Proteins > Amine oxidase [flavin-containing] A
Page last updated: 2024-08-07 16:09:55
Amine oxidase [flavin-containing] A
An amine oxidase [flavin-containing] A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21397]
Synonyms
EC 1.4.3.4;
Monoamine oxidase type A;
MAO-A
Research
Bioassay Publications (272)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (2.94) | 18.2507 |
| 2000's | 30 (11.03) | 29.6817 |
| 2010's | 188 (69.12) | 24.3611 |
| 2020's | 46 (16.91) | 2.80 |
Compounds (209)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4'-bromoflavone | Homo sapiens (human) | Ki | 1.2600 | 1 | 2 |
| 7,8-dihydroxyflavone | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| 7-hydroxyflavanone | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| azobenzene | Homo sapiens (human) | IC50 | 12.7800 | 1 | 2 |
| benzo(a)pyrene | Homo sapiens (human) | IC50 | 5.9720 | 1 | 0 |
| 5-methoxypsoralen | Homo sapiens (human) | IC50 | 13.8000 | 1 | 1 |
| caffeine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| chelerythrine | Homo sapiens (human) | IC50 | 0.5500 | 1 | 1 |
| chelerythrine | Homo sapiens (human) | Ki | 0.2200 | 1 | 1 |
| chloroxylenol | Homo sapiens (human) | IC50 | 1.8290 | 1 | 0 |
| ciglitazone | Homo sapiens (human) | IC50 | 29.1930 | 1 | 0 |
| clonidine | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| danthron | Homo sapiens (human) | IC50 | 10.7000 | 1 | 1 |
| disulfiram | Homo sapiens (human) | IC50 | 13.7340 | 1 | 0 |
| donepezil | Homo sapiens (human) | IC50 | 925.0000 | 2 | 2 |
| emodin | Homo sapiens (human) | IC50 | 4.3200 | 1 | 1 |
| fentanyl | Homo sapiens (human) | Ki | 5.4620 | 1 | 1 |
| harmaline | Homo sapiens (human) | IC50 | 0.0329 | 1 | 1 |
| phenelzine | Homo sapiens (human) | IC50 | 0.1920 | 2 | 1 |
| phenelzine | Homo sapiens (human) | Ki | 1.6277 | 2 | 3 |
| iproniazid | Homo sapiens (human) | IC50 | 5.7032 | 74 | 76 |
| juglone | Homo sapiens (human) | IC50 | 3.0350 | 1 | 2 |
| leflunomide | Homo sapiens (human) | IC50 | 20.6960 | 1 | 0 |
| vitamin k 3 | Homo sapiens (human) | IC50 | 6.6100 | 1 | 2 |
| vitamin k 3 | Homo sapiens (human) | Ki | 26.0000 | 1 | 1 |
| methoxsalen | Homo sapiens (human) | IC50 | 85.1100 | 1 | 1 |
| nocodazole | Homo sapiens (human) | IC50 | 24.0990 | 1 | 0 |
| 3,7-bis(dimethylamino)phenothiazin-5-ium | Homo sapiens (human) | IC50 | 0.0700 | 1 | 1 |
| moclobemide | Homo sapiens (human) | IC50 | 286.7724 | 33 | 34 |
| moclobemide | Homo sapiens (human) | Ki | 0.3226 | 8 | 10 |
| clorgyline | Homo sapiens (human) | IC50 | 1.5713 | 107 | 110 |
| clorgyline | Homo sapiens (human) | Ki | 0.0907 | 3 | 3 |
| nabumetone | Homo sapiens (human) | IC50 | 0.9980 | 1 | 0 |
| quinone | Homo sapiens (human) | IC50 | 4.8200 | 1 | 1 |
| pargyline | Homo sapiens (human) | IC50 | 6.9136 | 18 | 19 |
| pentamidine | Homo sapiens (human) | IC50 | 0.7930 | 1 | 0 |
| pioglitazone | Homo sapiens (human) | IC50 | 35.0690 | 1 | 0 |
| primaquine | Homo sapiens (human) | IC50 | 75.7000 | 1 | 1 |
| proxymetacaine | Homo sapiens (human) | IC50 | 1.7770 | 1 | 0 |
| 1,2,5,8-tetrahydroxy anthraquinone | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| raloxifene | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| carbamylhydrazine | Homo sapiens (human) | IC50 | 6.7000 | 1 | 1 |
| alkannin | Homo sapiens (human) | IC50 | 1.2550 | 1 | 2 |
| vorinostat | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| tetracaine | Homo sapiens (human) | IC50 | 0.3170 | 1 | 0 |
| 2-phenylcyclopropan-1-amine | Homo sapiens (human) | IC50 | 8.1100 | 2 | 2 |
| trioxsalen | Homo sapiens (human) | IC50 | 0.8310 | 1 | 0 |
| troglitazone | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| dextroamphetamine | Homo sapiens (human) | Ki | 14.4000 | 1 | 1 |
| 2-acetylaminofluorene | Homo sapiens (human) | IC50 | 0.0590 | 1 | 0 |
| p-dimethylaminoazobenzene | Homo sapiens (human) | IC50 | 2.3273 | 1 | 2 |
| methylene blue | Homo sapiens (human) | IC50 | 0.0700 | 1 | 1 |
| ficusin | Homo sapiens (human) | IC50 | 20.6500 | 2 | 2 |
| alizarin | Homo sapiens (human) | IC50 | 30.1000 | 1 | 1 |
| purpurin | Homo sapiens (human) | IC50 | 3.8725 | 4 | 4 |
| purpurin | Homo sapiens (human) | Ki | 0.4220 | 1 | 1 |
| 1,4-dihydroxyanthraquinone | Homo sapiens (human) | IC50 | 0.0650 | 1 | 1 |
| 1,4-dihydroxyanthraquinone | Homo sapiens (human) | Ki | 0.0390 | 1 | 1 |
| 9,10-phenanthrenequinone | Homo sapiens (human) | IC50 | 1.9200 | 1 | 1 |
| 2,6-dihydroxyanthraquinone | Homo sapiens (human) | IC50 | 11.5000 | 1 | 1 |
