penicillamine has been researched along with Necrosis in 24 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Liver enzymes were followed in 99 patients treated with D-penicillamine for rheumatoid arthritis." | 7.66 | Liver abnormalities in penicillamine treated rheumatoid arthritis. ( Lindström, CG; Wollheim, FA, 1979) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 7.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "Because Wilson disease was never associated with ANCA-related nephritis, this case strongly supports that d-penicillamine can induce ANCA-vasculitis." | 5.34 | D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease. ( Bienaimé, F; Clerbaux, G; Mougenot, B; Plaisier, E; Ronco, P; Rougier, JP, 2007) |
| "The nitric oxide (N0-releasing agents sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) inhibit dioxygenase activity of lipoxygenase in human platelets and human CHP100 neuroblastoma cells, leading the latter to necrosis." | 3.69 | Nitric oxide-donor compounds inhibit lipoxygenase activity. ( Corasaniti, MT; Finazzi Agrò, A; Guerrieri, P; Maccarrone, M; Nisticò, G, 1996) |
| "Liver enzymes were followed in 99 patients treated with D-penicillamine for rheumatoid arthritis." | 3.66 | Liver abnormalities in penicillamine treated rheumatoid arthritis. ( Lindström, CG; Wollheim, FA, 1979) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 3.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "Because Wilson disease was never associated with ANCA-related nephritis, this case strongly supports that d-penicillamine can induce ANCA-vasculitis." | 1.34 | D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease. ( Bienaimé, F; Clerbaux, G; Mougenot, B; Plaisier, E; Ronco, P; Rougier, JP, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fehsel, K | 1 |
| Kolb-Bachofen, V | 1 |
| Kröncke, KD | 1 |
| Oh, HM | 1 |
| Choi, SC | 1 |
| Lee, HS | 1 |
| Chun, CH | 1 |
| Seo, GS | 1 |
| Choi, EY | 1 |
| Lee, HJ | 1 |
| Lee, MS | 1 |
| Yeom, JJ | 1 |
| Choi, SJ | 1 |
| Han, WC | 1 |
| Oh, JM | 1 |
| Chung, YT | 1 |
| Chun, JS | 1 |
| Lee, KM | 1 |
| Jun, CD | 1 |
| Kwon, KB | 1 |
| Kim, EK | 1 |
| Lim, JG | 1 |
| Shin, BC | 1 |
| Han, SC | 1 |
| Song, BK | 1 |
| Kim, KS | 1 |
| Seo, EA | 1 |
| Ryu, DG | 1 |
| Vicente, S | 1 |
| Pérez-Rodríguez, R | 1 |
| Oliván, AM | 1 |
| Martínez Palacián, A | 1 |
| González, MP | 1 |
| Oset-Gasque, MJ | 1 |
| Bienaimé, F | 1 |
| Clerbaux, G | 1 |
| Plaisier, E | 1 |
| Mougenot, B | 1 |
| Ronco, P | 1 |
| Rougier, JP | 1 |
| Chan, HL | 1 |
| Murphy, KC | 1 |
| Atkins, CJ | 1 |
| Offer, RC | 1 |
| Hogg, JC | 1 |
| Stein, HB | 1 |
| Zera, RT | 1 |
| Nagasawa, HT | 1 |
| Mitrovic, B | 1 |
| Ignarro, LJ | 1 |
| Vinters, HV | 1 |
| Akers, MA | 1 |
| Schmid, I | 1 |
| Uittenbogaart, C | 1 |
| Merrill, JE | 1 |
| Maccarrone, M | 1 |
| Corasaniti, MT | 2 |
| Guerrieri, P | 1 |
| Nisticò, G | 2 |
| Finazzi Agrò, A | 1 |
| Melino, G | 1 |
| Bernassola, F | 1 |
| Knight, RA | 1 |
| Finazzi-Agro, A | 1 |
| Okuno, S | 1 |
| Shimizu, S | 1 |
| Ito, T | 1 |
| Nomura, M | 1 |
| Hamada, E | 1 |
| Tsujimoto, Y | 1 |
| Matsuda, H | 1 |
| Taimor, G | 1 |
| Lorenz, H | 1 |
| Hofstaetter, B | 1 |
| Schlüter, KD | 1 |
| Piper, HM | 1 |
| Angulo, P | 1 |
| Larson, DR | 1 |
| Therneau, TM | 1 |
| LaRusso, NF | 1 |
| Batts, KP | 1 |
| Lindor, KD | 1 |
| Kim, YM | 1 |
| Chung, HT | 1 |
| Simmons, RL | 1 |
| Billiar, TR | 1 |
| Gocan, NC | 1 |
| Scott, JA | 1 |
| Tyml, K | 1 |
| Prescott, LF | 1 |
| Sutherland, GR | 1 |
| Park, J | 1 |
| Smith, IJ | 1 |
| Proudfoot, AT | 1 |
| Wollheim, FA | 1 |
| Lindström, CG | 1 |
| Nisman, RM | 1 |
| Ganderson, AP | 1 |
| Vlahcevic, ZR | 1 |
| Gregory, DH | 1 |
| Sato, M | 1 |
| Yoshida, H | 1 |
| Kasukawa, R | 1 |
| Yoshida, T | 1 |
| Grand, RJ | 1 |
| Vawter, GF | 1 |
| Ross, IN | 1 |
| Dass, PK | 1 |
| Riede, UN | 1 |
| Navashin, SM | 1 |
| Zhukov, VG | 1 |
| Berezina, EK | 1 |
24 other studies available for penicillamine and Necrosis
| Article | Year |
|---|---|
Necrosis is the predominant type of islet cell death during development of insulin-dependent diabetes mellitus in BB rats.
