Proteins > Calcium/calmodulin-dependent protein kinase type 1G
Page last updated: 2024-08-07 19:34:43

Calcium/calmodulin-dependent protein kinase type 1G

A calcium/calmodulin-dependent protein kinase type 1G that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96NX5]

Synonyms

EC 2.7.11.17;
CaM kinase I gamma;
CaM kinase IG;
CaM-KI gamma;
CaMKI gamma;
CaMKIG;
CaMK-like CREB kinase III;
CLICK III

Research

Bioassay Publications (6)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Compounds (95)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.004622

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd10.000022
pyrazolanthroneHomo sapiens (human)Kd4.200011
staurosporineHomo sapiens (human)Kd0.033033
gefitinibHomo sapiens (human)Kd10.000022
lestaurtinibHomo sapiens (human)Kd0.470011
vatalanibHomo sapiens (human)Kd10.000022
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd10.000022
birb 796Homo sapiens (human)Kd10.000022
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd10.000022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd10.000022
pd 173955Homo sapiens (human)Kd10.000011
s 1033Homo sapiens (human)Kd10.000011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd10.000022
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd10.000022
zd 6474Homo sapiens (human)Kd10.000022
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
sirolimusHomo sapiens (human)Kd30.000011
alvocidibHomo sapiens (human)Kd10.000022
bosutinibHomo sapiens (human)Kd10.000011
su 11248Homo sapiens (human)Kd0.623333
jnj-7706621Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd8.250022
ekb 569Homo sapiens (human)Kd10.000011
axitinibHomo sapiens (human)Kd10.000011
temsirolimusHomo sapiens (human)Kd30.000011
pd 184352Homo sapiens (human)Kd10.000011
telatinibHomo sapiens (human)Kd30.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd1.800022
ki 20227Homo sapiens (human)Kd10.000011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd16.666733
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd10.000011
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd3.700022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd10.626733
bibw 2992Homo sapiens (human)Kd10.000011
crenolanibHomo sapiens (human)Kd30.000011
tg100-115Homo sapiens (human)Kd10.000011
bms 599626Homo sapiens (human)Kd30.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.460011
brivanibHomo sapiens (human)Kd10.000011
mp470Homo sapiens (human)Kd30.000011
at 7519Homo sapiens (human)Kd10.000011
bms-690514Homo sapiens (human)Kd30.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd10.000022
kw 2449Homo sapiens (human)Kd2.100011
abt 869Homo sapiens (human)Kd10.000022
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamideHomo sapiens (human)Kd30.000011
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd20.000022
osi 906Homo sapiens (human)Kd30.000012
chir-265Homo sapiens (human)Kd10.000022
motesanibHomo sapiens (human)Kd10.000022
mln8054Homo sapiens (human)Kd10.000022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd10.000022
nvp-tae684Homo sapiens (human)Kd3.000011
2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinoneHomo sapiens (human)Kd30.000011
fedratinibHomo sapiens (human)Kd3.200011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd6.800011
plx 4720Homo sapiens (human)Kd10.000011
mln 8237Homo sapiens (human)Kd30.000011
sgx 523Homo sapiens (human)Kd10.000011
pci 32765Homo sapiens (human)Kd30.000012
quizartinibHomo sapiens (human)Kd20.000022
sns 314Homo sapiens (human)Kd30.000011
dcc-2036Homo sapiens (human)Kd30.000011
incb-018424Homo sapiens (human)Kd2.200011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd10.000011
baricitinibHomo sapiens (human)Kd30.000011
n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamideHomo sapiens (human)Kd30.000011
ribociclibHomo sapiens (human)Kd30.000011
encorafenibHomo sapiens (human)Kd30.000011
osimertinibHomo sapiens (human)Kd30.000011
chir 258Homo sapiens (human)Kd6.667033
nintedanibHomo sapiens (human)Kd0.260011
pp242Homo sapiens (human)Kd10.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein serine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]
calmodulin-dependent protein kinase activitymolecular functionCalmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. [GOC:mah, PMID:11264466]
calmodulin bindingmolecular functionBinding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
Golgi membranecellular componentThe lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
intracellular anatomical structurecellular componentA component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. [ISBN:0198506732]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
calcium- and calmodulin-dependent protein kinase complexcellular componentAn enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. [PMID:20668654]

Involved In

This protein is involved in 1 target(s):

TargetCategoryDefinition
peptidyl-serine phosphorylationbiological processThe phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]