| 9,10-anthraquinone | Homo sapiens (human) | IC50 | 122.0000 | 1 | 1 |
| phthalimide | Homo sapiens (human) | IC50 | 165.0000 | 1 | 1 |
| phthalide | Homo sapiens (human) | IC50 | 44.9000 | 1 | 1 |
| anthrone | Homo sapiens (human) | IC50 | 1.8900 | 1 | 1 |
| aminacrine | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| xanthone | Homo sapiens (human) | IC50 | 0.7315 | 2 | 2 |
| 1,2,3,4-tetrahydroisoquinoline | Homo sapiens (human) | Ki | 210.0000 | 1 | 1 |
| isatin | Homo sapiens (human) | IC50 | 107.4824 | 6 | 6 |
| isatin | Homo sapiens (human) | Ki | 9.8600 | 5 | 8 |
| xanthenes | Homo sapiens (human) | IC50 | 24.8000 | 1 | 1 |
| phenothiazine | Homo sapiens (human) | IC50 | 0.5920 | 1 | 0 |
| anthrarufin | Homo sapiens (human) | IC50 | 30.8000 | 1 | 1 |
| dichlone | Homo sapiens (human) | IC50 | 2.3050 | 1 | 2 |
| 1,4-naphthoquinone | Homo sapiens (human) | IC50 | 5.9150 | 1 | 2 |
| 1,4-naphthoquinone | Homo sapiens (human) | Ki | 7.7000 | 1 | 1 |
| 4-aminodiphenyl ether | Homo sapiens (human) | IC50 | 91.4000 | 1 | 1 |
| 4-aminodiphenyl ether | Homo sapiens (human) | Ki | 24.1000 | 1 | 1 |
| ethynodiol diacetate | Homo sapiens (human) | IC50 | 4.2900 | 1 | 0 |
| n-phenethylpiperidine | Homo sapiens (human) | IC50 | 757.3000 | 1 | 1 |
| n-phenethylpiperidine | Homo sapiens (human) | Ki | 1,901.2000 | 2 | 2 |
| phenylbenzoquinone | Homo sapiens (human) | IC50 | 5.0300 | 1 | 1 |
| naphthazarin | Homo sapiens (human) | IC50 | 2.0250 | 1 | 2 |
| plumbagin | Homo sapiens (human) | IC50 | 3.0000 | 1 | 2 |
| aloe emodin | Homo sapiens (human) | IC50 | 1.7700 | 1 | 1 |
| 4-chromone | Homo sapiens (human) | IC50 | 39.9000 | 1 | 1 |
| angelicin | Homo sapiens (human) | IC50 | 0.8800 | 1 | 1 |
| angelicin | Homo sapiens (human) | Ki | 0.4600 | 1 | 1 |
| flavone | Homo sapiens (human) | Ki | 1.7800 | 1 | 2 |
| 1-naphthylisothiocyanate | Homo sapiens (human) | IC50 | 22.4420 | 1 | 0 |
| 7,9-dimethylbenz(c)acridine | Homo sapiens (human) | IC50 | 95.1000 | 1 | 1 |
| 1,2-diaminoanthraquinone | Homo sapiens (human) | IC50 | 2.2800 | 1 | 1 |
| amiloride | Homo sapiens (human) | IC50 | 3.9090 | 1 | 0 |
| 3-aminobiphenyl | Homo sapiens (human) | IC50 | 68.6000 | 1 | 1 |
| 3-aminobiphenyl | Homo sapiens (human) | Ki | 18.1000 | 1 | 1 |
| 2-methoxy-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 22.6000 | 1 | 2 |
| tranylcypromine | Homo sapiens (human) | IC50 | 5.6881 | 8 | 8 |
| tranylcypromine | Homo sapiens (human) | Ki | 102.0000 | 2 | 2 |
| 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline | Homo sapiens (human) | Ki | 4.0000 | 1 | 1 |
| (1S,2R)-tranylcypromine | Homo sapiens (human) | IC50 | 2.2084 | 4 | 5 |
| selegiline | Homo sapiens (human) | IC50 | 53.7655 | 61 | 61 |
| selegiline | Homo sapiens (human) | Ki | 14.8280 | 8 | 10 |
| selegiline hydrochloride, (r)-isomer | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| 1,4-diaminoanthraquinone | Homo sapiens (human) | IC50 | 1.0600 | 1 | 1 |
| toloxatone | Homo sapiens (human) | IC50 | 2.8479 | 19 | 19 |
| toloxatone | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| idazoxan | Homo sapiens (human) | Ki | 0.0190 | 2 | 2 |
| norharman | Homo sapiens (human) | Ki | 0.2600 | 1 | 1 |
| isoimperatorin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| rilmenidine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| malvidin chloride | Homo sapiens (human) | IC50 | 22.1000 | 1 | 1 |
| 9-chloroacridine | Homo sapiens (human) | IC50 | 12.1000 | 1 | 1 |
| n-methylphenothiazine | Homo sapiens (human) | IC50 | 24.9000 | 1 | 1 |
| 2-Methoxyxanthone | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| lazabemide | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| lazabemide | Homo sapiens (human) | Ki | 4,075.0000 | 2 | 2 |
| thioxolone | Homo sapiens (human) | IC50 | 9.7700 | 1 | 1 |
| xanthydrol | Homo sapiens (human) | IC50 | 28.4000 | 1 | 1 |
| 4'-methoxyflavone | Homo sapiens (human) | Ki | 2.2200 | 1 | 2 |
| rosiglitazone | Homo sapiens (human) | Ki | 27.6000 | 1 | 1 |
| 4-phenylbutylamine | Homo sapiens (human) | Ki | 31.0000 | 1 | 1 |
| 2,3,6-trimethyl-1,4-naphthoquinone | Homo sapiens (human) | Ki | 4.5000 | 2 | 2 |
| inermin | Homo sapiens (human) | IC50 | 85.8000 | 1 | 1 |
| oxoglaucine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| 3,7-dimethyl-1-propargylxanthine | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| benzo(g)isoquinoline-5,10-dione | Homo sapiens (human) | IC50 | 20.2000 | 1 | 1 |
| cinnabarinic acid | Homo sapiens (human) | IC50 | 45.3000 | 1 | 1 |
