Proteins > Hydroxycarboxylic acid receptor 2
Page last updated: 2024-08-08 00:01:22
Hydroxycarboxylic acid receptor 2
A hydroxycarboxylic acid receptor 2 that is encoded in the genome of rat. [OMA:Q80Z39, PRO:DNx]
Synonyms
G-protein coupled receptor 109;
G-protein coupled receptor 109A;
G-protein coupled receptor HM74;
Niacin receptor 1;
Nicotinic acid receptor;
Protein PUMA-G
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| niacin | Rattus norvegicus (Norway rat) | EC50 | 0.2493 | 3 | 3 |
| mk 0354 | Rattus norvegicus (Norway rat) | EC50 | 2.3000 | 1 | 1 |
| mk 6892 | Rattus norvegicus (Norway rat) | EC50 | 4.6000 | 1 | 1 |
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.ACS medicinal chemistry letters, , Jan-12, Volume: 3, Issue:1, 2012
Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008