Proteins > Sodium- and chloride-dependent GABA transporter 3
Page last updated: 2024-08-07 23:32:12

Sodium- and chloride-dependent GABA transporter 3

A sodium- and chloride-dependent GABA transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48066]

Synonyms

GAT-3;
Solute carrier family 6 member 11

Research

Bioassay Publications (10)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's8 (80.00)24.3611
2020's1 (10.00)2.80

Compounds (14)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)IC505.396245
beta-alanineHomo sapiens (human)IC5041.200022
2,3-diaminopropionic acidHomo sapiens (human)IC5031.622811
guvacineHomo sapiens (human)IC50114.500022
nipecotic acidHomo sapiens (human)IC50108.000022
tiagabineHomo sapiens (human)IC50917.000011
ci 966Homo sapiens (human)IC50333.000011
hinokininHomo sapiens (human)IC50500.000011
n-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamideHomo sapiens (human)IC50405.696023
n-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamideHomo sapiens (human)Ki100.000011
nipecotic acidHomo sapiens (human)IC5051.000022
nipecotic acid, (s)-isomerHomo sapiens (human)IC502,320.000022
2-ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamideHomo sapiens (human)IC50500.000011
nnc 05-2090Homo sapiens (human)IC508.920011
snap 5114Homo sapiens (human)IC503.427266

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
gamma-aminobutyric acid:sodium:chloride symporter activitymolecular functionEnables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). [PMID:7589472, PMID:7861179]
taurine:sodium symporter activitymolecular functionEnables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). [TC:2.A.22.3.3]
monocarboxylic acid transmembrane transporter activitymolecular functionEnables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. [GOC:ai]
amino acid bindingmolecular functionBinding to an amino acid, organic acids containing one or more amino substituents. [GOC:ai]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
presynaptic membranecellular componentA specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
postsynaptic membranecellular componentA specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]
GABA-ergic synapsecellular componentA synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell projectioncellular componentA prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
amino acid transmembrane transportbiological processThe process in which an amino acid is transported across a membrane. [GOC:dph, GOC:tb]
response to xenobiotic stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
monocarboxylic acid transportbiological processThe directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
taurine transmembrane transportbiological processThe directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
gamma-aminobutyric acid reuptakebiological processThe uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]
sodium ion transmembrane transportbiological processA process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
amino acid transportbiological processThe directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]