Compounds > mumbaistatin
Page last updated: 2024-11-11

mumbaistatin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

mumbaistatin: inhibits glucose-6-phosphate translocase; isolated from Streptomyces sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9850474
CHEMBL ID238371
SCHEMBL ID13238512
MeSH IDM0393711

Synonyms (9)

Synonym
CHEMBL238371
mumbaistatin
SCHEMBL13238512
bdbm50476959
1-[2-(5-carboxy-4-hydroxypentanoyl)-6-hydroxybenzoyl]-3,8-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
mumbaistatin (1)
Q44207859
DTXSID701037340
252961-22-1

Research Excerpts

Overview

Mumbaistatin is an anthraquinone derivative, whose open-chain diketo form acts as a specific and powerful inhibitor of glucose-6-phosphate translocase.

ExcerptReferenceRelevance
"Mumbaistatin is an anthraquinone derivative, whose open-chain diketo form acts as a specific and powerful inhibitor of glucose-6-phosphate translocase: IC50=5 nM."( The chemical structure of mumbaistatin, a novel glucose-6-phosphate translocase inhibitor produced by Streptomyces sp. DSM 11641.
Hammann, P; Kurz, M; Paulus, EF; Schummer, D; Vértesy, L, 2001)		1.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Glucose-6-phosphate exchanger SLC37A4Homo sapiens (human)IC50 (µMol)0.00500.00300.00400.0050AID299949
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
glucose metabolic processGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
gluconeogenesisGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
glucose-6-phosphate transportGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
phosphate ion transmembrane transportGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
protein bindingGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
glucose-6-phosphate transmembrane transporter activityGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
glucose 6-phosphate:phosphate antiporter activityGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
endoplasmic reticulumGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
endoplasmic reticulum membraneGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
membraneGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
endoplasmic reticulum membraneGlucose-6-phosphate exchanger SLC37A4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID299949Inhibition of glucose 6 phosphate translocase 12007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Structure-activity relationships of semisynthetic mumbaistatin analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.33 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.28 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.0510cobalt group element atom;
metal allergen		micronutrient
chlorogenic acid
caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.		2.0510cinnamate ester;
tannin		food component;
plant metabolite
cobaltous chloride
cobaltous chloride: RN given refers to unlabeled cpd; RN in Chemline for cobalt trichloride: 10241-04-0; RN for 60-labeled cpd: 14543-09-0; RN for 57-labeled cpd: 164113-89-1; RN for 58-labeled cpd: 29377-09-1; structure. cobalt dichloride : A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.		2.0510cobalt salt;
inorganic chloride		allergen;
calcium channel blocker;
sensitiser;
two-colour indicator
s 4048
S 4048: structure in first source		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.0510