| 1-ethylphenoxathiin 10,10-dioxide | Homo sapiens (human) | Ki | 0.0100 | 1 | 1 |
| safinamide | Homo sapiens (human) | IC50 | 63.5235 | 13 | 13 |
| safinamide | Homo sapiens (human) | Ki | 365.0000 | 2 | 2 |
| 2'-methoxyflavone | Homo sapiens (human) | Ki | 2.4350 | 1 | 2 |
| 1-(1,3-benzodioxol-5-yl)-3-(1-piperidinyl)-1-propanone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4'-chloroflavone | Homo sapiens (human) | Ki | 2.2500 | 1 | 2 |
| harmalan | Homo sapiens (human) | Ki | 0.1480 | 1 | 1 |
| corydalmine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| 2'-hydroxyflavone | Homo sapiens (human) | Ki | 3.2500 | 1 | 2 |
| corynoline | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole | Homo sapiens (human) | IC50 | 20.5045 | 1 | 2 |
| tv3326 | Homo sapiens (human) | IC50 | 95.0000 | 3 | 3 |
| tv3326 | Homo sapiens (human) | Ki | 222.3333 | 2 | 3 |
| 4'-hydroxyflavone | Homo sapiens (human) | Ki | 3.0550 | 1 | 2 |
| 4-methoxyxanthone | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| naringenin | Homo sapiens (human) | IC50 | 955.0000 | 1 | 1 |
| linezolid | Homo sapiens (human) | IC50 | 46.0000 | 1 | 1 |
| linezolid | Homo sapiens (human) | Ki | 33.9750 | 4 | 4 |
| decursin | Homo sapiens (human) | IC50 | 1.7600 | 3 | 3 |
| farnesol | Homo sapiens (human) | Ki | 430.0714 | 1 | 7 |
| resveratrol | Homo sapiens (human) | IC50 | 9.8298 | 4 | 3 |
| u 100480 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| 8-prenylnaringenin | Homo sapiens (human) | IC50 | 38.8000 | 1 | 1 |
| 3'-methoxyflavone | Homo sapiens (human) | Ki | 1.4250 | 1 | 2 |
| chalcone | Homo sapiens (human) | IC50 | 1.4100 | 1 | 1 |
| piperine | Homo sapiens (human) | IC50 | 58.9800 | 1 | 1 |
| 4'-methoxychalcone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| N-[3-(4-morpholinyl)propyl]-2-oxo-1-benzopyran-3-carboxamide | Homo sapiens (human) | IC50 | 42.3200 | 1 | 1 |
| 3',4'-dimethoxyflavone | Homo sapiens (human) | Ki | 2.4800 | 1 | 2 |
| curcumin | Homo sapiens (human) | IC50 | 3.5000 | 3 | 3 |
| curcumin | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| 3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | Homo sapiens (human) | IC50 | 1.0400 | 1 | 1 |
| 4-aminostilbene | Homo sapiens (human) | IC50 | 25.3000 | 1 | 1 |
| 4-aminostilbene | Homo sapiens (human) | Ki | 6.6700 | 1 | 1 |
| (1R,2S)-tranylcypromine hydrochloride | Homo sapiens (human) | IC50 | 11.7000 | 3 | 3 |
| N5-(2-chloro-6-phenoxybenzyl)-1H-1,2,4-triazole-3,5-diamine | Homo sapiens (human) | IC50 | 150.0000 | 2 | 2 |
| mdl 72527 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| azilect | Homo sapiens (human) | IC50 | 15.1050 | 2 | 2 |
| rasagiline | Homo sapiens (human) | IC50 | 64.8532 | 41 | 42 |
| rasagiline | Homo sapiens (human) | Ki | 5.1667 | 4 | 6 |
| 2-(2-benzofuranyl)-2-imidazoline | Homo sapiens (human) | Ki | 17.0000 | 1 | 1 |
| bakuchicin | Homo sapiens (human) | IC50 | 1.7800 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 2.6200 | 2 | 2 |
| biochanin a | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| formononetin | Homo sapiens (human) | IC50 | 31.2000 | 1 | 1 |
| acacetin | Homo sapiens (human) | IC50 | 0.1670 | 3 | 3 |
| acacetin | Homo sapiens (human) | Ki | 0.0592 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 1.3980 | 5 | 5 |
| luteolin | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| scopoletin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| harmine | Homo sapiens (human) | IC50 | 0.0044 | 3 | 3 |
| harmine | Homo sapiens (human) | Ki | 0.0152 | 4 | 4 |
| genistein | Homo sapiens (human) | IC50 | 4.1840 | 5 | 4 |
| gardenia yellow | Homo sapiens (human) | IC50 | 170.0000 | 1 | 1 |
| hispidol | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| hispidol | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| sulfuretin | Homo sapiens (human) | IC50 | 4.1600 | 1 | 1 |
| chrysin | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| galangin | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| bellidifolin | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| demethylbellidifolin | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| gentisein | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| norathyriol | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| 1,2,8-trihydroxy-6-methoxyxanthone | Homo sapiens (human) | IC50 | 8.5000 | 1 | 1 |
| kaempferide | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| daidzein | Homo sapiens (human) | IC50 | 14.0000 | 2 | 2 |
