Page last updated: 2024-08-03 12:42:32

ver 155008

Description

VER 155008: structure in first source [MeSH]

4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]-9-purinyl]-3,4-dihydroxy-2-oxolanyl]methoxymethyl]benzonitrile : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	25195348
CHEMBL ID	470334
SCHEMBL ID	16046542
CHEBI ID	95010
MeSH ID	M0548134

Synonyms (48)

Synonym
4-[[(2r,3s,4r,5r)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile
3fd ,
adenosine-derived inhibitor, 12
adenosine-derived inhibitor (grp78), 13
bdbm32378
ver-155008
CHEMBL470334
1134156-31-2
5'-o-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
AKOS016003983
4IO8
S7751
BRD-K32330832-001-01-0
smr004701641
MLS006010638
4-((((2r,3s,4r,5r)-5-(6-amino-8-(3,4-dichlorobenzylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile
CS-3823
SCHEMBL16046542
c25h23cl2n7o4
4-((((2r,3s,4r,5r)-5-(6-amino-8-((3,4-dichlorobenzyl)amino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile
ver 155008
HY-10941
5'-o-[(4-cyanophenyl)methyl]-8-{[(3,4-dichlorophenyl)methyl]amino}adenosine
DTXSID00649014
ver155008
J-002962
4-({[(2r,3s,4r,5r)-5-(6-amino-8-{[(3,4-dichlorophenyl)methyl]amino}-9h-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}methyl)benzonitrile
CHEBI:95010
8-(3,4-dichlorobenzyl)amino-5-o-(4-cyano-benzyl)adenosine
mfcd18086892
AS-73530
AC-33008
ver-155008, >=98% (hplc)
NCGC00263143-04
5'-o-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)-methyl]amino]-adenosine
5'-o-(4-cyanobenzyl)-8-[(3,4-dichlorobenzyl)amino]adenosine
4-[[(2r,3s,4r,5r)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethyl]benzonitrile
Q27166771
4-[[(2r,3s,4r,5r)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]-9-purinyl]-3,4-dihydroxy-2-oxolanyl]methoxymethyl]benzonitrile
EX-A2275
ver-155008;ver155008
BCP11966
adenosine, 5'-o-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-
CCG-270034
A848921
5'-o-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine;4-((((2s,3r,4s,5s)-5-(8-(3,4-dichlorobenzylamino)-6-amino-9h-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methoxy)methyl)benzonitrile
F12804
NCGC00263143-02

Drug Classes (1)

Class	Description
purine nucleoside

Protein Targets (12)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
PPM1D protein	Homo sapiens (human)	Potency	37.0259	AID1347411
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	0.0674	AID1645841
G	Vesicular stomatitis virus	Potency	10.6840	AID1645842
cytochrome P450 2D6	Homo sapiens (human)	Potency	10.6840	AID1645840
Interferon beta	Homo sapiens (human)	Potency	30.4404	AID1347411; AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	10.6840	AID1645842
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	10.6840	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	10.6840	AID1645842

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Heat shock 70 kDa protein 1A	Homo sapiens (human)	IC50	0.5000	AID1799195
Heat shock 70 kDa protein 1A	Homo sapiens (human)	Ki	0.1200	AID1799593
Endoplasmic reticulum chaperone BiP	Homo sapiens (human)	IC50	0.8000	AID1590352
Heat shock cognate 71 kDa protein	Homo sapiens (human)	IC50	10.4000	AID527458
Heat shock-related 70 kDa protein 2	Homo sapiens (human)	Ki	0.1998	AID1617534

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Heat shock 70 kDa protein 1A	Homo sapiens (human)	Kd	0.2267	AID1799196; AID1799592
Endoplasmic reticulum chaperone BiP	Homo sapiens (human)	Kd	0.1650	AID1799592; AID600785; AID600788

Bioassays (32)