Topics: Animals; Annexin A5; Apoptosis; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; | 2003 |
Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death.
Topics: Apoptosis; Blotting, Western; Carcinogens; Caspase 3; Caspase 8; Caspases; Catalysis; Cell Line, Tum | 2004 |
Protective effect of Coptidis Rhizoma on S-nitroso-N-acetylpenicillamine (SNAP)-induced apoptosis and necrosis in pancreatic RINm5F cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Coptis chinensis; Dose-Response Relationship, Drug; Drugs, Chi | 2005 |
Nitric oxide and peroxynitrite induce cellular death in bovine chromaffin cells: evidence for a mixed necrotic and apoptotic mechanism with caspases activation.
Topics: Analysis of Variance; Animals; Caspase 3; Caspases; Cattle; Cell Cycle; Cell Death; Cells, Cultured; | 2006 |
D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease.
Topics: Adult; Antibodies, Antineutrophil Cytoplasmic; Chelating Agents; Creatinine; Disease Progression; Fe | 2007 |
Observations on drug-induced toxic epidermal necrolysis in Singapore.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antipyrine; Barbiturates; Burns; Child; Diagnosis, Differenti | 1984 |
Obliterative bronchiolitis in two rheumatoid arthritis patients treated with penicillamine.
Topics: Arthritis, Rheumatoid; Bronchitis; Drug Hypersensitivity; Female; Humans; Middle Aged; Necrosis; Pen | 1981 |
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis | 1980 |
Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes.
Topics: Animals; Apoptosis; Astrocytes; Cell Death; Cell Membrane; Cells, Cultured; DNA; Electrophoresis, Ag | 1995 |
Nitric oxide-donor compounds inhibit lipoxygenase activity.
Topics: Blood Platelets; Cell Death; Cell Line; Humans; Kinetics; Lipoxygenase; Lipoxygenase Inhibitors; Nec | 1996 |
S-nitrosylation regulates apoptosis.
Topics: Apoptosis; Caspase 3; Caspases; Cysteine; Cysteine Endopeptidases; fas Receptor; GTP Phosphohydrolas | 1997 |
Bcl-2 prevents caspase-independent cell death.
Topics: Adrenal Gland Neoplasms; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase Inhibito | 1998 |
Induction of necrosis but not apoptosis after anoxia and reoxygenation in isolated adult cardiomyocytes of rat.
Topics: Analysis of Variance; Animals; Apoptosis; Cells, Cultured; DNA; Hydrogen Peroxide; In Situ Nick-End | 1999 |
Time course of histological progression in primary sclerosing cholangitis.
Topics: Adolescent; Adult; Aged; Biopsy; Cholagogues and Choleretics; Cholangitis, Sclerosing; Disease Progr | 1999 |
Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cytochrome c Group; Ir | 2000 |
Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle.
Topics: Acetylcholine; Animals; Arterioles; Enzyme Inhibitors; Lactic Acid; Male; Muscle, Skeletal; Necrosis | 2000 |
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1976 |
Liver abnormalities in penicillamine treated rheumatoid arthritis.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspartate Aminotransferases | 1979 |
Acute viral hepatitis with bridging hepatic necrosis. An overview.
Topics: Adrenal Cortex Hormones; Biopsy; Hepatitis, Viral, Human; Humans; Liver; Liver Cirrhosis; Necrosis; | 1979 |
[Effect of D-penicillamine on rheumatoid factor, necrotizing factor and vascular permeability factor].
Topics: Arthritis, Rheumatoid; Capillary Permeability; Humans; Immunoglobulin M; In Vitro Techniques; Mercap | 1977 |
Juvenile Wilson disease: histologic and functional studies during penicillamine therapy.
Topics: Adolescent; Adult; Cell Nucleus; Ceruloplasmin; Connective Tissue; Copper; Fatty Liver; Female; Hepa | 1975 |
Cholestasis due to D-penicillamine toxicity.
Topics: Adult; Cholestasis, Intrahepatic; Female; Humans; Necrosis; Penicillamine | 1985 |
[Cells and matrix of epiphyseal plate after administration of D-penicillamine].
Topics: Animals; Bone Diseases; Calcium; Calcium Phosphates; Cartilage; Collagen; Epiphyses; Male; Microscop | 1971 |
[Experimental study of D-penicillamine].
Topics: Animals; Kidney; Mercury Poisoning; Mice; Necrosis; Nephrosis; Penicillamine | 1969 |