A serine hydroxymethyltransferase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34897]
SHMT;
EC 2.1.2.1;
Glycine hydroxymethyltransferase;
Serine methylase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0) | 18.7374 |
| 1990's | 0 (0) | 18.2507 |
| 2000's | 0 (0) | 29.6817 |
| 2010's | 0 (0) | 24.3611 |
| 2020's | 0 (0) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| oxaprozin | Homo sapiens (human) | IC50 | 1.9498 | 1 | 0 |
| papaverine | Homo sapiens (human) | IC50 | 2.6915 | 1 | 0 |
| primaquine | Homo sapiens (human) | IC50 | 0.4365 | 1 | 0 |
| flupirtine | Homo sapiens (human) | IC50 | 0.9332 | 1 | 0 |
| duloxetine | Homo sapiens (human) | IC50 | 6.9183 | 1 | 0 |
| N-[7-(2-furanyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]acetamide | Homo sapiens (human) | IC50 | 4.5700 | 1 | 0 |
| pyrvinium | Homo sapiens (human) | IC50 | 2.5704 | 1 | 0 |
| 2-(2-furanylmethyl)-3-[[2-(3-pyridinyl)-3H-benzimidazol-5-yl]amino]-3H-isoindol-1-one | Homo sapiens (human) | IC50 | 9.7700 | 1 | 0 |
| gw2974 | Homo sapiens (human) | IC50 | 2.4547 | 1 | 0 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin binding | molecular function | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130] |
| glycine hydroxymethyltransferase activity | molecular function | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. [RHEA:15481] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| L-allo-threonine aldolase activity | molecular function | Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde. [PMID:9228760, RHEA:26209] |
| amino acid binding | molecular function | Binding to an amino acid, organic acids containing one or more amino substituents. [GOC:ai] |
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial inner membrane | cellular component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
| microtubule cytoskeleton | cellular component | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172] |
| mitochondrial nucleoid | cellular component | The region of a mitochondrion to which the DNA is confined. [GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| BRISC complex | cellular component | A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. [GOC:mah, PMID:19214193] |
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|---|---|
| regulation of oxidative phosphorylation | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. [GOC:dph] |
| glycine metabolic process | biological process | The chemical reactions and pathways involving glycine, aminoethanoic acid. [GOC:go_curators] |
| L-serine metabolic process | biological process | The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg] |
| L-serine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg] |
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |
| positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| response to type I interferon | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] |
| tetrahydrofolate interconversion | biological process | The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. [GOC:yaf, PMID:1825999] |
| tetrahydrofolate metabolic process | biological process | The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732] |
| protein tetramerization | biological process | The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. [GOC:ecd] |
| protein homotetramerization | biological process | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators] |
| regulation of mitochondrial translation | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. [GOC:mah] |
| protein K63-linked deubiquitination | biological process | A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. [GOC:mah, PMID:19202061, PMID:19214193] |
| regulation of aerobic respiration | biological process | Any process that modulates the frequency, rate or extent of aerobic respiration. [GO_REF:0000058, GOC:TermGenie, PMID:19266076] |
| glycine biosynthetic process from serine | biological process | The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine. [GOC:go_curators] |