A protein orai-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BRQ5]
Transmembrane protein 142C
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| diphenhydramine | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| benzohydrol | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| diphenylborinic acid | Homo sapiens (human) | IC50 | 9.2500 | 2 | 2 |
| methaneboronic acid | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| gsk-7975a | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| store-operated calcium channel activity | molecular function | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| store-operated calcium entry | biological process | A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. [GOC:hjd, PMID:11120592, PMID:17956991] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |