Protein mono-ADP-ribosyltransferase PARP6

A protein mono-ADP-ribosyltransferase PARP6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2NL67]

EC 2.4.2.-;
ADP-ribosyltransferase diphtheria toxin-like 17;
ARTD17;
Poly [ADP-ribose] polymerase 6;
PARP-6

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
olaparib	Homo sapiens (human)	IC50	1.8000	1	1
xav939	Homo sapiens (human)	IC50	10.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
nucleotidyltransferase activity	molecular function	Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]
NAD+- protein-cysteine ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. [PMID:25043379, RHEA:56612]
NAD+- protein-aspartate ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:54424]
protein serine/threonine kinase activator activity	molecular function	Binds to and increases the activity of a protein serine/threonine kinase. [GOC:go_curators]
kinase binding	molecular function	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]
NAD+ ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]

This protein is active in 2 target(s):

Target	Category	Definition
nuclear envelope	cellular component	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
endoplasmic reticulum tubular network	cellular component	A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. [GOC:vw, PMID:16469703, PMID:20434336]

This protein is involved in 3 target(s):

Target	Category	Definition
positive regulation of dendrite morphogenesis	biological process	Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]
protein auto-ADP-ribosylation	biological process	The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl]
endoplasmic reticulum unfolded protein response	biological process	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. [GOC:mah, PMID:12042763]