Page last updated: 2024-11-04

sevoflurane and Necrosis

sevoflurane has been researched along with Necrosis in 11 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"This research aimed to explore the influence of TLR deletion on sevoflurane-induced postoperative cognitive dysfunction in neonatal mice."8.12TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction. ( Guo, J; Li, Y; Wang, Q; Yin, C; Yu, J; Zhang, Q; Zhao, J, 2022)
"To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect."7.81Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury. ( Cavalcante, FP; Chaib, E; Coelho, AM; D'Albuquerque, LA; Diniz, MA; Machado, MC; Patzina, RA; Sampietre, SN, 2015)
"Sevoflurane is an inhaled anesthetic used worldwide."5.34A fatal case of fulminant hepatic necrosis following sevoflurane anesthesia. ( D'Errico, S; Fineschi, V; Neri, M; Riezzo, I; Turillazzi, E, 2007)
"This research aimed to explore the influence of TLR deletion on sevoflurane-induced postoperative cognitive dysfunction in neonatal mice."4.12TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction. ( Guo, J; Li, Y; Wang, Q; Yin, C; Yu, J; Zhang, Q; Zhao, J, 2022)
"To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect."3.81Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury. ( Cavalcante, FP; Chaib, E; Coelho, AM; D'Albuquerque, LA; Diniz, MA; Machado, MC; Patzina, RA; Sampietre, SN, 2015)
"Pre-ischaemic sevoflurane was found to reduce the extent of myocardial necrosis, but the change was not significant, whereas IP reduced IS by 50% (P= 0."3.74Pre-occlusion ischaemia, not sevoflurane, successfully preconditions the myocardium against further damage in porcine in vivo hearts. ( Aagaard, SR; Hasenkam, JM; Larsen, JR; Sloth, E, 2007)
"The liver of all rats given halothane (14% O(2)) had extensive centrilobular necrosis and denaturation."3.73Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. ( Li, Q; Liu, ZQ; Yang, LQ; Yu, WF; Zhou, MT, 2005)
"Compound A, a degradation product of sevoflurane, causes renal corticomedullary necrosis in rats."3.70Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats. ( Borkowf, CB; Marchick, MR; Martin, JL; Njoku, DB; Pohl, LR; Sokoloski, EA, 1999)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Zhang, Q1
Li, Y1
Yu, J1
Yin, C1
Guo, J1
Zhao, J1
Wang, Q1
Wang, WY1
Yi, WQ1
Liu, YS1
Hu, QY1
Qian, SJ1
Liu, JT1
Mao, H1
Cai, F1
Yang, HL1
Chondrogiannis, K1
Hadziyannis, E1
Fassoulaki, A1
Cavalcante, FP1
Coelho, AM1
Machado, MC1
Sampietre, SN1
Patzina, RA1
Diniz, MA1
Chaib, E1
D'Albuquerque, LA1
Zangrillo, A1
Testa, V1
Aldrovandi, V1
Tuoro, A1
Casiraghi, G1
Cavenago, F1
Messina, M1
Bignami, E1
Landoni, G1
Yu, WF1
Yang, LQ1
Zhou, MT1
Liu, ZQ1
Li, Q1
Bouwman, RA1
van't Hof, FN1
de Ruijter, W1
van Beek-Harmsen, BJ1
Musters, RJ1
de Lange, JJ1
Boer, C1
Larsen, JR1
Aagaard, SR1
Hasenkam, JM1
Sloth, E1
Turillazzi, E1
D'Errico, S1
Neri, M1
Riezzo, I1
Fineschi, V1
Yan, M1
Chen, C1
Zhang, F1
Chen, G1
Njoku, DB1
Pohl, LR1
Sokoloski, EA1
Marchick, MR1
Borkowf, CB1
Martin, JL1

Trials

1 trial available for sevoflurane and Necrosis

ArticleYear
Volatile agents for cardiac protection in noncardiac surgery: a randomized controlled study.
    Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:6

    Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave

2011

Other Studies

10 other studies available for sevoflurane and Necrosis

ArticleYear
TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction.
    Aging, 2022, 06-06, Volume: 14, Issue:11

    Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cognitive Dysfunction; Hippocampus; Methyl Ethers; Mice

2022
Z-DNA/RNA Binding Protein 1 Senses Mitochondrial DNA to Induce Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Driven Necroptosis in Developmental Sevoflurane Neurotoxicity.
    Neuroscience, 2022, 12-15, Volume: 507

    Topics: Apoptosis; DNA, Mitochondrial; DNA, Z-Form; Humans; Necroptosis; Necrosis; Protein Kinases; Receptor

2022
Propofol or sevoflurane anaesthesia does not affect hepatic integrity as assessed by the M30 & M65 cell death markers & liver enzymes.
    The Indian journal of medical research, 2014, Volume: 140, Issue:5

    Topics: Aged; Alanine Transaminase; Anesthesia; Apoptosis; Aspartate Aminotransferases; Female; Humans; Kera

2014
Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury.
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:11

    Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Aspartate Aminotransferases; Capillary Perme

2015
Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats.
    World journal of gastroenterology, 2005, Aug-28, Volume: 11, Issue:32

    Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Calcium; Chemical and Drug Induced Liver Inj

2005
The mechanism of sevoflurane-induced cardioprotection is independent of the applied ischaemic stimulus in rat trabeculae.
    British journal of anaesthesia, 2006, Volume: 97, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Apoptosis; Enzyme Activation; Heart Ventricles; Hypoxia; Ischemic

2006
Pre-occlusion ischaemia, not sevoflurane, successfully preconditions the myocardium against further damage in porcine in vivo hearts.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Cardiotonic Agents; Coronary Circulation; Disease

2007
A fatal case of fulminant hepatic necrosis following sevoflurane anesthesia.
    Toxicologic pathology, 2007, Volume: 35, Issue:6

    Topics: Aged; Anesthetics, Inhalation; Calcium; Fatal Outcome; Humans; Liver; Male; Methyl Ethers; Microscop

2007
Lidocaine abolishes the myocardial protective effect of sevoflurane post-conditioning.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:1

    Topics: Animals; Biomarkers; Cardiotonic Agents; Heart; Heart Ventricles; In Vitro Techniques; KATP Channels

2008
Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats.
    Anesthesiology, 1999, Volume: 90, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Carbon-Sulfur Lyases; Ethers; Hydrocarbons, Fluorinated; Kidney; M

1999