phenacetin has been researched along with Necrosis in 14 studies
Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both phenacetin and paracetamol produce acute centrilobular liver necrosis in the homozygous Gunn rat." | 3.66 | Hepatotoxicity of phenacetin and paracetamol in the Gunn rat. ( Calder, IC; Hart, SJ; Smail, MC; Tange, JD, 1981) |
| "Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats." | 1.26 | Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ROSS, P | 1 |
| LINDENEG, O | 1 |
| FISCHER, S | 1 |
| PEDERSEN, J | 1 |
| NISSEN, NI | 1 |
| Johansson, S | 1 |
| Kunze, E | 1 |
| Wöltjen, HH | 1 |
| Hartmann, B | 1 |
| Engelhardt, W | 1 |
| Calder, IC | 1 |
| Hart, SJ | 1 |
| Smail, MC | 1 |
| Tange, JD | 1 |
| Mathew, TH | 1 |
| Mitchell, JR | 2 |
| Potter, WZ | 1 |
| Prescott, LF | 1 |
| Nelson, SD | 2 |
| Forte, AJ | 1 |
| McMurtry, RJ | 2 |
| Thorgeirsson, SS | 1 |
| Dybing, E | 1 |
| Gault, MH | 1 |
| Blennerhassett, J | 1 |
| Muehrcke, RC | 1 |
| Gloor, F | 1 |
| Brown, DM | 1 |
| Hardy, TL | 1 |
| Boyd, EM | 1 |
| Bereczky, GM | 1 |
3 reviews available for phenacetin and Necrosis
| Article | Year |
|---|---|
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1979 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
11 other studies available for phenacetin and Necrosis
| Article | Year |
|---|---|
THE RELATIONSHIP OF KIDNEY DISEASE AND PHENACETIN.
Topics: Drug Therapy; Humans; Kidney Diseases; Necrosis; Nephritis; Pathology; Phenacetin; Prognosis; Statis | 1964 |
Necrosis of the renal papillae and prolonged abuse of phenacetin.
Topics: Humans; Kidney; Kidney Diseases; Kidney Medulla; Necrosis; Phenacetin | 1959 |
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar | 1981 |
Animal experiments regarding a possible carcinogenic effect of phenacetin on the resting and proliferating urothelium stimulated by cyclophosphamide.
Topics: Animals; Cell Division; Cocarcinogenesis; Cyclophosphamide; Diet; Endothelium; Female; Hyperplasia; | 1983 |
Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.
Topics: Acetaminophen; Animals; Female; Liver; Necrosis; Nephritis, Interstitial; Phenacetin; Rats; Rats, Gu | 1981 |
Analgesic nephropathy.
Topics: Acidosis; Analgesics, Opioid; Aspirin; Australia; Dehydration; Health Education; Humans; Kidney Dise | 1976 |
Decreased toxicity of the N-methyl analogs of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Male; Mesocricetus; Meth | 1978 |
Analgesic nephropathy. A clinicopathologic study using electron microscopy.
Topics: Adult; Aspirin; Autopsy; Bacterial Infections; Basement Membrane; Beta-Globulins; Biopsy; Collagen; | 1971 |
[Bilateral chronic non-obstructive interstitial nephritides].
Topics: Aged; Female; Humans; Male; Middle Aged; Necrosis; Nephritis, Interstitial; Phenacetin | 1965 |
Short-term study of the effect of phenacetin, phenazone and amidopyrine on the rat kidney.
Topics: Albuminuria; Aminopyrine; Animals; Antipyrine; Blood Urea Nitrogen; Body Weight; Carbohydrates; Crea | 1968 |
Liver necrosis from paracetamol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Organ Size; Phenacet | 1966 |