Assay ID	Title	Year	Journal	Article
AID393510	Inhibition of HSP70 in human HCT116 cells assessed as reduction of Raf1 protein levels after 24 hrs by Western blot	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID393506	Displacement of fluorescein labeled N6-(6-amino)hexyl-ATP-5-FAM from HSP70 by fluorescence polarization assay	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID1617534	Covalent inhibition of HSP72-NBD (unknown origin) nucleotide-derived FP probe displacement based by fluorescence polarization assay	2019	Journal of medicinal chemistry, 12-26, Volume: 62, Issue:24 ISSN: 1520-4804	Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.
AID600789	Antiproliferative activity against human HCT116 cells	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12 ISSN: 1520-4804	Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
AID1315393	Inhibition of HSP70 (unknown origin) ATPase activity at 200 uM incubated on shaker for 10 mins followed by 30 mins incubation by malachite green reagent based colorimetric assay	2016	European journal of medicinal chemistry, Aug-25, Volume: 119ISSN: 1768-3254	Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N'-disubstituted thiourea derivatives.
AID393508	Cytotoxicity against human HCT116 cells by SRB assay	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID600788	Binding affinity to Grp78 by isothermal titration calorimetric analysis	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12 ISSN: 1520-4804	Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
AID1315394	Inhibition of HSP70 (unknown origin) ATPase activity incubated on shaker for 10 mins followed by 30 mins incubation by malachite green reagent based colorimetric assay	2016	European journal of medicinal chemistry, Aug-25, Volume: 119ISSN: 1768-3254	Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N'-disubstituted thiourea derivatives.
AID1202677	Inhibition of HSP70 (unknown origin) at 200 uM pre-incubated for 30 mins followed by ATP addiction and measured after 3 hrs by malachite green reagent based colorimetric assay	2015	European journal of medicinal chemistry, Jun-05, Volume: 97ISSN: 1768-3254	Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors.
AID600785	Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12 ISSN: 1520-4804	Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
AID393507	Binding affinity to HSP70 by Biocore direct binding assay	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID1590353	Inhibition of GRP78 (26 to 636 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 cells pre-incubated for 10 mins before FITC-NRLLLTG fluorescent peptide addition in presence of 100 uM ADP followed by further incubation for 2 hrs by fluores	2019	Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14 ISSN: 1464-3405	A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
AID600786	Binding affinity to HSP70 by surface plasmon resonance analysis	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12 ISSN: 1520-4804	Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
AID527458	Binding affinity to Hsp70 nucleotide binding domain in human BT474 cells	2010	Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 ISSN: 1520-4804	ATPases as drug targets: insights from heat shock proteins 70 and 90.
AID527459	Binding affinity to Hsp70 nucleotide binding domain	2010	Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20 ISSN: 1520-4804	ATPases as drug targets: insights from heat shock proteins 70 and 90.
AID600787	Inhibition of HSP70 by fluorescence polarization assay	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12 ISSN: 1520-4804	Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
AID1691289	Binding affinity to N-terminal His-tagged GRP78 (unknown origin) assessed as change in melting temperature at 500 uM by differential scanning fluorimetry	2020	European journal of medicinal chemistry, May-01, Volume: 193ISSN: 1768-3254	Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy.
AID393511	Binding affinity to HSP90 by fluorescence polarization assay	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID1202675	Binding affinity to human HSP70 at 25 degC by surface plasmon resonance assay	2015	European journal of medicinal chemistry, Jun-05, Volume: 97ISSN: 1768-3254	Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors.
AID393509	Inhibition of HSP70 in human HCT116 cells assessed as reduction of He2 protein levels after 24 hrs by Western blot	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID1590352	Inhibition of GRP78 (26 to 636 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 cells pre-incubated for 10 mins before FITC-NRLLLTG fluorescent peptide addition in presence of 10 uM ADP followed by further incubation for 2 hrs by fluoresc	2019	Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14 ISSN: 1464-3405	A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 ISSN: 2472-5560	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1799592	SPR assay from Article 10.1021/jm101625x: \\Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.\\	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12 ISSN: 1520-4804	Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
AID1799195	HSP70 Fluorescence Polarization Assay from Article 10.1021/jm801627a: \\Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.\\	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID1799593	Fluorescence-Polarization (FP) Binding Assay from Article 10.1021/jm101625x: \\Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.\\	2011	Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12 ISSN: 1520-4804	Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
AID1799196	HSP70 Biacore Direct Binding Assay from Article 10.1021/jm801627a: \\Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.\\	2009	Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6 ISSN: 1520-4804	Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
AID1347411	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2013	PloS one, , Volume: 8, Issue:11 ISSN: 1932-6203	Functional analysis of Hsp70 inhibitors.

