A thymidine kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00142]
EC 2.7.1.21;
Mt-TK
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cytarabine | Homo sapiens (human) | IC50 | 1,000.0000 | 2 | 2 |
| thymine arabinoside | Homo sapiens (human) | IC50 | 285.0000 | 2 | 2 |
| 5-propyl-2'-deoxyuridine | Homo sapiens (human) | Ki | 20.0000 | 1 | 1 |
| sorivudine | Homo sapiens (human) | IC50 | 43.0000 | 1 | 1 |
| sorivudine | Homo sapiens (human) | Ki | 10.4000 | 1 | 1 |
| 9-arabinofuranosylguanine | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| deoxycytidine kinase activity | molecular function | Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. [EC:2.7.1.74] |
| thymidine kinase activity | molecular function | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. [EC:2.7.1.21] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| nucleoside kinase activity | molecular function | Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. [GOC:ai] |
| deoxynucleoside kinase activity | molecular function | Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. [EC:2.7.1.145] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| deoxyribonucleoside monophosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732] |
| nucleotide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). [GOC:go_curators] |
| pyrimidine nucleoside salvage | biological process | Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. [GOC:jl] |
| deoxycytidine metabolic process | biological process | The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. [GOC:go_curators] |
| thymidine metabolic process | biological process | The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. [GOC:go_curators] |
| DNA biosynthetic process | biological process | The biosynthetic process resulting in the formation of DNA. [GOC:mah] |