| epsilon-viniferin | Homo sapiens (human) | IC50 | 19.6000 | 1 | 1 |
| 7-hydroxyflavone | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| 4',7-dihydroxyflavone | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| 4'-hydroxychalcone | Homo sapiens (human) | IC50 | 52.2500 | 2 | 2 |
| as 605240 | Homo sapiens (human) | IC50 | 165.8000 | 1 | 1 |
| osthenol | Homo sapiens (human) | IC50 | 0.7400 | 1 | 1 |
| osthenol | Homo sapiens (human) | Ki | 0.2600 | 1 | 1 |
| kaempferol-7-methyl ether | Homo sapiens (human) | IC50 | 0.0510 | 1 | 1 |
| 8-(3-chlorostyryl)caffeine | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| alternariol monomethyl ether | Homo sapiens (human) | IC50 | 1.7100 | 2 | 2 |
| 1-hydroxyxanthone | Homo sapiens (human) | IC50 | 0.3100 | 1 | 1 |
| decussatin | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| 4'-chloroaurone | Homo sapiens (human) | IC50 | 0.7090 | 1 | 1 |
| guanabenz | Homo sapiens (human) | IC50 | 1.7870 | 1 | 0 |
| geiparvarin | Homo sapiens (human) | IC50 | 26.9154 | 1 | 1 |
| derricidin | Homo sapiens (human) | IC50 | 18.7600 | 1 | 1 |
| salsolinol hydrobromide | Homo sapiens (human) | Ki | 284.0000 | 1 | 1 |
| ciproxifan | Homo sapiens (human) | IC50 | 11.2667 | 3 | 3 |
| mofegiline | Homo sapiens (human) | IC50 | 1.2650 | 2 | 2 |
| mofegiline | Homo sapiens (human) | Ki | 1.1000 | 1 | 1 |
| 2-(3,4-dimethoxyphenyl)-3-fluoroallylamine | Homo sapiens (human) | Ki | 231.0000 | 1 | 1 |
| tracizoline | Homo sapiens (human) | Ki | 0.0019 | 2 | 2 |
| pf9601n | Homo sapiens (human) | IC50 | 0.2873 | 1 | 1 |
| 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| delta-viniferin | Homo sapiens (human) | IC50 | 8.9300 | 1 | 1 |
| tedizolid | Homo sapiens (human) | IC50 | 8.7000 | 1 | 1 |
| tedizolid | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone | Homo sapiens (human) | IC50 | 7.2022 | 1 | 2 |
| nitd 609 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 5-(2,5-difluorophenyl)-N-(2,6-dimethylphenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-(2,6-dimethoxyphenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 10.5400 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-[2,6-di(propan-2-yl)phenyl]-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-(2,6-diethylphenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| N-(2,6-dimethylphenyl)-5-(4-methyl-3-thiophenyl)-2-furancarboxamide | Homo sapiens (human) | IC50 | 25.0000 | 1 | 0 |
| 1-(4-methyl-1-piperazinyl)-2-[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]ethanone | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| ass234 | Homo sapiens (human) | IC50 | 0.0169 | 6 | 6 |
| gsk2879552 | Homo sapiens (human) | IC50 | 100.0000 | 3 | 3 |
| methylaplysinopsin | Homo sapiens (human) | IC50 | 0.0980 | 1 | 1 |
| aplysinopsin | Homo sapiens (human) | IC50 | 3.3623 | 3 | 3 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ellagic acid | Homo sapiens (human) | EC50 | 1.6000 | 1 | 1 |
Drugs with Other Measurements
Studies on the monoamine oxidase (MAO)-catalyzed oxidation of phenyl-substituted 1-methyl-4-phenoxy-1,2,3,6-tetrahydropyridine derivatives: factors contributing to MAO-A and MAO-B selectivity.Journal of medicinal chemistry, , May-26, Volume: 38, Issue:11, 1995
Novel 4-(aryloxy)tetrahydropyridine analogs of MPTP as monoamine oxidase A and B substrates.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
A selective phenelzine analogue inhibitor of histone demethylase LSD1.ACS chemical biology, , Jun-20, Volume: 9, Issue:6, 2014
[no title available],
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Development of MAO-A and 5-HTJournal of medicinal chemistry, , 10-13, Volume: 65, Issue:19, 2022
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-15, Volume: 28, Issue:8, 2020
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.RSC medicinal chemistry, , Feb-01, Volume: 11, Issue:2, 2020
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 03-01, Volume: 26, Issue:5, 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.Bioorganic chemistry, , Volume: 71, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens.Journal of natural products, , 04-28, Volume: 80, Issue:4, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis and evaluation of small molecules bearing a benzyloxy substituent as novel and potent monoamine oxidase inhibitors.MedChemComm, , Feb-01, Volume: 8, Issue:2, 2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.European journal of medicinal chemistry, , May-05, Volume: 95, 2015