Research

Studies (56)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (1.79)	29.6817
2010's	41 (73.21)	24.3611
2020's	14 (25.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (1.79%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	55 (98.21%)	84.16%

Substance	Classes	Roles	Relationship Strength
9-xylosyladenine	purine nucleoside		low
2-[6-(cyclohexylamino)-9-purinyl]-5-(hydroxymethyl)oxolane-3,4-diol	purine nucleoside		low
apnea	purine nucleoside		low
2-chloroadenosine	purine nucleoside		low
hyaluronoglucosaminidase	purine nucleoside		low
vidarabine	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic	low
isoguanosine	purine nucleoside		low
psicofuranine	psicose derivative; purine nucleoside		low
4-nitrobenzylthioinosine	purine nucleoside		low
2-aminoadenosine	purine nucleoside		low
phenylisopropyladenosine	aromatic amine; benzenes; hydrocarbyladenosine; purine nucleoside; secondary amino compound	adenosine A1 receptor agonist; neuroprotective agent	low
8-bromoadenosine	purine nucleoside		low
n-allyladenosine	purine nucleoside		low
adenosine-5'-carboxylic acid	purine nucleoside		low
n(6)-phenyladenosine	purine nucleoside		low
1,7-dimethylguanosine	purine nucleoside		low
8-methyladenosine	purine nucleoside		low
regadenoson	purine nucleoside		low
fludarabine	purine nucleoside		low
6-thioguanosine	purine nucleoside		low
5-(6-aminopurin-9-yl)-N-ethyl-3,4-dihydroxy-2-oxolanecarboxamide	purine nucleoside		low
nelarabine	beta-D-arabinoside; monosaccharide derivative; purine nucleoside	antineoplastic agent; DNA synthesis inhibitor; prodrug	low
(2R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	purine nucleoside		low
cv 1808	purine nucleoside		low
n-((1s,trans)-2-hydroxycyclopentyl)adenosine	purine nucleoside		low
8-hydroxyguanosine	purine nucleoside		low
8-bromoguanosine	purine nucleoside		low
9-arabinofuranosylguanine	beta-D-arabinoside; purine nucleoside	antineoplastic agent; DNA synthesis inhibitor	low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's
bithionol	1	aryl sulfide; bridged diphenyl antifungal drug; bridged diphenyl fungicide; dichlorobenzene; organochlorine pesticide; polyphenol	antifungal agrochemical; antiplatyhelmintic drug	2019	2019	5.0	low	0	1
dichlorophen	1	bridged diphenyl fungicide; diarylmethane		2019	2019	5.0	low	0	1
hexachlorophene	1	bridged diphenyl fungicide; polyphenol; trichlorobenzene	acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug	2019	2019	5.0	low	0	1
triclosan	1	aromatic ether; dichlorobenzene; monochlorobenzenes; phenols	antibacterial agent; antimalarial; drug allergen; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; fungicide; persistent organic pollutant; xenobiotic	2019	2019	5.0	low	0	1
adenosine diphosphate	4	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite	2009	2020	11.5	low	2	2
2,2'-methylenebis(ethyl-6-tert-butylphenol)	1			2019	2019	5.0	medium	0	1
2,2'-methylenebis(4-methyl-6-tert-butylphenol)	1	diarylmethane		2019	2019	5.0	medium	0	1
oxyclozanide	1			2019	2019	5.0	low	0	1
paclitaxel	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent	2019	2019	5.0	low	0	1
adenosine	1	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent	2009	2009	15.0	low	1	0
epigallocatechin gallate	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite	2020	2020	4.0	low	0	1
honokiol	1	biphenyls		2020	2020	4.0	low	0	1
2,2'-bisphenol f	1	diarylmethane		2019	2019	5.0	medium	0	1
8-aminoadenosine	2			2009	2011	14.0	medium	1	1
5'-(sulfonylbenzoyl)adenosine	1			2019	2019	5.0	medium	0	1
lapatinib	1	furans; organochlorine compound; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor	2015	2015	9.0	low	0	1
