Page last updated: 2024-08-07 16:54:00
Casein kinase II subunit beta
A casein kinase II subunit beta that is encoded in the genome of human. [PRO:DNx]
Synonyms
CK II beta;
Phosvitin;
Protein G5a
Research
Bioassay Publications (53)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (3.77) | 18.2507 |
| 2000's | 15 (28.30) | 29.6817 |
| 2010's | 30 (56.60) | 24.3611 |
| 2020's | 6 (11.32) | 2.80 |
Compounds (48)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4,5,6,7-tetrabromo-2-azabenzimidazole | Homo sapiens (human) | IC50 | 0.7325 | 8 | 7 |
| 4,5,6,7-tetrabromo-2-azabenzimidazole | Homo sapiens (human) | Ki | 1.5500 | 2 | 2 |
| chromone-2-carboxylic acid | Homo sapiens (human) | IC50 | 5.9800 | 1 | 1 |
| emodin | Homo sapiens (human) | IC50 | 0.8667 | 6 | 5 |
| emodin | Homo sapiens (human) | Ki | 1.9000 | 1 | 1 |
| n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide | Homo sapiens (human) | Ki | 950.0000 | 1 | 1 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | Homo sapiens (human) | IC50 | 6.9000 | 1 | 1 |
| mitoxantrone | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| 1,2,5,8-tetrahydroxy anthraquinone | Homo sapiens (human) | Ki | 0.0600 | 1 | 1 |
| 3,4-dichlorobenzoic acid | Homo sapiens (human) | IC50 | 5,000.0000 | 1 | 1 |
| dichlororibofuranosylbenzimidazole | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| boldine | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| staurosporine | Homo sapiens (human) | IC50 | 35.6000 | 3 | 3 |
| norharman | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| 7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| purvalanol b | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| h 89 | Homo sapiens (human) | Ki | 136.7000 | 1 | 1 |
| purvalanol a | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4,5,6,7-tetrabromobenzimidazole | Homo sapiens (human) | IC50 | 0.8100 | 3 | 2 |
| 4,5,6,7-tetrabromobenzimidazole | Homo sapiens (human) | Ki | 0.3000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 1.6500 | 5 | 5 |
| quercetin | Homo sapiens (human) | Ki | 1.1800 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 0.8500 | 4 | 4 |
| luteolin | Homo sapiens (human) | IC50 | 0.8333 | 3 | 2 |
| kaempferol | Homo sapiens (human) | IC50 | 0.7000 | 2 | 2 |
| baicalein | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| chrysin | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| fisetin | Homo sapiens (human) | IC50 | 0.5667 | 3 | 3 |
| fisetin | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| morin | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| myricetin | Homo sapiens (human) | IC50 | 0.9400 | 3 | 3 |
| coumestrol | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| coumestrol | Homo sapiens (human) | Ki | 7.6700 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | IC50 | 0.0400 | 2 | 2 |
| as 605240 | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| casein kinase ii | Homo sapiens (human) | IC50 | 2.2300 | 5 | 5 |
| casein kinase ii | Homo sapiens (human) | Ki | 0.0400 | 2 | 2 |
| jnj-7706621 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| jnj 10198409 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ps1145 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| leucettamine b | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| danusertib | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| as 252424 | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| 2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamide | Homo sapiens (human) | IC50 | 0.7300 | 1 | 1 |
| (e)-3-(2,3,4,5-tetrabromophenyl)acrylic acid | Homo sapiens (human) | IC50 | 0.1100 | 1 | 0 |
| cx 4945 | Homo sapiens (human) | IC50 | 1.0930 | 12 | 12 |
| cx 4945 | Homo sapiens (human) | Ki | 0.0003 | 3 | 3 |
| entrectinib | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| nms-p118 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| cx 5011 | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| palinurin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one) | Homo sapiens (human) | IC50 | 0.4150 | 2 | 2 |
| XL413 | Homo sapiens (human) | IC50 | 0.2150 | 1 | 1 |
| nms-e973 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4,5,6,7-tetrabromo-2-azabenzimidazole | Homo sapiens (human) | Kd | 0.7900 | 1 | 1 |
| pd 184352 | Homo sapiens (human) | EC50 | 0.1000 | 1 | 1 |
| cx 4945 | Homo sapiens (human) | EC50 | 3.1500 | 2 | 2 |
| cx 5011 | Homo sapiens (human) | EC50 | 0.2700 | 1 | 1 |
Enables
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin binding | molecular function | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130] |
| protein serine/threonine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] |
| signaling receptor binding | molecular function | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein kinase regulator activity | molecular function | Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai] |
| protein domain specific binding | molecular function | Binding to a specific domain of a protein. [GOC:go_curators] |
| protein-macromolecule adaptor activity | molecular function | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| RNA polymerase II-specific DNA-binding transcription factor binding | molecular function | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw] |
Located In
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| secretory granule lumen | cellular component | The volume enclosed by the membrane of a secretory granule. [GOC:rph] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| PML body | cellular component | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. [GOC:ma, PMID:10944585] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Part Of
This protein is part of 3 target(s):
| Target | Category | Definition |
|---|---|---|
| PcG protein complex | cellular component | A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. [PMID:9372908] |
| protein kinase CK2 complex | cellular component | A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. [GOC:mah, PMID:10994779] |
| chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
Involved In
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|---|---|
| signal transduction | biological process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| negative regulation of cell population proliferation | biological process | Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] |
| Wnt signaling pathway | biological process | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397] |
| peptidyl-threonine phosphorylation | biological process | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038] |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah] |
| positive regulation of activin receptor signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl] |
| adiponectin-activated signaling pathway | biological process | The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:20536390] |
| negative regulation of blood vessel endothelial cell migration | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators] |
| regulation of DNA binding | biological process | Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:ai, GOC:dph, GOC:tb] |
| positive regulation of SMAD protein signal transduction | biological process | Any process that increases the rate, frequency or extent of SMAD protein signal transduction. [GOC:BHF, GOC:dph, GOC:tb] |
| endothelial tube morphogenesis | biological process | The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. [GOC:dph, GOC:yaf] |
| protein-containing complex assembly | biological process | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. [GOC:jl] |
| symbiont-mediated disruption of host cell PML body | biological process | The process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:BHF, GOC:jl] |
| negative regulation of viral life cycle | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle. [GO_REF:0000058, GOC:TermGenie, PMID:18005716] |