New 2H-chromene-3-carboxamide derivatives: design, synthesis and use as inhibitors of hMAO.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
New coumarin derivatives: design, synthesis and use as inhibitors of hMAO.Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.European journal of medicinal chemistry, , Volume: 63, 2013
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Hydroxycoumarins as selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.European journal of medicinal chemistry, , Volume: 48, 2012
Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:4, 2011
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.Journal of medicinal chemistry, , Jul-28, Volume: 54, Issue:14, 2011
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase.Chemical biology & drug design, , Volume: 87, Issue:5, 2016
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Synthesis of novel thiazolyl hydrazone derivatives as potent dual monoamine oxidase-aromatase inhibitors.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors - design, synthesis, biological evaluation and molecular modelling.RSC medicinal chemistry, , Sep-01, Volume: 11, Issue:9, 2020
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
[no title available]MedChemComm, , Jul-01, Volume: 9, Issue:7, 2018
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, MedChemComm, , Sep-01, Volume: 8, Issue:9, 2017
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.ACS medicinal chemistry letters, , Jan-14, Volume: 7, Issue:1, 2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies.Bioorganic chemistry, , Volume: 62, 2015
Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.Bioorganic chemistry, , Volume: 58, 2015
Synthesis of some novel hydrazone and 2-pyrazoline derivatives: monoamine oxidase inhibitory activities and docking studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Monoamine oxidase inhibitory activity of 3,5-biaryl-4,5-dihydro-1H-pyrazole-1-carboxylate derivatives.European journal of medicinal chemistry, , Volume: 69, 2013
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.European journal of medicinal chemistry, , Volume: 48, 2012
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
[no title available]Journal of medicinal chemistry, , 02-10, Volume: 65, Issue:3, 2022
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent.Journal of medicinal chemistry, , 12-23, Volume: 64, Issue:24, 2021
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 211, 2021
Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 07-15, Volume: 42, 2021
Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 41, 2021
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
4-Oxoquinolines and monoamine oxidase: When tautomerism matters.European journal of medicinal chemistry, , Mar-05, Volume: 213, 2021
Bioactive Azepine-Indole Alkaloids from Journal of natural products, , 04-24, Volume: 83, Issue:4, 2020
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.Journal of medicinal chemistry, , 12-24, Volume: 63, Issue:24, 2020
Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors - design, synthesis, biological evaluation and molecular modelling.RSC medicinal chemistry, , Sep-01, Volume: 11, Issue:9, 2020
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-15, Volume: 28, Issue:8, 2020
Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.Journal of medicinal chemistry, , 12-10, Volume: 63, Issue:23, 2020
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 29, Issue:9, 2019
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.Bioorganic & medicinal chemistry, , 05-15, Volume: 27, Issue:10, 2019
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.Journal of medicinal chemistry, , 08-23, Volume: 61, Issue:16, 2018
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Design, synthesis and in vitro evaluation of stilbene derivatives as novel LSD1 inhibitors for AML therapy.Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 03-01, Volume: 26, Issue:5, 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
[no title available]MedChemComm, , Feb-01, Volume: 9, Issue:2, 2018
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.Bioorganic chemistry, , Volume: 71, 2017
Symmetrical aryl linked bis-iminothiazolidinones as new chemical entities for the inhibition of monoamine oxidases: Synthesis, in vitro biological evaluation and molecular modelling analysis.Bioorganic chemistry, , Volume: 70, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, MedChemComm, , Sep-01, Volume: 8, Issue:9, 2017
