Page last updated: 2024-08-07 15:09:39
Genome polyprotein
[no definition available]
Synonyms
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4,5,6,7-tetrabromo-2-azabenzimidazole | | IC50 | 20.0000 | 1 | 1 |
| patulin | | IC50 | 3.8000 | 1 | 1 |
| trifluoperazine | | IC50 | 0.7000 | 1 | 1 |
| iodoalphionic acid | | Ki | 140.0000 | 1 | 1 |
| paclitaxel | | IC50 | 1.0000 | 1 | 1 |
| epirubicin | | IC50 | 0.7500 | 1 | 1 |
| 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | | IC50 | 1.6000 | 1 | 1 |
| ribavirin 5'-triphosphate | | IC50 | 180.0000 | 1 | 1 |
| ribavirin 5'-diphosphate | | IC50 | 250.0000 | 1 | 1 |
| 1,2,6-tri-o-galloyl-beta-d-glucopyranose | | IC50 | 1.8900 | 1 | 1 |
| biln 2061 | | IC50 | 3.0000 | 1 | 1 |
| biln 2061 | | Ki | 0.0068 | 3 | 3 |
| n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide | | Ki | 0.0140 | 1 | 1 |
| grazoprevir | | Ki | 0.0012 | 15 | 0 |
Drugs with Activation Measurements
Pan-NS3 protease inhibitors of hepatitis C virus based on an REuropean journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 15, Issue:3, 2007
Control of hepatitis C: a medicinal chemistry perspective.Journal of medicinal chemistry, , Jan-13, Volume: 48, Issue:1, 2005
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailaJournal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006