| Assay ID | Title | Year | Journal | Article |
|---|
| AID1423736 | Selectivity index, ratio of IC50 for HAF to IC50 for human HCT8 cells | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423729 | Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423746 | Induction of apoptosis in human HCT116 cells at 1 uM after 48 hrs by Annexin V/propidium iodide staining based flow cytometry relative to control | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423728 | Effect on total Ring1b protein expression in human HCT116 cells at 0.5 to 4 uM after 8 hrs by Western blot analysis | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423745 | Inhibition of cancer stem cell proliferation in human HCT116 cells assessed as CD133/CD44-positive cell population at 1 uM after 48 hrs by flow cytometry (Rvb = 85.1 to 86.6%) | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423760 | Decrease in Bmi1 expression in tumors of nude mouse xenografted with human HCT116 cells at 10 mg/kg/day, ip for 18 days by IHC analysis | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423759 | Antitumor activity against human HCT116 cells xenografted in nude mouse assessed as reduction in Ki67 expression in tumor at 10 mg/kg/day, ip for 18 days by IHC analysis | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423743 | Inhibition of colony formation in human HCT116 cells at 0.1 to 0.4 uM after 7 days by crystal violet staining based assay | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423731 | Antiproliferative activity against human HT-29 cells after 72 hrs by SRB assay | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423749 | Antitumor activity against human HCT116 cells xenografted in nude mouse assessed as tumor growth inhibition at 10 mg/kg/day, ip for 18 days | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423730 | Inhibition of Bmi1 protein expression in human HCT116 cells after 8 hrs by Western blot analysis | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID384253 | Modulation of RE1/NRSE expressed in ST14A cells assessed as increase in luciferase reporter activity at 50 nM after 72 hrs relative to control | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10
| SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease. |
| AID1423727 | Effect on total H2A protein expression in human HCT116 cells at 0.5 to 4 uM after 8 hrs by Western blot analysis | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423732 | Antiproliferative activity against human HCT8 cells after 72 hrs by SRB assay | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423735 | Selectivity index, ratio of IC50 for HAF to IC50 for human HT-29 cells | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423739 | Antimigratory activity against human HCT116 cells after 24 hrs by crystal violet staining based transwell migration assay | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423733 | Antiproliferative activity against HAF after 72 hrs by SRB assay | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423738 | Inhibition of Bmi1 in human HCT116 cells assessed as reduction in H2A-K119Ub level after 8 hrs by Western blot analysis | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423751 | Toxicity in nude mouse xenografted with human HCT116 cells assessed as change in body weight at 10 mg/kg/day, ip for 18 days | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1423734 | Selectivity index, ratio of IC50 for HAF to IC50 for human HCT116 cells | 2018 | ACS medicinal chemistry letters, Nov-08, Volume: 9, Issue:11
| Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |