Proteins > Casein kinase II subunit beta
Page last updated: 2024-08-07 16:54:00

Casein kinase II subunit beta

A casein kinase II subunit beta that is encoded in the genome of human. [PRO:DNx]

Synonyms

CK II beta;
Phosvitin;
Protein G5a

Research

Bioassay Publications (53)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (3.77)18.2507
2000's15 (28.30)29.6817
2010's30 (56.60)24.3611
2020's6 (11.32)2.80

Compounds (48)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4,5,6,7-tetrabromo-2-azabenzimidazoleHomo sapiens (human)IC500.732587
4,5,6,7-tetrabromo-2-azabenzimidazoleHomo sapiens (human)Ki1.550022
chromone-2-carboxylic acidHomo sapiens (human)IC505.980011
emodinHomo sapiens (human)IC500.866765
emodinHomo sapiens (human)Ki1.900011
n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamideHomo sapiens (human)Ki950.000011
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-oneHomo sapiens (human)IC506.900011
mitoxantroneHomo sapiens (human)IC500.660011
1,2,5,8-tetrahydroxy anthraquinoneHomo sapiens (human)Ki0.060011
3,4-dichlorobenzoic acidHomo sapiens (human)IC505,000.000011
dichlororibofuranosylbenzimidazoleHomo sapiens (human)Ki23.000011
boldineHomo sapiens (human)IC500.700011
staurosporineHomo sapiens (human)IC5035.600033
norharmanHomo sapiens (human)IC5025.000011
7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazineHomo sapiens (human)IC50100.000011
purvalanol bHomo sapiens (human)IC5010.000011
h 89Homo sapiens (human)Ki136.700011
purvalanol aHomo sapiens (human)IC5010.000011
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dioneHomo sapiens (human)IC50100.000011
4,5,6,7-tetrabromobenzimidazoleHomo sapiens (human)IC500.810032
4,5,6,7-tetrabromobenzimidazoleHomo sapiens (human)Ki0.300011
quercetinHomo sapiens (human)IC501.650055
quercetinHomo sapiens (human)Ki1.180011
apigeninHomo sapiens (human)IC500.850044
luteolinHomo sapiens (human)IC500.833332
kaempferolHomo sapiens (human)IC500.700022
baicaleinHomo sapiens (human)IC5010.000011
chrysinHomo sapiens (human)IC509.000011
fisetinHomo sapiens (human)IC500.566733
fisetinHomo sapiens (human)Ki0.170011
morinHomo sapiens (human)IC5010.000022
myricetinHomo sapiens (human)IC500.940033
coumestrolHomo sapiens (human)IC500.200011
coumestrolHomo sapiens (human)Ki7.670011
ellagic acidHomo sapiens (human)IC500.040022
as 605240Homo sapiens (human)IC500.020011
casein kinase iiHomo sapiens (human)IC502.230055
casein kinase iiHomo sapiens (human)Ki0.040022
jnj-7706621Homo sapiens (human)IC50100.000011
jnj 10198409Homo sapiens (human)IC50100.000011
ps1145Homo sapiens (human)IC5025.000011
leucettamine bHomo sapiens (human)IC50100.000011
danusertibHomo sapiens (human)IC5010.000011
as 252424Homo sapiens (human)IC500.020011
2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamideHomo sapiens (human)IC500.730011
(e)-3-(2,3,4,5-tetrabromophenyl)acrylic acidHomo sapiens (human)IC500.110010
cx 4945Homo sapiens (human)IC501.09301212
cx 4945Homo sapiens (human)Ki0.000333
entrectinibHomo sapiens (human)IC5010.000011
nms-p118Homo sapiens (human)IC5010.000011
cx 5011Homo sapiens (human)IC500.003011
palinurinHomo sapiens (human)IC50100.000011
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)Homo sapiens (human)IC500.415022
XL413Homo sapiens (human)IC500.215011
nms-e973Homo sapiens (human)IC500.010011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4,5,6,7-tetrabromo-2-azabenzimidazoleHomo sapiens (human)Kd0.790011
pd 184352Homo sapiens (human)EC500.100011
cx 4945Homo sapiens (human)EC503.150022
cx 5011Homo sapiens (human)EC500.270011

Enables

This protein enables 10 target(s):

TargetCategoryDefinition
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
protein serine/threonine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
signaling receptor bindingmolecular functionBinding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein kinase regulator activitymolecular functionModulates the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]
protein domain specific bindingmolecular functionBinding to a specific domain of a protein. [GOC:go_curators]
protein-macromolecule adaptor activitymolecular functionThe binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
RNA polymerase II-specific DNA-binding transcription factor bindingmolecular functionBinding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]

Located In

This protein is located in 8 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
secretory granule lumencellular componentThe volume enclosed by the membrane of a secretory granule. [GOC:rph]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
ficolin-1-rich granule lumencellular componentAny membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
PML bodycellular componentA class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. [GOC:ma, PMID:10944585]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
PcG protein complexcellular componentA chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. [PMID:9372908]
protein kinase CK2 complexcellular componentA protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. [GOC:mah, PMID:10994779]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 14 target(s):

TargetCategoryDefinition
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
negative regulation of cell population proliferationbiological processAny process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
Wnt signaling pathwaybiological processThe series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397]
peptidyl-threonine phosphorylationbiological processThe phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038]
negative regulation of proteasomal ubiquitin-dependent protein catabolic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]
positive regulation of activin receptor signaling pathwaybiological processAny process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]
adiponectin-activated signaling pathwaybiological processThe series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:20536390]
negative regulation of blood vessel endothelial cell migrationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]
regulation of DNA bindingbiological processAny process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:ai, GOC:dph, GOC:tb]
positive regulation of SMAD protein signal transductionbiological processAny process that increases the rate, frequency or extent of SMAD protein signal transduction. [GOC:BHF, GOC:dph, GOC:tb]
endothelial tube morphogenesisbiological processThe process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. [GOC:dph, GOC:yaf]
protein-containing complex assemblybiological processThe aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. [GOC:jl]
symbiont-mediated disruption of host cell PML bodybiological processThe process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:BHF, GOC:jl]
negative regulation of viral life cyclebiological processAny process that stops, prevents or reduces the frequency, rate or extent of viral life cycle. [GO_REF:0000058, GOC:TermGenie, PMID:18005716]