caffeic acid phenethyl ester	1	alkyl caffeate ester	anti-inflammatory agent; antibacterial agent; antineoplastic agent; antioxidant; antiviral agent; immunomodulator; metabolite; neuroprotective agent	2020	2020	4.0	low	0	1
cnf 2024	1	2-aminopurines; aromatic ether; organochlorine compound; pyridines	antineoplastic agent; Hsp90 inhibitor	2010	2010	14.0	low	1	0
ver 52296	1	aromatic amide; isoxazoles; monocarboxylic acid amide; morpholines; resorcinols	angiogenesis inhibitor; antineoplastic agent; Hsp90 inhibitor	2010	2010	14.0	low	1	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2010's	post-2020
carbamates	1	amino-acid anion		2019	2019	5.0	low	1	0
urea	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2021	2021	3.0	low	0	1
phenylephrine	1	phenols; phenylethanolamines; secondary amino compound	alpha-adrenergic agonist; cardiotonic drug; mydriatic agent; nasal decongestant; protective agent; sympathomimetic agent; vasoconstrictor agent	2020	2020	4.0	low	1	0
rhodamine b	1	organic chloride salt; xanthene dye	fluorescent probe; fluorochrome; histological dye	2015	2015	9.0	low	1	0
isoxazoles	1	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		2022	2022	2.0	low	0	1
thiazoles	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		2014	2014	10.0	low	1	0
pyrazines	1	diazine; pyrazines	Daphnia magna metabolite	2015	2015	9.0	low	1	0
kainic acid	1	dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid	antinematodal drug; excitatory amino acid agonist	2015	2015	9.0	low	1	0
thiazolidines	2	thiazolidine		2017	2018	6.5	low	2	0
2-tert-butylhydroquinone	1	hydroquinones	food antioxidant	2012	2012	12.0	low	1	0
gold	1	copper group element atom; elemental gold		2015	2015	9.0	low	1	0
triazoles	1	1,2,3-triazole		2015	2015	9.0	low	1	0
hp 873	1	1,2-benzoxazoles; aromatic ether; aromatic ketone; methyl ketone; monoamine; organofluorine compound; piperidines; tertiary amino compound	dopaminergic antagonist; second generation antipsychotic; serotonergic antagonist	2022	2022	2.0	low	0	1
fibrinogen	1	iditol	fungal metabolite	2017	2017	7.0	low	1	0
sb 203580	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent	2017	2017	7.0	low	1	0
2-phenylethylenesulfonamide	1			2013	2013	11.0	medium	1	0
pifithrin mu	2	benzenes		2014	2018	8.0	low	2	0
bortezomib	3	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor	2015	2020	6.0	low	3	0
leupeptins	1			2019	2019	5.0	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1	amino aldehyde; carbamate ester; tripeptide	proteasome inhibitor	2019	2019	5.0	low	1	0
shikonin	1	hydroxy-1,4-naphthoquinone		2015	2015	9.0	low	1	0
methyl-thiohydantoin-tryptophan	1	organonitrogen compound; organooxygen compound		2015	2015	9.0	low	1	0
naphthoquinones	1			2015	2015	9.0	low	1	0
quercetin	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger	2017	2017	7.0	low	1	0
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	1	1,4-benzoquinones; ansamycin; carbamate ester; secondary amino compound; tertiary amino compound	Hsp90 inhibitor	2013	2013	11.0	low	1	0
geldanamycin	2			2015	2018	7.5	low	2	0
monorden	2	cyclic ketone; enone; epoxide; macrolide antibiotic; monochlorobenzenes; phenols	antifungal agent; metabolite; tyrosine kinase inhibitor	2014	2019	7.5	low	2	0
mkt 077	1			2014	2014	10.0	low	1	0
piperidines	1			2022	2022	2.0	low	0	1
epidermal growth factor	1			2018	2018	6.0	low	1	0
transforming growth factor beta	1			2017	2017	7.0	low	1	0
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	1			2014	2014	10.0	low	1	0
sta 9090	1	ring assembly; triazoles		2015	2015	9.0	low	1	0
pyrimidinones	1			2019	2019	5.0	low	1	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
