Phospholipase D1

A phospholipase D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13393]

Synonyms

PLD 1;
hPLD1;
EC 3.1.4.4;
Choline phosphatase 1;
Phosphatidylcholine-hydrolyzing phospholipase D1

Research

Bioassay Publications (9)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	5 (55.56)	24.3611
2020's	1 (11.11)	2.80

Compounds (13)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-NA-PP1	Homo sapiens (human)	IC50	0.3870	1	3
raloxifene	Homo sapiens (human)	IC50	7.6875	7	8
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	IC50	4.8000	1	1
halopemide	Homo sapiens (human)	IC50	0.1305	8	8
1-(4-pyridyl)piperazine	Homo sapiens (human)	IC50	3.6000	1	1
1-(2-pyridinyl)piperazine	Homo sapiens (human)	IC50	3.6000	1	1
afimoxifene	Homo sapiens (human)	IC50	13.2500	1	2
tamoxifen	Homo sapiens (human)	IC50	20.0000	1	1
5-fluoro-2-indolyldeschlorohalopemide	Homo sapiens (human)	IC50	0.0263	6	8
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide	Homo sapiens (human)	IC50	0.2070	8	10
vu0155069	Homo sapiens (human)	IC50	0.2034	7	7
ml298	Homo sapiens (human)	IC50	15.0888	3	4
ml299	Homo sapiens (human)	IC50	0.0203	3	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
raloxifene	Homo sapiens (human)	EC50	9.2500	2	2
halopemide	Homo sapiens (human)	EC50	0.1605	2	2
5-fluoro-2-indolyldeschlorohalopemide	Homo sapiens (human)	EC50	0.0225	2	2
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide	Homo sapiens (human)	EC50	0.2005	2	2
vu0155069	Homo sapiens (human)	EC50	0.9055	2	2

Enables

This protein enables 4 target(s):

Target	Category	Definition
phospholipase D activity	molecular function	Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. [EC:3.1.4.4]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
phosphatidylinositol binding	molecular function	Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417]
N-acylphosphatidylethanolamine-specific phospholipase D activity	molecular function	Catalysis of the reaction: H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine (NAE) + H+. [PMID:14634025, PMID:15878693, RHEA:33159]

Located In

This protein is located in 13 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
endosome	cellular component	A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
endocytic vesicle	cellular component	A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. [GOC:go_curators, PMID:19696797]
late endosome membrane	cellular component	The lipid bilayer surrounding a late endosome. [GOC:pz]
specific granule membrane	cellular component	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
tertiary granule membrane	cellular component	The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
cholinergic synapse	cellular component	A synapse that uses acetylcholine as a neurotransmitter. [GOC:dos]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
plasma membrane region	cellular component	A membrane that is a (regional) part of the plasma membrane. [GOC:dos]

Involved In

This protein is involved in 10 target(s):

Target	Category	Definition
phosphatidic acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [ISBN:0198506732]
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
small GTPase-mediated signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase relays a signal. [GOC:mah]
Ras protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]
cellular response to nutrient	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:mah]
regulation of microvillus assembly	biological process	A process that modulates the formation of a microvillus. [GOC:mah]
positive regulation of translation	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:dph, GOC:go_curators, GOC:tb]
regulation of synaptic vesicle cycle	biological process	Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. [GOC:dos]
phospholipid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
regulation of vesicle-mediated transport	biological process	Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. [GOC:dph, GOC:tb]