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?Journal of medicinal chemistry, , 08-24, Volume: 60, Issue:16, 2017
Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, MedChemComm, , Feb-01, Volume: 8, Issue:2, 2017
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains.European journal of medicinal chemistry, , May-05, Volume: 131, 2017
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Novel tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one: Design, synthesis, model and use as hMAO-B inhibitors.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 24, Issue:20, 2016
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.European journal of medicinal chemistry, , Volume: 70, 2013
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Jul-25, Volume: 56, Issue:14, 2013
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 62, 2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 22, Issue:24, 2012
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 22, Issue:15, 2012
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.European journal of medicinal chemistry, , Volume: 48, 2012
Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B).Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: deBioorganic & medicinal chemistry, , Nov-01, Volume: 18, Issue:21, 2010
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.Journal of medicinal chemistry, , Jul-24, Volume: 51, Issue:14, 2008
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 07-15, Volume: 42, 2021
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease.MedChemComm, , Jul-01, Volume: 8, Issue:7, 2017
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 11-01, Volume: 25, Issue:21, 2017
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015
Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.Journal of medicinal chemistry, , Sep-26, Volume: 56, Issue:18, 2013
Inhibition of monoamine oxidase by phthalide analogues.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 23, Issue:5, 2013
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.Bioorganic & medicinal chemistry, , May-01, Volume: 21, Issue:9, 2013
Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 01-15, Volume: 54, 2022
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches.MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 27, Issue:5, 2017
Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 01-15, Volume: 54, 2022
QSAR modeling of the MAO inhibitory activity of xanthones derivatives.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 14, Issue:22, 2004
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
The inhibition of monoamine oxidase by 2H-1,4-benzothiazin-3(4H)-ones.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.European journal of medicinal chemistry, , Volume: 70, 2013
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Inhibition of monoamine oxidase by (E)-styrylisatin analogues.Bioorganic & medicinal chemistry letters, , May-01, Volume: 19, Issue:9, 2009
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.The Journal of biological chemistry, , Apr-22, Volume: 280, Issue:16, 2005
Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase.Chemical biology & drug design, , Volume: 87, Issue:5, 2016
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
Novel 4-(aryloxy)tetrahydropyridine analogs of MPTP as monoamine oxidase A and B substrates.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective.Journal of medicinal chemistry, , 12-10, Volume: 63, Issue:23, 2020
Dual inhibitors of LSD1 and spermine oxidase.MedChemComm, , May-01, Volume: 10, Issue:5, 2019
Identification of selective and reversible LSD1 inhibitors with anti-metastasis activity by high-throughput docking.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 29, Issue:4, 2019
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 28, Issue:2, 2018
Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.Journal of medicinal chemistry, , Feb-25, Volume: 59, Issue:4, 2016
Lysine demethylases inhibitors.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-15, Volume: 18, Issue:10, 2008
Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).European journal of medicinal chemistry, , Mar-05, Volume: 231, 2022
Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.Chemical biology & drug design, , Volume: 85, Issue:6, 2015
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 29, Issue:9, 2019
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
[no title available]MedChemComm, , Jul-01, Volume: 9, Issue:7, 2018
