium occidentale fruits.
AID401419Growth inhibition of human MCF7 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID1082436Inhibition of fruit-infesting behavior of Cydia pomonella (codling moth) neonates infested in apple fruit plugs assessed as feeding deterrence index at 1 mg/mL2011Journal of agricultural and food chemistry, Oct-26, Volume: 59, Issue:20
Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
AID348953Antibacterial activity against Escherichia coli ATCC 9637 up to 200 ug/ml after 2 days by twofold broth dilution method2008European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
Design and evaluation of anacardic acid derivatives as anticavity agents.
AID401420Growth inhibition of human HCT15 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID401415Inhibition of bovine brain PI-PLCgamma11998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID332912Antimicrobial activity Propionibacterium acnes ATCC 11827 after 2 days by broth dilution method1994Journal of natural products, Jan, Volume: 57, Issue:1
Naturally occurring antiacne agents.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID332455Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA at 0.8 mM1994Journal of natural products, Apr, Volume: 57, Issue:4
Tyrosinase inhibitors from Anacardium occidentale fruits.
AID727132Inhibition of recombinant SAE1(unknown origin)-mediated SUMOylation of RanGAP1-C22013Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6
Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes.
AID402793Inhibition of pig pancreatic trypsin after 15 mins1998Journal of natural products, Nov, Volume: 61, Issue:11
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
AID401421Growth inhibition of human SKOV3 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID1600502Inhibition of SMS2 (unknown origin)2019ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice.
AID401422Growth inhibition of human HT1197 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID402794Octanol-water partition coefficient, log P of the compound1998Journal of natural products, Nov, Volume: 61, Issue:11
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
AID401414Inhibition of bovine brain PI-PLCgamma1 at 125 ug/mL1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID1600501Inhibition of SMS1 (unknown origin)2019ACS medicinal chemistry letters, Aug-08, Volume: 10, Issue:8
Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice.
AID1082429Inhibition of fruit-infesting behavior of Cydia pomonella (codling moth) neonates infested in apple fruit plugs assessed as feeding deterrence index at 5 mg/mL2011Journal of agricultural and food chemistry, Oct-26, Volume: 59, Issue:20
Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
AID1803260FAS Inhibitory Assay from Article 10.3109/14756366.2012.658786: \\Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity.\\2013Journal of enzyme inhibition and medicinal chemistry, Jun, Volume: 28, Issue:3
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity.
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (132)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (5.30)18.2507
2000's32 (24.24)29.6817
2010's69 (52.27)24.3611
2020's24 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.80 (24.57)
Research Supply Index4.91 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index48.16 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews8 (5.93%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other127 (94.07%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]