Proteins > Peroxisome proliferator-activated receptor gamma
Page last updated: 2024-08-07 16:36:25
Peroxisome proliferator-activated receptor gamma
A peroxisome proliferator-activated receptor gamma that is encoded in the genome of mouse. [OMA:P37238, PRO:DNx]
Synonyms
PPAR-gamma;
Nuclear receptor subfamily 1 group C member 3
Research
Bioassay Publications (15)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (31)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pioglitazone | Mus musculus (house mouse) | IC50 | 0.7000 | 1 | 1 |
| tesaglitazar | Mus musculus (house mouse) | Ki | 0.2000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gw 2433 | Mus musculus (house mouse) | EC50 | 1.5000 | 1 | 1 |
| ciglitazone | Mus musculus (house mouse) | EC50 | 3.0000 | 1 | 1 |
| clofibrate | Mus musculus (house mouse) | EC50 | 500.0000 | 1 | 1 |
| clofibric acid | Mus musculus (house mouse) | EC50 | 450.0000 | 2 | 2 |
| fenofibrate | Mus musculus (house mouse) | EC50 | 250.0000 | 1 | 1 |
| pioglitazone | Mus musculus (house mouse) | EC50 | 0.6200 | 2 | 2 |
| troglitazone | Mus musculus (house mouse) | EC50 | 0.8900 | 2 | 2 |
| pirinixic acid | Mus musculus (house mouse) | EC50 | 32.0000 | 1 | 1 |
| bezafibrate | Mus musculus (house mouse) | EC50 | 55.0000 | 2 | 2 |
| fenofibric acid | Mus musculus (house mouse) | EC50 | 250.0000 | 1 | 1 |
| betulinic acid | Mus musculus (house mouse) | EC50 | 100.0000 | 1 | 1 |
| telmisartan | Mus musculus (house mouse) | EC50 | 4.0600 | 1 | 1 |
| rosiglitazone | Mus musculus (house mouse) | EC50 | 0.0553 | 3 | 3 |
| mk 767 | Mus musculus (house mouse) | EC50 | 0.1400 | 1 | 1 |
| jtt 501 | Mus musculus (house mouse) | EC50 | 0.0890 | 1 | 1 |
| pectolinarin | Mus musculus (house mouse) | EC50 | 100.0000 | 1 | 1 |
| farglitazar | Mus musculus (house mouse) | EC50 | 0.0004 | 2 | 2 |
| tesaglitazar | Mus musculus (house mouse) | EC50 | 0.2500 | 2 | 2 |
| gw 7647 | Mus musculus (house mouse) | EC50 | 1.3000 | 1 | 1 |
| apigenin | Mus musculus (house mouse) | EC50 | 24.9000 | 1 | 1 |
| luteolin | Mus musculus (house mouse) | EC50 | 2.3000 | 1 | 1 |
| hispidulin | Mus musculus (house mouse) | EC50 | 7.3000 | 1 | 1 |
| scutellarein | Mus musculus (house mouse) | EC50 | 16.4000 | 1 | 1 |
| gw 1929 | Mus musculus (house mouse) | EC50 | 0.0131 | 3 | 3 |
| l-165041 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| gw 501516 | Mus musculus (house mouse) | EC50 | 1.0000 | 1 | 1 |
| gw 9578 | Mus musculus (house mouse) | EC50 | 1.8333 | 3 | 3 |
| gw 7845 | Mus musculus (house mouse) | EC50 | 0.0012 | 1 | 1 |
| l 796449 | Mus musculus (house mouse) | EC50 | 0.0100 | 1 | 1 |
| gw0742 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| gw 590735 | Mus musculus (house mouse) | EC50 | 9.8500 | 2 | 2 |
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
New PPARgamma ligands based on barbituric acid: virtual screening, synthesis and receptor binding studies.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.Bioorganic & medicinal chemistry, , May-01, Volume: 19, Issue:9, 2011
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis.Journal of natural products, , Jul-25, Volume: 77, Issue:7, 2014
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.Journal of medicinal chemistry, , Dec-03, Volume: 41, Issue:25, 1998
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.Journal of medicinal chemistry, , Aug-12, Volume: 47, Issue:17, 2004
Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 20, Issue:4, 2010
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.Journal of medicinal chemistry, , Dec-03, Volume: 41, Issue:25, 1998
Glycine amides as PPARalpha agonists.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 20, Issue:11, 2010
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007