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.Journal of medicinal chemistry, , 08-23, Volume: 61, Issue:16, 2018
[no title available]European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens.Journal of natural products, , 04-28, Volume: 80, Issue:4, 2017
Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, MedChemComm, , Sep-01, Volume: 8, Issue:9, 2017
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?Journal of medicinal chemistry, , 08-24, Volume: 60, Issue:16, 2017
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.ACS medicinal chemistry letters, , Jan-14, Volume: 7, Issue:1, 2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 24, Issue:20, 2016
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies.Bioorganic chemistry, , Volume: 62, 2015
Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.Bioorganic chemistry, , Volume: 58, 2015
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.European journal of medicinal chemistry, , Volume: 63, 2013
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.European journal of medicinal chemistry, , Volume: 59, 2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Monoamine oxidase inhibitory activity of 3,5-biaryl-4,5-dihydro-1H-pyrazole-1-carboxylate derivatives.European journal of medicinal chemistry, , Volume: 69, 2013
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.European journal of medicinal chemistry, , Volume: 58, 2012
Hydroxycoumarins as selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.European journal of medicinal chemistry, , Volume: 48, 2012
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:4, 2011
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.Journal of medicinal chemistry, , Jul-28, Volume: 54, Issue:14, 2011
Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 21, Issue:14, 2011
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.European journal of medicinal chemistry, , Volume: 45, Issue:10, 2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
[no title available],
The inhibition of monoamine oxidase by 2H-1,4-benzothiazin-3(4H)-ones.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 29, Issue:1, 2019
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 29, Issue:21, 2019
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Synthesis and evaluation of 2-substituted 4(3H)-quinazolinone thioether derivatives as monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , 11-01, Volume: 26, Issue:20, 2018
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 27, Issue:5, 2017
An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 26, Issue:9, 2016
Inhibition of monoamine oxidase by benzoxathiolone analogues.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 26, Issue:4, 2016
Monoamine oxidase inhibitory activities of heterocyclic chalcones.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 25, Issue:22, 2015
Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 25, Issue:6, 2015
α-Tetralone derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Recent development of potent analogues of oxazolidinone antibacterial agents.Bioorganic & medicinal chemistry, , Feb-01, Volume: 21, Issue:3, 2013
Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
[no title available]MedChemComm, , Jul-01, Volume: 9, Issue:7, 2018
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
Studies on the monoamine oxidase (MAO)-catalyzed oxidation of phenyl-substituted 1-methyl-4-phenoxy-1,2,3,6-tetrahydropyridine derivatives: factors contributing to MAO-A and MAO-B selectivity.Journal of medicinal chemistry, , May-26, Volume: 38, Issue:11, 1995
Novel 4-(aryloxy)tetrahydropyridine analogs of MPTP as monoamine oxidase A and B substrates.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry, , 07-15, Volume: 42, 2021
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.Journal of medicinal chemistry, , 12-10, Volume: 63, Issue:23, 2020
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.Journal of medicinal chemistry, , 08-23, Volume: 61, Issue:16, 2018
[no title available]European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Acetylene Group, Friend or Foe in Medicinal Chemistry.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
[no title available]MedChemComm, , Feb-01, Volume: 9, Issue:2, 2018
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.Journal of medicinal chemistry, , Mar-25, Volume: 47, Issue:7, 2004
Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives.European journal of medicinal chemistry, , Dec-01, Volume: 106, 2015
