vorinostat and Necrosis
vorinostat has been researched along with Necrosis in 4 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report on a 51-year-old patient with tumor-stage mycosis fungoides who developed several unusual features such as extensive necrosis of lymphoma lesions, granulomatous reaction, and venular thromboses while under treatment with bexarotene, vorinostat, and high-dose fenofibrate." | 7.74 | Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate. ( Assaf, C; Beyer, M; Lukowsky, A; Roewert-Huber, J; Steinhoff, M; Sterry, W, 2008) |
| " We report on a 51-year-old patient with tumor-stage mycosis fungoides who developed several unusual features such as extensive necrosis of lymphoma lesions, granulomatous reaction, and venular thromboses while under treatment with bexarotene, vorinostat, and high-dose fenofibrate." | 3.74 | Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate. ( Assaf, C; Beyer, M; Lukowsky, A; Roewert-Huber, J; Steinhoff, M; Sterry, W, 2008) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wang, D | 1 |
| Zhao, M | 1 |
| Chen, G | 1 |
| Cheng, X | 1 |
| Han, X | 1 |
| Lin, S | 1 |
| Zhang, X | 1 |
| Yu, X | 1 |
| Lai, F | 1 |
| Guo, ST | 1 |
| Jin, L | 1 |
| Jiang, CC | 1 |
| Wang, CY | 1 |
| Croft, A | 1 |
| Chi, MN | 1 |
| Tseng, HY | 1 |
| Farrelly, M | 1 |
| Atmadibrata, B | 1 |
| Norman, J | 1 |
| Liu, T | 1 |
| Hersey, P | 1 |
| Zhang, XD | 1 |
| Booth, L | 1 |
| Roberts, JL | 1 |
| Conley, A | 1 |
| Cruickshanks, N | 1 |
| Ridder, T | 1 |
| Grant, S | 1 |
| Poklepovic, A | 1 |
| Dent, P | 1 |
| Steinhoff, M | 1 |
| Beyer, M | 1 |
| Roewert-Huber, J | 1 |
| Lukowsky, A | 1 |
| Assaf, C | 1 |
| Sterry, W | 1 |
Other Studies
4 other studies available for vorinostat and Necrosis
| Article | Year |
|---|---|
The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; CASP8 and FADD-Like Apoptosis Regulatin | 2013 |
Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Synergism; Gene Knockdown Tech | 2013 |
HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Fem | 2014 |
Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate.
Topics: Acute Disease; Anticarcinogenic Agents; Bexarotene; Biopsy; Drug Eruptions; Female; Fenofibrate; Fev | 2008 |