Acute Brain Injuries	1	2012	2012	12.0	low	0	1	0
Acute Confusional Senile Dementia	1	2023	2023	1.0	low	0	0	1
Acute Myelogenous Leukemia	2	2013	2018	8.5	low	0	2	0
Alzheimer Disease	1	2023	2023	1.0	low	0	0	1
Angiogenesis, Pathologic	1	2016	2016	8.0	low	0	1	0
Asthma	1	2017	2017	7.0	low	0	1	0
Asthma, Bronchial	1	2017	2017	7.0	low	0	1	0
Autosomal Dominant Cerebellar Ataxia, Type II	1	2019	2019	5.0	low	0	1	0
B Virus Infection	1	2015	2015	9.0	low	0	1	0
Bladder Cancer	2	2015	2018	7.5	low	0	2	0
Body Weight	1	2017	2017	7.0	low	0	1	0
Bone Cancer	1	2016	2016	8.0	low	0	1	0
Bone Neoplasms	1	2016	2016	8.0	low	0	1	0
Brain Injuries	1	2012	2012	12.0	low	0	1	0
Break-Bone Fever	1	2015	2015	9.0	low	0	1	0
Breast Cancer	5	2010	2019	8.6	low	1	4	0
Breast Neoplasms	5	2010	2019	8.6	low	1	4	0
Cancer of Colon	1	2010	2010	14.0	low	1	0	0
Cancer of Lung	2	2016	2019	6.5	low	0	2	0
Cancer of Prostate	2	2017	2020	5.5	low	0	2	0
Cancer of Stomach	1	2021	2021	3.0	low	0	0	1
Cancer of the Thyroid	2	2014	2014	10.0	low	0	2	0
Carcinoma, Non-Small Cell Lung	1	2016	2016	8.0	low	0	1	0
Carcinoma, Non-Small-Cell Lung	1	2016	2016	8.0	low	0	1	0
Cognition Disorders	1	2012	2012	12.0	low	0	1	0
Colonic Neoplasms	1	2010	2010	14.0	low	1	0	0
Colorectal Cancer	2	2016	2019	6.5	low	0	2	0
Colorectal Neoplasms	2	2016	2019	6.5	low	0	2	0
Congenital Zika Syndrome	1	2020	2020	4.0	low	0	1	0
Dengue	1	2015	2015	9.0	low	0	1	0
Diffuse Large B-Cell Lymphoma	1	2017	2017	7.0	low	0	1	0
Disease Exacerbation	1	2021	2021	3.0	low	0	0	1
Disease Models, Animal	3	2012	2020	8.3	low	0	3	0
ER-Negative PR-Negative HER2-Negative Breast Cancer	1	2019	2019	5.0	low	0	1	0
Fish Diseases	2	2018	2019	5.5	low	0	2	0
Infections, Paramyxoviridae	1	2017	2017	7.0	low	0	1	0
Infections, Reoviridae	1	2018	2018	6.0	low	0	1	0
Infections, Respiratory Syncytial Virus	1	2017	2017	7.0	low	0	1	0
Inflammation	2	2015	2019	7.0	low	0	2	0
Injuries, Spinal Cord	1	2015	2015	9.0	low	0	1	0
Innate Inflammatory Response	2	2015	2019	7.0	low	0	2	0
Invasiveness, Neoplasm	2	2015	2019	7.0	low	0	2	0
Kahler Disease	2	2015	2020	6.5	low	0	2	0
Kaposi Sarcoma	1	2015	2015	9.0	low	0	1	0
Leukemia, Myeloid, Acute	2	2013	2018	8.5	low	0	2	0
Local Neoplasm Recurrence	1	2016	2016	8.0	low	0	1	0
Lung Neoplasms	2	2016	2019	6.5	low	0	2	0
Lymphoma, Large B-Cell, Diffuse	1	2017	2017	7.0	low	0	1	0
Mesothelioma	1	2021	2021	3.0	low	0	0	1
Multiple Myeloma	2	2015	2020	6.5	low	0	2	0
Necrosis	1	2015	2015	9.0	low	0	1	0
Neoplasms, Pleural	1	2021	2021	3.0	low	0	0	1
Neuroblastoma	1	2012	2012	12.0	low	0	1	0
Osteogenic Sarcoma	1	2016	2016	8.0	low	0	1	0
Osteosarcoma	1	2016	2016	8.0	low	0	1	0
Paramyxoviridae Infections	1	2017	2017	7.0	low	0	1	0
Poultry Diseases	1	2020	2020	4.0	low	0	1	0
Prostatic Neoplasms	2	2017	2020	5.5	low	0	2	0
Respiratory Syncytial Virus Infections	1	2017	2017	7.0	low	0	1	0
Sarcoma, Kaposi	1	2015	2015	9.0	low	0	1	0
Spinal Cord Injuries	1	2015	2015	9.0	low	0	1	0
Spinocerebellar Ataxias	1	2019	2019	5.0	low	0	1	0
Stomach Neoplasms	1	2021	2021	3.0	low	0	0	1
Tauopathies	1	2023	2023	1.0	low	0	0	1
Thyroid Cancer, Anaplastic	2	2014	2014	10.0	low	0	2	0
Thyroid Carcinoma, Anaplastic	2	2014	2014	10.0	low	0	2	0
Thyroid Neoplasms	2	2014	2014	10.0	low	0	2	0
Triple Negative Breast Neoplasms	1	2019	2019	5.0	low	0	1	0
Urinary Bladder Neoplasms	2	2015	2018	7.5	low	0	2	0
Zika Virus Infection	1	2020	2020	4.0	low	0	1	0

Bioavailability (1)

Article	Year
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5	2019

Dosage (1)

Article	Year
An additional physiological role for HSP70: Assistance of vascular reactivity. Life sciences, , Sep-01, Volume: 256	2020