Recent development of potent analogues of oxazolidinone antibacterial agents.Bioorganic & medicinal chemistry, , Feb-01, Volume: 21, Issue:3, 2013
Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 17, Issue:2, 2007
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available],
The inhibition of monoamine oxidase by 2H-1,4-benzothiazin-3(4H)-ones.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 30, Issue:12, 2020
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.ACS medicinal chemistry letters, , Jan-14, Volume: 7, Issue:1, 2016
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.Journal of medicinal chemistry, , Jan-09, Volume: 57, Issue:1, 2014
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxidase.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Dual inhibitors of LSD1 and spermine oxidase.MedChemComm, , May-01, Volume: 10, Issue:5, 2019
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.MedChemComm, , Volume: 5, Issue:12, 2014
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
4-Oxoquinolines and monoamine oxidase: When tautomerism matters.European journal of medicinal chemistry, , Mar-05, Volume: 213, 2021
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-15, Volume: 28, Issue:8, 2020
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.European journal of medicinal chemistry, , Jul-01, Volume: 173, 2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 03-01, Volume: 26, Issue:5, 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.Bioorganic chemistry, , Volume: 71, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?Journal of medicinal chemistry, , 08-24, Volume: 60, Issue:16, 2017
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.European journal of medicinal chemistry, , Volume: 63, 2013
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.The Journal of biological chemistry, , Apr-22, Volume: 280, Issue:16, 2005
Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis.Journal of medicinal chemistry, , Dec-29, Volume: 48, Issue:26, 2005
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.Journal of medicinal chemistry, , Mar-25, Volume: 47, Issue:7, 2004
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.Journal of natural products, , 10-28, Volume: 79, Issue:10, 2016
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
The inhibition of monoamine oxidase by 2H-1,4-benzothiazin-3(4H)-ones.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
A critical update on the strategies towards small molecule inhibitors targeting Serine/arginine-rich (SR) proteins and Serine/arginine-rich proteins related kinases in alternative splicing.Bioorganic & medicinal chemistry, , 09-15, Volume: 70, 2022
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.Journal of medicinal chemistry, , Aug-11, Volume: 54, Issue:15, 2011
Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 20, Issue:2, 2010
Binding of beta-carbolines at 5-HT(2) serotonin receptors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
[no title available],
Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.Bioorganic & medicinal chemistry, , 04-01, Volume: 27, Issue:7, 2019
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
Selective inhibition of monoamine oxidase A by hispidol.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
[no title available]European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 74, 2022
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1).Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 30, Issue:3, 2020
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 22, Issue:15, 2012
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| primary amine oxidase activity | molecular function | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. [EC:1.4.3.21] |
| aliphatic amine oxidase activity | molecular function | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. [MetaCyc:AMINEOXID-RXN] |
| monoamine oxidase activity | molecular function | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. [GOC:pr, PMID:15279562, PMID:16129825] |
| flavin adenine dinucleotide binding | molecular function | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|
| biogenic amine metabolic process | biological process | The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. [GOC:jl, ISBN:0395825172] |
| positive regulation of signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction. [GOC:sm] |
| dopamine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732] |