Page last updated: 2024-11-04

vorinostat and Necrosis

vorinostat has been researched along with Necrosis in 4 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" We report on a 51-year-old patient with tumor-stage mycosis fungoides who developed several unusual features such as extensive necrosis of lymphoma lesions, granulomatous reaction, and venular thromboses while under treatment with bexarotene, vorinostat, and high-dose fenofibrate."7.74Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate. ( Assaf, C; Beyer, M; Lukowsky, A; Roewert-Huber, J; Steinhoff, M; Sterry, W, 2008)
" We report on a 51-year-old patient with tumor-stage mycosis fungoides who developed several unusual features such as extensive necrosis of lymphoma lesions, granulomatous reaction, and venular thromboses while under treatment with bexarotene, vorinostat, and high-dose fenofibrate."3.74Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate. ( Assaf, C; Beyer, M; Lukowsky, A; Roewert-Huber, J; Steinhoff, M; Sterry, W, 2008)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, D1
Zhao, M1
Chen, G1
Cheng, X1
Han, X1
Lin, S1
Zhang, X1
Yu, X1
Lai, F1
Guo, ST1
Jin, L1
Jiang, CC1
Wang, CY1
Croft, A1
Chi, MN1
Tseng, HY1
Farrelly, M1
Atmadibrata, B1
Norman, J1
Liu, T1
Hersey, P1
Zhang, XD1
Booth, L1
Roberts, JL1
Conley, A1
Cruickshanks, N1
Ridder, T1
Grant, S1
Poklepovic, A1
Dent, P1
Steinhoff, M1
Beyer, M1
Roewert-Huber, J1
Lukowsky, A1
Assaf, C1
Sterry, W1

Other Studies

4 other studies available for vorinostat and Necrosis

ArticleYear
The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways.
    Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; CASP8 and FADD-Like Apoptosis Regulatin

2013
Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3.
    Cell death & disease, 2013, Jun-06, Volume: 4

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Synergism; Gene Knockdown Tech

2013
HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells.
    Cancer biology & therapy, 2014, Mar-01, Volume: 15, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Fem

2014
Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate.
    Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:5 Suppl 1

    Topics: Acute Disease; Anticarcinogenic Agents; Bexarotene; Biopsy; Drug Eruptions; Female; Fenofibrate; Fev

2008